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CIRCULATION RESEARCH, ISSN 0009-7330, 07/2017, Volume 121, Issue 2, pp. 181 - 195
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 10, pp. 2562 - 2567
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2015, Volume 763, Issue Pt B, pp. 143 - 148
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2016, Volume 18, Issue 3, pp. 303 - 310
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 02/2018, Volume 39, Issue 2, pp. 200 - 208
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7501, pp. 492 - 496
The BRAF kinase is mutated, typically Val 600 -> Glu (V600E), to induce an active oncogenic state in a large fraction of melanomas, thyroid cancers, hairy cell... 
ACTIVATION | MELANOMA | MEK INHIBITION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | RAS ONCOGENESIS | CATALYZED OXIDATION REACTIONS | MUTATIONS | CANCER | BETA-ADRENERGIC RECEPTOR | MASS-SPECTROMETRY | Lung Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Kinases - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Copper - metabolism | Cation Transport Proteins - genetics | Female | Hepatolenticular Degeneration - drug therapy | Indoles - pharmacology | Phosphorylation - drug effects | Cation Transport Proteins - deficiency | Chelating Agents - therapeutic use | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Lung Neoplasms - genetics | Copper - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Chelating Agents - pharmacology | Drug Repositioning | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins B-raf - genetics | Survival Analysis | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Copper in the body | Cellular signal transduction | Growth | Health aspects | Cancer cells | Proteins | Signal transduction | Phosphorylation | Diet | Melanoma | Tumorigenesis | Mutation | Kinases | Tumors
Journal Article