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06/2013
The cWnt activator, Rspondin-1 (Rspo1), has been identified as a regulator of β-cell growth and function, although its role in pathophysiological conditions... 
beta-cell | neogenesis | apoptosis | 0719 | Rspondin-1 | diabetes
Dissertation
11/2012
In order to elucidate how uncoupling protein 2 (UCP2) influences pancreatic β cells and glucose homeostasis, I have generated and characterized an inducible β... 
beta-cell function | 0719 | Physiology | Diabetes | Endocrinology
Dissertation
Endokrynologia Polska, ISSN 0423-104X, 11/2017, Volume 68, Issue 5, pp. 568 - 578
Journal Article
Journal of diabetes investigation, ISSN 2040-1116, 06/2019
We investigated associations between glucose tolerance and β-cell function using a series of estimation methods in a population-based study. Data from the... 
Journal Article
Biomedicine and Pharmacotherapy, ISSN 0753-3322, 12/2017, Volume 96, pp. 336 - 347
Diabetes mellitus is a major public health problem worldwide. Oxidative stress plays a pivotal role in the pathogenesis of diabetes as it is one of the... 
Hypoglycemic | Beta cell | Hypolipidemic | Antioxidant | Insulin | Streptozotocin
Journal Article
Experimental Cell Research, ISSN 0014-4827, 11/2019, Volume 384, Issue 1, p. 111613
The lipotoxicity is considered as one of the risk for diabetes. Here we report C-type lectin domain family 11, member A (Clec11a) as a new regulator in islet... 
Clec11a | Islet | Proliferation | Lipotoxicity | Beta cell
Journal Article
06/2011
Mechanisms to augment the cellular function and mass of beta-cells may be effective means of treating type 2 diabetes. Important in the physiological control... 
GLP-1 | beta-cell | 0564 | incretin | 0719 | diabetes | GIP
Dissertation
European Journal of Pharmacology, ISSN 0014-2999, 05/2019, Volume 850, pp. 88 - 96
Signaling through A adenosine receptor specifically prevent pancreatic β-cells (PBCs) loses under diabetogenic conditions. However, signaling mediators of this... 
adenosine receptor | Pancreatic beta Cell | CGS 21680 | Diabetes | IPP-1
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 10/2019, Volume 496, p. 110523
Xenin-25 undergoes rapid enzyme metabolism following secretion. Early studies demonstrated bioactivity of a C-terminal hexapeptide fragment of xenin-25, namely... 
Xenin-6 | Beta-cell | Diabetes | Glucagon | Insulin | Xenin-25
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 05/2019, Volume 850, pp. 88 - 96
Signaling through A adenosine receptor specifically prevent pancreatic β-cells (PBCs) loses under diabetogenic conditions. However, signaling mediators of this... 
Pancreatic beta Cell | A2a adenosine receptor | CGS 21680 | Diabetes | IPP-1
Journal Article
11/2010
Zinc levels in pancreatic islets are amongst the highest in the body and reduction in its levels in the pancreas has been associated with diabetes. The link... 
beta cell | pancreatic islet | insulin | 0719 | diabetes | zinc
Dissertation
11/2010
GABA and GABA type A receptor (GABAAR) are expressed in pancreatic β-cells and comprise an autocrine signaling system. How the GABA-GABAAR system is regulated... 
Beta-cell | GABA | Electrophysiology | GABA receptor | 0719 | Islet | Autocrine | Insulin
Dissertation
11/2013
Endoplasmic reticulum (ER) stress has been implicated as a causative factor in the development of pancreatic beta-cell dysfunction and death resulting in type... 
ATF6beta | unfolded protein response | pancreatic beta-cell | ER stress | ATF6 signaling pathway | 0719 | Diabetes | Apoptosis
Dissertation
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2017, Volume 60, Issue 5, pp. 1860 - 1875
CMPF (2-(2-carboxyethyl)-4-methyl-5-propyl- furan-3-carboxylic acid) is a metabolite that circulates at high concentrations in type 2 and gestational diabetes... 
CHEMISTRY, MEDICINAL | BETA-CELL DYSFUNCTION | 3-CARBOXY-4-METHYL-5-PROPYL-2-FURANPROPANOIC ACID | FURAN FATTY-ACIDS
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 146, Issue 5, pp. 682 - 695
Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging... 
LIFE-SPAN EXTENSION | NEURODEGENERATIVE DISEASE | CAENORHABDITIS-ELEGANS | MEDIATED AUTOPHAGY | PROMOTE LONGEVITY | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALORIC RESTRICTION | MAMMALIAN AUTOPHAGY | BETA-CELL MASS | DIETARY RESTRICTION | CELL BIOLOGY | Aging | Animals | Signal Transduction | Autophagy | Humans | Analysis | Medical genetics | Resveratrol
Journal Article
mAbs, ISSN 1942-0862, 07/2018, Volume 10, Issue 5, pp. 796 - 802
Loss-of-function mutations of the ß-cell ATP-sensitive potassium channels (K ATP ) cause the most common and severe form of congenital hyperinsulinism (K ATP... 
beta cell | hyperinsulinism | insulin | pancreas | hypoglycemia
Journal Article
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, ISSN 0021-972X, 10/2014, Volume 99, Issue 10, pp. 3551 - 3560
Context: Observational studies report consistent associations between low vitamin D concentration and increased glycemia and risk of type 2 diabetes, but... 
INSULIN-RESISTANCE | BLOOD-GLUCOSE | D-DEFICIENT | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | WEIGHT-LOSS | RANDOMIZED CONTROLLED-TRIAL | PLACEBO-CONTROLLED TRIAL | ENDOTHELIAL FUNCTION | CARDIOVASCULAR RISK-FACTORS | BETA-CELL FUNCTION
Journal Article
Clinical Nutrition, ISSN 0261-5614, 2018
Background & aims: Obesity is associated with lower breastfeeding rates. The underlying pathophysiological mechanisms are not well-understood, but there is... 
Obesity | Breastfeeding | Prolactin | Beta-cell function | Insulin secretion | Postpartum
Journal Article
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