Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 4, pp. 626 - 629
A new tricoumarin glycoside, triumbelletin-7- -β- -glucoside ( ) and a new biflavonoid, wikstroflavone A ( ), together with two known compounds, wikstaiwanone...
Biflavonoid | Cytotoxicity | Wikstroemia indica | Tricoumarin glycoside | Oligophenol | CHEMISTRY, MEDICINAL | ROOT | BIFLAVONOIDS | CHEMISTRY, ORGANIC | DERIVATIVES | Biflavonoids - pharmacology | Polyphenols - isolation & purification | Biflavonoids - chemistry | Apoptosis - drug effects | Stereoisomerism | Humans | Polyphenols - pharmacology | Coumarins - chemistry | Antineoplastic Agents - chemistry | Coumarins - pharmacology | Wikstroemia - chemistry | Biflavonoids - isolation & purification | Coumarins - isolation & purification | Proton Magnetic Resonance Spectroscopy | Rhizome - chemistry | Antineoplastic Agents - isolation & purification | Polyphenols - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Molecular Structure
Biflavonoid | Cytotoxicity | Wikstroemia indica | Tricoumarin glycoside | Oligophenol | CHEMISTRY, MEDICINAL | ROOT | BIFLAVONOIDS | CHEMISTRY, ORGANIC | DERIVATIVES | Biflavonoids - pharmacology | Polyphenols - isolation & purification | Biflavonoids - chemistry | Apoptosis - drug effects | Stereoisomerism | Humans | Polyphenols - pharmacology | Coumarins - chemistry | Antineoplastic Agents - chemistry | Coumarins - pharmacology | Wikstroemia - chemistry | Biflavonoids - isolation & purification | Coumarins - isolation & purification | Proton Magnetic Resonance Spectroscopy | Rhizome - chemistry | Antineoplastic Agents - isolation & purification | Polyphenols - chemistry | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Molecular Structure
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2010, Volume 38, Issue 2, pp. 287 - 291
Procyanidins are important biologically active compounds, but the pathway and extent of absorption and metabolism are controversial. We conducted a mass...
PROCYANIDIN B2 | POLYPHENOLS | (-)-EPICATECHIN | PROANTHOCYANIDINS | PLASMA | METABOLISM | EPICATECHIN-(4-BETA-8)-EPICATECHIN | URINARY-EXCRETION | PHARMACOLOGY & PHARMACY | DIMERS | (+)-CATECHIN | Injections, Intravenous | Rats, Wistar | Administration, Oral | Biflavonoids - blood | Half-Life | Rats | Biological Availability | Catechin - administration & dosage | Male | Catechin - urine | Proanthocyanidins - blood | Random Allocation | Intestinal Absorption | Biflavonoids - administration & dosage | Proanthocyanidins - administration & dosage | Animals | Feces - chemistry | Proanthocyanidins - urine | Catechin - blood | Proanthocyanidins - pharmacokinetics | Biflavonoids - pharmacokinetics | Catechin - pharmacokinetics | Biflavonoids - urine
PROCYANIDIN B2 | POLYPHENOLS | (-)-EPICATECHIN | PROANTHOCYANIDINS | PLASMA | METABOLISM | EPICATECHIN-(4-BETA-8)-EPICATECHIN | URINARY-EXCRETION | PHARMACOLOGY & PHARMACY | DIMERS | (+)-CATECHIN | Injections, Intravenous | Rats, Wistar | Administration, Oral | Biflavonoids - blood | Half-Life | Rats | Biological Availability | Catechin - administration & dosage | Male | Catechin - urine | Proanthocyanidins - blood | Random Allocation | Intestinal Absorption | Biflavonoids - administration & dosage | Proanthocyanidins - administration & dosage | Animals | Feces - chemistry | Proanthocyanidins - urine | Catechin - blood | Proanthocyanidins - pharmacokinetics | Biflavonoids - pharmacokinetics | Catechin - pharmacokinetics | Biflavonoids - urine
Journal Article
Nature, ISSN 0028-0836, 11/2006, Volume 444, Issue 7119, pp. 566 - 566
Regular, moderate consumption of red wine is linked to a reduced risk of coronary heart disease and to lower overall mortality, but the relative contribution...
Biflavonoids - pharmacology | Wine | Vascular Diseases - prevention & control | Biflavonoids - chemistry | Humans | Cells, Cultured | Male | Longevity | Proanthocyanidins - chemistry | Catechin - analysis | Biflavonoids - analysis | Proanthocyanidins - pharmacology | Protective Agents - pharmacology | Endothelin-1 - biosynthesis | Female | Proanthocyanidins - analysis | Aged | Protective Agents - analysis | Catechin - pharmacology | France | Endothelium, Vascular | Catechin - chemistry | Prevention | Red wines | Atherosclerosis | Polyphenols | Properties | Health aspects | Heart diseases | Alcohols | Wines | Medical research | Cardiovascular disease | Biochemistry | Preventive medicine | Mortality
Biflavonoids - pharmacology | Wine | Vascular Diseases - prevention & control | Biflavonoids - chemistry | Humans | Cells, Cultured | Male | Longevity | Proanthocyanidins - chemistry | Catechin - analysis | Biflavonoids - analysis | Proanthocyanidins - pharmacology | Protective Agents - pharmacology | Endothelin-1 - biosynthesis | Female | Proanthocyanidins - analysis | Aged | Protective Agents - analysis | Catechin - pharmacology | France | Endothelium, Vascular | Catechin - chemistry | Prevention | Red wines | Atherosclerosis | Polyphenols | Properties | Health aspects | Heart diseases | Alcohols | Wines | Medical research | Cardiovascular disease | Biochemistry | Preventive medicine | Mortality
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2015, Volume 23, Issue 13, pp. 3730 - 3737
As part of an ongoing search for new antidiabetic agents from medicinal plants, the methanol extract of the aerial parts of was found to possess stimulatory...
2-NBDG | Biflavonoids | Selaginella tamariscina | PTP1B inhibitors | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIZE | CHEMISTRY, ORGANIC | FLAVONOIDS | SINENSIS | OBESITY | CIRCULAR-DICHROISM | ABSOLUTE-CONFIGURATION | BIOSYNTHESIS | INSULIN MIMETICS | DERIVATIVES | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Plant Extracts - chemistry | Deoxyglucose - metabolism | Cyclohexanones - chemistry | Biflavonoids - chemistry | Humans | Cyclohexanones - isolation & purification | Deoxyglucose - analogs & derivatives | Biphenyl Compounds - pharmacology | Biological Transport - drug effects | Biphenyl Compounds - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Republic of Korea | Methanol | Cell Survival - drug effects | Solvents | Biphenyl Compounds - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Hypoglycemic Agents - chemistry | 3T3-L1 Cells | Cyclohexanones - pharmacology | Hypoglycemic Agents - pharmacology | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Hypoglycemic Agents - isolation & purification | Biflavonoids - isolation & purification | Animals | 4-Chloro-7-nitrobenzofurazan - metabolism | Glucose - metabolism | Mice | Plants, Medicinal | Tyrosine | Glucose metabolism | Phosphatases | Glucose | Dextrose | Medicinal plants | Information management | Alcohol industry | Analysis | Pharmacy | Medicine, Botanic | Hypoglycemic agents | Medicine, Herbal
2-NBDG | Biflavonoids | Selaginella tamariscina | PTP1B inhibitors | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIZE | CHEMISTRY, ORGANIC | FLAVONOIDS | SINENSIS | OBESITY | CIRCULAR-DICHROISM | ABSOLUTE-CONFIGURATION | BIOSYNTHESIS | INSULIN MIMETICS | DERIVATIVES | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Plant Extracts - chemistry | Deoxyglucose - metabolism | Cyclohexanones - chemistry | Biflavonoids - chemistry | Humans | Cyclohexanones - isolation & purification | Deoxyglucose - analogs & derivatives | Biphenyl Compounds - pharmacology | Biological Transport - drug effects | Biphenyl Compounds - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - chemistry | Republic of Korea | Methanol | Cell Survival - drug effects | Solvents | Biphenyl Compounds - isolation & purification | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Hypoglycemic Agents - chemistry | 3T3-L1 Cells | Cyclohexanones - pharmacology | Hypoglycemic Agents - pharmacology | 4-Chloro-7-nitrobenzofurazan - analogs & derivatives | Hypoglycemic Agents - isolation & purification | Biflavonoids - isolation & purification | Animals | 4-Chloro-7-nitrobenzofurazan - metabolism | Glucose - metabolism | Mice | Plants, Medicinal | Tyrosine | Glucose metabolism | Phosphatases | Glucose | Dextrose | Medicinal plants | Information management | Alcohol industry | Analysis | Pharmacy | Medicine, Botanic | Hypoglycemic agents | Medicine, Herbal
Journal Article
Molecules, ISSN 1420-3049, 08/2011, Volume 16, Issue 8, pp. 6206 - 6214
Seven 3',8 ''-linked bioflavonoids, including one new compound, (2 '' S)-2 '',3 ''-dihydroamentoflavone-4'-methyl ether (1) and six known compounds:...
Protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether | Selaginella uncinata (Desv.) Spring | 3′,8′′-linked biflavonoids | ACTIVATION | protective effect against anoxia | CHEMISTRY, ORGANIC | 3 ',8 ''-linked biflavonoids | PC12 CELLS | (2 '' S) 2 '',3 ''-dihydroamentoflavone-4 '-methyl ether | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Altitude Sickness - drug therapy | Cell Survival - drug effects | Plant Extracts - chemistry | Hypoxia - drug therapy | Biflavonoids - chemistry | Magnetic Resonance Spectroscopy | Plant Extracts - pharmacology | Humans | Rats | Trypan Blue - analysis | PC12 Cells | Altitude Sickness - prevention & control | Plant Extracts - analysis | Animals | Biflavonoids - analysis | Ethanol - chemistry | Altitude Sickness - physiopathology | Hypoxia - prevention & control | Hypoxia - physiopathology | Flavonoids - pharmacology | Carbohydrate Conformation | Circular Dichroism | (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether
Protective effect against anoxia; (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether | Selaginella uncinata (Desv.) Spring | 3′,8′′-linked biflavonoids | ACTIVATION | protective effect against anoxia | CHEMISTRY, ORGANIC | 3 ',8 ''-linked biflavonoids | PC12 CELLS | (2 '' S) 2 '',3 ''-dihydroamentoflavone-4 '-methyl ether | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Altitude Sickness - drug therapy | Cell Survival - drug effects | Plant Extracts - chemistry | Hypoxia - drug therapy | Biflavonoids - chemistry | Magnetic Resonance Spectroscopy | Plant Extracts - pharmacology | Humans | Rats | Trypan Blue - analysis | PC12 Cells | Altitude Sickness - prevention & control | Plant Extracts - analysis | Animals | Biflavonoids - analysis | Ethanol - chemistry | Altitude Sickness - physiopathology | Hypoxia - prevention & control | Hypoxia - physiopathology | Flavonoids - pharmacology | Carbohydrate Conformation | Circular Dichroism | (2′′S) 2′′,3′′-dihydroamentoflavone-4′-methyl ether
Journal Article
Molecules, ISSN 1420-3049, 02/2017, Volume 22, Issue 2, pp. 325 - 325
Selaginella doederleinii Hieron has been traditionally used as a folk antitumor herbal medicine in China. In this paper, the phytochemical components of the...
Murine B16 melanoma cell | Selaginella doederleinii | Biflavonoids | HPLC-ESI-QTOF MS/MS | LLC mouse model | Mouse lewis lung cancer (LLC) cell | TAMARISCINA | APOPTOSIS | mouse lewis lung cancer (LLC) cell | MECHANISM | HPLC-ESI-QTOF MS | BIOCHEMISTRY & MOLECULAR BIOLOGY | biflavonoids | FLAVONOIDS | IDENTIFICATION | FRAGMENTATION | CHEMISTRY, MULTIDISCIPLINARY | HIERON | CYTOTOXIC BIFLAVONOIDS | murine B16 melanoma cell | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Cell Survival - drug effects | Plant Extracts - chemistry | Biflavonoids - chemistry | Plant Extracts - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Male | Chromatography, High Pressure Liquid | Tandem Mass Spectrometry | Animals | Melanoma, Experimental | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Antineoplastic Agents, Phytogenic - pharmacology | Lung cancer | Ions | Mass spectroscopy | Liquid chromatography | High-performance liquid chromatography | Anticancer properties | Herbal medicine | Ionization | Xenografts | In vivo methods and tests | In vitro methods and tests | Mass spectrometry | Cancer
Murine B16 melanoma cell | Selaginella doederleinii | Biflavonoids | HPLC-ESI-QTOF MS/MS | LLC mouse model | Mouse lewis lung cancer (LLC) cell | TAMARISCINA | APOPTOSIS | mouse lewis lung cancer (LLC) cell | MECHANISM | HPLC-ESI-QTOF MS | BIOCHEMISTRY & MOLECULAR BIOLOGY | biflavonoids | FLAVONOIDS | IDENTIFICATION | FRAGMENTATION | CHEMISTRY, MULTIDISCIPLINARY | HIERON | CYTOTOXIC BIFLAVONOIDS | murine B16 melanoma cell | Biflavonoids - pharmacology | Selaginellaceae - chemistry | Cell Survival - drug effects | Plant Extracts - chemistry | Biflavonoids - chemistry | Plant Extracts - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Male | Chromatography, High Pressure Liquid | Tandem Mass Spectrometry | Animals | Melanoma, Experimental | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Antineoplastic Agents, Phytogenic - pharmacology | Lung cancer | Ions | Mass spectroscopy | Liquid chromatography | High-performance liquid chromatography | Anticancer properties | Herbal medicine | Ionization | Xenografts | In vivo methods and tests | In vitro methods and tests | Mass spectrometry | Cancer
Journal Article
Biomedical Chromatography, ISSN 0269-3879, 08/2018, Volume 32, Issue 8, pp. e4241 - n/a
A sensitive and rapid LC–MS/MS method was developed and validated for quantitation of sciadopitysin in rat plasma using amentoflavone as an internal standard....
pharmacokinetic study | bioavailability | LC–MS/MS | sciadopitysin | CHEMISTRY, ANALYTICAL | LC-MS | GINKGO-BILOBA | BIFLAVONOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PHARMACOLOGY & PHARMACY | Reproducibility of Results | Biflavonoids - chemistry | Rats, Wistar | Biflavonoids - blood | Drug Stability | Rats | Biological Availability | Linear Models | Male | Animals | Sensitivity and Specificity | Biflavonoids - pharmacokinetics | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Nitriles | Methods | Index Medicus
pharmacokinetic study | bioavailability | LC–MS/MS | sciadopitysin | CHEMISTRY, ANALYTICAL | LC-MS | GINKGO-BILOBA | BIFLAVONOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PHARMACOLOGY & PHARMACY | Reproducibility of Results | Biflavonoids - chemistry | Rats, Wistar | Biflavonoids - blood | Drug Stability | Rats | Biological Availability | Linear Models | Male | Animals | Sensitivity and Specificity | Biflavonoids - pharmacokinetics | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Nitriles | Methods | Index Medicus
Journal Article
Food Chemistry, ISSN 0308-8146, 07/2014, Volume 155, pp. 31 - 37
is an aromatic shrub used in South China as an ornamental and as a spice. Four unusual -methylated biflavonoids named baeckeins F–I ( – ) were isolated from...
Anti-inflammatory activity | C-methylated biflavonoid | Baeckea frutescens | Baeckeins F–I | Absolute configuration | Baeckeins F-I | NUTRITION & DIETETICS | OIL | FOOD SCIENCE & TECHNOLOGY | FLAVONOIDS | CHEMISTRY, APPLIED | Biflavonoids - pharmacology | Cell Line | Biflavonoids - chemistry | Anti-Inflammatory Agents - pharmacology | Drugs, Chinese Herbal - pharmacology | Myrtaceae - chemistry | Biflavonoids - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Drugs, Chinese Herbal - chemistry | Plant Roots - chemistry | Macrophages - drug effects | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Drugs, Chinese Herbal - isolation & purification | Macrophages - immunology | Anti-inflammatory drugs | Analysis
Anti-inflammatory activity | C-methylated biflavonoid | Baeckea frutescens | Baeckeins F–I | Absolute configuration | Baeckeins F-I | NUTRITION & DIETETICS | OIL | FOOD SCIENCE & TECHNOLOGY | FLAVONOIDS | CHEMISTRY, APPLIED | Biflavonoids - pharmacology | Cell Line | Biflavonoids - chemistry | Anti-Inflammatory Agents - pharmacology | Drugs, Chinese Herbal - pharmacology | Myrtaceae - chemistry | Biflavonoids - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Drugs, Chinese Herbal - chemistry | Plant Roots - chemistry | Macrophages - drug effects | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Drugs, Chinese Herbal - isolation & purification | Macrophages - immunology | Anti-inflammatory drugs | Analysis
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2017, Volume 40, Issue 6, pp. 860 - 866
The polyphenolic compound theaflavin, the main red pigment in black tea, possesses many beneficial properties, such as fat-reducing and glucose-lowering...
polyphenol oxidase | theaflavin | peroxidase | hydrolase | fresh green tea leaf | Peroxidase | Hydrolase | Fresh green tea leaf | Theaflavin | Polyphenol oxidase | Biflavonoids - pharmacology | Water | Obesity - drug therapy | Humans | Middle Aged | Plant Leaves | Male | Catechin - urine | Obesity - blood | Young Adult | Biotransformation | Diet, High-Fat | Plant Preparations - pharmacology | Plant Preparations - therapeutic use | Plant Preparations - pharmacokinetics | Adult | Catechin - therapeutic use | Female | Weight Gain - drug effects | Catechin - pharmacology | Biflavonoids - urine | Mice, Inbred C57BL | Fermentation | Plant Preparations - urine | Blood Glucose - drug effects | Camellia sinensis | Animals | Biflavonoids - therapeutic use | Biflavonoids - pharmacokinetics | Catechin - pharmacokinetics | Adipose Tissue - drug effects
polyphenol oxidase | theaflavin | peroxidase | hydrolase | fresh green tea leaf | Peroxidase | Hydrolase | Fresh green tea leaf | Theaflavin | Polyphenol oxidase | Biflavonoids - pharmacology | Water | Obesity - drug therapy | Humans | Middle Aged | Plant Leaves | Male | Catechin - urine | Obesity - blood | Young Adult | Biotransformation | Diet, High-Fat | Plant Preparations - pharmacology | Plant Preparations - therapeutic use | Plant Preparations - pharmacokinetics | Adult | Catechin - therapeutic use | Female | Weight Gain - drug effects | Catechin - pharmacology | Biflavonoids - urine | Mice, Inbred C57BL | Fermentation | Plant Preparations - urine | Blood Glucose - drug effects | Camellia sinensis | Animals | Biflavonoids - therapeutic use | Biflavonoids - pharmacokinetics | Catechin - pharmacokinetics | Adipose Tissue - drug effects
Journal Article
Molecules, ISSN 1420-3049, 02/2017, Volume 22, Issue 2, p. 299
Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important...
Amentoflavone | Biflavonoid | Pharmacology | Pharmacokinetics | Phytochemistry | Natural derivatives | natural derivatives | EX DC CONNARACEAE | GINKGO-BILOBA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CNESTIS-FERRUGINEA | NORMAL HUMAN FIBROBLASTS | CHEMISTRY, MULTIDISCIPLINARY | amentoflavone | HEPATOPROTECTIVE ACTIVITY | BREAST-CANCER CELLS | IN-VITRO | SELAGINELLA-TAMARISCINA | CHEMICAL-CONSTITUENTS | pharmacology | pharmacokinetics | ACID SYNTHASE INHIBITION | biflavonoid | phytochemistry | Biflavonoids - pharmacology | Plant Extracts - chemistry | Antioxidants - chemistry | Biflavonoids - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Biflavonoids - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Anti-Infective Agents - chemistry | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology
Amentoflavone | Biflavonoid | Pharmacology | Pharmacokinetics | Phytochemistry | Natural derivatives | natural derivatives | EX DC CONNARACEAE | GINKGO-BILOBA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CNESTIS-FERRUGINEA | NORMAL HUMAN FIBROBLASTS | CHEMISTRY, MULTIDISCIPLINARY | amentoflavone | HEPATOPROTECTIVE ACTIVITY | BREAST-CANCER CELLS | IN-VITRO | SELAGINELLA-TAMARISCINA | CHEMICAL-CONSTITUENTS | pharmacology | pharmacokinetics | ACID SYNTHASE INHIBITION | biflavonoid | phytochemistry | Biflavonoids - pharmacology | Plant Extracts - chemistry | Antioxidants - chemistry | Biflavonoids - chemistry | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Biflavonoids - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Anti-Infective Agents - chemistry | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology
Journal Article
Phytochemistry, ISSN 0031-9422, 2010, Volume 71, Issue 7, pp. 785 - 791
Six compounds were isolated from S. Moore (Papilionaceae), in addition to six known components. Isochamaejasmin showed the highest antiplasmodial activity with...
Antiplasmodial activity | Ormocarpum kirkii | Papilionaceae | (I-3,II-3)-Biflavonoids | STELLERA-CHAMAEJASME L | BIFLAVONOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LEAVES | PLANT SCIENCES | CIRCULAR-DICHROISM | ABSOLUTE-CONFIGURATION | ANTIMALARIAL ACTIVITY | PLANTS | TANZANIA | Biflavonoids - pharmacology | Animals | Biflavonoids - chemistry | Magnetic Resonance Spectroscopy | Fabaceae - chemistry | Mass Spectrometry | Antimalarials - chemistry | Plasmodium falciparum - drug effects | Antimalarials - pharmacology
Antiplasmodial activity | Ormocarpum kirkii | Papilionaceae | (I-3,II-3)-Biflavonoids | STELLERA-CHAMAEJASME L | BIFLAVONOIDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LEAVES | PLANT SCIENCES | CIRCULAR-DICHROISM | ABSOLUTE-CONFIGURATION | ANTIMALARIAL ACTIVITY | PLANTS | TANZANIA | Biflavonoids - pharmacology | Animals | Biflavonoids - chemistry | Magnetic Resonance Spectroscopy | Fabaceae - chemistry | Mass Spectrometry | Antimalarials - chemistry | Plasmodium falciparum - drug effects | Antimalarials - pharmacology
Journal Article
American Journal of Clinical Nutrition, ISSN 0002-9165, 04/2012, Volume 95, Issue 4, pp. 851 - 858
Background: Accumulating data show a causal role for flavanols in the mediation of cardiovascular benefits associated with the consumption of flavanol- and...
CONTROLLED-TRIAL | B2 EPICATECHIN-(4-BETA-8)-EPICATECHIN | NUTRITION & DIETETICS | VASCULAR FUNCTION | URINARY-EXCRETION | FLAVONOID INTAKE | NITRIC-OXIDE | PHENOLIC-ACIDS | GRAPE SEED EXTRACT | RICH COCOA | BLOOD-PRESSURE | Molecular Weight | Biflavonoids - blood | Humans | Male | Catechin - urine | Biflavonoids - metabolism | Glucuronides - blood | Proanthocyanidins - chemistry | Young Adult | Lactones - blood | Glucuronides - metabolism | Catechin - blood | Lactones - urine | Postprandial Period | Adult | Catechin - metabolism | Biflavonoids - urine | Double-Blind Method | Proanthocyanidins - metabolism | Polymerization | Glucuronides - urine | Proanthocyanidins - blood | Lactones - metabolism | Cross-Over Studies | Proanthocyanidins - urine | Diet | Flavonoids - blood | Flavonoids - metabolism | Adolescent | Analytic Sample Preparation Methods | Methylation | Flavonoids - urine | Prevention | Blood circulation disorders | Flavonoids | Flavones | Bioflavonoids | Research | Health aspects
CONTROLLED-TRIAL | B2 EPICATECHIN-(4-BETA-8)-EPICATECHIN | NUTRITION & DIETETICS | VASCULAR FUNCTION | URINARY-EXCRETION | FLAVONOID INTAKE | NITRIC-OXIDE | PHENOLIC-ACIDS | GRAPE SEED EXTRACT | RICH COCOA | BLOOD-PRESSURE | Molecular Weight | Biflavonoids - blood | Humans | Male | Catechin - urine | Biflavonoids - metabolism | Glucuronides - blood | Proanthocyanidins - chemistry | Young Adult | Lactones - blood | Glucuronides - metabolism | Catechin - blood | Lactones - urine | Postprandial Period | Adult | Catechin - metabolism | Biflavonoids - urine | Double-Blind Method | Proanthocyanidins - metabolism | Polymerization | Glucuronides - urine | Proanthocyanidins - blood | Lactones - metabolism | Cross-Over Studies | Proanthocyanidins - urine | Diet | Flavonoids - blood | Flavonoids - metabolism | Adolescent | Analytic Sample Preparation Methods | Methylation | Flavonoids - urine | Prevention | Blood circulation disorders | Flavonoids | Flavones | Bioflavonoids | Research | Health aspects
Journal Article
Journal of Natural Products, ISSN 0163-3864, 08/2017, Volume 80, Issue 8, pp. 2224 - 2231
Ceratodon purpureus is a cosmopolitan moss that survives some of the harshest places on Earth: from frozen Antarctica to hot South Australian deserts. In a...
CHEMISTRY, MEDICINAL | PHENOLIC-COMPOUNDS | DNA-DAMAGE | POLLEN | UV-B FLUX | FLAVONOIDS | CERATODON-PURPUREUS | RADIATION | COUMARIC ACID | CELL-WALLS | PLANT SCIENCES | FERULIC ACID | PHARMACOLOGY & PHARMACY | Antarctic Regions | Biflavonoids - pharmacology | Antioxidants - chemistry | Biflavonoids - chemistry | Coumaric Acids - chemistry | Bryophyta - chemistry | Antioxidants - pharmacology | Bryopsida - chemistry | Biflavonoids - isolation & purification | Ultraviolet Rays | Propionates | Phenols - blood | Molecular Structure | Australia
CHEMISTRY, MEDICINAL | PHENOLIC-COMPOUNDS | DNA-DAMAGE | POLLEN | UV-B FLUX | FLAVONOIDS | CERATODON-PURPUREUS | RADIATION | COUMARIC ACID | CELL-WALLS | PLANT SCIENCES | FERULIC ACID | PHARMACOLOGY & PHARMACY | Antarctic Regions | Biflavonoids - pharmacology | Antioxidants - chemistry | Biflavonoids - chemistry | Coumaric Acids - chemistry | Bryophyta - chemistry | Antioxidants - pharmacology | Bryopsida - chemistry | Biflavonoids - isolation & purification | Ultraviolet Rays | Propionates | Phenols - blood | Molecular Structure | Australia
Journal Article
Phytochemistry, ISSN 0031-9422, 12/2013, Volume 96, pp. 305 - 311
Two bischromones (1,2) and a biflavone (3) have been isolated from whole plant of , together with five known flavonoids. The isolated compounds were...
Bischromone | Tyrosinase inhibition | Biflavonoid | Trifolium echinatum | Antioxidant activity | Fabaceae | PLANT | SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENTS | IDENTIFICATION | PLANT SCIENCES | Biflavonoids - pharmacology | Phenols - isolation & purification | Antioxidants - chemistry | Biflavonoids - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Antioxidants - pharmacology | Pyrones - pharmacology | beta Carotene - chemistry | Trifolium - chemistry | Chromones - chemistry | Biflavonoids - isolation & purification | Turkey | Antioxidants - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Chromones - isolation & purification | Phenols - chemistry | Molecular Structure | Chromones - pharmacology | Phenols - pharmacology | Antioxidants | Investigations
Bischromone | Tyrosinase inhibition | Biflavonoid | Trifolium echinatum | Antioxidant activity | Fabaceae | PLANT | SPECTROSCOPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPONENTS | IDENTIFICATION | PLANT SCIENCES | Biflavonoids - pharmacology | Phenols - isolation & purification | Antioxidants - chemistry | Biflavonoids - chemistry | Monophenol Monooxygenase - antagonists & inhibitors | Antioxidants - pharmacology | Pyrones - pharmacology | beta Carotene - chemistry | Trifolium - chemistry | Chromones - chemistry | Biflavonoids - isolation & purification | Turkey | Antioxidants - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Chromones - isolation & purification | Phenols - chemistry | Molecular Structure | Chromones - pharmacology | Phenols - pharmacology | Antioxidants | Investigations
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 10, pp. 3060 - 3073
The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol...
Antifungal activity | Biflavonoids | Ullmann condensation | STELLERA-CHAMAEJASME L | CHEMISTRY, MEDICINAL | HYDROGEN-BOND | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | FLAVONOIDS | HYPNUM-CUPRESSIFORME | GARCINIA-MULTIFLORA | SELAGINELLA-TAMARISCINA | AFLATOXIN | B-RING | ASPERGILLUS-FLAVUS | Antifungal Agents - pharmacology | Biflavonoids - pharmacology | Microbial Sensitivity Tests | Biflavonoids - chemistry | Fungi - drug effects | Humans | Mycoses - drug therapy | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Molecular Structure | Biflavonoids - chemical synthesis | Chemical synthesis | Antifungal agents
Antifungal activity | Biflavonoids | Ullmann condensation | STELLERA-CHAMAEJASME L | CHEMISTRY, MEDICINAL | HYDROGEN-BOND | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | FLAVONOIDS | HYPNUM-CUPRESSIFORME | GARCINIA-MULTIFLORA | SELAGINELLA-TAMARISCINA | AFLATOXIN | B-RING | ASPERGILLUS-FLAVUS | Antifungal Agents - pharmacology | Biflavonoids - pharmacology | Microbial Sensitivity Tests | Biflavonoids - chemistry | Fungi - drug effects | Humans | Mycoses - drug therapy | Antifungal Agents - chemical synthesis | Antifungal Agents - chemistry | Molecular Structure | Biflavonoids - chemical synthesis | Chemical synthesis | Antifungal agents
Journal Article
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 02/2012, Volume 518, Issue 2, pp. 127 - 132
► We generate two mutants Ile87Lys of CYP158A2 and Lys90Ile of CYP158A1. ► We compare each mutant catalytic activity with corresponding wild type enzyme. ► We...
CYP158A1 | CYP158A2 | Oxidative coupling reaction | Regiospecificity | Cytochrome P450 | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASE | CYTOCHROME-P450 158A2 | BIOPHYSICS | STREPTOMYCES-COELICOLOR A3 | CLONING | BIOSYNTHESIS | CYPI58A2 | HETEROLOGOUS EXPRESSION | BINDING | FLAVIOLIN SUBSTRATE MOLECULES | Catalytic Domain | Biflavonoids - chemistry | Oxidation-Reduction | Streptomyces coelicolor - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Cytochrome P-450 Enzyme System - metabolism | Crystallography, X-Ray | Biflavonoids - genetics | Biflavonoids - metabolism | Mutation, Missense | Isoleucine - genetics | Isoleucine - metabolism | Cytochrome P-450 Enzyme System - chemistry | Isoleucine - chemistry | Cytochrome P-450 Enzyme System - genetics | Streptomyces coelicolor - enzymology | Bacterial Proteins - metabolism | Catalysis | Amino Acid Substitution | Structure | Enzymes | Crystals | Index Medicus
CYP158A1 | CYP158A2 | Oxidative coupling reaction | Regiospecificity | Cytochrome P450 | ACTIVE-SITE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASE | CYTOCHROME-P450 158A2 | BIOPHYSICS | STREPTOMYCES-COELICOLOR A3 | CLONING | BIOSYNTHESIS | CYPI58A2 | HETEROLOGOUS EXPRESSION | BINDING | FLAVIOLIN SUBSTRATE MOLECULES | Catalytic Domain | Biflavonoids - chemistry | Oxidation-Reduction | Streptomyces coelicolor - genetics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Cytochrome P-450 Enzyme System - metabolism | Crystallography, X-Ray | Biflavonoids - genetics | Biflavonoids - metabolism | Mutation, Missense | Isoleucine - genetics | Isoleucine - metabolism | Cytochrome P-450 Enzyme System - chemistry | Isoleucine - chemistry | Cytochrome P-450 Enzyme System - genetics | Streptomyces coelicolor - enzymology | Bacterial Proteins - metabolism | Catalysis | Amino Acid Substitution | Structure | Enzymes | Crystals | Index Medicus
Journal Article