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PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e93913
DNA is one of the major intracellular targets for a wide range of anticancer and antibiotic drugs. Elucidating the binding between small molecules and DNA... 
MIXED-LIGAND COMPLEXES | CIRCULAR-DICHROISM | GROOVE BINDING | RUTHENIUM(II) | MULTIDISCIPLINARY SCIENCES | TARGETS | HOECHST-33258 | FLUORESCENCE-SPECTRA | INTERCALATION | METAL-COMPLEXES | NUCLEIC-ACIDS | Iodides - pharmacology | Viscosity | Reactive Oxygen Species - metabolism | Thioinosine - pharmacology | Models, Molecular | Spectrometry, Fluorescence | DNA, Circular - drug effects | Static Electricity | Comet Assay | DNA - radiation effects | Spectrophotometry, Ultraviolet | Animals | Osmolar Concentration | Cattle | Light | Plasmids - drug effects | Superoxides - metabolism | Antimetabolites, Antineoplastic - pharmacology | Molecular Docking Simulation | DNA Damage | Nucleic Acid Conformation | Circular Dichroism | DNA - drug effects | DNA replication | DNA damage | Analysis | Physiological aspects | Genetic aspects | Health aspects | Mercaptopurine | Drugs | Fluorescence spectroscopy | Reactive oxygen species | Transcription | Toxicity | Nicking | Fluorescence | Biochemistry | Biopolymers | Experiments | Comet assay | Molecular docking | Life sciences | Deoxyribonucleic acid--DNA | Binding | Spectroscopy | Damage assessment | Bioassay | Bioassays | Metabolism | Electrostatic properties | Gene expression | DNA biosynthesis | Studies | Damage detection | Antibiotics | Spectrophotometry | Cancer | Calf thymus | Conformation | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Environmental Science and Pollution Research, ISSN 0944-1344, 1/2015, Volume 22, Issue 1, pp. 5 - 34
Since their discovery in the late 1980s, neonicotinoid pesticides have become the most widely used class of insecticides worldwide, with large-scale... 
Environmental Health | Ecotoxicology | Seed treatment | Environment, general | Neonicotinoid | Systemic insecticides | Metabolites | Environment | Agriculture | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | Trends | Mechanism of action | Environmental Chemistry | Atmospheric Protection/Air Quality Control/Air Pollution | Fipronil | APIS-MELLIFERA HYMENOPTERA | Mechanismof action | BEMISIA-TABACI HOMOPTERA | ANTENNAL LOBE NEURONS | ALPHA-BUNGAROTOXIN | ENVIRONMENTAL SCIENCES | COLONY COLLAPSE DISORDER | MOUSE-LIVER TUMORS | NICOTINIC ACETYLCHOLINE-RECEPTOR | BINDING-SITE | APHIS-GOSSYPII HOMOPTERA | MYZUS-PERSICAE HEMIPTERA | Nitro Compounds - metabolism | Seeds - metabolism | Agriculture - trends | Nitro Compounds - toxicity | Neonicotinoids | Herbivory | Agriculture - methods | Environmental Pollutants - metabolism | Pyrazoles - metabolism | Animals | Insecticides - metabolism | Pyrazoles - toxicity | Insecta - drug effects | Imidazoles - toxicity | Environmental Pollutants - toxicity | Insecticides - toxicity | Crops, Agricultural - metabolism | Imidazoles - metabolism | Insecticides | Studies | Agricultural pollution | Environmental science | Pesticides | Life Sciences | Biodiversity and Ecology | Environmental Sciences | Worldwide Integrated Assessment of the Impact of Systemic Pesticides on Biodiversity and Ecosystems
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 431 - 435
Therapies that target signalling molecules that are mutated in cancers can often have substantial short-term effects, but the emergence of resistant cancer... 
METASTATIC MELANOMA | BRAF INHIBITOR | SUBPOPULATIONS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | SINGLE MAMMALIAN-CELLS | STATE | MECHANISMS | MUTATIONS | VEMURAFENIB | PLASTICITY | Transcription, Genetic - drug effects | Humans | Male | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Single-Cell Analysis | Cellular Reprogramming - genetics | ErbB Receptors - metabolism | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Signal Transduction - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Genetic Markers - drug effects | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Genetic Markers - genetics | Cell Line, Tumor | Oncogene Protein p65(gag-jun) - metabolism | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Antimitotic agents | Cell interaction | Dosage and administration | Antineoplastic agents | Drug resistance | Observations | Health aspects | Subpopulations | Transcription factors | Substance abuse treatment | Variability | Activator protein 1 | Melanoma | Genomes | Kinases | Gene expression | Sox10 protein | Signal transduction | Signaling | Converting | Population | Mutation | Differentiation | Deoxyribonucleic acid--DNA | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53326 - e53326
Arasin 1 is a 37 amino acid long proline-rich antimicrobial peptide isolated from the spider crab, Hyas araneus. In this work the active region of arasin 1 was... 
PIG INTESTINE | SPIDER CRAB | CECROPIN P1 | CHITIN-BINDING ACTIVITY | HYAS-ARANEUS | MEMBRANE | MULTIDISCIPLINARY SCIENCES | SEQUENCE | SECONDARY STRUCTURE | PR-39 | ANTIBACTERIAL PEPTIDE | Hemolysis - drug effects | Anti-Infective Agents - pharmacology | Escherichia coli - drug effects | Humans | Molecular Sequence Data | Peptide Fragments - pharmacology | Antifungal Agents - chemistry | Structure-Activity Relationship | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Anti-Infective Agents - chemistry | Chitin - metabolism | Circular Dichroism | Antifungal Agents - pharmacology | Amino Acid Sequence | Microbial Viability - drug effects | Peptides - chemistry | Antimicrobial Cationic Peptides - chemistry | Antimicrobial Cationic Peptides - pharmacology | Peptides - pharmacology | Proline-Rich Protein Domains | Peptide Fragments - chemistry | Cell Membrane Permeability - drug effects | Anti-Bacterial Agents - pharmacology | Kinetics | Peptides | Proline | Membranes | Erythrocytes | Amino acids | Biochemistry | Structure-activity relationships | Drug resistance | Antiinfectives and antibacterials | Fragmentation | Proteins | Crustaceans | Red blood cells | Arginine | Cecropin | Bacteria | Life sciences | Gram-negative bacteria | Killing | Bacterial infections | Cell walls | Crabs | Blood cells | Antimicrobial agents | Chitin | Pharmacology | Mode of action | Antibiotics | Fishery sciences | Minimum inhibitory concentration | Index Medicus | VDP |