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1. Full Text HIV‐1 neutralizing antibodies: understanding nature's pathways
by Mascola, John R and Haynes, Barton F
Immunological reviews, ISSN 0105-2896, 07/2013, Volume 254, Issue 1, pp. 225 - 244
unmutated ancestor (UA) | immune tolerance | monoclonal antibodies (mAbs) | broadly neutralizing antibodies (BNAbs) | B‐cell lineages | B-cell lineages | Broadly neutralizing antibodies (BNAbs) | Unmutated ancestor (UA) | Immune tolerance | Monoclonal antibodies (mAbs) | Life Sciences & Biomedicine | Immunology | Science & Technology | HIV Antibodies - blood | HIV Infections - blood | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | HIV Antibodies - immunology | Humans | AIDS Vaccines - immunology | B-Lymphocyte Subsets - immunology | Research | Antibodies, Neutralizing - blood | Monoclonal antibodies | HIV (Viruses) | Index Medicus | broadly neutralizing antibodies (BNAb)
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2. Full Text bnAbs for HIV: shepherding towards improbable mutations
by Flemming, Alexandra
Nature reviews. Drug discovery, ISSN 1474-1776, 02/2020, Volume 19, Issue 2, pp. 90 - 90
Antibodies, Neutralizing | HIV Infections | HIV-1 - immunology | HIV Antibodies | Humans | AIDS Vaccines | Broadly Neutralizing Antibodies | Mutation | Viral antibodies | Vaccination | Antibodies | Genetic aspects | B cells | Vaccines | HIV (Viruses)
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3. Full Text bnAbs for HIV: shepherding towards improbable mutations
by Flemming, Alexandra
Nature reviews. Immunology, ISSN 1474-1733, 02/2020, Volume 20, Issue 2, pp. 71 - 71
Antibodies, Neutralizing | HIV Infections | AIDS Vaccines | Broadly Neutralizing Antibodies | Mutation | Humans | Viral antibodies | AIDS vaccines | Vaccination | Antibodies | Genetic aspects | B cells | HIV (Viruses) | Human immunodeficiency virus--HIV | Index Medicus
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4. Full Text Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs
by Seaman, Michael S and Bilska, Miroslawa and Ghantous, Fadi and Eaton, Amanda and LaBranche, Celia C and Greene, Kelli and Gao, Hongmei and Weiner, Joshua A and Ackerman, Margaret E and Garber, David A and Rosenberg, Yvonne J and Sarzotti-Kelsoe, Marcella and Montefiori, David C
Journal of immunological methods, ISSN 0022-1759, 04/2020, Volume 479, pp. 112736 - 112736
HIV-1 | Anti-drug antibody | Broadly neutralizing antibodies | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Index Medicus
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5. Full Text Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
by Kerwin, Bruce A and Bennett, Chelsey and Brodsky, Yan and Clark, Rutilio and Floyd, J. Alaina and Gillespie, Alison and Mayer, Bryan T and McClure, Megan and Siska, Christine and Seaman, Michael S and Seaton, Kelly E and Shaver, Jeremy and Tomaras, Georgia D and Yates, Nicole L and Ketchem, Randal R
Journal of pharmaceutical sciences, ISSN 0022-3549, 01/2020, Volume 109, Issue 1, pp. 233 - 246
high throughput technology(s) | HIV/AIDS | antibody(s) | developability | stabilization | fluorescence spectroscopy | physical stability | analytical biochemistry | protein structure | biopharmaceutical characterization | protein aggregation | pharmacokinetics | protein folding | stability | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | HMW, High molecular weight | mAb, monoclonal antibody | DSF, Differential scanning fluorimetry | LC, Light chain | PEG, Polyethylene glycol | CDR, Complementary determining region | COGs, Cost of goods | bnAbs, broadly neutralizing antibodies | CDCA, Stability design by covariance analysis | HC, Heavy chain | AIDS | PK, Pharmacokinetic | Gdn-HCl, Guanidine hydrochloride | HIV | HP-SEC, High performance size exclusion chromatography | PBS, Phosphate buffered saline
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6. Full Text Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention
by Stephenson, Kathryn E and Wagh, Kshitij and Korber, Bette and Barouch, Dan H
Annual review of immunology, ISSN 0732-0582, 4/2020, Volume 38, Issue 1, pp. 673 - 703
HIV-1 | bNAb | vaccine | broadly neutralizing antibody | viral diversity | prevention | Index Medicus
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7. Full Text Protein and Glycan Mimicry in HIV Vaccine Design
by Seabright, Gemma E and Doores, Katie J and Burton, Dennis R and Crispin, Max
Journal of molecular biology, ISSN 0022-2836, 05/2019, Volume 431, Issue 12, pp. 2223 - 2247
human immunodeficiency virus | glycosylation | antibodies | structure | vaccinology | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Epitopes - immunology | HIV Infections - immunology | HIV Infections - prevention & control | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Molecular Mimicry | env Gene Products, Human Immunodeficiency Virus - immunology | Humans | AIDS Vaccines - immunology | Models, Molecular | AIDS Vaccines - therapeutic use | Polysaccharides - immunology | AIDS vaccines | HIV (Viruses) | Health aspects | Antigenic determinants | Index Medicus | Env, envelope spike | CHO, Chinese hamster ovary | UFO, uncleaved prefusion-optimized | BCR, B cell receptor | EM, electron microscopy | MPER, membrane proximal external region | HIV-1, human immunodeficiency virus type 1 | 2, heptad repeat 1 or 2 | Glc, glucose | bnAb(s), broadly neutralizing antibody(ies) | HCDR3, third heavy-chain complementarity-determining regions | NFL, native flexibly linked | GlcNAc, N-acetylglucosamine | CT, cytoplasmic tail | PNGS, potential N-glycosylation sites | Neu5Ac, N-acetylneuraminic acid (sialic acid) | nAb(s), neutralizing antibody(ies) | CDR, complementarity-determining regions | α-man I and II, α-mannosidase I and II | gl-bnAb(s), germline-bnAb(s) | TAMP, trimer-associated mannose patch | HEK, human embryonic kidney | LOS, lipooligosaccharides | GnT I, N-acetylglucosaminyltransferase I | AIDS, acquired immune deficiency syndrome | CD4bs, CD4 binding site | Gal, galactose | PBMC, peripheral blood mononuclear cell | CCR5, C-C chemokine receptor type 5 | TM, transmembrane region | SP, signal peptide | Man, mannose | founder | HR1 | KDO, 2-keto-3-deoxy-D-manno-octulosonic acid | SC, single-chain | Fuc, fucose | PNS, peripheral nervous system | CXCR4, C-X-C chemokine receptor type 4 | TF, transmitted | GlcN, glucosamine | cGMP, current good manufacturing practices | ER, endoplasmic reticulum | IMP, intrinsic mannose patch
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