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1. Full Text Poly-and autoreactivity of HIV-1 bNAbs: Implications for vaccine design
by Finney, Joel and Kelsoe, Garnett
Retrovirology, ISSN 1742-4690, 07/2018, Volume 15, Issue 1, pp. 53 - 8
A central puzzle in HIV-1 research is the inability of vaccination or even infection to reliably elicit humoral responses against broadly neutralizing epitopes... 
HIV-1 | Autoreactivity | Antibody | Immunological tolerance | Polyreactivity | AUTOANTIBODIES | SELF-REACTIVITY | AFFINITY MATURATION | IG KNOCKIN MICE | SOLUBLE-ANTIGEN | VIROLOGY | REACTIVE B-LYMPHOCYTES | BROADLY NEUTRALIZING ANTIBODIES | CELL TOLERANCE | CLONAL DELETION | GERMINAL-CENTERS | Antibody Specificity | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | B-Lymphocytes - immunology | HIV Antibodies - immunology | Antibodies, Neutralizing - biosynthesis | Immune Tolerance - immunology | Humans | AIDS Vaccines - immunology | HIV Antibodies - biosynthesis | Viral antibodies | Prevention | AIDS vaccines | Physiological aspects | Antibodies | Genetic aspects | Research | HIV (Viruses)
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2. Full Text Introduction of the YTE mutation into the non immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques
by Rosenberg, YJ and Lewis, GK and Montefiori, DC and LaBranche, CC and Lewis, MG and Urban, LA and Lees, JP and Mao, LJ and Jiang, XM
PLOS ONE, ISSN 1932-6203, 02/2019, Volume 14, Issue 2, pp. e0212649 - e0212649
Recombinant antibodies play increasingly important roles as immunotherapeutic treatments for human cancers as well as inflammatory and infectious diseases and... 
HALF-LIFE | MUCOSAL SHIV CHALLENGE | NEONATAL FC-RECEPTOR | POTENT NEUTRALIZATION | PROTECTION | RECOGNITION | BROADLY NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | MONOCLONAL-ANTIBODIES | COMBINATION | BINDING | Usage | Gene mutations | HIV antibodies | Macaques | Genetic aspects | Research | Pharmacokinetics | Comparative analysis | Structure | Antibody-drug conjugates | Binding | Immunoglobulins | Viremia | Immune clearance | Clinical trials | Viruses | Pharmacology | Immune status | Injection | Bioavailability | Domains | Proteins | Infectious diseases | Immunogenicity | Human immunodeficiency virus--HIV | Monoclonal antibodies | Mutation | Binding sites | Recombinant | Neutralization | Index Medicus | HIV | Human immunodeficiency virus
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3. Full Text Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs
by Seaman, Michael S and Bilska, Miroslawa and Ghantous, Fadi and Eaton, Amanda and LaBranche, Celia C and Greene, Kelli and Gao, Hongmei and Weiner, Joshua A and Ackerman, Margaret E and Garber, David A and Rosenberg, Yvonne J and Sarzotti-Kelsoe, Marcella and Montefiori, David C
Journal of immunological methods, ISSN 0022-1759, 01/2020, p. 112736
The recent identification of human monoclonal antibodies with broad and potent neutralizing activity against HIV-1 (bnAbs) has resulted in substantial efforts... 
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4. Full Text HIV‐1 neutralizing antibodies: understanding nature's pathways
by Mascola, John R and Haynes, Barton F
Immunological Reviews, ISSN 0105-2896, 07/2013, Volume 254, Issue 1, pp. 225 - 244
Summary The development of an effective vaccine has been hindered by the enormous diversity of human immunodeficiency virus‐1 (HIV‐1) and its ability to escape... 
unmutated ancestor (UA) | immune tolerance | monoclonal antibodies (mAbs) | broadly neutralizing antibodies (BNAbs) | B‐cell lineages | B-cell lineages | Broadly neutralizing antibodies (BNAbs) | Unmutated ancestor (UA) | Immune tolerance | Monoclonal antibodies (mAbs) | B-CELL RESPONSES | GP120 ENVELOPE GLYCOPROTEIN | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | DEFICIENCY SYNDROME AIDS | RECOMBINANT GLYCOPROTEIN-120 VACCINE | CROSS-CLADE NEUTRALIZATION | 2ND HYPERVARIABLE REGION | HUMAN MONOCLONAL-ANTIBODIES | HTLV-III LAV | SUBTYPE-B | HIV Antibodies - blood | HIV Infections - blood | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | HIV Antibodies - immunology | Humans | AIDS Vaccines - immunology | B-Lymphocyte Subsets - immunology | Research | Antibodies, Neutralizing - blood | Monoclonal antibodies | HIV (Viruses)
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5. Full Text Broadly Neutralizing Antibodies for HIV Prevention
by Karuna, Shelly T and Corey, Lawrence
Annual review of medicine, ISSN 0066-4219, 1/2020, Volume 71, Issue 1, pp. 329 - 346
In the last decade, over a dozen potent broadly neutralizing antibodies (bnAbs) to several HIV envelope protein epitopes have been identified, and their in... 
passive immunization | HIV prevention | broadly neutralizing antibodies | bnAbs
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6. Full Text Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage
by Sacks, D and Bhiman, JN and Wiehe, K and Gorman, J and Kwong, PD and Morris, L and Moore, PL
PLOS PATHOGENS, ISSN 1553-7366, 09/2019, Volume 15, Issue 9, p. e1008005
Previously we have described the V2-directed CAP256-VRC26 lineage that includes broadly neutralizing antibodies (bNAbs) that neutralize globally diverse... 
B-CELL RECEPTORS | GERMLINE | COEVOLUTION | NEUTRALIZING ANTI-HIV-1 ANTIBODIES | MICROBIOLOGY | BROAD | INDUCTION | MATURATION | ESCAPE | POTENT | VIROLOGY | INFECTION | PARASITOLOGY | Broadly Neutralizing Antibodies - immunology | Amino Acid Sequence | Epitope Mapping | HIV-1 - pathogenicity | env Gene Products, Human Immunodeficiency Virus - immunology | HIV Seropositivity | Humans | Immunophenotyping | Neutralization Tests | HIV - immunology | HIV - pathogenicity | HIV-1 - genetics | Epitopes - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | HIV Antibodies - immunology | Female | Prevention | Control | AIDS vaccines | HIV antibodies | Gene mutations | HIV infection | Health aspects | Testing | Health sciences | Laboratories | Funding | Antibodies | Chains | Viruses | Infections | Mapping | Vaccines | Drug resistance | Immunology | Pathways | Acquired immune deficiency syndrome--AIDS | Complementarity-determining region | Human immunodeficiency virus--HIV | Epitope mapping | Chimeras | Antigens | Phenotypes | Immunoglobulins | Mutants | Somatic hypermutation | Infectious diseases | Mutation | Binding sites | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
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7. Full Text Understanding the determinants of BnAb induction in acute HCV infection
by Underwood, Alexander P and Underwood, Alexander P and Walker, Melanie R and Walker, Melanie R and Brasher, Nicholas A and Brasher, Nicholas A and Eltahla, Auda A and Eltahla, Auda A and Maher, Lisa and Maher, Lisa and Luciani, Fabio and Luciani, Fabio and Lloyd, Andrew R and Lloyd, Andrew R and Bull, Rowena A and Bull, Rowena A
Viruses, ISSN 1999-4915, 11/2018, Volume 10, Issue 11, p. 659
Despite recent advances in curative therapy, hepatitis C virus (HCV) still remains a global threat. In order to achieve global elimination, a prophylactic... 
Vaccine | Hepatitis C virus | Neutralising antibodies | Reinfection | neutralising antibodies | CLEARANCE | reinfection | COEVOLUTION | APPEARANCE | GENOTYPE DISTRIBUTION | HEPATITIS-C-VIRUS | vaccine | TRANSMISSION | VIROLOGY | BROADLY NEUTRALIZING ANTIBODIES | hepatitis C virus | PEOPLE | ASSOCIATION | Enzyme-Linked Immunosorbent Assay | Hepacivirus - immunology | Humans | Middle Aged | Genotype | Male | Neutralization Tests | Antibodies, Viral - blood | Drug Carriers | Viral Vaccines - administration & dosage | Young Adult | Hepatitis C - immunology | Adolescent | Adult | Female | Lentivirus - genetics | Genetic Vectors | Longitudinal Studies | Viral Vaccines - immunology | Antibodies, Neutralizing - blood
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8. Full Text A novel anti‐HIV‐1 bispecific bNAb‐lectin fusion protein engineered in a plant‐based transient expression system
by Seber Kasinger, Lauren E and Dent, Matthew W and Mahajan, Garima and Hamorsky, Krystal Teasley and Matoba, Nobuyuki
Plant Biotechnology Journal, ISSN 1467-7644, 08/2019, Volume 17, Issue 8, pp. 1646 - 1656
Summary The discovery of broadly neutralizing antibodies (bNAbs) has been a major step towards better prophylactic and therapeutic agents against human... 
human immunodeficiency virus | broadly neutralizing antibody | Nicotiana benthamiana | high‐mannose‐type glycan | bispecific fusion protein | plant virus vector | SIMIAN/HUMAN IMMUNODEFICIENCY VIRUS | high-mannose-type glycan | GRIFFITHSIN | GP120 | PLANT SCIENCES | POTENT | CYANOVIRIN-N | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RESISTANCE | MONOCLONAL-ANTIBODIES | NEUTRALIZATION | INACTIVATING PROTEIN | BREADTH | Antiviral agents | Genetic vectors | Viral proteins | Immunoglobulin G | Lectins | HIV (Viruses) | Health aspects | Chromatography | Sugars | Enzyme-linked immunosorbent assay | Protein binding | Monosaccharides | Antibodies | Viruses | Infections | Experiments | Proteins | Human immunodeficiency virus--HIV | Fusion protein | Protein engineering | Antigens | Immunoglobulins | Pharmacology | Gene expression | Chemical compounds | Glycan | CD4 antigen | Tobacco | Neutralizing | Software | Surface plasmon resonance | Dimers | Binding sites | Neutralization | Index Medicus
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9. Full Text Polyreactivity and autoreactivity among HIV-1 antibodies
by Liu, Mengfei and Yang, Guang and Wiehe, Kevin and Nicely, Nathan I and Vandergrift, Nathan A and Rountree, Wes and Bonsignori, Mattia and Munir Alam, S and Gao, Jingyun and Haynes, Barton F and Kelsoe, Garnett
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 1, pp. 784 - 798
It is generally acknowledged that human broadly neutralizing antibodies (bNAbs) capable of neutralizing multiple HIV-1 clades are often polyreactive or... 
B-CELLS | POTENT NEUTRALIZATION | EPITOPE | VIROLOGY | BROADLY NEUTRALIZING ANTIBODIES | HUMAN MONOCLONAL-ANTIBODY | HUMAN-IMMUNODEFICIENCY-VIRUS | ANGELMAN SYNDROME | IMMUNE TOLERANCE | BINDING-SITES | RATIONAL DESIGN | Autoantibodies - immunology | HIV-1 - immunology | HIV Antibodies - immunology | Microarray Analysis | Humans | Protein Array Analysis | Protein Binding
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10. Full Text Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
by Kerwin, Bruce A and Bennett, Chelsey and Brodsky, Yan and Clark, Rutilio and Floyd, J. Alaina and Gillespie, Alison and Mayer, Bryan T and McClure, Megan and Siska, Christine and Seaman, Michael S and Seaton, Kelly E and Shaver, Jeremy and Tomaras, Georgia D and Yates, Nicole L and Ketchem, Randal R
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2020, Volume 109, Issue 1, pp. 233 - 246
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series... 
high throughput technology(s) | HIV/AIDS | antibody(s) | developability | stabilization | fluorescence spectroscopy | physical stability | analytical biochemistry | protein structure | biopharmaceutical characterization | protein aggregation | pharmacokinetics | protein folding | stability | MONOCLONAL-ANTIBODY | VARIABLE DOMAINS | SELF-ASSOCIATION | FCRN-TRANSGENIC MICE | SEQUENCE | PHARMACOLOGY & PHARMACY | CHEMISTRY, MEDICINAL | HIV PREEXPOSURE PROPHYLAXIS | CHEMISTRY, MULTIDISCIPLINARY | POTENT | SCREENING TOOL | AGGREGATION | Index Medicus | HMW, High molecular weight | mAb, monoclonal antibody | DSF, Differential scanning fluorimetry | LC, Light chain | PEG, Polyethylene glycol | CDR, Complementary determining region | COGs, Cost of goods | bnAbs, broadly neutralizing antibodies | CDCA, Stability design by covariance analysis | HC, Heavy chain | AIDS | PK, Pharmacokinetic | Gdn-HCl, Guanidine hydrochloride | HIV | HP-SEC, High performance size exclusion chromatography | PBS, Phosphate buffered saline
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11. Full Text Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities
by Liu, Yubin and Cao, Wei and Sun, Ming and Li, Taisheng
Emerging Microbes & Infections, ISSN 2222-1751, 01/2020, Volume 9, Issue 1, pp. 194 - 206
Combination antiretroviral therapy (cART) is effective but not curative, and no successful vaccine is currently available for human immunodeficiency virus-1... 
HIV-1 | broadly neutralizing antibodies (bNAbs) | challenges | opportunities | efficacies
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