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1. Full Text bnAbs for HIV: shepherding towards improbable mutations
by Flemming, Alexandra
Nature reviews. Drug discovery, ISSN 1474-1776, 02/2020, Volume 19, Issue 2, pp. 90 - 90
Antibodies, Neutralizing | HIV Infections | HIV-1 - immunology | HIV Antibodies | Humans | AIDS Vaccines | Broadly Neutralizing Antibodies | Mutation | Viral antibodies | Vaccination | Antibodies | Genetic aspects | B cells | Vaccines | HIV (Viruses)
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2. Full Text bnAbs for HIV: shepherding towards improbable mutations
by Flemming, Alexandra
Nature reviews. Immunology, ISSN 1474-1733, 02/2020, Volume 20, Issue 2, pp. 71 - 71
Antibodies, Neutralizing | HIV Infections | AIDS Vaccines | Broadly Neutralizing Antibodies | Mutation | Humans | Viral antibodies | AIDS vaccines | Vaccination | Antibodies | Genetic aspects | B cells | HIV (Viruses) | Human immunodeficiency virus--HIV | Index Medicus
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3. Full Text HIV‐1 neutralizing antibodies: understanding nature's pathways
by Mascola, John R and Haynes, Barton F
Immunological reviews, ISSN 0105-2896, 07/2013, Volume 254, Issue 1, pp. 225 - 244
unmutated ancestor (UA) | immune tolerance | monoclonal antibodies (mAbs) | broadly neutralizing antibodies (BNAbs) | B‐cell lineages | B-cell lineages | Broadly neutralizing antibodies (BNAbs) | Unmutated ancestor (UA) | Immune tolerance | Monoclonal antibodies (mAbs) | Life Sciences & Biomedicine | Immunology | Science & Technology | HIV Antibodies - blood | HIV Infections - blood | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | HIV Antibodies - immunology | Humans | AIDS Vaccines - immunology | B-Lymphocyte Subsets - immunology | Research | Antibodies, Neutralizing - blood | Monoclonal antibodies | HIV (Viruses) | Index Medicus | broadly neutralizing antibodies (BNAb)
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4. Full Text Optimization and qualification of a functional anti-drug antibody assay for HIV-1 bnAbs
by Seaman, Michael S and Bilska, Miroslawa and Ghantous, Fadi and Eaton, Amanda and LaBranche, Celia C and Greene, Kelli and Gao, Hongmei and Weiner, Joshua A and Ackerman, Margaret E and Garber, David A and Rosenberg, Yvonne J and Sarzotti-Kelsoe, Marcella and Montefiori, David C
Journal of immunological methods, ISSN 0022-1759, 04/2020, Volume 479, pp. 112736 - 112736
HIV-1 | Anti-drug antibody | Broadly neutralizing antibodies | Biochemistry & Molecular Biology | Immunology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Index Medicus
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5. Full Text Delivery of anti-HIV bNAbs by viral vectors
by Caskey, Marina
The lancet HIV, ISSN 2352-3018, 04/2019, Volume 6, Issue 4, pp. e207 - e208
Infectious Diseases | Immunology | Life Sciences & Biomedicine | Science & Technology | HIV Infections | Broadly Neutralizing Antibodies | HIV-1 - immunology | Dependovirus | HIV Antibodies | Humans | Index Medicus | AIDS/HIV
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6. Full Text Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
by Kerwin, Bruce A and Bennett, Chelsey and Brodsky, Yan and Clark, Rutilio and Floyd, J. Alaina and Gillespie, Alison and Mayer, Bryan T and McClure, Megan and Siska, Christine and Seaman, Michael S and Seaton, Kelly E and Shaver, Jeremy and Tomaras, Georgia D and Yates, Nicole L and Ketchem, Randal R
Journal of pharmaceutical sciences, ISSN 0022-3549, 01/2020, Volume 109, Issue 1, pp. 233 - 246
high throughput technology(s) | HIV/AIDS | antibody(s) | developability | stabilization | fluorescence spectroscopy | physical stability | analytical biochemistry | protein structure | biopharmaceutical characterization | protein aggregation | pharmacokinetics | protein folding | stability | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Index Medicus | HMW, High molecular weight | mAb, monoclonal antibody | DSF, Differential scanning fluorimetry | LC, Light chain | PEG, Polyethylene glycol | CDR, Complementary determining region | COGs, Cost of goods | bnAbs, broadly neutralizing antibodies | CDCA, Stability design by covariance analysis | HC, Heavy chain | AIDS | PK, Pharmacokinetic | Gdn-HCl, Guanidine hydrochloride | HIV | HP-SEC, High performance size exclusion chromatography | PBS, Phosphate buffered saline
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7. Full Text Broadly Neutralizing Antibodies for HIV Prevention
by Karuna, Shelly T and Corey, Lawrence
Annual review of medicine, ISSN 0066-4219, 1/2020, Volume 71, Issue 1, pp. 329 - 346
passive immunization | HIV prevention | broadly neutralizing antibodies | bnAbs | Prevention | Immunoglobulins | Genital tract | Immunomodulation | Human immunodeficiency virus--HIV | Mucosa | Clinical trials | Envelope protein | Monoclonal antibodies | Genetic engineering | Epitopes | Pharmacokinetics | Index Medicus
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8. Full Text Glycans Function as Anchors for Antibodies and Help Drive HIV Broadly Neutralizing Antibody Development
by Andrabi, Raiees and Su, Ching-Yao and Liang, Chi-Hui and Shivatare, Sachin S and Briney, Bryan and Voss, James E and Nawazi, Salar Khan and Wu, Chung-Yi and Wong, Chi-Huey and Burton, Dennis R
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2017, Volume 47, Issue 3, pp. 524 - 537.e3
B cell affinity maturation | virus escape | HIV envelope trimer | glycan engineering | Env glycans | broadly neutralizing antibodies | bnAbs | V2 apex epitope | Polysaccharides | HIV antibodies | HIV (Viruses) | Antigenic determinants | International relief | AIDS vaccines | Research institutes | Organic acids | Immunization | Immunoglobulins | Nuclear magnetic resonance--NMR | Maturation | Antibodies | Amino acids | Vaccines | Optimization | Glycan | Studies | Core protein | Protein folding | Coding | Human immunodeficiency virus--HIV | Neutralizing | Mutation | Recognition | Neutralization | Index Medicus
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9. Full Text Vaccines and Broadly Neutralizing Antibodies for HIV-1 Prevention
by Stephenson, Kathryn E and Wagh, Kshitij and Korber, Bette and Barouch, Dan H
Annual review of immunology, ISSN 0732-0582, 4/2020, Volume 38, Issue 1, pp. 673 - 703
HIV-1 | bNAb | vaccine | broadly neutralizing antibody | viral diversity | prevention | Index Medicus
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10. Full Text Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies
by Gardner, Matthew R and Fetzer, Ina and Kattenhorn, Lisa M and Davis-Gardner, Meredith E and Zhou, Amber S and Alfant, Barnett and Weber, Jesse A and Kondur, Hema R and Martinez-Navio, Jose M and Fuchs, Sebastian P and Desrosiers, Ronald C and Gao, Guangping and Lifson, Jeffrey D and Farzan, Michael
Molecular therapy, ISSN 1525-0016, 03/2019, Volume 27, Issue 3, pp. 650 - 660
PGT121 | HIV-1 | 10-1074 | anti-drug antibodies | NIH45-46 | AAV | 3BNC117 | broadly neutralizing antibodies | ADA | bNAbs | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Dependovirus - genetics | Antibodies, Neutralizing - immunology | HIV-1 - immunology | Animals | Immunoglobulin G - genetics | Antibodies, Neutralizing - metabolism | Kaplan-Meier Estimate | Macaca mulatta | HIV-1 - genetics | Immunoglobulin G - metabolism | Studies | Medical research | Immunoglobulins | Immunogenicity | Human immunodeficiency virus--HIV | Immunoglobulin G | Prophylaxis | Monoclonal antibodies | Infections | Experiments | Binding sites | Cancer | Index Medicus | Original
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