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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
by Chu, Y and Yang, X
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 9, pp. 1108 - 1116
SUMOylation governs numerous cellular processes and is essential to most eukaryotic life. Despite increasing recognition of the importance of this process, an... 
Mdm2 | TRIM proteins | sumoylation | SUMOE3 ligase | PML | p53 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PML NUCLEAR-BODIES | DNA-DAMAGE | REGULATES P53 | FAMILY PROTEINS | SUMO E3 ligase | UBIQUITIN LIGASES | CELL BIOLOGY | RET FINGER PROTEIN | ONCOLOGY | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | C-JUN | Immunoprecipitation | Transcription Factors - chemistry | Humans | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - genetics | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Small Ubiquitin-Related Modifier Proteins - chemistry | Ubiquitin-Conjugating Enzymes - metabolism | Protein Binding | Sumoylation | RNA, Small Interfering | Ubiquitin-Protein Ligases - genetics | Microscopy, Fluorescence | Promyelocytic Leukemia Protein | Physiological aspects | Tumor suppressor genes | Research | Tumor proteins | Ligases | Proteins | Enzymes | Biochemistry | Cellular biology | Gene expression | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1480 - 11
Our previous studies have demonstrated that activation of group I metabotropic glutamate receptors downregulated Kir channels in chronic ocular hypertension... 
ACTIVATED PROTEIN-KINASE | MESSENGER-RNA | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | GANGLION-CELLS | MEMBRANE CONDUCTANCE | INTRAOCULAR-PRESSURE | OCULAR HYPERTENSION MODEL | GLIAL-CELLS | EXPERIMENTAL GLAUCOMA | NUCLEUS-ACCUMBENS | Retina - drug effects | Glial Fibrillary Acidic Protein - genetics | Retina - metabolism | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ependymoglial Cells - metabolism | Gliosis - chemically induced | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Ocular Hypertension - metabolism | Glial Fibrillary Acidic Protein - metabolism | Ocular Hypertension - drug therapy | Gliosis - pathology | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Ependymoglial Cells - pathology | Disease Models, Animal | Barium Compounds - administration & dosage | Butadienes - pharmacology | Gliosis - genetics | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Ocular Hypertension - pathology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Proto-Oncogene Proteins c-fos - metabolism | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Potassium Channels, Inwardly Rectifying - genetics | Ependymoglial Cells - drug effects | Rats, Sprague-Dawley | Ocular Hypertension - genetics | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Chlorides - administration & dosage | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Proto-Oncogene Proteins c-fos - genetics | Gliosis - drug therapy | Protein Kinase Inhibitors - pharmacology | Chronic Disease | Potassium Channels, Inwardly Rectifying - metabolism | Retina - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Transcription factors | Potassium channels (inwardly-rectifying) | P elements | Glial fibrillary acidic protein | c-Jun protein | Extracellular signal-regulated kinase | MAP kinase | Retina | Glutamic acid receptors | Injection | Cyclic AMP response element-binding protein | Kinases | Proteins | Signal transduction | Gliosis | Protein kinase | Rodents | c-Fos protein | Glutamic acid receptors (metabotropic) | Index Medicus
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2004, Volume 23, Issue 8, pp. 1889 - 1899
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, pp. e97675 - e97675
Obesity is associated with inflammation that can drive metabolic defects such as hyperlipidemia and insulin resistance. Specific metabolites can contribute to... 
3T3-L1 ADIPOCYTES | INDEPENDENT MECHANISM | ACTIVATION | RECOGNITION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | ENDOTOXEMIA | MICROBIOTA | NF-KAPPA-B | INDUCED INSULIN-RESISTANCE | INNATE IMMUNITY | Lipolysis - drug effects | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gonads - drug effects | Nod1 Signaling Adaptor Protein - deficiency | Adipose Tissue - cytology | Adipocytes - cytology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | NF-kappa B - metabolism | Adipocytes - drug effects | Adipose Tissue - metabolism | Gonads - cytology | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | JNK Mitogen-Activated Protein Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Tissue Culture Techniques | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | 3T3-L1 Cells | Mice, Knockout | Gonads - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Adipocytes - metabolism | Mitogen-Activated Protein Kinases - genetics | Mice | Protein Kinase Inhibitors - pharmacology | Peptidoglycan - pharmacology | Adipose Tissue - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Nod1 Signaling Adaptor Protein - genetics | Obesity | Metabolites | Insulin resistance | Inflammation | Lipase | Phosphotransferases | Protein binding | Protein kinase A | Pediatrics | Transcription factors | Adipose tissue | Pollution load | Lipids | Activation | Biochemistry | Hormones | Adipocytes | Glucose | Kinases | Defects | Proteins | Receptors | Microbiota | Nutrient loading | Rodents | Animal tissues | Bacteria | Inhibition | Nod1 protein | Endotoxemia | Explants | Cues | Pathogens | NF-κB protein | Oligomerization | Cytokines | Hyperlipidemia | Peptidoglycans | Extracellular signal-regulated kinase | c-Jun protein | Glycerol | MAP kinase | Metabolism | Insulin | Lipolysis | Ligands | Index Medicus
Journal Article
Science, ISSN 0036-8075, 2/2004, Volume 303, Issue 5662, pp. 1371 - 1374
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e68574 - e68574
F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination-mediated suppression of several... 
FBXW7 EXPRESSION | NETWORK | P53 GENE | MULTIDISCIPLINARY SCIENCES | MUTATION | TUMOR-SUPPRESSOR | DIFFERENTIATION | FBW7 | HCDC4 | CANCER | CLINICAL-SIGNIFICANCE | F-Box-WD Repeat-Containing Protein 7 | Genetic Therapy | Liver - pathology | Humans | Gene Expression Regulation, Neoplastic | Liver Neoplasms - therapy | Cyclin E - genetics | Tumor Suppressor Protein p53 - genetics | Tumor Suppressor Protein p53 - therapeutic use | RNA Interference | Carcinoma, Hepatocellular - genetics | Cell Cycle Proteins - genetics | Female | Liver Neoplasms - pathology | Liver Neoplasms - genetics | Signal Transduction | F-Box Proteins - metabolism | Liver - metabolism | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Animals | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Adenoviruses, Human - genetics | Carcinoma, Hepatocellular - therapy | Mice | Mice, Inbred BALB C | Proto-Oncogene Proteins c-myc - genetics | Cyclin E - metabolism | Mutation | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Apoptosis | Carcinoma, Hepatocellular - metabolism | Ubiquitin | Hepatoma | Gene therapy | Tumor proteins | Adenoviruses | Cell culture | Biotechnology | Transcription factors | p53 Protein | c-Myc protein | Hepatocellular carcinoma | Myc protein | Tissues | Phase transitions | Cdc4 protein | Anticancer properties | Proteins | Liver cancer | Ubiquitination | Cell growth | Antitumor agents | Surgery | Cell cycle | Cyclin E | Recombinant | Enzymes | c-Jun protein | Pharmacology | Breast cancer | siRNA | Injection | Tumor cell lines | Chemical compounds | Medical prognosis | Cell lines | Proteasomes | Tumor suppressor genes | Protein expression | Index Medicus
Journal Article
Journal Article
Analytical Chemistry, ISSN 0003-2700, 11/2018, Volume 90, Issue 22, pp. 13299 - 13305
Protein protein interactions (PPIs) occur in a vast variety of cellular processes, and many processes are regulated by multiple protein interactions.... 
VISUALIZATION | CHEMISTRY, ANALYTICAL | PROTEIN | INTEGRATION | BAF | LEDGF/P75 | MICROSCOPY | LIVING CELLS | RETROVIRAL DNA | AUTOINTEGRATION | Humans | Protein Multimerization | Bacterial Proteins - chemistry | Cercopithecus aethiops | Fluorescence | Multiprotein Complexes - genetics | HIV Integrase - metabolism | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | HEK293 Cells | Luminescent Proteins - chemistry | Nuclear Proteins - genetics | Peptide Fragments - genetics | Vero Cells | Proto-Oncogene Proteins c-jun - genetics | NFATC Transcription Factors - metabolism | Bacterial Proteins - genetics | Proto-Oncogene Proteins c-fos - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Microscopy, Confocal - methods | Transcription Factors - metabolism | Peptide Fragments - chemistry | Animals | HIV Integrase - genetics | Microscopy, Fluorescence - methods | Multiprotein Complexes - analysis | Virus Integration - physiology | Proto-Oncogene Proteins c-jun - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Luminescent Proteins - genetics | Proto-Oncogene Proteins c-fos - genetics | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | NFATC Transcription Factors - genetics | Proteins | Visualization | Integration | Molecular modelling | Human immunodeficiency virus--HIV | Cells (biology) | Identification | Physiology | Protein interaction | Index Medicus
Journal Article
11.