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Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3909 - 3919
KIT or alpha-platelet-derived growth factor receptor (alpha-PDGFR) activating mutations are the pathogenic mechanisms that characterize gastrointestinal... 
Kit mutations | Tyrosine kinases | GIST | Morphological change | SURVIVAL | morphological change | CELL-ADHESION MOLECULE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-KIT | RECEPTOR | tyrosine kinases | IDENTIFICATION | CELL BIOLOGY | MICROENVIRONMENT | ONCOLOGY | GROWTH | GENETICS & HEREDITY | MUTATIONS | INHIBITOR | Gene Expression Regulation, Enzymologic - drug effects | Oncogene Proteins - genetics | Taxoids - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Antineoplastic Agents - therapeutic use | Green Fluorescent Proteins - genetics | Proto-Oncogene Proteins c-kit - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gastrointestinal Stromal Tumors - genetics | Protein Structure, Tertiary | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Models, Molecular | Piperazines - therapeutic use | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Blotting, Western | Cell Shape - drug effects | Drug Synergism | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Proto-Oncogene Proteins c-kit - chemistry | Receptor Protein-Tyrosine Kinases - chemistry | Control | Gastrointestinal tumors | Protein tyrosine kinase | Genetic aspects | Research | Gene expression | Health aspects | Gastroenterology | Oncology | Kinases | Drug resistance | Tumors
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2004, Volume 24, Issue 4, pp. 1439 - 1452
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TRANSCRIPTION FACTOR SCL | HEMATOPOIETIC-CELLS | LOOP-HELIX PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTION | C-KIT EXPRESSION | T-CELL LEUKEMIA | ZINC-FINGER PROTEIN | GENE-EXPRESSION | ACTIVITY IN-VIVO | RED-BLOOD-CELLS | CELL BIOLOGY | Transcription Factors - chemistry | Molecular Sequence Data | Sp1 Transcription Factor - metabolism | Proto-Oncogene Proteins - chemistry | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | GATA1 Transcription Factor | Metalloproteins - metabolism | Base Sequence | TCF Transcription Factors | Electrophoretic Mobility Shift Assay | Binding Sites | T-Cell Acute Lymphocytic Leukemia Protein 1 | Basic Helix-Loop-Helix Transcription Factors | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | LIM Domain Proteins | Response Elements | Gene Expression Regulation | Transcription Factor 7-Like 1 Protein | Glycophorin - genetics | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | DNA-Binding Proteins - chemistry | Macromolecular Substances | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Protein Binding | Erythroid-Specific DNA-Binding Factors | Mice | Glycophorin A | SCL protein | E47 protein | TAL1 protein | GPA gene | Ldb1 protein | FOG protein | LMO2 protein | Transcriptional Regulation
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e37776
The KIT-inhibitor imatinib mesylate (IM) has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong... 
APOPTOSIS | ACTIVATION | HEAT-SHOCK-PROTEIN-90 | INHIBITION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MDM2 | GENE AMPLIFICATION | C-KIT | MUTATIONS | IMATINIB MESYLATE | Phosphorylation | Gastrointestinal Neoplasms - genetics | Apoptosis - drug effects | Gastrointestinal Neoplasms - drug therapy | Humans | Caspase 3 - metabolism | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Transcription, Genetic | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Gastrointestinal Stromal Tumors - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Gastrointestinal Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Imidazoles - pharmacology | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Sequence Analysis, DNA | Transcription Factors - metabolism | Heterogeneous-Nuclear Ribonucleoprotein K - metabolism | Tumor Protein p73 | Signal Transduction - drug effects | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Cell Cycle - drug effects | Care and treatment | Analysis | Drug therapy, Combination | Metastasis | Tumor proteins | Health aspects | Apoptosis | Drugs | Biotechnology | p53 Protein | Cytotoxicity | Oncology | Activation | Bone surgery | Medical schools | Metastases | Signal transduction | Modulation | Cell cycle | Remission | Medical research | MDM2 protein | Imatinib | Heat shock proteins | Exploration | Pathology | Gene amplification | Inhibitors | Cell lines | Stem cells | Cancer | Tumors
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, p. 6127
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 09/2007, Volume 102, Issue 6, pp. 1749 - 1757
Imatinib, a protein tyrosine kinase inhibitor, may prevent the growth of glioblastoma cells. Unfortunately, its brain distribution is restricted by... 
CGP74588 | mouse | p‐glycoprotein | imatinib | blood–brain barrier | breast cancer resistance protein | Imatinib | Blood-brain barrier | Mouse | Breast cancer resistance protein | p-glycoproteinz | blood-brain barrier | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | p-glycoprotein | C-KIT | DRUG-RESISTANCE | DEFICIENT MICE | GF120918 | NEUROSCIENCES | REVERSAL | IN-VITRO | PHARMACOKINETICS | TYROSINE KINASE INHIBITOR | MULTIDRUG-RESISTANCE | Male | Piperazines - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | ATP Binding Cassette Transporter, Subfamily B, Member 1 | ATP-Binding Cassette Transporters - genetics | Biological Transport, Active - physiology | ATP-Binding Cassette Transporters - metabolism | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Subfamily B - genetics | Piperazines - pharmacokinetics | Immunosuppressive Agents - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Tetrahydroisoquinolines - pharmacology | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Blood-Brain Barrier - drug effects | Imatinib Mesylate | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Mice | Benzamides | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Breast cancer | Proteins | Neurosciences | Inhibitor drugs | Rodents | Biochemistry | Glycoproteins
Journal Article
Blood, ISSN 0006-4971, 12/2000, Volume 96, Issue 12, pp. 3907 - 3914
Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemia.... 
INTERNAL TANDEM DUPLICATION | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | HUMAN BONE-MARROW | CONSTITUTIVE ACTIVATION | C-KIT | MURINE FLT3 | GROWTH-FACTOR | HEMATOLOGY | RECEPTOR TYROSINE KINASE | HUMAN HOMOLOG | Clone Cells - cytology | Recombinant Fusion Proteins - pharmacology | Apoptosis - drug effects | Apoptosis - radiation effects | DNA Replication - drug effects | Humans | Leukemia, Myeloid - genetics | Myeloid Cells - physiology | Protein-Serine-Threonine Kinases | fms-Like Tyrosine Kinase 3 | ras Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Transfection | Milk Proteins | Female | Myeloid Cells - drug effects | Neoplasms, Experimental - mortality | Tumor Cells, Cultured | Tandem Repeat Sequences - genetics | ras Proteins - physiology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | Acute Disease | DNA-Binding Proteins - physiology | Receptor Protein-Tyrosine Kinases - pharmacology | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Cell Division - drug effects | Mice, Inbred C3H | Proto-Oncogene Proteins c-akt | Animals | STAT5 Transcription Factor | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Leukemia, Myeloid - physiopathology | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Cell Transformation, Neoplastic - drug effects | Mutation
Journal Article
Nature Medicine, ISSN 1078-8956, 2011, Volume 17, Issue 6, pp. 700 - 707
The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30... 
MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | HUMAN DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-10 PRODUCTION | C-KIT | TRIGGERING RECEPTOR | CELL BIOLOGY | NK CELLS | CLASS-III | CYTOTOXICITY RECEPTORS | HUMAN MHC | EXPRESSION | Prognosis | Alternative Splicing - genetics | Humans | Interleukin-12 - physiology | Lysosomal-Associated Membrane Protein 1 - physiology | Interferon-gamma - physiology | Alternative Splicing - physiology | Gastrointestinal Stromal Tumors - physiopathology | Natural Cytotoxicity Triggering Receptor 3 - genetics | Natural Cytotoxicity Triggering Receptor 3 - physiology | Killer Cells, Natural - physiology | Proto-Oncogene Proteins c-kit - physiology | Gastrointestinal Stromal Tumors - diagnosis | Protein Isoforms | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Polymorphism, Single Nucleotide - genetics | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Dendritic cells | Gastrointestinal tumors | Physiological aspects | Genetic aspects | Research | Gene expression | Interferon | Medical prognosis | Gastrointestinal diseases | Tumors | Cancer | Interferon-gamma | Killer Cells, Natural | Alternative Splicing | Natural Cytotoxicity Triggering Receptor 3 | Interleukin-12 | Proto-Oncogene Proteins c-kit | Tumor Necrosis Factor-alpha | Life Sciences | Lysosomal-Associated Membrane Protein 1 | Immunology | Polymorphism, Single Nucleotide | Gastrointestinal Stromal Tumors
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2005, Volume 338, Issue 3, pp. 1307 - 1315
Journal Article