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Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3909 - 3919
Kit mutations | Tyrosine kinases | GIST | Morphological change | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Medical sciences | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Tumors | Gene Expression Regulation, Enzymologic - drug effects | Oncogene Proteins - genetics | Taxoids - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Antineoplastic Agents - therapeutic use | Green Fluorescent Proteins - genetics | Proto-Oncogene Proteins c-kit - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gastrointestinal Stromal Tumors - genetics | Protein Structure, Tertiary | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Models, Molecular | Piperazines - therapeutic use | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Blotting, Western | Cell Shape - drug effects | Drug Synergism | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Proto-Oncogene Proteins c-kit - chemistry | Receptor Protein-Tyrosine Kinases - chemistry | Control | Gastrointestinal tumors | Protein tyrosine kinase | Genetic aspects | Research | Gene expression | Health aspects | Gastroenterology | Kinases | Drug resistance | Index Medicus
Journal Article
Nature medicine, ISSN 1078-8956, 2011, Volume 17, Issue 6, pp. 700 - 707
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Prognosis | Alternative Splicing - genetics | Humans | Interleukin-12 - physiology | Lysosomal-Associated Membrane Protein 1 - physiology | Interferon-gamma - physiology | Alternative Splicing - physiology | Gastrointestinal Stromal Tumors - physiopathology | Natural Cytotoxicity Triggering Receptor 3 - genetics | Natural Cytotoxicity Triggering Receptor 3 - physiology | Killer Cells, Natural - physiology | Proto-Oncogene Proteins c-kit - physiology | Gastrointestinal Stromal Tumors - diagnosis | Protein Isoforms | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Polymorphism, Single Nucleotide - genetics | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Dendritic cells | Gastrointestinal tumors | Physiological aspects | Genetic aspects | Research | Gene expression | Interferon | Medical prognosis | Gastrointestinal diseases | Tumors | Cancer | Index Medicus | Interferon-gamma | Killer Cells, Natural | Alternative Splicing | Natural Cytotoxicity Triggering Receptor 3 | Interleukin-12 | Proto-Oncogene Proteins c-kit | Tumor Necrosis Factor-alpha | Life Sciences | Lysosomal-Associated Membrane Protein 1 | Immunology | Polymorphism, Single Nucleotide | Gastrointestinal Stromal Tumors
Journal Article
Scientific reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, pp. 6127 - 6127
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Peptides - chemistry | Tacrolimus Binding Proteins - chemistry | Tacrolimus - chemistry | Tumor Suppressor Protein p53 - metabolism | Tacrolimus - metabolism | Tacrolimus Binding Proteins - metabolism | Tacrolimus - analogs & derivatives | Proto-Oncogene Proteins c-kit - metabolism | Tacrolimus Binding Proteins - genetics | Protein Interaction Mapping - methods | Animals | Peptides - metabolism | Tacrolimus - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Cell Proliferation - drug effects | Mice | Protein Interaction Domains and Motifs | Tumor Suppressor Protein p53 - chemistry | Dimerization | Proto-Oncogene Proteins c-kit - chemistry | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Amino Acid Substitution | Background levels | MDM2 protein | Cytokines | Peptides | Kinases | c-Kit protein | Mammalian cells | Proteins | Tacrolimus-binding protein | Interleukin 3 | Affinity | Chimeras | Protein interaction | Index Medicus
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2005, Volume 338, Issue 3, pp. 1307 - 1315
Dysgerminoma | Acute myelogenous leukemia | Germ cells | Flt3 | Oncogene | Chronic myelogenous leukemia | Bcr-Abl | Abl | Nasal T-cell lymphoma | Gleevec | Cell signaling | Seminoma | Mast cells | STI-571 | Targeted cancer therapy | Proto-oncogene | Activation loop | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Signal Transduction | Humans | Pyrimidines - pharmacology | Mutation - genetics | Proto-Oncogene Proteins c-kit - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Neoplasms - therapy | Animals | Neoplasms - genetics | Proto-Oncogene Proteins c-kit - genetics | Benzamides | Proto-Oncogene Proteins c-kit - chemistry | Tyrosine | Phosphatidylinositol | Enzymes | Sexually transmitted diseases | Platelet-derived growth factor | Leukemia | Non-Hodgkin's lymphomas | T cells | Embryonic stem cells | Protein kinases | Index Medicus
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2005, Volume 337, Issue 1, pp. 1 - 13
Lyn | Grb7 | APS | Bad | Piebaldism | Ras | Oncogene | Src family kinase | MAP kinase | Akt | Cbl | Shp2 | Dok1 | Shp1 | Hematopoiesis | Protein kinase | Leukemia cell lines | Fyn | Grb2 | Mast cell | Protein phosphatase | Proto-oncogene | Cancer | Erk | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Type C Phospholipases - metabolism | Protein Tyrosine Phosphatases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Animals | Phospholipase C gamma | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-kit - chemistry | Tyrosine | Phosphatidylinositol | Enzymes | Platelet-derived growth factor | Phosphatases | Endothelial growth factors | Leukemia | Embryonic stem cells | Protein kinases | Protein binding | Index Medicus
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 15278 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | HSP90 Heat-Shock Proteins - biosynthesis | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Male | Apoptotic Protease-Activating Factor 1 - genetics | Proto-Oncogene Proteins c-kit - metabolism | Drug Delivery Systems | Leukemia, Myeloid, Acute - drug therapy | Female | Proto-Oncogene Proteins c-kit - genetics | Benzamides - pharmacology | HSP90 Heat-Shock Proteins - genetics | Leukemia, Myeloid, Acute - pathology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins c-kit - analysis | Apoptotic Protease-Activating Factor 1 - metabolism | Dasatinib - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Mice | Pyrazines - pharmacology | Leukemia, Myeloid, Acute - genetics | Tyrosine | BCR protein | Myeloid leukemia | Leukemia | Heat shock proteins | Caspase | Abl protein | Chronic myeloid leukemia | c-Kit protein | Endocytosis | Cell death | Apaf-1 protein | Xenografts | Dynamin | Fusion protein | Acute myeloid leukemia | Protein-tyrosine kinase | Apoptosis
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 78226 - 78241
ICC | Arsenic trioxide | GIST | Imatinib-resistant | GLI | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gastrointestinal Neoplasms - genetics | Zinc Finger Protein GLI1 - metabolism | Gastrointestinal Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Proto-Oncogene Proteins c-kit - metabolism | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Gastrointestinal Neoplasms - pathology | Interstitial Cells of Cajal - metabolism | Transfection | RNA Interference | Zinc Finger Protein Gli2 - antagonists & inhibitors | Gastrointestinal Stromal Tumors - pathology | Zinc Finger Protein GLI1 - antagonists & inhibitors | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Binding Sites | Gastrointestinal Stromal Tumors - genetics | Zinc Finger Protein Gli2 - genetics | Gastrointestinal Neoplasms - metabolism | Promoter Regions, Genetic | Zinc Finger Protein Gli3 - metabolism | Cilia - pathology | Cell Survival | Imatinib Mesylate - pharmacology | Zinc Finger Protein GLI1 - genetics | Arsenicals - pharmacology | RNA, Messenger - genetics | Interstitial Cells of Cajal - drug effects | Interstitial Cells of Cajal - pathology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Zinc Finger Protein Gli3 - genetics | Cilia - metabolism | Zinc Finger Protein Gli2 - metabolism | Nerve Tissue Proteins - metabolism | Oxides - pharmacology | Signal Transduction - drug effects | Gastrointestinal Stromal Tumors - drug therapy | Receptor, Platelet-Derived Growth Factor alpha - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Mutation | Index Medicus
Journal Article
Analytical chemistry (Washington), ISSN 0003-2700, 05/2017, Volume 89, Issue 9, pp. 4824 - 4830
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Cell proliferation | Cell culture | Phosphorylation | RNA-protein interactions | Src protein | c-Kit protein | Cells | Mammalian cells | Proteins | Sensitivity | Tacrolimus-binding protein | Interleukin 3 | Ligands | Protein-tyrosine kinase receptors | Affinity | Mutation | Intracellular | Protein interaction | Dimerization | Index Medicus
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The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
Cell death & disease, ISSN 2041-4889, 04/2019, Volume 10, Issue 4, pp. 300 - 300
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lysosomes - drug effects | Cell Survival - drug effects | Unfolded Protein Response - drug effects | Adenine - analogs & derivatives | eIF-2 Kinase - metabolism | Endocytosis - drug effects | Humans | Adenine - pharmacology | Proto-Oncogene Proteins c-kit - metabolism | Adenine - chemistry | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | eIF-2 Kinase - antagonists & inhibitors | Hep G2 Cells | HEK293 Cells | Indoles - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Kinetics | Indoles - chemistry | eIF-2 Kinase - genetics | Tyrosine | Endocytosis | Cell death | Protein folding | Lysosomes | Kinases | Mast cell leukemia | Protein-tyrosine kinase | Mammalian cells | Index Medicus | Life Sciences | Cancer | unclassified drug | computer model | protein kinase R like endoplasmic reticulum kinase | Article | concentration response | binding assay | dissociation constant | protein kinase | gsk 2606414 | kira 6 | protein tyrosine kinase inhibitor | cytoplasm | protein domain | unfolded protein response | drug binding site | molecular docking | controlled study | Biokemi och molekylärbiologi | cell culture | adenosine triphosphate | Biochemistry and Molecular Biology | priority journal
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