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1. Full Text A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors
by Mahadevan, D and Cooke, L and Riley, C and Swart, R and Simons, B and Della Croce, K and Wisner, L and Iorio, M and Shakalya, K and Garewal, H and Nagle, R and Bearss, D
Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3909 - 3919
KIT or alpha-platelet-derived growth factor receptor (alpha-PDGFR) activating mutations are the pathogenic mechanisms that characterize gastrointestinal... 
Kit mutations | Tyrosine kinases | GIST | Morphological change | SURVIVAL | morphological change | CELL-ADHESION MOLECULE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-KIT | RECEPTOR | tyrosine kinases | IDENTIFICATION | CELL BIOLOGY | MICROENVIRONMENT | ONCOLOGY | GROWTH | GENETICS & HEREDITY | MUTATIONS | INHIBITOR | Gene Expression Regulation, Enzymologic - drug effects | Oncogene Proteins - genetics | Taxoids - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Antineoplastic Agents - therapeutic use | Green Fluorescent Proteins - genetics | Proto-Oncogene Proteins c-kit - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gastrointestinal Stromal Tumors - genetics | Protein Structure, Tertiary | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Models, Molecular | Piperazines - therapeutic use | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Blotting, Western | Cell Shape - drug effects | Drug Synergism | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Proto-Oncogene Proteins c-kit - chemistry | Receptor Protein-Tyrosine Kinases - chemistry | Control | Gastrointestinal tumors | Protein tyrosine kinase | Genetic aspects | Research | Gene expression | Health aspects | Gastroenterology | Oncology | Kinases | Drug resistance | Tumors
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2. Full Text SCL Assembles a Multifactorial Complex That Determines Glycophorin A Expression
by Rachid Lahlil and Eric Lécuyer and Sabine Herblot and Trang Hoang
Molecular and Cellular Biology, ISSN 0270-7306, 02/2004, Volume 24, Issue 4, pp. 1439 - 1452
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TRANSCRIPTION FACTOR SCL | HEMATOPOIETIC-CELLS | LOOP-HELIX PROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-PROTEIN INTERACTION | C-KIT EXPRESSION | T-CELL LEUKEMIA | ZINC-FINGER PROTEIN | GENE-EXPRESSION | ACTIVITY IN-VIVO | RED-BLOOD-CELLS | CELL BIOLOGY | Transcription Factors - chemistry | Molecular Sequence Data | Sp1 Transcription Factor - metabolism | Proto-Oncogene Proteins - chemistry | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - metabolism | GATA1 Transcription Factor | Metalloproteins - metabolism | Base Sequence | TCF Transcription Factors | Electrophoretic Mobility Shift Assay | Binding Sites | T-Cell Acute Lymphocytic Leukemia Protein 1 | Basic Helix-Loop-Helix Transcription Factors | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | LIM Domain Proteins | Response Elements | Gene Expression Regulation | Transcription Factor 7-Like 1 Protein | Glycophorin - genetics | Hematopoietic Stem Cells - metabolism | Reverse Transcriptase Polymerase Chain Reaction | DNA-Binding Proteins - chemistry | Macromolecular Substances | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Protein Binding | Erythroid-Specific DNA-Binding Factors | Mice | Glycophorin A | SCL protein | E47 protein | TAL1 protein | GPA gene | Ldb1 protein | FOG protein | LMO2 protein | Transcriptional Regulation
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3. Full Text Oncogenic kinase signalling
by Hunter, Tony and Blume-Jensen, Peter
Nature, ISSN 0028-0836, 05/2001, Volume 411, Issue 6835, pp. 355 - 365
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in... 
CATALYTIC SUBUNIT | C-KIT RECEPTOR | NEOPLASIA TYPE 2B | PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | MYELOID-LEUKEMIA | STEM-CELL FACTOR | SRC FAMILY KINASES | GASTROINTESTINAL STROMAL TUMORS | PROTEIN-TYROSINE-PHOSPHATASE | Neoplasms - metabolism | Oncogene Proteins - genetics | Oncogenes - genetics | Ribosomal Protein S6 Kinases - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Oncogene Proteins - metabolism | Retroviridae Proteins, Oncogenic - metabolism | Neoplasms - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Oncogene Protein v-akt | Oncogene Proteins - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - genetics | Protein-Tyrosine Kinases - genetics | Animals | Neoplasms - genetics | Receptor Protein-Tyrosine Kinases - genetics | Retroviridae Proteins, Oncogenic - genetics | Neoplasms - pathology | Ribosomal Protein S6 Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Genetics | Mutation | Human Genome Project | Cells | Cancer
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4. Full Text P53 modulation as a therapeutic strategy in gastrointestinal stromal tumors
by Henze, Joern and Mühlenberg, Thomas and Simon, Susanne and Grabellus, Florian and Rubin, Brian and Taeger, Georg and Schuler, Martin and Treckmann, Juergen and Debiec-Rychter, Maria and Taguchi, Takahiro and Fletcher, Jonathan A and Bauer, Sebastian
PLoS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5, p. e37776
The KIT-inhibitor imatinib mesylate (IM) has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong... 
APOPTOSIS | ACTIVATION | HEAT-SHOCK-PROTEIN-90 | INHIBITION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MDM2 | GENE AMPLIFICATION | C-KIT | MUTATIONS | IMATINIB MESYLATE | Phosphorylation | Gastrointestinal Neoplasms - genetics | Apoptosis - drug effects | Gastrointestinal Neoplasms - drug therapy | Humans | Caspase 3 - metabolism | Antineoplastic Agents - therapeutic use | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Transcription, Genetic | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Gastrointestinal Stromal Tumors - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Gastrointestinal Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Imidazoles - pharmacology | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Imatinib Mesylate | Piperazines - pharmacology | Sequence Analysis, DNA | Transcription Factors - metabolism | Heterogeneous-Nuclear Ribonucleoprotein K - metabolism | Tumor Protein p73 | Signal Transduction - drug effects | Gastrointestinal Stromal Tumors - drug therapy | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Cell Cycle - drug effects | Care and treatment | Analysis | Drug therapy, Combination | Metastasis | Tumor proteins | Health aspects | Apoptosis | Drugs | Biotechnology | p53 Protein | Cytotoxicity | Oncology | Activation | Bone surgery | Medical schools | Metastases | Signal transduction | Modulation | Cell cycle | Remission | Medical research | MDM2 protein | Imatinib | Heat shock proteins | Exploration | Pathology | Gene amplification | Inhibitors | Cell lines | Stem cells | Cancer | Tumors
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5. Full Text Identifying Residues that Determine SCF Molecular-Level Interactions through a Combination of Experimental and In silico Analyses
by Rabinovich, Eitan and Heyne, Michael and Bakhman, Anna and Kosloff, Mickey and Shifman, Julia M and Papo, Niv
Journal of Molecular Biology, ISSN 0022-2836, 01/2017, Volume 429, Issue 1, pp. 97 - 114
The stem cell factor (SCF)/c-Kit receptor tyrosine kinase complex—with its significant roles in hematopoiesis and angiogenesis—is an attractive target for... 
protein–protein interactions | binding affinity | protein engineering | computational protein design | combinatorial selection | TYROSINE KINASE-ACTIVITY | C-KIT RECEPTOR | MAMMALIAN EYE | SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SCANNING MUTAGENESIS | EXPRESSION SYSTEM | protein-protein interactions | PROTEIN-PROTEIN RECOGNITION | AFFINITY | STEM-CELL FACTOR | YEAST SURFACE DISPLAY | Stem Cell Factor - metabolism | Saccharomyces cerevisiae - genetics | Computational Biology | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Stem Cell Factor - chemistry | Stem Cell Factor - genetics | Proto-Oncogene Proteins c-kit - metabolism | Protein Interaction Mapping | Saccharomyces cerevisiae - metabolism | Point Mutation | DNA Mutational Analysis | Cell Surface Display Techniques | Mutant Proteins - chemistry | Protein Binding | Protein Conformation | Tyrosine | Analysis | Stem cells | Antigenic determinants | Protein binding
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6. Full Text Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells
by Mabe, Satoru and Nagamune, Teruyuki and Kawahara, Masahiro
Scientific Reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, p. 6127
Detection of protein-protein interactions (PPIs) is important for understanding numerous processes in mammalian cells; however, existing PPI detection methods... 
YEAST 2-HYBRID SYSTEM | SIGNAL-TRANSDUCTION | PROXIMITY LIGATION ASSAYS | ACTIVATION | DOMAIN | RECEPTOR TYROSINE KINASES | SPECIFICITY | MULTIDISCIPLINARY SCIENCES | RESONANCE ENERGY-TRANSFER | C-KIT | BINDING | Cell Line | Peptides - chemistry | Tacrolimus Binding Proteins - chemistry | Tacrolimus - chemistry | Tumor Suppressor Protein p53 - metabolism | Tacrolimus - metabolism | Tacrolimus Binding Proteins - metabolism | Tacrolimus - analogs & derivatives | Proto-Oncogene Proteins c-kit - metabolism | Tacrolimus Binding Proteins - genetics | Protein Interaction Mapping - methods | Animals | Peptides - metabolism | Tacrolimus - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Cell Proliferation - drug effects | Mice | Protein Interaction Domains and Motifs | Tumor Suppressor Protein p53 - chemistry | Dimerization | Proto-Oncogene Proteins c-kit - chemistry | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Amino Acid Substitution | Background levels | MDM2 protein | Cytokines | Peptides | Kinases | c-Kit protein | Mammalian cells | Proteins | Tacrolimus-binding protein | Interleukin 3 | Affinity | Chimeras | Protein interaction
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7. Full Text Influence of breast cancer resistance protein (Abcg2) and p‐glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec®) across the mouse blood–brain barrier
by Bihorel, Sébastien and Camenisch, Gian and Lemaire, Michel and Scherrmann, Jean‐Michel
Journal of Neurochemistry, ISSN 0022-3042, 09/2007, Volume 102, Issue 6, pp. 1749 - 1757
Imatinib, a protein tyrosine kinase inhibitor, may prevent the growth of glioblastoma cells. Unfortunately, its brain distribution is restricted by... 
CGP74588 | mouse | p‐glycoprotein | imatinib | blood–brain barrier | breast cancer resistance protein | Imatinib | Blood-brain barrier | Mouse | Breast cancer resistance protein | p-glycoproteinz | blood-brain barrier | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | p-glycoprotein | C-KIT | DRUG-RESISTANCE | DEFICIENT MICE | GF120918 | NEUROSCIENCES | REVERSAL | IN-VITRO | PHARMACOKINETICS | TYROSINE KINASE INHIBITOR | MULTIDRUG-RESISTANCE | Male | Piperazines - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Antineoplastic Agents - metabolism | Brain - metabolism | Dose-Response Relationship, Drug | Brain - blood supply | ATP Binding Cassette Transporter, Subfamily B, Member 1 | ATP-Binding Cassette Transporters - genetics | Biological Transport, Active - physiology | ATP-Binding Cassette Transporters - metabolism | Dibenzocycloheptenes - pharmacology | ATP Binding Cassette Transporter, Subfamily B - genetics | Piperazines - pharmacokinetics | Immunosuppressive Agents - pharmacology | ATP Binding Cassette Transporter, Subfamily G, Member 2 | Tetrahydroisoquinolines - pharmacology | Biological Transport, Active - drug effects | Enzyme Inhibitors - pharmacology | Blood-Brain Barrier - drug effects | Imatinib Mesylate | ATP Binding Cassette Transporter, Subfamily B - metabolism | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Animals | ATP Binding Cassette Transporter, Subfamily B - antagonists & inhibitors | Acridines - pharmacology | Pyrimidines - pharmacokinetics | Mice | Benzamides | ATP-Binding Cassette Transporters - antagonists & inhibitors | Physiological aspects | Breast cancer | Proteins | Neurosciences | Inhibitor drugs | Rodents | Biochemistry | Glycoproteins
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8. Full Text Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
by Mizuki, M and Fenski, R and Halfter, H and Matsumura, I and Schmidt, R and Muller, C and Gruning, W and Kratz-Albers, K and Serve, S and Steur, C and Buchner, T and Kienast, J and Kanakura, Y and Berdel, W.E and Serve, H
Blood, ISSN 0006-4971, 12/2000, Volume 96, Issue 12, pp. 3907 - 3914
Somatic mutations of the receptor tyrosine kinase Flt3 consisting of internal tandem duplications (ITD) occur in 20% of patients with acute myeloid leukemia.... 
INTERNAL TANDEM DUPLICATION | STEM-CELLS | HEMATOPOIETIC PROGENITOR CELLS | HUMAN BONE-MARROW | CONSTITUTIVE ACTIVATION | C-KIT | MURINE FLT3 | GROWTH-FACTOR | HEMATOLOGY | RECEPTOR TYROSINE KINASE | HUMAN HOMOLOG | Clone Cells - cytology | Recombinant Fusion Proteins - pharmacology | Apoptosis - drug effects | Apoptosis - radiation effects | DNA Replication - drug effects | Humans | Leukemia, Myeloid - genetics | Myeloid Cells - physiology | Protein-Serine-Threonine Kinases | fms-Like Tyrosine Kinase 3 | ras Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Neoplasms, Experimental - pathology | Mitogen-Activated Protein Kinase Kinases - metabolism | Transfection | Milk Proteins | Female | Myeloid Cells - drug effects | Neoplasms, Experimental - mortality | Tumor Cells, Cultured | Tandem Repeat Sequences - genetics | ras Proteins - physiology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - pharmacology | Acute Disease | DNA-Binding Proteins - physiology | Receptor Protein-Tyrosine Kinases - pharmacology | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Cell Division - drug effects | Mice, Inbred C3H | Proto-Oncogene Proteins c-akt | Animals | STAT5 Transcription Factor | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Leukemia, Myeloid - physiopathology | Recombinant Fusion Proteins - genetics | Trans-Activators - metabolism | Mice | Cell Transformation, Neoplastic - drug effects | Mutation
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9. Full Text Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors
by Delahaye, Nicolas F and Rusakiewicz, Sylvie and Martins, Isabelle and Ménard, Cédric and Roux, Stephan and Lyonnet, Luc and Paul, Pascale and Sarabi, Matthieu and Chaput, Nathalie and Semeraro, Michaela and Minard-Colin, Véronique and Poirier-Colame, Vichnou and Chaba, Kariman and Flament, Caroline and Baud, Véronique and Authier, Hélène and Kerdine-Römer, Saadia and Pallardy, Marc and Cremer, Isabelle and Peaudecerf, Laetitia and Rocha, Bénédita and Valteau-Couanet, Dominique and Gutierrez, Javier Celis and Nunès, Jacques A and Commo, Frédéric and Bonvalot, Sylvie and Ibrahim, Nicolas and Terrier, Philippe and Opolon, Paule and Bottino, Cristina and Moretta, Alessandro and Tavernier, Jan and Rihet, Pascal and Coindre, Jean-Michel and Blay, Jean-Yves and Isambert, Nicolas and Emile, Jean-Franãois and Vivier, Eric and Lecesne, Axel and Kroemer, Guido and Zitvogel, Laurence
Nature Medicine, ISSN 1078-8956, 2011, Volume 17, Issue 6, pp. 700 - 707
The natural killer (NK) cell receptor NKp30 is involved in the recognition of tumor and dendritic cells (DCs). Here we describe the influence of three NKp30... 
MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | HUMAN DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-10 PRODUCTION | C-KIT | TRIGGERING RECEPTOR | CELL BIOLOGY | NK CELLS | CLASS-III | CYTOTOXICITY RECEPTORS | HUMAN MHC | EXPRESSION | Prognosis | Alternative Splicing - genetics | Humans | Interleukin-12 - physiology | Lysosomal-Associated Membrane Protein 1 - physiology | Interferon-gamma - physiology | Alternative Splicing - physiology | Gastrointestinal Stromal Tumors - physiopathology | Natural Cytotoxicity Triggering Receptor 3 - genetics | Natural Cytotoxicity Triggering Receptor 3 - physiology | Killer Cells, Natural - physiology | Proto-Oncogene Proteins c-kit - physiology | Gastrointestinal Stromal Tumors - diagnosis | Protein Isoforms | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Polymorphism, Single Nucleotide - genetics | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Dendritic cells | Gastrointestinal tumors | Physiological aspects | Genetic aspects | Research | Gene expression | Interferon | Medical prognosis | Gastrointestinal diseases | Tumors | Cancer | Interferon-gamma | Killer Cells, Natural | Alternative Splicing | Natural Cytotoxicity Triggering Receptor 3 | Interleukin-12 | Proto-Oncogene Proteins c-kit | Tumor Necrosis Factor-alpha | Life Sciences | Lysosomal-Associated Membrane Protein 1 | Immunology | Polymorphism, Single Nucleotide | Gastrointestinal Stromal Tumors
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10. Full Text Structure and regulation of Kit protein-tyrosine kinase—The stem cell factor receptor
by Roskoski, Robert
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2005, Volume 338, Issue 3, pp. 1307 - 1315
Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and... 
Dysgerminoma | Acute myelogenous leukemia | Germ cells | Flt3 | Oncogene | Chronic myelogenous leukemia | Bcr-Abl | Abl | Nasal T-cell lymphoma | Gleevec | Cell signaling | Seminoma | Mast cells | STI-571 | Targeted cancer therapy | Proto-oncogene | Activation loop | targeted cancer therapy | ACTIVATION | gleevec | PHOSPHORYLATION | acute myelogenous leukemia | DIMERIZATION | nasal T-cell lymphoma | mast cells | activation loop | proto-oncogene | dysgerminoma | MUTATIONS | germ cells | GASTROINTESTINAL STROMAL TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | chronic myelogenous leukemia | C-KIT | oncogene | AUTOINHIBITION | BIOPHYSICS | cell signaling | seminoma | INHIBITORS | INSIGHTS | Neoplasms - metabolism | Signal Transduction | Humans | Pyrimidines - pharmacology | Mutation - genetics | Proto-Oncogene Proteins c-kit - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Neoplasms - therapy | Animals | Neoplasms - genetics | Proto-Oncogene Proteins c-kit - genetics | Benzamides | Proto-Oncogene Proteins c-kit - chemistry | Tyrosine | Phosphatidylinositol | Enzymes | Sexually transmitted diseases | Platelet-derived growth factor | Leukemia | Non-Hodgkin's lymphomas | T cells | Embryonic stem cells | Protein kinases
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11. Full Text Signaling by Kit protein-tyrosine kinase—The stem cell factor receptor
by Roskoski, Robert
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2005, Volume 337, Issue 1, pp. 1 - 13
Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis, hematopoiesis, mast cell development and function, and... 
Lyn | Grb7 | APS | Bad | Piebaldism | Ras | Oncogene | Src family kinase | MAP kinase | Akt | Cbl | Shp2 | Dok1 | Shp1 | Hematopoiesis | Protein kinase | Leukemia cell lines | Fyn | Grb2 | Mast cell | Protein phosphatase | Proto-oncogene | Cancer | Erk | SI-LOCUS | ACTIVATION | leukemia cell lines | bad | PHOSPHORYLATION | MAST-CELLS | protein kinase | proto-oncogene | hematopoiesis | Eerk | PROGENITOR CELLS | LIGAND LACKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | mast cell | C-KIT | PI 3-KINASE | oncogene | protein phosphatase | piebaldism | BIOPHYSICS | cancer | GROWTH-FACTOR | SRC FAMILY KINASES | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Type C Phospholipases - metabolism | Protein Tyrosine Phosphatases - metabolism |