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1. Full Text A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors
by Mahadevan, D and Cooke, L and Riley, C and Swart, R and Simons, B and Della Croce, K and Wisner, L and Iorio, M and Shakalya, K and Garewal, H and Nagle, R and Bearss, D
Oncogene, ISSN 0950-9232, 06/2007, Volume 26, Issue 27, pp. 3909 - 3919
Kit mutations | Tyrosine kinases | GIST | Morphological change | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Medical sciences | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Tumors | Gene Expression Regulation, Enzymologic - drug effects | Oncogene Proteins - genetics | Taxoids - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Antineoplastic Agents - therapeutic use | Green Fluorescent Proteins - genetics | Proto-Oncogene Proteins c-kit - metabolism | Recombinant Fusion Proteins - metabolism | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Gastrointestinal Stromal Tumors - pathology | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gastrointestinal Stromal Tumors - genetics | Protein Structure, Tertiary | Cell Survival - drug effects | Green Fluorescent Proteins - metabolism | Oncogene Proteins - chemistry | Oncogene Proteins - metabolism | Models, Molecular | Piperazines - therapeutic use | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Imatinib Mesylate | Piperazines - pharmacology | Blotting, Western | Cell Shape - drug effects | Drug Synergism | Drug Resistance, Neoplasm - genetics | Receptor Protein-Tyrosine Kinases - genetics | Gastrointestinal Stromal Tumors - drug therapy | Pyrimidines - therapeutic use | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Protein Kinase Inhibitors - pharmacology | Benzamides | Mutation | Proto-Oncogene Proteins c-kit - chemistry | Receptor Protein-Tyrosine Kinases - chemistry | Control | Gastrointestinal tumors | Protein tyrosine kinase | Genetic aspects | Research | Gene expression | Health aspects | Gastroenterology | Kinases | Drug resistance | Index Medicus
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2. Full Text Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors
by Delahaye, Nicolas F and Rusakiewicz, Sylvie and Martins, Isabelle and Ménard, Cédric and Roux, Stephan and Lyonnet, Luc and Paul, Pascale and Sarabi, Matthieu and Chaput, Nathalie and Semeraro, Michaela and Minard-Colin, Véronique and Poirier-Colame, Vichnou and Chaba, Kariman and Flament, Caroline and Baud, Véronique and Authier, Hélène and Kerdine-Römer, Saadia and Pallardy, Marc and Cremer, Isabelle and Peaudecerf, Laetitia and Rocha, Bénédita and Valteau-Couanet, Dominique and Gutierrez, Javier Celis and Nunès, Jacques A and Commo, Frédéric and Bonvalot, Sylvie and Ibrahim, Nicolas and Terrier, Philippe and Opolon, Paule and Bottino, Cristina and Moretta, Alessandro and Tavernier, Jan and Rihet, Pascal and Coindre, Jean-Michel and Blay, Jean-Yves and Isambert, Nicolas and Emile, Jean-Franãois and Vivier, Eric and Lecesne, Axel and Kroemer, Guido and Zitvogel, Laurence
Nature medicine, ISSN 1078-8956, 2011, Volume 17, Issue 6, pp. 700 - 707
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Prognosis | Alternative Splicing - genetics | Humans | Interleukin-12 - physiology | Lysosomal-Associated Membrane Protein 1 - physiology | Interferon-gamma - physiology | Alternative Splicing - physiology | Gastrointestinal Stromal Tumors - physiopathology | Natural Cytotoxicity Triggering Receptor 3 - genetics | Natural Cytotoxicity Triggering Receptor 3 - physiology | Killer Cells, Natural - physiology | Proto-Oncogene Proteins c-kit - physiology | Gastrointestinal Stromal Tumors - diagnosis | Protein Isoforms | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Polymorphism, Single Nucleotide - genetics | Proto-Oncogene Proteins c-kit - genetics | Gastrointestinal Stromal Tumors - genetics | Dendritic cells | Gastrointestinal tumors | Physiological aspects | Genetic aspects | Research | Gene expression | Interferon | Medical prognosis | Gastrointestinal diseases | Tumors | Cancer | Index Medicus | Interferon-gamma | Killer Cells, Natural | Alternative Splicing | Natural Cytotoxicity Triggering Receptor 3 | Interleukin-12 | Proto-Oncogene Proteins c-kit | Tumor Necrosis Factor-alpha | Life Sciences | Lysosomal-Associated Membrane Protein 1 | Immunology | Polymorphism, Single Nucleotide | Gastrointestinal Stromal Tumors
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3. Full Text Detecting protein-protein interactions based on kinase-mediated growth induction of mammalian cells
by Mabe, Satoru and Nagamune, Teruyuki and Kawahara, Masahiro
Scientific reports, ISSN 2045-2322, 08/2014, Volume 4, Issue 1, pp. 6127 - 6127
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Line | Peptides - chemistry | Tacrolimus Binding Proteins - chemistry | Tacrolimus - chemistry | Tumor Suppressor Protein p53 - metabolism | Tacrolimus - metabolism | Tacrolimus Binding Proteins - metabolism | Tacrolimus - analogs & derivatives | Proto-Oncogene Proteins c-kit - metabolism | Tacrolimus Binding Proteins - genetics | Protein Interaction Mapping - methods | Animals | Peptides - metabolism | Tacrolimus - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Cell Proliferation - drug effects | Mice | Protein Interaction Domains and Motifs | Tumor Suppressor Protein p53 - chemistry | Dimerization | Proto-Oncogene Proteins c-kit - chemistry | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Amino Acid Substitution | Background levels | MDM2 protein | Cytokines | Peptides | Kinases | c-Kit protein | Mammalian cells | Proteins | Tacrolimus-binding protein | Interleukin 3 | Affinity | Chimeras | Protein interaction | Index Medicus
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4. Full Text Structure and regulation of Kit protein-tyrosine kinase—The stem cell factor receptor
by Roskoski, Robert
Biochemical and biophysical research communications, ISSN 0006-291X, 2005, Volume 338, Issue 3, pp. 1307 - 1315
Dysgerminoma | Acute myelogenous leukemia | Germ cells | Flt3 | Oncogene | Chronic myelogenous leukemia | Bcr-Abl | Abl | Nasal T-cell lymphoma | Gleevec | Cell signaling | Seminoma | Mast cells | STI-571 | Targeted cancer therapy | Proto-oncogene | Activation loop | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Neoplasms - metabolism | Signal Transduction | Humans | Pyrimidines - pharmacology | Mutation - genetics | Proto-Oncogene Proteins c-kit - metabolism | Imatinib Mesylate | Piperazines - pharmacology | Neoplasms - therapy | Animals | Neoplasms - genetics | Proto-Oncogene Proteins c-kit - genetics | Benzamides | Proto-Oncogene Proteins c-kit - chemistry | Tyrosine | Phosphatidylinositol | Enzymes | Sexually transmitted diseases | Platelet-derived growth factor | Leukemia | Non-Hodgkin's lymphomas | T cells | Embryonic stem cells | Protein kinases | Index Medicus
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5. Full Text Signaling by Kit protein-tyrosine kinase—The stem cell factor receptor
by Roskoski, Robert
Biochemical and biophysical research communications, ISSN 0006-291X, 2005, Volume 337, Issue 1, pp. 1 - 13
Lyn | Grb7 | APS | Bad | Piebaldism | Ras | Oncogene | Src family kinase | MAP kinase | Akt | Cbl | Shp2 | Dok1 | Shp1 | Hematopoiesis | Protein kinase | Leukemia cell lines | Fyn | Grb2 | Mast cell | Protein phosphatase | Proto-oncogene | Cancer | Erk | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Humans | Type C Phospholipases - metabolism | Protein Tyrosine Phosphatases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Animals | Phospholipase C gamma | Mice | Adaptor Proteins, Signal Transducing - metabolism | Proto-Oncogene Proteins c-kit - chemistry | Tyrosine | Phosphatidylinositol | Enzymes | Platelet-derived growth factor | Phosphatases | Endothelial growth factors | Leukemia | Embryonic stem cells | Protein kinases | Protein binding | Index Medicus
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6. Full Text Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death
by Heo, Sook-Kyoung and Noh, Eui-Kyu and Kim, Jeong Yi and Jeong, Yoo Kyung and Jo, Jae-Cheol and Choi, Yunsuk and Koh, SuJin and Baek, Jin Ho and Min, Young Joo and Kim, Hawk
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 15278 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | HSP90 Heat-Shock Proteins - biosynthesis | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Male | Apoptotic Protease-Activating Factor 1 - genetics | Proto-Oncogene Proteins c-kit - metabolism | Drug Delivery Systems | Leukemia, Myeloid, Acute - drug therapy | Female | Proto-Oncogene Proteins c-kit - genetics | Benzamides - pharmacology | HSP90 Heat-Shock Proteins - genetics | Leukemia, Myeloid, Acute - pathology | Gene Expression Regulation, Leukemic - drug effects | Proto-Oncogene Proteins c-kit - analysis | Apoptotic Protease-Activating Factor 1 - metabolism | Dasatinib - pharmacology | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Mice | Pyrazines - pharmacology | Leukemia, Myeloid, Acute - genetics | Tyrosine | BCR protein | Myeloid leukemia | Leukemia | Heat shock proteins | Caspase | Abl protein | Chronic myeloid leukemia | c-Kit protein | Endocytosis | Cell death | Apaf-1 protein | Xenografts | Dynamin | Fusion protein | Acute myeloid leukemia | Protein-tyrosine kinase | Apoptosis
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7. Full Text Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression
by Tang, Chih-Min and Lee, Tracy E and Syed, Sabriya A and Burgoyne, Adam M and Leonard, Stephanie Y and Gao, Fei and Chan, Jonathan C and Shi, Eileen and Chmielecki, Juliann and Morosini, Deborah and Wang, Kai and Ross, Jeffrey S and Kendrick, Michael L and Bardsley, Michael R and De Siena, Martina and Mao, Junhao and Harismendy, Olivier and Ordog, Tamas and Sicklick, Jason K
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 78226 - 78241
ICC | Arsenic trioxide | GIST | Imatinib-resistant | GLI | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gastrointestinal Neoplasms - genetics | Zinc Finger Protein GLI1 - metabolism | Gastrointestinal Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Proto-Oncogene Proteins c-kit - metabolism | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Gastrointestinal Neoplasms - pathology | Interstitial Cells of Cajal - metabolism | Transfection | RNA Interference | Zinc Finger Protein Gli2 - antagonists & inhibitors | Gastrointestinal Stromal Tumors - pathology | Zinc Finger Protein GLI1 - antagonists & inhibitors | Proto-Oncogene Proteins c-kit - genetics | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Binding Sites | Gastrointestinal Stromal Tumors - genetics | Zinc Finger Protein Gli2 - genetics | Gastrointestinal Neoplasms - metabolism | Promoter Regions, Genetic | Zinc Finger Protein Gli3 - metabolism | Cilia - pathology | Cell Survival | Imatinib Mesylate - pharmacology | Zinc Finger Protein GLI1 - genetics | Arsenicals - pharmacology | RNA, Messenger - genetics | Interstitial Cells of Cajal - drug effects | Interstitial Cells of Cajal - pathology | Nuclear Proteins - metabolism | Nerve Tissue Proteins - genetics | Zinc Finger Protein Gli3 - genetics | Cilia - metabolism | Zinc Finger Protein Gli2 - metabolism | Nerve Tissue Proteins - metabolism | Oxides - pharmacology | Signal Transduction - drug effects | Gastrointestinal Stromal Tumors - drug therapy | Receptor, Platelet-Derived Growth Factor alpha - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Gastrointestinal Stromal Tumors - metabolism | Mutation | Index Medicus
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8. Full Text A Chemically Inducible Helper Module for Detecting Protein–Protein Interactions with Tunable Sensitivity Based on KIPPIS
by Kashima, Daiki and Kawade, Raiji and Nagamune, Teruyuki and Kawahara, Masahiro
Analytical chemistry (Washington), ISSN 0003-2700, 05/2017, Volume 89, Issue 9, pp. 4824 - 4830
Physical Sciences | Chemistry | Chemistry, Analytical | Science & Technology | Cell proliferation | Cell culture | Phosphorylation | RNA-protein interactions | Src protein | c-Kit protein | Cells | Mammalian cells | Proteins | Sensitivity | Tacrolimus-binding protein | Interleukin 3 | Ligands | Protein-tyrosine kinase receptors | Affinity | Mutation | Intracellular | Protein interaction | Dimerization | Index Medicus
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9. Full Text The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors
by Mahameed, Mohamed and Wilhelm, Thomas and Darawshi, Odai and Obiedat, Akram and Tommy, Weiss-Sadan and Chintha, Chetan and Schubert, Thomas and Samali, Afshin and Chevet, Eric and Eriksson, Leif A and Huber, Michael and Tirosh, Boaz and Institutionen för kemi och molekylärbiologi and Naturvetenskapliga fakulteten and Faculty of Sciences and Göteborgs universitet and Gothenburg University and Department of Chemistry and Molecular Biology
Cell death & disease, ISSN 2041-4889, 04/2019, Volume 10, Issue 4, pp. 300 - 300
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lysosomes - drug effects | Cell Survival - drug effects | Unfolded Protein Response - drug effects | Adenine - analogs & derivatives | eIF-2 Kinase - metabolism | Endocytosis - drug effects | Humans | Adenine - pharmacology | Proto-Oncogene Proteins c-kit - metabolism | Adenine - chemistry | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | eIF-2 Kinase - antagonists & inhibitors | Hep G2 Cells | HEK293 Cells | Indoles - pharmacology | Proto-Oncogene Proteins c-kit - genetics | Kinetics | Indoles - chemistry | eIF-2 Kinase - genetics | Tyrosine | Endocytosis | Cell death | Protein folding | Lysosomes | Kinases | Mast cell leukemia | Protein-tyrosine kinase | Mammalian cells | Index Medicus | Life Sciences | Cancer | unclassified drug | computer model | protein kinase R like endoplasmic reticulum kinase | Article | concentration response | binding assay | dissociation constant | protein kinase | gsk 2606414 | kira 6 | protein tyrosine kinase inhibitor | cytoplasm | protein domain | unfolded protein response | drug binding site | molecular docking | controlled study | Biokemi och molekylärbiologi | cell culture | adenosine triphosphate | Biochemistry and Molecular Biology | priority journal
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