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11/2013
Colorectal cancer (CRC) is the third leading cause of death from cancer in North America. The KRAS gene is mutated in approximately 40-50% of all CRC, and this... 
0379 | c-MET | KRAS
Dissertation
Oncogene, ISSN 0950-9232, 03/2011, Volume 30, Issue 13, pp. 1566 - 1576
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 11/2019, Volume 92, p. 103272
Novel series of some triazolo[4,3- ]pyridazine derivatives were designed and synthesized. All the newly synthesized compounds were evaluated for their... 
Pyridazines | Triazolopyridazines | Cytotoxic activity | c-Met kinase
Journal Article
Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, 06/2012, Volume 1822, Issue 6, pp. 942 - 951
HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. HGF treatment accelerates resolution of... 
C-met | Fibrosis | Microarray | CCl
Journal Article
Nature Communications, ISSN 2041-1723, 04/2017, Volume 8, Issue 1, p. 15016
The metastatic organotropism has been one of the cancer's greatest mysteries since the 'seed and soil' hypothesis. Although the role of EGFR in cancer cells is... 
MELANOMA EXOSOMES | SERUM-LEVEL | MULTIDISCIPLINARY SCIENCES | HEPATOCYTE GROWTH-FACTOR | PANCREATIC-CANCER | C-MET | MICROVESICLES | MEDIATED TRANSFER | TUMOR-GROWTH | TUMORIGENESIS | T-CELLS
Journal Article
Nature Communications, ISSN 2041-1723, 01/2011, Volume 2, Issue 1, p. 162
Androgen depletion is a key strategy for treating human prostate cancer, but the presence of hormone-independent cells escaping treatment remains a major... 
ANDROGEN RECEPTOR | ORIGIN | INTERMEDIATE CELLS | EPITHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-MET | MODEL | EXPRESSION | CARCINOMA | BASAL-CELLS
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 04/2008, Volume 68, Issue 7, pp. 2329 - 2339
E-cadherin loss is frequently associated with ovarian cancer metastasis. Given that adhesion to the abdominal peritoneum is the first step in ovarian cancer... 
HUMAN MESOTHELIAL CELLS | ADHESION | IN-VITRO | INVASION | PROGNOSTIC-FACTOR | ONCOLOGY | C-MET OVEREXPRESSION | ACTIVATOR RECEPTOR EXPRESSION | INTEGRIN | TUMOR-CELLS | CARCINOMA
Journal Article
Chemical Biology and Drug Design, ISSN 1747-0277, 04/2019, Volume 93, Issue 4, pp. 447 - 453
A novel Tc-tricine-EDDA-Hynic-c-Met molecular probe was synthetized, and nude mice models of human non-small-cell lung cancer (NSCLC) were established in order... 
micro-SPECT/CT | c-Met | non-small-cell lung cancer
Journal Article
Oncotarget, ISSN 1949-2553, 01/2019, Volume 10, Issue 2, pp. 184 - 197
C-Met is a frequently overexpressed or amplified receptor tyrosine kinase involved in metastatic-related functions, including migration, invasion, cell... 
Microenvironment | Small molecule inhibitor | HGF | C-Met | Cancer
Journal Article
Biomolecules & Therapeutics(구 응용약물학회지), ISSN 1976-9148, 2019, Volume 27, Issue 2, pp. 216 - 221
The c-Met protein is a receptor tyrosine kinase involved in cell growth, proliferation, survival, and angiogenesis of several human tumors. Overexpression of... 
c-Met | Indirubin | Gastric cancer | LDD-1937
Journal Article
世界胃肠病学杂志:英文版, ISSN 1007-9327, 2015, Issue 12, pp. 3706 - 3710
AIM: To assess the prognostic value of c-Met status in colorectal cancer. METHODS: We conducted a search in Pub Med, Web of Science, and the Cochrane Library... 
Colorectal | cancer;Prognosis;c-Met;Metaanalysis;Ove
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 480 - 490
Matriptase and hepsin belong to the family of type II transmembrane serine proteases (TTSPs). Increased activity of these and the plasma protease, hepatocyte... 
RON | PROSTATE | DESIGN | CHEMISTRY, MEDICINAL | PATHWAY | HEPATOCYTE GROWTH-FACTOR | C-MET | FACTOR ACTIVATION | RESISTANCE | EXPRESSION | PROGRESSION
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 4915 - 4935
Anaplastic lymphoma kinase (ALK), a member of the receptor tyrosine kinase family, is predominantly expressed in the brain and implicated in neuronal... 
REFINEMENT | TRANSPORT | DESIGN | IMPACT | CHEMISTRY, MEDICINAL | C-MET | BARRIER | PROLIFERATION | PF-2341066 | RECEPTOR TYROSINE KINASE | P-GLYCOPROTEIN
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111607
Development of small-molecule agents with the ability to facilitate oncoprotein degradation has emerged as a promising strategy for cancer therapy. Since EGFR... 
Oncoprotein degradation | 1,2,4-Oxadiazoles | c-Met | TKI resistant NSCLC | EGFR
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 02/2010, Volume 17, Issue 2, pp. 193 - 199
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2012, Volume 18, Issue 6, pp. 883 - 891
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 08/2006, Volume 6, Issue 8, pp. 637 - 645
Metastasis follows the inappropriate activation of a genetic programme termed invasive growth, which is a physiological process that occurs during embryonic... 
EPITHELIAL-MESENCHYMAL TRANSITION | HUMAN BREAST-CARCINOMA | TUMOR PROGRESSION | ONCOLOGY | FACTOR SCATTER FACTOR | C-MET | BONE-MARROW | ACUTE MYELOID-LEUKEMIA | RECEPTOR TYROSINE KINASE | HGF RECEPTOR | FACTOR/SCATTER FACTOR
Journal Article
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