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Journal of Immunology, ISSN 0022-1767, 07/2015, Volume 195, Issue 1, pp. 217 - 226
Proper regulation of microbial-induced cytokines is critical to intestinal immune homeostasis. Acute stimulation of nucleotide-binding oligomerization domain 2... 
CELLS | PROTEIN | CROHNS-DISEASE | MURAMYL DIPEPTIDE | SAETHRE-CHOTZEN SYNDROME | CROSS-TOLERANCE | IMMUNOLOGY | NF-KAPPA-B | C-MAF | HUMAN MONOCYTES | IL-10 GENE-EXPRESSION | RNA, Small Interfering - genetics | Humans | Polycomb Repressive Complex 1 - immunology | Nod2 Signaling Adaptor Protein - genetics | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Activating Transcription Factor 4 - immunology | Polycomb Repressive Complex 1 - genetics | RNA, Small Interfering - immunology | CCAAT-Enhancer-Binding Proteins - antagonists & inhibitors | Twist-Related Protein 1 - immunology | Transforming Growth Factor beta - antagonists & inhibitors | Nod2 Signaling Adaptor Protein - agonists | Transcription, Genetic | CCAAT-Enhancer-Binding Proteins - genetics | Nuclear Proteins - genetics | Macrophages - immunology | Proto-Oncogene Proteins c-maf - immunology | Transforming Growth Factor beta - immunology | Promoter Regions, Genetic | Activating Transcription Factor 4 - antagonists & inhibitors | Signal Transduction | Core Binding Factor Alpha 2 Subunit - antagonists & inhibitors | Proto-Oncogene Proteins c-maf - genetics | Gene Expression Regulation | Activating Transcription Factor 4 - genetics | Core Binding Factor Alpha 1 Subunit - immunology | Nod2 Signaling Adaptor Protein - immunology | Repressor Proteins - genetics | Antibodies, Neutralizing - pharmacology | Macrophages - cytology | Nuclear Proteins - immunology | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Core Binding Factor Alpha 2 Subunit - immunology | Transforming Growth Factor beta - genetics | CCAAT-Enhancer-Binding Proteins - immunology | Interleukin-10 - antagonists & inhibitors | Interleukin-10 - genetics | Repressor Proteins - immunology | Twist-Related Protein 1 - genetics | Protein Binding | Macrophages - drug effects | Primary Cell Culture | Macrophage Activation - drug effects | Core Binding Factor Alpha 2 Subunit - genetics | Interleukin-10 - immunology | Core Binding Factor Alpha 1 Subunit - genetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2012, Volume 188, Issue 8, pp. 3734 - 3744
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e54507
Pax6 encodes a specific DNA-binding transcription factor that regulates the development of multiple organs, including the eye, brain and pancreas. Previous... 
PAIRED DOMAIN | TRANSCRIPTION FACTOR PAX6 | DNA-BINDING | REGULATORY NETWORKS | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | HIGH-RESOLUTION | MOUSE MODEL | ALPHA-A-CRYSTALLIN | EYE DEVELOPMENT | C-MAF | Paired Box Transcription Factors - genetics | Chromatin - metabolism | Homeodomain Proteins - metabolism | Computational Biology | Lens, Crystalline - metabolism | Repressor Proteins - genetics | PAX6 Transcription Factor | Homeodomain Proteins - genetics | Animals | Chromatin Immunoprecipitation | Eye Proteins - metabolism | Protein Binding | Mice | Eye Proteins - genetics | Prosencephalon - metabolism | Paired Box Transcription Factors - metabolism | Repressor Proteins - metabolism | Brain | Embryonic development | Chromatin | Genetic transcription | RNA | Genes | Cell proliferation | Transcription factors | Cerebral cortex | Immunoprecipitation | Target recognition | Genomics | Forebrain | Science | Identification | Tissues | Eye | Proteins | Transient receptor potential proteins | Embryogenesis | Cell fate | Rodents | Genetics | Sodium channels (voltage-gated) | Physiology | Pancreas | Ventricular zone | Deoxyribonucleic acid--DNA | Binding | Medical research | Cortex | Organs | Telencephalon | Gene expression | Ribonucleic acid--RNA | Promoters | Embryonic growth stage | Medicine | Studies | Pax6 protein | DNA microarrays | Molecular modelling | Islet-1 protein | Stem cells | Islet cells | Islets of Langerhans | Ventricle | Mutation | Alzheimers disease | Lenses | Eye lens | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2014, Volume 289, Issue 33, pp. 22980 - 22990
Programmed cell death protein 4 (PDCD4) is a tumor suppressor and has also been shown to suppress production of the immunomodulatory cytokine IL-10. The... 
MAMMALIAN TARGET | RAPAMYCIN | INNATE INFLAMMATORY RESPONSE | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUPPRESSOR PDCD4 | LIPOPOLYSACCHARIDE | KINASE-AKT | TRANSLATION | EXPRESSION | IL-10 | RNA-Binding Proteins - genetics | Transcription, Genetic - drug effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Proteolysis - drug effects | TOR Serine-Threonine Kinases - genetics | Apoptosis Regulatory Proteins - genetics | Repressor Proteins - metabolism | Cell Line | Proto-Oncogene Proteins c-maf - genetics | Gene Expression Regulation - physiology | Repressor Proteins - genetics | Macrophages - cytology | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Phosphatidylinositol 3-Kinases - genetics | Macrophages - metabolism | Transcription, Genetic - physiology | Promoter Regions, Genetic - physiology | Interleukin-10 - genetics | Lipopolysaccharides - pharmacology | Twist-Related Protein 1 - genetics | Interleukin-10 - biosynthesis | Proto-Oncogene Proteins c-maf - metabolism | Apoptosis - physiology | Twist-Related Protein 1 - metabolism | RNA-Binding Proteins - metabolism | c-maf | mTOR Complex (mTORC) | Immunology | Interleukin | PDCD4 | Inflammation | Rapamycin | Transcription Factor | Twist2 | Lipopolysaccharide (LPS)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2013, Volume 288, Issue 52, pp. 37256 - 37266
The type III histone deacetylase Sirt1 has recently emerged as a critical immune regulator by suppressing T cell immunity and macrophage activation during... 
ACTIVATION | Dendritic Cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-27 | ALPHA | INDUCTION | C-MAF | CUTTING EDGE | T Cell | Autoimmune Diseases | IRF1 | Epigenetics | GENE-EXPRESSION | Sirt1 | Acetylation | TRANSCRIPTION FACTOR | IL-17 PRODUCTION | T-CELLS | Inflammation - chemically induced | Sirtuin 1 - metabolism | Interferon-beta - immunology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Dendritic Cells - immunology | Humans | Dendritic Cells - pathology | Encephalomyelitis, Autoimmune, Experimental - immunology | Sirtuin 1 - genetics | Interleukins - metabolism | Cell Differentiation - genetics | Interleukins - genetics | Inflammation - metabolism | Myelin-Oligodendrocyte Glycoprotein - toxicity | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Th17 Cells - metabolism | Interleukins - immunology | HEK293 Cells | Interferon-beta - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Dendritic Cells - metabolism | Th17 Cells - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Interferon Regulatory Factor-1 - immunology | Inflammation - immunology | Interferon Regulatory Factor-1 - genetics | Mice, Knockout | Cell Differentiation - immunology | Animals | Interferon-beta - metabolism | Sirtuin 1 - immunology | Inflammation - genetics | Th17 Cells - immunology | Mice | Interferon Regulatory Factor-1 - metabolism | Immunology
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 09/2003, Volume 23, Issue 17, pp. 6049 - 6062
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2003, Volume 198, Issue 5, pp. 797 - 807
Journal Article
Immunological Reviews, ISSN 0105-2896, 03/2013, Volume 252, Issue 1, pp. 139 - 145
Summary T‐follicular helper (Tfh) cells are a new subset of effector CD4+ T cells that are specialized in helping B cells in the germinal center reaction. Tfh... 
T‐cell lineages and subsets | Tfh cells | dendritic cells | Dendritic cells | T-cell lineages and subsets | GERMINAL-CENTER FORMATION | FACTOR BATF CONTROLS | IMMUNOLOGY | PROVIDE HELP | CXC CHEMOKINE RECEPTOR-5 | TERNARY COMPLEX | IMMUNE-RESPONSES | IN-VIVO | BCL6 EXPRESSION | CENTER B-CELL | B-Lymphocytes - cytology | DNA-Binding Proteins - immunology | Receptors, CXCR5 - genetics | Signal Transduction | Germinal Center - immunology | Humans | Proto-Oncogene Proteins c-maf - genetics | Gene Expression Regulation | Interferon Regulatory Factors - genetics | Basic-Leucine Zipper Transcription Factors - immunology | STAT Transcription Factors - immunology | Basic-Leucine Zipper Transcription Factors - genetics | DNA-Binding Proteins - genetics | Receptors, CXCR5 - immunology | Interferon Regulatory Factors - immunology | STAT Transcription Factors - genetics | B-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - immunology | T-Lymphocytes, Helper-Inducer - cytology | Transcription, Genetic | Germinal Center - cytology | Cell Lineage - immunology | Proto-Oncogene Proteins c-bcl-6 | Proto-Oncogene Proteins c-maf - immunology | Genetic aspects | Genetic transcription | T cells | Memory cells | Transcription | Gene regulation | Helper cells | Stat3 protein | Effector cells | Lymphocytes T | Ontogeny | c-Maf protein | Follicles | Gene expression | CD4 antigen | Molecular modelling | Germinal centers | Lymphocytes B | CXCR5 protein | Interferon regulatory factor 4 | Differentiation | Cell migration | Bcl-6 protein
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 43259 - 43271
Tissue morphogenesis requires intricate temporal and spatial control of gene expression that is executed through specific gene regulatory networks (GRNs). GRNs... 
NASAL DEVELOPMENT | PAIRED DOMAIN | TRANSCRIPTION FACTOR PAX6 | DNA-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | EMBRYONIC STEM-CELLS | LENS DEVELOPMENT | FACTOR C-MAF | MOUSE LENS | FIBER CELL-DIFFERENTIATION | GENE REGULATORY NETWORKS | Paired Box Transcription Factors - genetics | Retinal Pigment Epithelium - metabolism | Homeodomain Proteins - metabolism | Gene Expression Regulation, Developmental - genetics | Green Fluorescent Proteins - genetics | Gene Regulatory Networks - physiology | Chromatin Immunoprecipitation | Electrophoretic Mobility Shift Assay | Eye Proteins - genetics | Binding Sites | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Green Fluorescent Proteins - metabolism | Gene Regulatory Networks - genetics | Lens, Crystalline - embryology | Proto-Oncogene Proteins c-maf - genetics | Lens, Crystalline - metabolism | Repressor Proteins - genetics | Mice, Transgenic | PAX6 Transcription Factor | Reverse Transcriptase Polymerase Chain Reaction | Homeodomain Proteins - genetics | Animals | Eye Proteins - metabolism | Retinal Pigment Epithelium - embryology | Proto-Oncogene Proteins c-maf - metabolism | Mice | Paired Box Transcription Factors - metabolism | Index Medicus | Gene Regulation | Eye | c-Maf | Transcription Enhancers | Gene Regulatory Network | DNA-Protein Interaction | Transcription Factors | Pax6 | Lens | Differentiation | Homeodomain
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e108037
Various studies suggest that Hedgehog (Hh) signalling plays roles in human and zebrafish ocular development. Recent studies (Kerr et al., Invest Ophthalmol Vis... 
EMBRYONIC-DEVELOPMENT | SONIC HEDGEHOG | MULTIDISCIPLINARY SCIENCES | RECEPTOR EXPRESSION | ANTERIOR SEGMENT | CELL-CYCLE PROGRESSION | NEURAL CREST | EPITHELIAL PROLIFERATION | EYE MORPHOGENESIS | MICE LACKING | HEDGEHOG SIGNALING PATHWAY | Neuropilin-2 - metabolism | Epithelial Cells - metabolism | Receptors, G-Protein-Coupled - metabolism | Embryo, Mammalian | Zinc Finger Protein Gli2 | Zinc Finger Protein Gli3 | Lens, Crystalline - pathology | Morphogenesis | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Neuropilin-2 - genetics | Smoothened Receptor | Integrases - metabolism | Cornea - pathology | Patched Receptors | Mesenchymal Stem Cells - metabolism | Cornea - growth & development | Animals, Newborn | Signal Transduction | Endothelial Cells - metabolism | Lens, Crystalline - growth & development | Zebrafish Proteins | Lens, Crystalline - metabolism | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Mesenchymal Stem Cells - pathology | Nerve Tissue Proteins - metabolism | Cornea - metabolism | Animals | Cell Cycle | Mice | Receptors, G-Protein-Coupled - genetics | Endothelial Cells - pathology | Integrases - genetics | Kruppel-Like Transcription Factors - genetics | Patched-1 Receptor | Cell Movement | Receptors, Cell Surface - genetics | Cell proliferation | Neurosciences | Cornea | Transcription factors | Mesenchyme | Laboratories | Epithelial cells | Genes | Cytosol | Nuclei | E-cadherin | Defects | Proteins | Smoothened gene | Signal transduction | Cell growth | Clonal deletion | Rodents | Cell cycle | Deletion | Growth factors | Cell survival | Phase transformations | Transgenic mice | Zebrafish | c-Maf protein | Mammals | Gene expression | Epithelium | Neural crest | Pax6 protein | Polymerase chain reaction | Signaling | Cell death | Hedgehog protein | S phase | Ligands | Mutation | Aberration | Differentiation | Immunofluorescence | Cell migration | Lenses | Phase transition
Journal Article