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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 3002 - 3024
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155911
A considerable proportion of protein-protein interactions (PPIs) in the cell are estimated to be mediated by very short peptide segments that approximately conform to specific sequence patterns known as linear motifs (LMs... 
RECOGNITION | ROLES | MYC | MULTIDISCIPLINARY SCIENCES | BINDING SITES | INTERFACES | INTERACTION NETWORKS | LINEAR MOTIFS | IDENTIFICATION | WEB SERVER | DISCOVERY | Adenomatous Polyposis Coli Protein - genetics | Neoplasms - metabolism | Amino Acid Sequence | Computational Biology - methods | Proto-Oncogene Proteins c-mdm2 - genetics | Humans | Peptides - genetics | Neoplasm Proteins - chemistry | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Proto-Oncogene Proteins c-myc - metabolism | Adenomatous Polyposis Coli Protein - chemistry | Protein Interaction Mapping | Neoplasms - chemistry | Peptides - metabolism | Neoplasms - genetics | Adenomatous Polyposis Coli Protein - metabolism | Protein Binding | Proto-Oncogene Proteins c-myc - genetics | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-myc - chemistry | Binding Sites | Proto-Oncogene Proteins c-mdm2 - metabolism | Physiological aspects | Genetic aspects | Research | Tumor proteins | Protein-protein interactions | Ubiquitin | Peptides | Identification | Myc protein | Modulators | Cdc4 protein | Proteins | Databases | Cell cycle | Bioinformatics | Ubiquitin-protein ligase | MDM2 protein | Therapeutic applications | Kalam, Abdul | Adenomatous polyposis coli | Inhibitors | Acids | Computation | Computer applications | Predictions | Proteasomes | Mutation | Protein interaction | Binding sites | Cancer
Journal Article
Genes & development, ISSN 0890-9369, 2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Research Paper
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 3, pp. 493 - 506
.... However, pharmacological strategies that directly target N-Myc, the protein encoded by MYCN, remain elusive... 
BI6727 | targeted therapy | ubiquitination | Myc | PLK1 | neuroblastoma | Fbw7 | small cell lung carcinoma | ABT199 | TARGETED THERAPY | INHIBITOR VOLASERTIB | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-MYC | C-MYC | F-BOX PROTEINS | AMPLIFIED NEUROBLASTOMA | AURORA KINASE | FBW7 UBIQUITIN LIGASE | CANCER-THERAPY | HUMAN NEUROBLASTOMA | CELL BIOLOGY | RNA, Small Interfering - genetics | Humans | Neuroblastoma - mortality | N-Myc Proto-Oncogene Protein - antagonists & inhibitors | Transcription, Genetic | Neurons - metabolism | Brain Neoplasms - mortality | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Sulfonamides - pharmacology | Drug Synergism | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Feedback, Physiological | Mice, Nude | Survival Analysis | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | RNA, Small Interfering - metabolism | F-Box-WD Repeat-Containing Protein 7 | Neurons - pathology | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | N-Myc Proto-Oncogene Protein - genetics | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Neurons - drug effects | Neuroblastoma - pathology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Pteridines - pharmacology | F-Box Proteins - metabolism | Neuroblastoma - genetics | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Tumor Burden - drug effects | N-Myc Proto-Oncogene Protein - metabolism | Neuroblastoma - drug therapy | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Ubiquitin | Polo | Ligases | Lung cancer | Therapeutics | Homeopathy | Materia medica and therapeutics | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137210
Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors.... 
SIGNAL | PROTEIN | CANCER CELLS | MANTLE CELL LYMPHOMA | CYCLIN D1 | MULTIDISCIPLINARY SCIENCES | RESPONSIVE TRANSCRIPTION FACTOR | KINASE | GENE-EXPRESSION | PROLIFERATION | CRM1 | Cyclin D1 - metabolism | Transcription, Genetic - drug effects | Humans | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins c-pim-1 - metabolism | Elongation Factor 2 Kinase - metabolism | Ribosomes - metabolism | Tumor Suppressor Protein p53 - genetics | Elongation Factor 2 Kinase - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Organelle Biogenesis | Proto-Oncogene Proteins c-bcl-2 - metabolism | Acrylates - pharmacology | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | Peptide Elongation Factor 1 - genetics | B-Lymphocytes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | HSP70 Heat-Shock Proteins - genetics | Proto-Oncogene Proteins - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Triazoles - pharmacology | B-Lymphocytes - drug effects | Karyopherins - metabolism | Cyclin D1 - genetics | Active Transport, Cell Nucleus - drug effects | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Ribosomes - drug effects | Cell Line, Tumor | Karyopherins - genetics | Proto-Oncogene Proteins c-pim-1 - genetics | Protein Biosynthesis - drug effects | Proto-Oncogene Proteins c-myc - genetics | Karyopherins - antagonists & inhibitors | Peptide Elongation Factor 1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Physiological aspects | Genetic aspects | Research | Biological transport | Cell cycle | Ribosomes | Transcription factors | Biomedical research | Transcription | Bcl-2 protein | Laboratories | p53 Protein | Leukemia | c-Myc protein | Multiple myeloma | Immunoblotting | Biosynthesis | Myc protein | Glucose | Cyclin D1 | Cancer therapies | Anticancer properties | Heat shock factors | Proteins | Ribosomal subunits | Cell growth | Translation | Cell survival | Hematology | Hsp70 protein | Gene expression | Lymphoma | Nuclear transport | Molecular chains | Medicine | Molecular modelling | Lymphocytes B | Medical prognosis | Proteomics | Mantle cell lymphoma | Lymphomas | Viability | Heat shock | Apoptosis | Tumors | B-cell lymphoma
Journal Article
Scientific reports, ISSN 2045-2322, 2018, Volume 8, Issue 1, pp. 998 - 10
.... And histological evaluation and protein expressions of irradiated tissue were analyzed to confirm the potential anti-fibrosis effect of JQ1 and its underlying mechanisms... 
CANCER PATIENTS | BROMODOMAINS | TGF-BETA | THERAPY | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | BRD4 INHIBITION | PNEUMONITIS | MECHANISMS | PULMONARY-FIBROSIS | NORMAL TISSUE-INJURY | Humans | NF-kappa B - metabolism | Smad2 Protein - antagonists & inhibitors | Collagen Type I - genetics | MCF-7 Cells | Smad2 Protein - genetics | Lung - radiation effects | Pulmonary Fibrosis - etiology | Fibroblasts - metabolism | NF-kappa B - antagonists & inhibitors | Smad2 Protein - metabolism | Rats | Pulmonary Fibrosis - pathology | Rats, Sprague-Dawley | Smad3 Protein - antagonists & inhibitors | Fibroblasts - drug effects | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Pulmonary Fibrosis - prevention & control | Cell Line, Tumor | Gene Expression Regulation - radiation effects | Fibroblasts - cytology | Proto-Oncogene Proteins c-myc - genetics | Hydroxyproline - antagonists & inhibitors | Proteins - antagonists & inhibitors | Gamma Rays - adverse effects | Hydroxyproline - biosynthesis | Pulmonary Fibrosis - genetics | Smad3 Protein - metabolism | Molecular Targeted Therapy | Smad3 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Female | Lung - metabolism | Nuclear Proteins - genetics | Lung - pathology | Collagen Type I - metabolism | Collagen Type I - antagonists & inhibitors | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Proto-Oncogene Proteins c-myc - metabolism | Azepines - pharmacology | Gene Expression Regulation - drug effects | Proteins - genetics | Transcription Factors - metabolism | Triazoles - pharmacology | Animals | Proteins - metabolism | Transforming Growth Factor beta - genetics | Fibroblasts - radiation effects | NF-kappa B - genetics | Nuclear Proteins - antagonists & inhibitors | Cell Proliferation - drug effects | Transforming Growth Factor beta - metabolism | NF-κB protein | Collagen (type I) | Animal models | Cell survival | Lung diseases | Hydroxyproline | Radiation | c-Myc protein | Smad3 protein | Thorax | Breast cancer | Inflammation | Radiation therapy | Myc protein | Esophagus | Computed tomography | Smad2 protein | Rodents | Fibrosis | Fibroblasts | Cancer
Journal Article
Leukemia, ISSN 1476-5551, 2014, Volume 29, Issue 6, pp. 1390 - 1401
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a relatively good prognosis, aggressive forms exist. We have... 
NPM-ALK | ACTIVATION | FUSION | SIGNATURES | ONCOLOGY | KINASE | GENE-EXPRESSION | HODGKIN | T-CELL | HEMATOLOGY | NF-KAPPA-B | HUMANIZED MICE | Immunoprecipitation | Humans | Drug Resistance, Neoplasm | NF-kappa B - metabolism | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Flow Cytometry | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Repressor Proteins - metabolism | Lymphoma, Large-Cell, Anaplastic - genetics | Proteasome Inhibitors - pharmacology | Signal Transduction | RNA, Messenger - genetics | TNF Receptor-Associated Factor 1 - metabolism | Tumor Suppressor Protein p53 - metabolism | Repressor Proteins - genetics | TNF Receptor-Associated Factor 1 - genetics | In Situ Hybridization, Fluorescence | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Proto-Oncogene Proteins c-myc - metabolism | Blotting, Western | Lymphoma, Large-Cell, Anaplastic - mortality | Xenograft Model Antitumor Assays | Animals | NF-kappa B - genetics | Receptor Protein-Tyrosine Kinases - genetics | Lymphoma, Large-Cell, Anaplastic - drug therapy | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Proto-Oncogene Proteins c-myc - genetics | Positive Regulatory Domain I-Binding Factor 1 | Translocation, Genetic - genetics | Molecular targeted therapy | Translocation (Genetics) | Innovations | Development and progression | Lymphomas | Genetic aspects | Health aspects | Translocation | NF-κB protein | Phenotypes | p53 Protein | Leukemia | c-Myc protein | Activation | Myc protein | Kinases | Lymphoma | Patients | Proteasome inhibitors | Gene amplification | Cell activation | In vivo methods and tests | Anaplastic large-cell lymphoma | Protein-tyrosine kinase | targeted therapy | Patient Derived Tumorgraft (PDT) | anaplastic large cell lymphoma (ALCL) | Tyrosine kinase fusion proteins | personalized medicine
Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 58, Issue 6, pp. 1028 - 1039
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in leukemia, yet its regulatory function in this disease is not well understood... 
SELECTIVE-INHIBITION | RECRUITMENT | C/EBP-ALPHA | CREB-BINDING PROTEIN | CHROMATIN | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | C-MYC | P-TEFB | BRD4 | CELL BIOLOGY | Transcriptional Regulator ERG | NIH 3T3 Cells | Oncogene Proteins - genetics | Humans | Leukemia, Myeloid - genetics | Proto-Oncogene Proteins c-myb - genetics | Gene Expression Profiling | Leukemia, Myeloid - pathology | RNA Interference | Proto-Oncogene Protein c-fli-1 - metabolism | Protein Binding - drug effects | Trans-Activators - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Acute Disease | Proto-Oncogene Protein c-fli-1 - genetics | CCAAT-Enhancer-Binding Protein-beta - genetics | Oncogene Proteins - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | CCAAT-Enhancer-Binding Protein-beta - metabolism | Proto-Oncogene Proteins c-myb - metabolism | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Acetylation - drug effects | Animals | Hematopoietic System - metabolism | Leukemia, Myeloid - metabolism | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Trans-Activators - metabolism | Mice | Histones - metabolism | DNA binding proteins | Medicine, Experimental | Medical research | Chromatin | Lysine
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2013, Volume 210, Issue 2, pp. 269 - 285
.... Helios and the proapoptotic protein Bim were coinduced in 55% of nascent CCR7− CD4+ CD69+ thymocytes. These were short-lived cells that up-regulated PD-1 and down-regulated CD4 and CD8 during Bim-dependent apoptosis... 
DEVELOPING THYMOCYTES | MEDICINE, RESEARCH & EXPERIMENTAL | TISSUE-RESTRICTED ANTIGENS | SELF-PEPTIDE | RECEPTOR TRANSGENIC MICE | IN-VIVO | BIM | NEGATIVE SELECTION | C-MYC | CLONAL DELETION | IMMUNOLOGY | EXPRESSION | Autoimmunity | Cell Proliferation | NF-kappa B - immunology | Proto-Oncogene Proteins c-rel - metabolism | Proto-Oncogene Proteins - biosynthesis | Proto-Oncogene Proteins c-rel - immunology | CARD Signaling Adaptor Proteins - genetics | CD4-Positive T-Lymphocytes - immunology | Membrane Proteins - deficiency | CARD Signaling Adaptor Proteins - metabolism | Bcl-2-Like Protein 11 | Receptors, CCR7 - metabolism | Apoptosis Regulatory Proteins - deficiency | Programmed Cell Death 1 Receptor - biosynthesis | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Transcription Factors - immunology | Apoptosis Regulatory Proteins - biosynthesis | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | DNA-Binding Proteins - immunology | Lymphocyte Activation | Membrane Proteins - genetics | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Self Tolerance | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Transcription Factors - biosynthesis | Proto-Oncogene Proteins - deficiency | Clonal Deletion - immunology | Mice, Knockout | Membrane Proteins - biosynthesis | Animals | Apoptosis - immunology | Proto-Oncogene Proteins c-rel - genetics | NF-kappa B - biosynthesis | Mice | Mutation | Programmed Cell Death 1 Receptor - immunology | DNA-Binding Proteins - biosynthesis | 309
Journal Article
Molecular cell, ISSN 1097-2765, 2016, Volume 64, Issue 4, pp. 774 - 789
For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2... 
MYC | circadian rhythm | CRY2 | cryptochrome | FBXL3 | circadian clock | ubiquitin | CIRCADIAN CLOCK | CRYPTOCHROME | PROTEIN | UBIQUITIN LIGASE | TUMOR SUPPRESSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | GENE-EXPRESSION | CANCER-RISK | FACTOR PERIOD 2 | CELL BIOLOGY | Humans | Gene Expression Regulation, Neoplastic | Cryptochromes - genetics | Circadian Clocks - genetics | Lymphoma - mortality | Lymphoma - metabolism | S-Phase Kinase-Associated Proteins - chemistry | Cell Transformation, Neoplastic - genetics | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Fibroblasts | Carrier Proteins - chemistry | Lymphoma - pathology | Protein Stability | Cryptochromes - metabolism | Protein Structure, Secondary | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Circadian Rhythm - genetics | Lymphoma - genetics | Models, Molecular | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Cullin Proteins - chemistry | Cullin Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Survival Analysis | S-Phase Kinase-Associated Proteins - genetics | Cryptochromes - chemistry | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-myc - chemistry | F-Box Proteins - genetics | Ubiquitin | Physiological aspects | Drug discovery | Research institutes | Ligases | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell and Molecular Biology | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article