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Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 49, pp. 18933 - 18943
Mitochondrial dysfunction is a key pathological feature of many different types of neurodegenerative disease. Sterile alpha and Toll/interleukin receptor... 
PARKIN | AXONAL DEGENERATION | ACTIVATION | PINK1 | UBIQUITIN | TRIGGERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | LINKS | CELL-DEATH | DELETION | NAD | cell death | nicotinamide adenine dinucleotide (NAD) | mitochondria | c-Jun N-terminal kinase (JNK) | SARM1 | ATP | Cell Biology
Journal Article
Journal of Diabetes Investigation, ISSN 2040-1116, 07/2017, Volume 8, Issue 4, pp. 434 - 445
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 03/2017, Volume 56, Issue 3, pp. 393 - 401
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2017, Volume 118, Issue 8, pp. 2409 - 2419
ABSTRACT Stimulation of transient receptor potential M3 (TRPM3) cation channels with pregnenolone sulfate induces an influx of Ca2+ ions into the cells and a... 
CALCINEURIN | c‐JUN | PREGNENOLONE SULFATE | JNK | TRPM3 | ERK | c-JUN | CA2+ IONS | PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN KERATINOCYTES | CELL BIOLOGY | DESIGNER RECEPTORS | STIMULATED INSULINOMA CELLS | PANCREATIC BETA-CELLS | EGR-1 | CHANNELS | EXPRESSION | GENE-TRANSCRIPTION | RNA, Small Interfering - genetics | Transcription Factor AP-1 - genetics | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Transcription Factor AP-1 - metabolism | Blotting, Western | Calcineurin - genetics | HEK293 Cells | Pregnenolone - pharmacology | TRPM Cation Channels - genetics | Lentivirus - genetics | TRPM Cation Channels - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Calcineurin - metabolism | Phosphatases | Progesterone | Sulfates | Protein kinases | Calmodulin | Phosphorylation | Regulators | Transcription factors | Calcineurin | Stimulation | Activation | Biochemistry | Kinases | Phosphatase | Channels | Calcium influx | Pregnenolone | MAP kinase phosphatase | Proteins | Transient receptor potential proteins | Calcium-binding protein | Transcription activation | Attenuation | c-Fos protein | Calcium (intracellular) | Activator protein 1 | Extracellular signal-regulated kinase | c-Jun protein | MAP kinase | Ions | Pharmacology | Pregnenolone sulfate | Protein kinase | Terminal protein | Ca2+/calmodulin-dependent protein phosphatase | Protein phosphatase | Cations | Sulfate | Intracellular
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 04/2011, Volume 108, Issue 8, pp. 950 - 959
Journal Article
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2004, Volume 90, Issue 2, pp. 352 - 358
Microtubule‐associated protein tau in a hyperphosphorylated state is the major component of the filamentous lesions that define a number of neurodegenerative... 
stress‐activated protein kinase | tauopathy | tau protein | c‐Jun N‐terminal kinase | c-Jun N-terminal kinase | Stress-activated protein kinase | Tau protein | Tauopathy | NEUROFIBRILLARY TANGLES | NERVOUS-SYSTEM | ALZHEIMERS-DISEASE BRAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | DEPENDENT MONOCLONAL-ANTIBODY | NEUROSCIENCES | GLYCOGEN-SYNTHASE KINASE-3-BETA | FTDP-17 MUTATIONS | stress-activated protein kinase | PAIRED HELICAL FILAMENTS | SITES | NANOELECTROSPRAY MASS-SPECTROMETRY | Phosphorylation | Epitopes - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | tau Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Immunoblotting | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | tau Proteins - chemistry | Mitogen-Activated Protein Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | Protein-Tyrosine Kinases - genetics | Cyclic AMP-Dependent Protein Kinases - genetics | tau Proteins - genetics | Isoenzymes - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein-Tyrosine Kinases - chemistry | JNK Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Glycogen Synthase Kinase 3 - chemistry | Isoenzymes - genetics | Protein-Serine-Threonine Kinases - genetics | Recombinant Fusion Proteins - chemistry | Epitopes - genetics | Glycogen Synthase Kinase 3 - metabolism | Animals | Mitogen-Activated Protein Kinase 10 | Mitogen-Activated Protein Kinase 8 | Glycogen Synthase Kinase 3 - genetics | Mitogen-Activated Protein Kinase 9 | Recombinant Fusion Proteins - genetics | Mitogen-Activated Protein Kinases - genetics | Mice | Protein-Serine-Threonine Kinases - chemistry | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism
Journal Article