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Experimental Cell Research, ISSN 0014-4827, 07/2012, Volume 318, Issue 11, pp. 1269 - 1277
Journal Article
Oncotarget, ISSN 1949-2553, 11/2017, Volume 8, Issue 60, p. 101072
Epithelial cancers (carcinomas) comprise the top four causes of cancer-related deaths in the United States. While overall survival has been steadily improving,... 
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2018, Volume 293, Issue 52, pp. 20062 - 20072
The linear ubiquitin chain assembly complex (LUBAC) regulates NF-κB activation by modifying proteins with linear (M1-linked) ubiquitination chains. Although... 
RNF31 | ubiquitylation (ubiquitination) | tumor necrosis factor (TNF) | cell death | cFLIP | apoptosis | linear ubiquitination | LUBAC | caspase
Journal Article
Cell Reports, ISSN 2211-1247, 04/2017, Volume 19, Issue 4, pp. 785 - 797
Journal Article
Journal of Cell Science, ISSN 0021-9533, 11/2004, Volume 117, Issue 24, pp. 5815 - 5823
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2006, Volume 351, Issue 4, pp. 1024 - 1030
We established TRAIL-resistant MDA-231/TR cells from MDA-231 parent cells to understand the mechanism of TRAIL resistance in breast cancer cells. The selected... 
XIAP protein | ERK activation | MDA-231 cells | cFLIP(L) | TRAIL resistance
Journal Article
Oncology Reports, ISSN 1021-335X, 05/2018, Volume 39, Issue 5, pp. 2443 - 2449
cFLIP is a key regulator of the anti-apoptotic mechanism and its association with FAS-mediated apoptosis has been widely studied and well documented. However,... 
CFLIP(L)/(S) | FasL | ROS | Apoptosis | CARCINOMA-CELLS | DOWN-REGULATION | apoptosis | RECEPTOR | SIGNALING COMPLEX | CASPASE-8 ACTIVATION | REGULATOR | S | ONCOLOGY | cFLIP(L) | RESISTANCE | NECROTIC CELL-DEATH | PROTEINS | CYTOTOXICITY | Oxidative stress | Genetic aspects | Gene expression | Health aspects | Studies | Proteins | Ligands | Tumor necrosis factor-TNF | Cancer
Journal Article
Apoptosis, ISSN 1360-8185, 11/2013, Volume 18, Issue 11, pp. 1348 - 1362
Histone deacetylase (HDAC) inhibitors are novel anticancer reagents that have recently been reported to have anti-inflammatory and neuroprotective effects;... 
Biochemistry, general | cFLIP L | Signal transduction | TNFα | Biomedicine | Necroptosis | Vorinostat | Cancer Research | Oncology | RIP1 | Cell Biology | Virology | cFLIP | INDUCED CELL-DEATH | SAHA | TNF alpha | HUMAN LEUKEMIA-CELLS | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | CELL BIOLOGY | JNK ACTIVATION | L929 CELLS | REACTIVE OXYGEN | NECROSIS | cFLIP(L) | NF-KAPPA-B | TOR Serine-Threonine Kinases - metabolism | Oncogene Protein v-akt - antagonists & inhibitors | NF-kappa B - metabolism | Autophagy - drug effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | TOR Serine-Threonine Kinases - genetics | Oncogene Protein v-akt - genetics | MAP Kinase Kinase 4 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - metabolism | Oncogene Protein v-akt - metabolism | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Hydroxamic Acids - pharmacology | Fibroblasts - metabolism | NF-kappa B - agonists | Signal Transduction | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Gene Expression Regulation | p38 Mitogen-Activated Protein Kinases - genetics | Fibroblasts - pathology | CASP8 and FADD-Like Apoptosis Regulating Protein - agonists | Necrosis - prevention & control | Tumor Necrosis Factor-alpha - pharmacology | Animals | NF-kappa B - genetics | Fibroblasts - drug effects | Cell Line, Tumor | MAP Kinase Kinase 4 - genetics | Histone Deacetylase Inhibitors - pharmacology | Mice
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 1, pp. 60 - 65
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received attention as an anticancer therapy because it mediates apoptosis of several cancer... 
Genome editing | Tumor necrosis factor-related apoptosis-inducing ligand | cFLIP | Anticancer therapy | DR5 | ACTIVATION | INHIBITORY PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CANCER | BIOPHYSICS | PATHWAY | C-FLIP | EXPRESSION
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 23, pp. 16521 - 16532
We recently reported that the Smac mimetic BV6 and glucocorticoids, e.g. Dexamethasone (Dexa), synergize to induce cell death in acute lymphoblastic leukemia... 
CFLIP | Smac mimetic | Glucocorticoid | Apoptosis
Journal Article
Apoptosis, ISSN 1360-8185, 7/2008, Volume 13, Issue 7, pp. 938 - 949
Activation of the initiator-caspase, caspase-8 is under tight control of multiple antiapoptotic regulators including ARC, cFlipS, cFlipL and PED/PEA-15. Since... 
Biochemistry, general | cFlip L | Oncology | PED/PEA-15 | Virology | Cell Biology | Caspase-8 | ARC | Biomedicine | Renal cell carcinoma | Cancer Research | cFlip S | Apoptosis | cFlip | cFlipL | caspase-8 | INCREASED EXPRESSION | ENDOMETRIAL CARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PED/PEA-15 | apoptosis | CD95 (APO-1/FAS)-MEDIATED APOPTOSIS | FAS-MEDIATED APOPTOSIS | HUMAN BREAST-CANCER | CELL-DEATH | SIGNALING COMPLEX | CELL BIOLOGY | renal cell carcinoma | C-FLIP | TRAIL-INDUCED APOPTOSIS | cFlipS | Kidney Neoplasms - genetics | Humans | Middle Aged | Caspase 8 - metabolism | Carcinoma, Renal Cell - genetics | Apoptosis - genetics | Male | DNA Primers - genetics | Kidney Neoplasms - metabolism | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Caspase 8 - genetics | Base Sequence | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Intracellular Signaling Peptides and Proteins - genetics | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Carcinoma, Renal Cell - pathology | RNA, Messenger - genetics | Phosphoproteins - genetics | Caspase Inhibitors | Muscle Proteins - genetics | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | RNA, Neoplasm - genetics | Kidney Neoplasms - pathology | Aged | Enzyme Activation | RNA | Gene expression | Index Medicus
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 05/2009, Volume 296, Issue 5, pp. 825 - 838
We have previously shown that transforming growth factor (TGF)-β1 protected against main pulmonary artery endothelial cell (PAEC) apoptosis induced by serum... 
Bcl-2 | SMAD | cFLIP | Pulmonary artery hypertension | ALK1 | pulmonary artery hypertension
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2011, Volume 286, Issue 15, pp. 13282 - 13291
RIPK1 is involved in signaling from TNF and TLR family receptors. After receptor ligation, RIPK1 not only modulates activation of both canonical and... 
WEAK INDUCER | UBIQUITINATION | COMPLEX | PROTEIN | NECROSIS-FACTOR TNF | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH DOMAIN KINASE | ALPHA-DEPENDENT APOPTOSIS | C-FLIP | DEGRADATION | INHIBITOR | NF-κB | Cycloheximide | Signal Transduction | cFLIP | Cell Death | RIP | RIPK1 | TRAF2 | cIAP | Apoptosis | Proteasome
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 11/2016, Volume 422, Issue 1, pp. 135 - 150
FADD and cFLIP both are pivotal components of death receptor signaling. The cellular signaling of apoptosis accomplished with death receptors and mitochondria... 
Life Sciences | Biochemistry, general | Mitochondrion | cFLIP | Medical Biochemistry | Oncology | FADD | Cardiology | Autophagy | Oxidative stress and cancer | Apoptosis
Journal Article