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Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 05/2019, Volume 197, pp. 225 - 242
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect millions of people all over the world. Cyclic adenosine... 
phosphodiesterases | cGMP | asthma | cAMP | COPD
Journal Article
ANNALS OF THE RHEUMATIC DISEASES, ISSN 0003-4967, 03/2018, Volume 77, Issue 3, pp. 459 - 463
Objectives Stimulators of soluble guanylate cyclase (sGC) are currently investigated in clinical trials for the treatment of fibrosis in systemic sclerosis... 
FIBROSIS | CGMP | RHEUMATOLOGY | GUANYLATE-CYCLASE
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 08/2011, Volume 15, Issue 8, pp. 1778 - 1787
In vertebrate rods, dark and light conditions produce changes in guanosine 3′,5′‐cyclic monophosphate (cGMP) and calcium (Ca 2+ ) levels, which are regulated... 
a mouse line carrying a missense mutation in | PDE, cGMP‐phosphodiesterase | gene therapy | H620Q | Pde6b | cGMP, guanosine 3′,5′‐cyclic monophosphate | CNGA1, cGMP‐gated cation channels | GNAT1, guanine nucleotide‐binding protein G(t) subunit alpha‐1 | (GUCY2e), (GUCY2f) guanylate cyclases 2e and 2f | ROS, rod outer segments | ERG, electroretinogram | shRNA, short hairpin RNA | lentivirus | Pde6b(H620Q), a mouse line carrying a missense mutation in Pde6b | CALCIUM-CHANNEL BLOCKER | EQUIVALENT-LIGHT HYPOTHESIS | MEDICINE, RESEARCH & EXPERIMENTAL | PDE, cGMP-phosphodiesterase | CNGA1, cGMP-gated cation channels | INHERITED RETINAL DEGENERATION | D-CIS-DILTIAZEM | MEDIATED GENE-TRANSFER | CELL BIOLOGY | RD MOUSE | IN-VIVO | GAMMA-SUBUNIT | LEBERS CONGENITAL AMAUROSIS | BETA-SUBUNIT | GNAT1, guanine nucleotide-binding protein G(t) subunit alpha-1 | cGMP, guanosine 3 ',5 '-cyclic monophosphate | Retina - metabolism | Calcium - metabolism | Humans | Molecular Sequence Data | Immunoblotting | Male | Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics | Sodium - metabolism | RNA Interference | Base Sequence | Light | Female | Retinitis Pigmentosa - physiopathology | Cyclic Nucleotide-Gated Cation Channels - metabolism | Disease Models, Animal | Electroretinography | Retina - radiation effects | Cyclic Nucleotide Phosphodiesterases, Type 6 - metabolism | Cell Survival | Mice, Inbred C57BL | Retina - physiopathology | Cyclic Nucleotide-Gated Cation Channels - genetics | Receptors, Cell Surface - metabolism | Retinitis Pigmentosa - genetics | Retinitis Pigmentosa - metabolism | Guanylate Cyclase - metabolism | Mice, Knockout | Animals | Cyclic GMP - metabolism | Guanylate Cyclase - genetics | Mice | Photoreceptor Cells, Vertebrate - metabolism | Photoreceptor Cells, Vertebrate - pathology | Receptors, Cell Surface - genetics | Survival analysis | T cell receptors | Calcium | Sodium | Rodents | Index Medicus | Pde6bH620Q, a mouse line carrying a missense mutation in Pde6b | cGMP, guanosine 3′,5′-cyclic monophosphate
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2007, Volume 407, Issue 1, pp. 69 - 77
The intracellular signalling molecule cGMP regulates a variety of physiological processes, and so the ability to monitor cGMP dynamics in living cells is... 
Phosphodiesterase (PDE) | cGMP-dependent protein kinase (cGK) | cGMP biosensor | Fluorescence resonance energy transfer (FRET) | DOMAIN | phosphodiesterase (PDE) | fluorescence resonance energy transfer (FRET) | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | GMP | GUANYLYL CYCLASE | I-ALPHA | SMOOTH-MUSCLE | BINDING SITES | INTRACELLULAR CGMP | CAMP | Cyclic Nucleotide Phosphodiesterases, Type 5 | Humans | Anabaena - enzymology | Cyclic GMP-Dependent Protein Kinases - chemistry | Trans-Activators - chemistry | Cyclic GMP-Dependent Protein Kinases - metabolism | Transfection | Cyclic GMP - chemistry | Radioimmunoassay | Binding Sites | Protein Structure, Tertiary | Cells, Cultured | Cyclic GMP - analysis | Escherichia coli Proteins - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - chemistry | Adenylyl Cyclases - metabolism | 3',5'-Cyclic-GMP Phosphodiesterases - metabolism | Cyclic GMP - metabolism | Models, Biological | Adenylyl Cyclases - chemistry | Fluorescence Resonance Energy Transfer - methods | Indicators and Reagents | Trans-Activators - metabolism | Kinetics | Escherichia coli Proteins - chemistry | Index Medicus | YFP, yellow fluorescent protein | FRET, fluorescence resonance energy transfer | GC, guanylyl cyclase | cGK, cGMP-dependent protein kinase | cNMP-BD, cyclic nucleotide monophosphate-binding domain of cGK | HEK-293, human embryonic kidney | PDE, phosphodiesterase | GAF, cGMP-specific and -stimulated PDEs, Anabaena adenylate cyclases and Escherichia coli FhlA | RIA, radioimmunoassay | CFP, cyan fluorescent protein
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 01/2015, Volume 21, Issue 3, pp. 317 - 331
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016
Guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinases (PKG) are kinases regulating diverse physiological functions including vascular smooth... 
cGMP-dependent protein kinase | PKG inhibitor | 8-nitro-cGMP | protein S-guanylation | cGMPS Rp-isomer | vascular relaxation
Journal Article
Talanta, ISSN 0039-9140, 01/2019, Volume 192, pp. 314 - 316
Current HPLC methods for analyzing cAMP Phosphodiesterase activity (PDE) use salts, limiting the life of the columns. For this reason, we have developed an... 
PDE | cAMP/AMP | cGMP/GMP | HPLC
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2009, Volume 106, Issue 43, pp. 18225 - 18230
Journal Article
FEBS letters, ISSN 0014-5793, 1/2017, Volume 591, Issue 1, pp. 221 - 230
The R-diastereomer of phosphorothioate analogs of cGMP, Rp-cGMPS, is one of few known inhibitors of cGMP-dependent protein kinase I (PKG I); however, its... 
Second messengers | Kinase inhibition | NO-cGMP signaling | cGMP dependent protein kinase, PKG
Journal Article
BBA - General Subjects, ISSN 0304-4165, 10/2018, Volume 1862, Issue 10, pp. 2183 - 2190
Phosphodiesterases (PDEs) are a superfamily of evolutionary conserved cyclic nucleotides (cAMP/cGMP) hydrolysing enzymes, components of transduction pathways... 
PDE5 | cGMP | Native PAGE-WB | Platelets | Quaternary assembly | SAXS | DOMAIN | ISOFORMS | MACROMOLECULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CGMP-BINDING | PAGE-WB | Native | BIOPHYSICS | MEMORY | PDE5 EXPRESSION | INHIBITORS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE | Impotence | Laws, regulations and rules | Pulmonary hypertension | Index Medicus | Life Sciences | Biomolecules | Biochemistry, Molecular Biology
Journal Article