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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019, Volume 518, Issue 1, pp. 14 - 18
Our previous study demonstrated that type II cGMP-dependent protein kinase (PKG II) inhibited epidermal growth factor (EGF) induced tyrosine... 
Phosphorylation | Type II cGMP-dependent protein kinase | Threonine 669 | Gastric cancer cells | Epidermal growth factor receptor | Tyrosine | Medical colleges | Epidermal growth factor | Mass spectrometry | Protein kinases
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 25, pp. 21509 - 21519
Journal Article
European Heart Journal, ISSN 0195-668X, 04/2013, Volume 34, Issue 16, pp. 1233 - 1244
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2018, Volume 293, Issue 43, pp. 16791 - 16802
The type I cGMP-dependent protein kinase (PKG I) is an essential regulator of vascular tone. It has been demonstrated that the type I isoform can be... 
cGMP-dependent protein kinase | signal transduction | PHOSPHORYLATION | PHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | constitutive activation | AGC kinases | IDENTIFICATION | PKG | BLOOD-PRESSURE | BETA | cyclic GMP (cGMP) | CHANNEL | oxidation-reduction (redox) | potassium channel | HYPERTENSION | BINDING | protein kinase G (PKG) | allostery | SUBUNIT | Enzymology
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2001, Volume 280, Issue 3, pp. 798 - 805
Journal Article
Kidney International, ISSN 0085-2538, 12/2013, Volume 84, Issue 6, pp. 1198 - 1206
Cyclic guanosine monophosphate (cGMP) is synthesized by nitric oxide or natriuretic peptide–stimulated guanylyl cyclases and exhibits pleiotropic regulatory... 
cGMP-dependent protein kinase | cGMP | nitric oxide | interstitial fibrosis | CELLS | TGF-BETA | TISSUE FIBROSIS | FIBROBLASTS | GUANYLYL CYCLASE | UROLOGY & NEPHROLOGY | MYOFIBROBLASTS | MICE | DIFFERENTIATION | EXPRESSION | RENAL INTERSTITIAL FIBROSIS | Enzyme Activators - pharmacology | Ureteral Obstruction - complications | Fibroblasts - enzymology | Kidney - pathology | S100 Calcium-Binding Protein A4 | Kidney - enzymology | Cyclic GMP-Dependent Protein Kinase Type I - genetics | Kidney Diseases - enzymology | Mice, 129 Strain | RNA, Messenger - metabolism | Cyclic GMP-Dependent Protein Kinase Type I - metabolism | S100 Proteins - genetics | Collagen Type I - genetics | rho-Associated Kinases - metabolism | Cyclic GMP-Dependent Protein Kinase Type I - deficiency | Disease Models, Animal | Collagen Type I - metabolism | Kidney - drug effects | Signal Transduction | Isoenzymes | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Cells, Cultured | Guanylate Cyclase - metabolism | S100 Proteins - metabolism | Fibroblasts - pathology | Fibronectins - metabolism | Gene Expression Regulation, Enzymologic | Animals | Transforming Growth Factor beta - genetics | rho GTP-Binding Proteins - metabolism | Fibrosis | Fibronectins - genetics | Mice | Enzyme Activation | Kidney Diseases - etiology | Transforming Growth Factor beta - metabolism
Journal Article
Circulation Research, ISSN 0009-7330, 11/2010, Volume 107, Issue 10, pp. 1232 - 1240
RATIONALE:We have shown recently that particulate (pGC) and soluble guanylyl (sGC) cyclases synthesize cGMP in different compartments in adult rat ventricular... 
cGMP-dependent protein kinase | natriuretic peptides | cGMP | nitric oxide | phosphodiesterase type 5 | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | PHOSPHORYLATION | NATRIURETIC-PEPTIDE RECEPTOR | HEART-FAILURE | PARTICULATE GUANYLYL CYCLASE | VENTRICULAR MYOCYTES | I-ALPHA | CA2+ CURRENT | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Phosphorylation | Sarcolemma - enzymology | Rats, Wistar | Male | Cyclic GMP-Dependent Protein Kinases - metabolism | Myocytes, Cardiac - enzymology | Cytosol - enzymology | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Transfection | Time Factors | Radioimmunoassay | Nitric Oxide Donors - pharmacology | Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism | Cyclic Nucleotide-Gated Cation Channels - metabolism | Second Messenger Systems - drug effects | Atrial Natriuretic Factor - metabolism | Cells, Cultured | Cyclic Nucleotide Phosphodiesterases, Type 2 - metabolism | Cyclic Nucleotide-Gated Cation Channels - genetics | Phosphodiesterase Inhibitors - pharmacology | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Feedback, Physiological | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - drug effects | Cyclic GMP - metabolism | Membrane Potentials | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Nitric Oxide - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2007, Volume 152, Issue 6, pp. 855 - 869
It is clear that multiple signalling pathways regulate the critical balance between cell death and survival in myocardial ischaemia–reperfusion. Recent... 
nitric oxide | cGMP‐dependent protein kinase | myocardial infarction | B‐type natriuretic peptide | nitric oxide synthase | atrial natriuretic peptide | cyclic guanosine 3′,5′‐monophosphate | soluble guanylate cyclase | particulate guanylate cyclase | Myocardial infarction | B-type natriuretic peptide | Nitric oxide | Soluble guanylate cyclase | Nitric oxide synthase | Atrial natriuretic peptide | Cyclic guanosine 3′,5′-monophosphate | Particulate guanylate cyclase | CGMP-dependent protein kinase | cGMP-dependent protein kinase | ISCHEMIA/REPERFUSION INJURY | REDUCES INFARCT SIZE | ATRIAL-NATRIURETIC-PEPTIDE | NITRIC-OXIDE SYNTHASE | ISOLATED RAT HEARTS | cyclic guanosine 30,50-monophosphate | INDUCED VENTRICULAR-FIBRILLATION | GUANYLYL CYCLASE | MITOCHONDRIAL PERMEABILITY TRANSITION | SMOOTH-MUSCLE | PHARMACOLOGY & PHARMACY | RABBIT HEARTS | Cell Survival - drug effects | Phosphodiesterase Inhibitors - therapeutic use | Cyclic GMP - physiology | Apoptosis - drug effects | Humans | Enzyme Inhibitors - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Cardiotonic Agents - pharmacology | Enzyme Inhibitors - therapeutic use | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - physiopathology | Cardiotonic Agents - therapeutic use | Myocardial Reperfusion Injury - metabolism | Natriuretic Peptides - physiology | Animals | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Signal Transduction - physiology | Apoptosis - physiology | Cell Survival - physiology | Reviews | cyclic guanosine 3′,5′-monophosphate
Journal Article
Journal Article