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Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e106164
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 05/2015, Volume 30, Issue 5, pp. 878 - 885
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 11/2016, Volume 16, Issue 11, pp. 3255 - 3261
Long‐term renal transplant outcome is limited by side effects of immunosuppressive drugs, particularly calcineurin inhibitor (CNI). We assumed that some... 
clinical trial | chronic allograft nephropathy | immunosuppression/immune modulation | clinical research/practice | kidney transplantation/nephrology | alloantibody | biopsy | immunosuppressant | SURGERY | IMMUNOSUPPRESSION | FOLLOW-UP | RISK | RENAL-TRANSPLANTATION | OUTCOMES | OPERATIONAL TOLERANCE | PEDIATRIC LIVER | WITHDRAWAL | MYCOPHENOLATE-MOFETIL | CYCLOSPORINE | TRANSPLANTATION | Prospective Studies | Follow-Up Studies | Weaning | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Transplant Recipients | Kidney Function Tests | Young Adult | Treatment Failure | Aged, 80 and over | Adult | Female | Postoperative Complications - drug therapy | Tacrolimus - administration & dosage | Graft Rejection - drug therapy | Glomerular Filtration Rate | Kidney Failure, Chronic - surgery | Double-Blind Method | Calcineurin Inhibitors - administration & dosage | Graft Rejection - etiology | Adolescent | Aged | Graft Survival - drug effects | Kidney Transplantation - adverse effects | Viral antibodies | Kidneys | Tacrolimus | Analysis | Clinical trials | Antibodies | Organ transplant recipients | Transplantation | Kidney diseases | Transplants & implants | Immunology | Immunization | Renal function | Calcineurin | Immunosuppressive agents | Graft rejection | Side effects | Allografts | Histocompatibility antigen HLA | Kidney transplantation | Life Sciences | Human health and pathology
Journal Article
Eukaryotic Cell, ISSN 1535-9778, 09/2013, Volume 12, Issue 9, pp. 1225 - 1234
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e20412
Tacrolimus (FK506) is an immunosuppressive drug that binds to the immunophilin FKBPB12. The FK506-FKBP12 complex associates with calcineurin and inhibits its... 
ACTIVATED T-CELLS | SIGNALING PATHWAY | PROTEIN-2 SFRP2 | GROWTH | TRANSCRIPTION | BIOLOGY | PROLIFERATION | NUCLEAR FACTOR | EXPRESSION | CARCINOMA | TUMORS | Humans | Microvessels - metabolism | Membrane Proteins - pharmacology | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Calcineurin Inhibitors | RNA Interference | Tacrolimus - pharmacology | Female | Gene Expression Regulation, Neoplastic - drug effects | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - metabolism | NFATC Transcription Factors - metabolism | beta Catenin - deficiency | Microvessels - drug effects | Mice, Transgenic | Breast Neoplasms - blood supply | Neovascularization, Pathologic - chemically induced | Breast Neoplasms - drug therapy | beta Catenin - metabolism | beta Catenin - genetics | Cell Movement - drug effects | Tacrolimus - therapeutic use | Animals | Breast Neoplasms - pathology | Tacrolimus Binding Protein 1A - metabolism | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Endothelial Cells - pathology | NFATC Transcription Factors - deficiency | Calcineurin - metabolism | Endothelial Cells - drug effects | NFATC Transcription Factors - genetics | Viral antibodies | Care and treatment | Phosphatases | Tacrolimus | Antibodies | Breast cancer | Genetic engineering | Drug therapy | T cells | Vascular endothelial growth factor | Cancer | Endothelium | Transcription factors | Frizzled-related protein | Growth rate | Transplants & implants | Frizzled protein | Calcineurin | Calcineurin inhibitors | Metastasis | NF-AT protein | Phosphatase | Immunosuppressive agents | Proteins | Angiogenesis | Liver cancer | Breast carcinoma | Reduction | Cell growth | Surgery | Inhibition | Translocation | Transgenic mice | Metabolism | ErbB-2 protein | Nuclear transport | Endothelial cells | Androgens | Surveillance | Pancreatic cancer | Breast | Ligands | Microvasculature | Laboratory animals | Prostate cancer | Secreted frizzled-related protein 2 | Tumors | Apoptosis
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 02/2013, Volume 15, Issue 1, pp. R26 - R26
Introduction: This study investigated whether the calcineurin inhibitor, tacrolimus, suppresses receptor activator of NF-kappa B ligand (RANKL) expression in... 
RHEUMATOID-ARTHRITIS | ADJUVANT-INDUCED ARTHRITIS | CYCLOSPORINE-A | RECEPTOR ACTIVATOR | OSTEOCLAST DIFFERENTIATION FACTOR | INFLAMMATORY ARTHRITIS | CYTOKINE | TNF-ALPHA | RHEUMATOLOGY | T-CELLS | KAPPA-B LIGAND | Arthritis, Experimental - drug therapy | Humans | Male | Mesenchymal Stromal Cells - immunology | RANK Ligand - immunology | Signal Transduction - immunology | Janus Kinase 2 - metabolism | Tacrolimus - pharmacology | Female | Interleukin-6 - metabolism | Real-Time Polymerase Chain Reaction | STAT3 Transcription Factor - metabolism | Fibroblasts - metabolism | Mesenchymal Stromal Cells - drug effects | Calcineurin Inhibitors - pharmacology | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Mice, Transgenic | Arthritis, Experimental - immunology | RANK Ligand - biosynthesis | Blotting, Western | Suppressor of Cytokine Signaling 3 Protein | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | Interleukin-6 - immunology | Fibroblasts - immunology | Mice | Suppressor of Cytokine Signaling Proteins - metabolism | Arthritis, Rheumatoid - immunology | Synovial Membrane - cytology | Phosphatases | Cytokines | Arthritis | Inflammation | Gene expression | Interleukin-6 | Proteins | Rheumatoid factor | Enzyme inhibitors | Tacrolimus | Analysis | Antiarthritic agents | Cellular signal transduction | Enzyme-linked immunosorbent assay
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 08/2010, Volume 161, Issue 2, pp. 364 - 377
Summary Rabbit anti-thymocyte globulins (rATG) induce CD4+CD25+forkhead box P3 (FoxP3+) regulatory T cells that control alloreactivity. In the present study,... 
regulatory T cells | rabbit immunoglobulins | calcineurin inhibitors | KIDNEY-TRANSPLANT PATIENTS | PERIPHERAL-BLOOD | IL-2 | IMMUNOLOGY | FOXP3 | CYCLOSPORINE-A | REGULATORY CELLS | INTERFERON-GAMMA | IN-VITRO EXPANSION | EXPRESSION | GRANZYME-B | Translational Studies
Journal Article
American Journal of Transplantation, ISSN 1600-6135, 12/2014, Volume 14, Issue 12, pp. 2796 - 2806
Journal Article