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Pharmacological reviews, ISSN 1521-0081, 2011, Volume 63, Issue 3, pp. 461 - 470
Journal Article
Journal Article
Philosophical transactions. Biological sciences, ISSN 1471-2970, 2012, Volume 367, Issue 1607, pp. 3353 - 3363
Human tissues express cannabinoid CB₁ and CB₂ receptors that can be activated by endogenously released 'endocannabinoids' or exogenously administered compounds... 
Receptors | Cannabinoids | Animal models | Pain | Medical treatment | Agonists | Morphine | Drug design | Endocannabinoids | Cannabinoid receptors | health and disease and epidemiology | Articles | And CB2 | Blood-brain barrier | Cannabinoid receptor agonists | Δ9-tetrahydrocannabinol | Cannabinoid CB1 | Therapeutic applications and strategies | blood-brain barrier | Delta-tetrahydrocannabinol | cannabinoid CB1 and CB2 receptors | CB2 RECEPTOR | LIVER-DISEASES | AMYOTROPHIC-LATERAL-SCLEROSIS | ANXIETY-LIKE BEHAVIOR | MU-OPIOID RECEPTOR | RAT FORMALIN TEST | therapeutic applications and strategies | cannabinoid receptor agonists | NEUROPATHIC PAIN | MOUSE MODEL | BIOLOGY | PENTYLENETETRAZOLE-INDUCED SEIZURE | CENTRAL-NERVOUS-SYSTEM | Endocannabinoids - metabolism | Analgesics - pharmacology | Receptor, Cannabinoid, CB2 - agonists | Cardiovascular Diseases - drug therapy | Humans | Cannabinoid Receptor Agonists - pharmacology | Neurodegenerative Diseases - drug therapy | Pain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Cannabinoid Receptor Agonists - therapeutic use | Dronabinol - pharmacology | Analgesics - therapeutic use | Cardiovascular Diseases - metabolism | Risk Assessment | Analgesics - administration & dosage | Clinical Trials as Topic | Neurodegenerative Diseases - metabolism | Blood-Brain Barrier - drug effects | Cannabinoid Receptor Agonists - administration & dosage | Drug Discovery | Blood-Brain Barrier - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Dronabinol - therapeutic use | Review
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, Issue 100, pp. 255 - 263
The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI) tract remains unknown. Here we studied... 
Cannabidiol | Gastrointestinal motility | Colon | Cannabinoid | GPR55 | ENDOCANNABINOID SYSTEM | MOUSE COLON | FUNCTIONAL GASTROINTESTINAL DISORDERS | NEUROSCIENCES | PATHOPHYSIOLOGY | IN-VITRO | CANNABINOID RECEPTOR | CB1 | LIGANDS | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | IRRITABLE-BOWEL-SYNDROME | Colon - cytology | Tissue Banks | Receptor, Cannabinoid, CB2 - agonists | Humans | Colon - drug effects | Gastrointestinal Motility - drug effects | Cannabidiol - analogs & derivatives | Colon - innervation | Colonic Diseases, Functional - drug therapy | Male | Neurons - cytology | Myenteric Plexus - metabolism | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Cannabinoid, CB2 - genetics | Receptors, Cannabinoid - metabolism | Muscle, Smooth - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Cannabidiol - therapeutic use | Neurons - metabolism | Neurons - drug effects | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Nerve Tissue Proteins - antagonists & inhibitors | Muscle, Smooth - innervation | Nerve Tissue Proteins - agonists | Gene Expression Regulation | Myenteric Plexus - drug effects | Cannabidiol - pharmacology | Myenteric Plexus - cytology | Muscle, Smooth - metabolism | Mice, Inbred Strains | Nerve Tissue Proteins - genetics | Colon - metabolism | Cannabinoids - pharmacology | Mice, Knockout | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - genetics | Mice | Colonic Diseases, Functional - metabolism | Muscle, Smooth - cytology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | In Vitro Techniques | Chronic diseases | Physiological aspects | Medical colleges | G proteins | Membrane proteins | G protein-coupled receptors | COX-2, cyclooxygenase-2 | CB2, cannabinoid-2 | GI, gastrointestinal | ECS, endocannabinoid system | cDNA, complementary DNA | MAGL, monoacylglycerol lipase | CBD, cannabidiol | CB1, cannabinoid-1 | GE, gastric emptying | LMMP, longitudinal muscle-myenteric plexus layer | GPR55, G protein-coupled receptor 55 | i.c.v., intracerebroventricular administration | i.p., intraperitoneal | FAAH, fatty acid amide hydrolase | EFS, electrical field stimulation | KRS, Krebs–Ringer solution | RT-PCR, reverse transcription polymerase chain reaction | PPARα, peroxisome proliferator-activated receptor-alpha | TRPV1, transient receptor potential vanilloid 1
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1744-7658, 2014, Volume 23, Issue 8, pp. 1123 - 1140
Introduction: Commercially available cannabinoids are subject to psychotomimetic and addiction (cannabinomimetic) adverse effects largely through activation of... 
enzyme | endocannabinoid | pain | receptor | ethanolamine | orphan cannabinoid receptor | cannabinoid | bifunctional | peroxisome proliferator-activated receptor | arachidonoyl | Bifunctional | Ethanolamine | Pain | Endocannabinoid | Peroxisome proliferator-activated receptor | Enzyme | Receptor | Orphan cannabinoid receptor | Arachidonoyl | Cannabinoid | BONE-TUMOR PAIN | ENDOCANNABINOID SYSTEM | PACLITAXEL-INDUCED NEUROPATHY | CONTROLLED CLINICAL-TRIAL | AGONIST WIN 55,212-2 | ACID AMIDE HYDROLASE | CHRONIC CONSTRICTION INJURY | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | N-ARACHIDONOYL GLYCINE | Endocannabinoids - metabolism | Analgesics - pharmacology | Analgesics - therapeutic use | Receptor, Cannabinoid, CB2 - agonists | Humans | Cannabinoid Receptor Antagonists - adverse effects | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - pharmacology | Cannabinoid Receptor Antagonists - therapeutic use | Cannabinoids - adverse effects | Cannabinoids - pharmacology | Cannabinoids - therapeutic use | Animals | Receptor, Cannabinoid, CB1 - agonists | Pain - drug therapy | Pain - physiopathology | Cannabinoid Receptor Agonists - adverse effects | Cannabinoid Receptor Agonists - therapeutic use | Drug Design | Cannabinoid Receptor Antagonists - pharmacology | Ligands | Receptor, Cannabinoid, CB1 - antagonists & inhibitors
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 07/2015, Volume 6, Issue 9, pp. 1546 - 1559
Synthetic cannabinoid (SC) designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains are encountered... 
FUBINACA | JWH-018 | Cannabinoid | PINACA | THC | SR 144528 | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | 1ST POTENT | RATS | ILLEGAL PRODUCTS | ALPHA-PVT | NEUROSCIENCES | RECEPTOR ANTAGONIST | INTERNATIONAL UNION | DERIVATIVES | SR141716A | Rats, Wistar | Receptor, Cannabinoid, CB2 - agonists | Body Temperature - drug effects | Indazoles - chemical synthesis | Humans | Indoles - chemical synthesis | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Cannabinoid Receptor Agonists - chemistry | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Dose-Response Relationship, Drug | Heart Rate - drug effects | Receptor, Cannabinoid, CB1 - agonists | Cannabinoid Receptor Antagonists - pharmacology | Indoles - pharmacology | Molecular Structure | Drug Evaluation, Preclinical | Membrane Potentials - drug effects | Designer Drugs - pharmacology | Indazoles - chemistry | Cannabinoid Receptor Agonists - chemical synthesis | Designer Drugs - chemical synthesis | Indazoles - pharmacology | Designer Drugs - chemistry | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Cell Line, Tumor | Mice | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Indoles - chemistry | Cohort Studies
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 06/2013, Volume 169, Issue 4, pp. 834 - 843
Background and Purpose GPR18 is a recently deorphaned lipid receptor that is activated by the endogenous lipid N‐arachidonoyl glycine (NAGly) as well the... 
eye | mouse | intraocular pressure | cannabinoid | GPR18 | THC | RAT | ANANDAMIDE | INTRAOCULAR-PRESSURE | IDENTIFICATION | ARRIVE GUIDELINES | MESSENGER-RNA | CANNABINOID RECEPTOR AGONISTS | PHARMACOLOGY & PHARMACY | RETINA | N-ARACHIDONOYL GLYCINE | CB1 RECEPTORS | Endocannabinoids - metabolism | Administration, Ophthalmic | Glycine - analogs & derivatives | Glycine - metabolism | Intraocular Pressure - drug effects | Receptors, G-Protein-Coupled - metabolism | Epithelium, Corneal - cytology | Male | Eye Proteins - agonists | Receptors, G-Protein-Coupled - agonists | Cannabinoid Receptor Agonists - pharmacology | Receptor, Cannabinoid, CB2 - genetics | Resorcinols - administration & dosage | Ciliary Body - metabolism | Anterior Eye Segment - metabolism | Receptors, Cannabinoid - metabolism | Resorcinols - pharmacology | Arachidonic Acids - metabolism | Arachidonic Acids - administration & dosage | Cannabinoid Receptor Antagonists - pharmacology | Epithelium, Corneal - drug effects | Eye Proteins - antagonists & inhibitors | Eye Proteins - genetics | Glycine - administration & dosage | Receptors, Cannabinoid - chemistry | Receptors, Cannabinoid - genetics | Resorcinols - metabolism | Ciliary Body - cytology | Mice, Inbred C57BL | Anterior Eye Segment - cytology | Cannabinoid Receptor Agonists - administration & dosage | Mice, Knockout | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Receptor, Cannabinoid, CB1 - genetics | Eye Proteins - metabolism | Signal Transduction - drug effects | Ciliary Body - drug effects | Receptors, G-Protein-Coupled - antagonists & inhibitors | Epithelium, Corneal - metabolism | Anterior Eye Segment - drug effects | Ligands | Cannabinoid Receptor Antagonists - administration & dosage | Mice | Receptors, G-Protein-Coupled - genetics | Immunohistochemistry | Glycine | Analysis | Glaucoma | Medical research | Cannabinoids 2012, Part Two | Themed Section
Journal Article