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1. Full Text Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide
by Hans Renata and Qianghui Zhou and Phil S. Baran
Science (American Association for the Advancement of Science), ISSN 0036-8075, 1/2013, Volume 339, Issue 6115, pp. 59 - 63
Hydroxyls | Molecules | Hydrogen bonds | Ketones | Alkenes | REPORTS | Reagents | Tetrahedrons | Cardenolides | Oxidation | Steroids | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cardenolides - chemical synthesis | Ouabain - therapeutic use | Oxidation-Reduction | Humans | Ouabain - analogs & derivatives | Ouabain - chemistry | Ouabain - chemical synthesis | Cardenolides - therapeutic use | Cardenolides - chemistry | Heart Failure - drug therapy | Oxidation-reduction reaction | Chemical properties | Research | Chemical synthesis | Production processes | Methods | Enzymes | Chemical reactions | Molecular chemistry | Index Medicus | Synthesis | Photochemical | Olefins | Placing | Chemists | Showcases | Transformations | Carbon
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2. Full Text First-in-human study of pbi-05204, an oleander-derived inhibitor of akt, fgf-2, nf-κΒ and p70s6k, in patients with advanced solid tumors
by Hong, D S and Henary, H and Falchook, G S and Naing, A and Fu, S and Moulder, S and Wheler, J J and Tsimberidou, A and Durand, J B and Khan, R and Yang, P and Johansen, M and Newman, R A and Kurzrock, R
Investigational new drugs, ISSN 0167-6997, 12/2014, Volume 32, Issue 6, pp. 1204 - 1212
Phase I | Medicine & Public Health | PBI-05204 | Nerium oleander | Oleandrin,NF-kB | Oncology | AKT | Pharmacology/Toxicology | Oleandrin NF-kB | Neoplasms - metabolism | Leukocytes, Mononuclear - metabolism | TOR Serine-Threonine Kinases - metabolism | Plant Extracts - pharmacology | Humans | Middle Aged | Cardenolides - therapeutic use | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Cardenolides - adverse effects | Adult | Female | Phytotherapy | Antineoplastic Agents, Phytogenic - therapeutic use | Proto-Oncogene Proteins c-akt - metabolism | Antineoplastic Agents, Phytogenic - pharmacokinetics | Cardenolides - blood | Antineoplastic Agents, Phytogenic - adverse effects | NF-kappa B - antagonists & inhibitors | Cardenolides - pharmacokinetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors | Neoplasms - drug therapy | Sodium-Potassium-Exchanging ATPase - metabolism | Fibroblast Growth Factor 2 - antagonists & inhibitors | Maximum Tolerated Dose | Plant Extracts - pharmacokinetics | Nerium | Aged | Antineoplastic Agents, Phytogenic - pharmacology | Plant Extracts - therapeutic use | Cardenolides - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Plant Extracts - adverse effects | Index Medicus
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3. Full Text Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives
by Michalak, Karol and Rárová, Lucie and Kubala, Martin and Čechová, Petra and Strnad, Miroslav and Wicha, Jerzy
European journal of medicinal chemistry, ISSN 0223-5234, 10/2019, Volume 180, pp. 417 - 429
Cardenolides | Cytotoxicity | Furan transformation | ATP-ase inhibition | Partial synthesis | Cell Line | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - chemical synthesis | Humans | Molecular Conformation | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Cardenolides - chemistry | Enzyme Inhibitors - chemical synthesis | Cardenolides - chemical synthesis | Dose-Response Relationship, Drug | Sodium-Potassium-Exchanging ATPase - metabolism | Enzyme Inhibitors - chemistry | Cell Proliferation - drug effects | Nerium - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Cardenolides - pharmacology | Drug Screening Assays, Antitumor | Index Medicus
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4. Full Text Coping with toxic plant compounds – The insect’s perspective on iridoid glycosides and cardenolides
by Dobler, Susanne and Petschenka, Georg and Pankoke, Helga
Phytochemistry (Oxford), ISSN 0031-9422, 2011, Volume 72, Issue 13, pp. 1593 - 1604
Insect metabolism | Excretion | Sequestration | Exclusion | Cardenolides | Iridoid glycosides | Na +/K +-ATPase | Target site insensitivity | ATPase | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Adaptation, Physiological | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Plants, Edible - chemistry | Cardenolides - metabolism | Enzyme Inhibitors - pharmacology | Plants, Toxic - metabolism | Insecta - metabolism | Plants, Toxic - chemistry | Cardenolides - toxicity | Iridoid Glycosides - toxicity | Animals | Iridoid Glycosides - metabolism | Plant Diseases | Plant Physiological Phenomena | Adenosine triphosphatase | Index Medicus
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5. Full Text Cardenolides and Bufadienolide Glycosides from Kalanchoe tubiflora and Evaluation of Cytotoxicity
by Huang, Hui-Chi and Lin, Ming-Kuem and Yang, Hsin-Ling and Hseu, You-Cheng and Liaw, Chih-Chuang and Tseng, Yen-Hsueh and Tsuzuki, Minoru and Kuo, Yueh-Hsiung
Planta medica, ISSN 0032-0943, 09/2013, Volume 79, Issue 14, pp. 1362 - 1369
Natural Product Chemistry | bufadienolide glycosides | apoptosis | cardenolides | Kalanchoe tubiflora | Crassulaceae | Chinese herb | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Plant Extracts - chemistry | Apoptosis - drug effects | Kalanchoe - chemistry | Plant Extracts - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Cardenolides - therapeutic use | Cardenolides - chemistry | Neoplasms - drug therapy | Cardenolides - isolation & purification | Cell Cycle Checkpoints - drug effects | HL-60 Cells | Phytotherapy | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - therapeutic use | Plant Extracts - therapeutic use | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Glycosides | Research | Health aspects | Analysis | Apoptosis
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6. Full Text Cytotoxic cardenolides and sesquiterpenoids from the fruits of Reevesia formosana
by Hsiao, Pei-Yu and Lee, Shiow-Ju and Chen, Ih-Sheng and Hsu, Hsing-Yu and Chang, Hsun-Shuo
Phytochemistry (Oxford), ISSN 0031-9422, 10/2016, Volume 130, pp. 282 - 290
Cardenolides | Cytotoxicity | Reevesia formosana | Sterculiaceae | Sesquiterpenoids | Sesquiterpenes - isolation & purification | Sesquiterpenes - chemistry | Fruit - chemistry | Humans | Sterculiaceae - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Cardenolides - chemistry | Glycosides - pharmacology | Hep G2 Cells | MCF-7 Cells | Cardenolides - isolation & purification | Glycosides - isolation & purification | Female | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Glycosides - chemistry | Sesterterpenes | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Drugstores | Medical colleges | Research institutes | Fruit | Pharmacy | Sesquiterpenes | Index Medicus
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7. Full Text Calotropin: A Cardenolide from Calotropis gigantea that Inhibits Wnt Signaling by Increasing Casein Kinase 1α in Colon Cancer Cells
by Park, Hyun Young and Toume, Kazufumi and Arai, Midori A and Sadhu, Samir K and Ahmed, Firoj and Ishibashi, Masami
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 04/2014, Volume 15, Issue 6, pp. 872 - 878
natural products | Calotropis gigantea | Wnt signaling | cardenolides | casein kinase 1alpha | signal transduction | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Humans | Casein Kinase Ialpha - antagonists & inhibitors | Casein Kinase Ialpha - genetics | Cardenolides - chemistry | RNA, Messenger - metabolism | Wnt Proteins - metabolism | beta Catenin - metabolism | Colonic Neoplasms - metabolism | Calotropis - metabolism | Signal Transduction - drug effects | Cardenolides - isolation & purification | beta Catenin - antagonists & inhibitors | Colonic Neoplasms - pathology | Cell Line, Tumor | Phosphorylation - drug effects | Wnt Proteins - antagonists & inhibitors | Calotropis - chemistry | Casein Kinase Ialpha - metabolism | Cardenolides - pharmacology | Index Medicus
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8. Full Text Cytotoxic cardenolides from the latex of Calotropis procera
by Mohamed, Nadia H and Liu, Miaomiao and Abdel-Mageed, Wael M and Alwahibi, Lamya H and Dai, Huanqin and Ismail, Mady Ahmed and Badr, Gamal and Quinn, Ronald J and Liu, Xueting and Zhang, Lixin and Shoreit, Ahmed A.M
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 20, pp. 4615 - 4620
Cardenolides | Cytotoxicity | Antimicrobial activity | Calotropis procera | Asclepiadaceae | Humans | Bacteria - drug effects | Antifungal Agents - chemistry | Structure-Activity Relationship | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Cardenolides - isolation & purification | Anti-Bacterial Agents - chemistry | Molecular Structure | Calotropis - chemistry | Antifungal Agents - pharmacology | Fungi - drug effects | Latex - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Anti-Bacterial Agents - isolation & purification | Cardenolides - chemistry | Antifungal Agents - isolation & purification | Cell Line, Tumor | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
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9. Full Text Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture
by Munkert, Jennifer and Santiago Franco, Marina and Nolte, Elke and Thaís Silva, Izabella and Oliveira Castilho, Rachel and Melo Ottoni, Flaviano and Schneider, Naira F. Z and Oliveira, Mônica C and Taubert, Helge and Bauer, Walter and Andrade, Saulo F and Alves, Ricardo J and Simões, Cláudia M. O and Braga, Fernão C and Kreis, Wolfgang and de Pádua, Rodrigo Maia
Planta medica, ISSN 0032-0943, 08/2017, Volume 83, Issue 12/13, pp. 1035 - 1043
Natural Product Chemistry and Analytical Studies | Plantaginaceae | regioselective glycosylation | Digitalis lanata | plant cell suspension culture | Cardiac glycosides | Digitalis mariana | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Cardiac Glycosides - pharmacology | Plant Extracts - chemistry | Cardenolides - metabolism | Humans | Antineoplastic Agents - metabolism | Digitalis - chemistry | Antineoplastic Agents - isolation & purification | Cardenolides - isolation & purification | Biotransformation | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology | Cardiac Glycosides - isolation & purification | Digitalis - metabolism | Digitoxin - isolation & purification | Cell Survival - drug effects | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Cells, Cultured | Plant Extracts - isolation & purification | Glycosylation | Antineoplastic Agents - chemistry | Enzyme Inhibitors - isolation & purification | Cardenolides - chemical synthesis | Sodium-Potassium-Exchanging ATPase - metabolism | Cardiac Glycosides - chemical synthesis | Cell Line, Tumor | Digitoxin - chemistry | Cardiac Glycosides - metabolism | Cardenolides - pharmacology | Care and treatment | Cardiotonic agents | Cancer cells | Dosage and administration | Research | Plant tissue culture | Carcinoma, Renal cell
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10. Full Text Elaeodendron orientale as a source of cytotoxic cardenolides
by Osorio, Alex A and López, Manuel R and Jiménez, Ignacio A and Moujir, Laila M and Rodríguez, Matías L and Bazzocchi, Isabel L
Phytochemistry (Oxford), ISSN 0031-9422, 09/2014, Volume 105, pp. 60 - 67
Antiproliferative | Cardenolides | Elaeodendron orientale | Celastraceae | Human cancer cell lines | Plant Leaves - chemistry | Humans | Cercopithecus aethiops | Antineoplastic Agents, Phytogenic - chemistry | Cardenolides - chemistry | Digoxin - pharmacology | Animals | Cardenolides - isolation & purification | X-Ray Diffraction | HL-60 Cells | Nuclear Magnetic Resonance, Biomolecular | Celastraceae - chemistry | Molecular Structure | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Vero Cells | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Index Medicus
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11. Full Text Cardiac Glycosides from the Seeds of Thevetia peruviana
by Tian, Dan-Mei and Cheng, Huo-Yun and Jiang, Miao-Miao and Shen, Wei-Zai and Tang, Jin-Shan and Yao, Xin-Sheng
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 01/2016, Volume 79, Issue 1, pp. 38 - 50
Cardiac Glycosides - pharmacology | Thevetia - chemistry | Humans | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Cardenolides - chemistry | Cardenolides - isolation & purification | Drugs, Chinese Herbal - chemistry | Cardiac Glycosides - chemistry | Inhibitory Concentration 50 | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | Seeds - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Cardiac Glycosides - isolation & purification | Drugs, Chinese Herbal - isolation & purification | Cardenolides - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
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12. Full Text Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica
by Li, Jun-Zhu and Qing, Chen and Chen, Chang-Xiang and Hao, Xiao-Jiang and Liu, Hai-Yang
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2009, Volume 19, Issue 7, pp. 1956 - 1959
Cardenolide glycoside | Cytotoxicity | Cardenolide | Asclepias curassavica | Asclepiadaceae | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Cell Line | Cardenolides - toxicity | Cardenolides - isolation & purification | Glycosides - toxicity | Humans | Glycosides - isolation & purification | Asclepias - chemistry | Cardenolides - chemistry | Glycosides - chemistry | Index Medicus
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