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Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2018, Volume 142, Issue 1, pp. 202 - 213
Mantle cell lymphoma (MCL) is an aggressive and incurable malignant disease. Despite of general chemotherapy, relapse and mortality are common, highlighting... 
mTOR inhibitor | targeted therapy | BTK inhibitor | drug combination | Mantle cell lymphoma | UNITED-STATES | ACTIVATION | PHOSPHORYLATION | PLUS RITUXIMAB | IBRUTINIB | PROLIFERATION | COMBINATION | ONCOLOGY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | SGK1 | Everolimus - pharmacology | Apoptosis - drug effects | Humans | Lymphoma, Mantle-Cell - drug therapy | Drug Synergism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Cell Proliferation - drug effects | Mice | Acrylamides - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Tyrosine | Chemotherapy | Analysis | Mortality | Phenols | Lymphomas | Drug therapy, Combination | Gene expression | Cancer | Drugs | Regulators | Animal models | Bax protein | AKT protein | Drug development | Kinases | B-cell receptor | Cyclin D1 | Caspase-3 | Phase transitions | Cyclin-dependent kinase 4 | Anticancer properties | Signal transduction | Antitumor agents | Bcl-x protein | Xenografts | Cell cycle | Inhibition | Mantle | G1 phase | Phase transformations | Poly(ADP-ribose) polymerase | Caspase | Pharmacology | Rapamycin | Lymphoma | Bruton's tyrosine kinase | Cyclin-dependent kinase 2 | Signaling | Inhibitors | Lymphocytes B | Cell lines | Bcl protein | Synergistic effect | Apoptosis | Index Medicus
Journal Article
British Journal of Haematology, ISSN 0007-1048, 12/2015, Volume 171, Issue 5, pp. 798 - 812
Journal Article
British Journal of Haematology, ISSN 0007-1048, 10/2013, Volume 163, Issue 1, pp. 72 - 80
Previously, we showed that inhibition of the protein kinase C β ( PKC β)/ AKT pathway augments engagement of the histone deacetylase inhibitor ( HDI )‐induced... 
chronic lymphocytic leukaemia | synergy | phosphatidylinositide 3‐kinase | apoptosis | non | histone deacetylase | odgkin lymphoma | Non-Hodgkin lymphoma | Histone deacetylase | Phosphatidylinositide 3-kinase | Synergy | Chronic lymphocytic leukaemia | Apoptosis | SURVIVAL | ACTIVATION | MECHANISM | SUBEROYLANILIDE HYDROXAMIC ACID | non-Hodgkin lymphoma | AKT | B-CELL LYMPHOMA | ABILITY | DRUGS | HEMATOLOGY | NF-KAPPA-B | phosphatidylinositide 3-kinase | Quinazolinones - toxicity | Apoptosis - drug effects | Humans | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Agents - toxicity | Caspases - metabolism | Purines - toxicity | Inhibitory Concentration 50 | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Hydroxamic Acids - pharmacology | Quinazolinones - pharmacology | Hydroxamic Acids - toxicity | Lymphoma, B-Cell - metabolism | Purines - pharmacology | Indoles - toxicity | Enzyme Activation - drug effects | Drug Synergism | Signal Transduction - drug effects | Histone Deacetylase Inhibitors - toxicity | Models, Biological | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | Analysis | Leukemia | Genetic research | Lymphomas | Phospholipids | Phosphotransferases | Index Medicus
Journal Article
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 05/2018, Volume 142, Issue 9, pp. 1926 - 1937
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article