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ACS chemical biology, ISSN 1554-8929, 11/2019, Volume 14, Issue 11, pp. 2335 - 2348
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Caspase Inhibitors - pharmacology | Signal Transduction | Caspase Inhibitors - chemistry | Humans | Caspase 3 - metabolism | Gene Expression Regulation | Zinc - chemistry | Enzyme Precursors - metabolism | Neoplasms - therapy | Animals | Caspase 3 - genetics | Cell Death | Cell Line, Tumor | Ligands | Chelation Therapy - methods | Apoptosis | Index Medicus | Zymogen: refers to a precursor protein that upon an activating stimulus (e.g., proteolytic cleavage, liberation of inhibitory entities) forms a more active enzyme; often synonymous with the term proenzyme | Apoptosis: a process of programmed-cell death that culminates in the activation of executioner caspases (caspase-3 and −7) and the cleavage of essential proteins | Labile zinc: the amount of “free” zinc ions within a given system; these ions are in equilibrium with their binding partners and not sequestered in proteins | or sustains high levels of DNA damage (e.g., double-strand DNA breaks); this landscape is considered a hallmark of cancer as it promotes mutation, a major driver of cancer | Proteolysis: the enzyme-catalyzed hydrolysis of peptide bonds found in a protein | Overexpression: an abnormally high level of an entity in a cell, in the context of this review is through the comparison of noncancerous and cancerous tissue | Procaspase-3 (PC-3): the zymogen form of caspase-3 that has minor proteolytic activity and can autoactivate to form caspase-3 | Caspase-3: cysteine protease that cleaves a variety of cellular substrates, leading to phenotypes associated with apoptosis | Genomic instability: a cellular state where the machinery to repair damaged DNA has been compromised (e.g., BRCA mutations) and | PAC-1: acronym for the first procaspase-activating compound; a small molecule that binds labile zinc, promoting autoactivation of PC-3 to caspase-3 and apoptosis of cancer cells
Journal Article
Chinese chemical letters, ISSN 1001-8417, 01/2021, Volume 32, Issue 1, pp. 168 - 178
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 11/2019, Volume 29, Issue 21, pp. 126672 - 126672
Journal Article
International journal of reproductive biomedicine (Yazd, Iran), ISSN 2476-4108, 06/2020, Volume 18, Issue 5, pp. 327 - 338
Journal Article