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Journal Article
Journal Article
Biochimie, ISSN 0300-9084, 11/2015, Volume 118, pp. 51 - 59
Journal Article
Toxicology Letters, ISSN 0378-4274, 09/2016, Volume 258, pp. 198 - 206
The recent attacks with the nerve agent sarin in Syria reveal the necessity of effective countermeasures against highly toxic organophosphorus compounds.... 
Therapy | In vivo | Bioscavenger | Phosphotriesterase | Catalytic | Nerve agents | Intraosseous | VITRO | TOXICITY IN-VIVO | NERVE AGENT | LIFE-SUPPORT | ACETYLCHOLINESTERASE | RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE | TOXICOLOGY | ORGANOPHOSPHORUS COMPOUNDS | VASCULAR ACCESS | RESUSCITATION | BLOOD | Recombinant Proteins - therapeutic use | Inactivation, Metabolic | Injections, Intravenous | Nerve Agents - analysis | Male | Organophosphate Poisoning - drug therapy | Recombinant Proteins - pharmacokinetics | Antidotes - administration & dosage | Organothiophosphorus Compounds - antagonists & inhibitors | Bacterial Proteins - therapeutic use | Phosphoric Triester Hydrolases - therapeutic use | Organothiophosphorus Compounds - toxicity | Pseudomonas - enzymology | Injections, Intralesional | Proteolysis | Injections, Subcutaneous | Organophosphate Poisoning - metabolism | Animals, Outbred Strains | Antidotes - pharmacokinetics | Bone Marrow | Antidotes - metabolism | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Guinea Pigs | Nerve Agents - metabolism | Organothiophosphorus Compounds - metabolism | Phosphoric Triester Hydrolases - genetics | Peptide Fragments - administration & dosage | Bacterial Proteins - genetics | Peptide Fragments - pharmacokinetics | Phosphoric Triester Hydrolases - administration & dosage | Injections, Intramuscular | Nerve Agents - toxicity | Bacterial Proteins - administration & dosage | Recombinant Proteins - administration & dosage | Organothiophosphorus Compounds - administration & dosage | Toxicokinetics | Animals | Bacterial Proteins - pharmacokinetics | Organophosphate Poisoning - blood | Organophosphate Poisoning - etiology | Peptide Fragments - therapeutic use | Phosphoric Triester Hydrolases - pharmacokinetics | Mutation | Antidotes - therapeutic use | Nerve gas | Analysis | Index Medicus | Toxicology | Sarin | Nerves | Erythrocytes | Biocompatibility | Mathematical models | In vivo methods and tests
Journal Article
Archives of Toxicology, ISSN 0340-5761, 6/2014, Volume 88, Issue 6, pp. 1257 - 1266
The potent human toxicity of organophosphorus (OP) nerve agents calls for the development of effective antidotes. Standard treatment for nerve agent poisoning... 
Bioscavenger | Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Mutant | Detoxification | Paraoxonase | Pharmacology/Toxicology | Nerve agents | Protection | Biomedicine general | CHOLINESTERASE | CATALYTIC SCAVENGERS | PROPHYLAXIS | OXIMES | ACETYLCHOLINESTERASE | PRETREATMENT | REACTIVATION | SARIN | TOXICOLOGY | ORGANOPHOSPHORUS COMPOUNDS | Cholinesterase Inhibitors - toxicity | Injections, Intravenous | Aryldialkylphosphatase - pharmacology | Aryldialkylphosphatase - administration & dosage | Male | Antidotes - administration & dosage | Brain - metabolism | Dose-Response Relationship, Drug | Organothiophosphorus Compounds - toxicity | Acetylcholinesterase - drug effects | Organophosphates - toxicity | Antidotes - pharmacology | Organophosphates - administration & dosage | Guinea Pigs | Aryldialkylphosphatase - genetics | Erythrocytes - drug effects | Brain - drug effects | Organothiophosphorus Compounds - administration & dosage | Animals | Cholinesterase Inhibitors - administration & dosage | Erythrocytes - metabolism | Organophosphorus Compounds - administration & dosage | Chemical Warfare Agents - toxicity | Organophosphorus Compounds - toxicity | Acetylcholinesterase - metabolism | Enzymes | Nerve gas | War use | Analysis | Mortality | Gases, Asphyxiating and poisonous | Nitriles | Toxicity | Nervous system | Mutation | Index Medicus
Journal Article