X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (355) 355
cdc25 phosphatases - metabolism (243) 243
cdc25 phosphatases - antagonists & inhibitors (213) 213
animals (186) 186
index medicus (173) 173
enzyme inhibitors - pharmacology (149) 149
phosphorylation (148) 148
biochemistry & molecular biology (138) 138
cell cycle (132) 132
cell line, tumor (114) 114
cell biology (109) 109
cell cycle proteins - metabolism (98) 98
oncology (98) 98
cancer (94) 94
mice (85) 85
phosphatases (84) 84
antineoplastic agents - pharmacology (83) 83
chemistry, medicinal (82) 82
cdc25 phosphatases (81) 81
cdc25 phosphatases - genetics (79) 79
apoptosis (74) 74
cell-cycle (73) 73
enzyme inhibitors - chemistry (70) 70
activation (69) 69
female (69) 69
cell cycle proteins - antagonists & inhibitors (68) 68
mitosis (68) 68
cell cycle - drug effects (65) 65
cdc2 protein kinase - metabolism (63) 63
cell proliferation - drug effects (63) 63
protein-serine-threonine kinases - metabolism (61) 61
apoptosis - drug effects (60) 60
tumor cells, cultured (58) 58
expression (55) 55
proteins (55) 55
enzyme inhibitors - chemical synthesis (50) 50
structure-activity relationship (50) 50
pharmacology & pharmacy (49) 49
cdc25 (46) 46
dna-damage (46) 46
cyclin-dependent kinases - metabolism (45) 45
chemistry, organic (44) 44
crystal-structure (44) 44
research (44) 44
phosphatase (43) 43
dose-response relationship, drug (42) 42
hela cells (40) 40
article (39) 39
cdc25 phosphatases - chemistry (39) 39
male (39) 39
models, molecular (39) 39
cdc25a (38) 38
cell line (38) 38
protein kinases - metabolism (38) 38
protein-kinase (38) 38
signal transduction (38) 38
phosphorylation - drug effects (37) 37
protein-serine-threonine kinases - antagonists & inhibitors (36) 36
blotting, western (35) 35
dna damage (34) 34
kinase (34) 34
kinases (34) 34
protein tyrosine phosphatases - antagonists & inhibitors (34) 34
time factors (34) 34
transfection (34) 34
cell survival - drug effects (32) 32
biological evaluation (31) 31
cell division (31) 31
checkpoint kinase 1 (31) 31
fission yeast (31) 31
growth (30) 30
protein binding (30) 30
signal transduction - drug effects (30) 30
antineoplastic agents - chemistry (29) 29
cell cycle proteins - genetics (29) 29
cell division - drug effects (29) 29
cyclin-dependent kinases - antagonists & inhibitors (29) 29
cancer-cells (28) 28
cells, cultured (28) 28
enzyme activation (28) 28
g2 phase - drug effects (28) 28
genetics & heredity (28) 28
phosphoprotein phosphatases - antagonists & inhibitors (28) 28
protein tyrosine phosphatases - metabolism (28) 28
analysis (27) 27
cycle (27) 27
in-vivo (27) 27
kinetics (27) 27
molecular structure (27) 27
phosphoprotein phosphatases - metabolism (27) 27
biological phenomena, cell phenomena, and immunity (26) 26
cdc25 phosphatase (26) 26
cells (26) 26
cyclin-dependent kinase 2 (26) 26
drug design (26) 26
dual-specificity phosphatase (26) 26
inhibition (26) 26
mitosis - drug effects (26) 26
neoplasms - drug therapy (26) 26
physiological aspects (26) 26
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Biology of the Cell, ISSN 1059-1524, 04/2011, Volume 22, Issue 8, pp. 1191 - 1206
Mitosis requires precise coordination of multiple global reorganizations of the nucleus and cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream... 
ANAPHASE-PROMOTING COMPLEX | XENOPUS EGG EXTRACTS | PROTEIN PHOSPHATASES | CYCLE-DEPENDENT PHOSPHORYLATION | UBIQUITIN LIGASE | M-PHASE | CHROMOSOME ALIGNMENT | CELL-CYCLE | TUMOR-CELLS | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Cyclin-Dependent Kinases - metabolism | Gene Expression - drug effects | Xenopus Proteins - genetics | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | G2 Phase - drug effects | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Cyclin B - genetics | cdc25 Phosphatases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Prometaphase - drug effects | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CDC2 Protein Kinase - genetics | Protein Phosphatase 2 - antagonists & inhibitors | CDC2 Protein Kinase - antagonists & inhibitors | Xenopus laevis | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - genetics | Xenopus Proteins - antagonists & inhibitors | Membrane Proteins | Animals | Phosphoprotein Phosphatases - genetics | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Cyclin B - metabolism | Feedback, Physiological - drug effects | Xenopus Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | S Phase - drug effects | HeLa Cells | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2005, Volume 280, Issue 19, pp. 19078 - 19086
Mitogen-activated protein kinase phosphatase-1 (MKP-1) is a dual specificity phosphatase that is overexpressed in many human tumors and can protect cells from... 
APOPTOSIS | OVEREXPRESSION | KOLMOGOROV-SMIRNOV TEST | MKP-1 | PYST1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | DEATH | DUAL-SPECIFICITY PHOSPHATASE | EXPRESSION | CATALYTIC ACTIVATION | Dual Specificity Phosphatase 1 | Phosphorylation | Models, Chemical | Isoquinolines | Plant Extracts - pharmacology | Humans | Electrophoresis, Gel, Two-Dimensional | JNK Mitogen-Activated Protein Kinases - metabolism | Protein Tyrosine Phosphatases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Dual Specificity Phosphatase 6 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | Dose-Response Relationship, Drug | Mitogen-Activated Protein Kinase Kinases - metabolism | Protein Tyrosine Phosphatases - antagonists & inhibitors | Protein Tyrosine Phosphatases - chemistry | MAP Kinase Kinase 4 | Transfection | Time Factors | Immediate-Early Proteins - chemistry | Inhibitory Concentration 50 | cdc25 Phosphatases - metabolism | Protein Phosphatase 1 | Catalytic Domain | Alkaloids - pharmacology | Gene Library | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | Phosphoprotein Phosphatases - antagonists & inhibitors | Models, Statistical | Neoplasms - drug therapy | Benzophenanthridines | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Cell Line, Tumor | DNA Damage | HeLa Cells | Alkaloids - chemistry | Immediate-Early Proteins - antagonists & inhibitors | Microscopy, Fluorescence | Phosphoprotein Phosphatases - chemistry
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2005, Volume 171, Issue 1, pp. 35 - 45
Cdc25 phosphatases are essential for the activation of mitotic cyclin-Cdks, but the precise roles of the three mammalian isoforms (A, B, and C) are unclear.... 
Phosphatases | HEK293 cells | Mitosis | Centrosomes | Cell cycle | Small interfering RNA | HeLa cells | Fluorescence | Condensation | Cyclins | FISSION YEAST | MESSENGER-RNA | PROTEIN-KINASE | PHOSPHATASE | Y TRANSCRIPTION FACTOR | NUCLEAR EXPORT | S-PHASE | CELL-CYCLE | MAMMALIAN-CELLS | CDK2-DEPENDENT PHOSPHORYLATION | CELL BIOLOGY | Cell Line | Cell Cycle Proteins - pharmacology | Cyclin-Dependent Kinases - metabolism | Humans | RNA, Small Interfering - pharmacology | Centrosome - drug effects | Cyclin-Dependent Kinases - analysis | cdc25 Phosphatases - physiology | Cell Nucleus Division - drug effects | Cyclin B1 | Centrosome - metabolism | Cyclin-Dependent Kinases - drug effects | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Centrosome - chemistry | Mitosis - drug effects | cdc25 Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - pharmacology | Mitosis - physiology | Enzyme Activation | HeLa Cells | cdc25 Phosphatases - metabolism | Cell Cycle Proteins - physiology | Research | Cytology | Mitosis/drug effects/physiology | RNA; Small Interfering/pharmacology | cdc25 Phosphatase/antagonists & inhibitors/metabolism/pharmacology/physiology | CDC2 Protein Kinase/metabolism | Cell Cycle Proteins/antagonists & inhibitors/pharmacology/physiology | Cell Nucleus Division/drug effects | Centrosome/chemistry/drug effects/metabolism | Cyclin-Dependent Kinases/analysis/drug effects/metabolism | Research Support; Non-U.S. Gov't | Hela Cells
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 31, pp. 12974 - 12979
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2008, Volume 15, Issue 25, pp. 2536 - 2544
Dual-specificity phosphatases (DSPs) are important, but poorly understood, cell signaling enzymes that remove phosphate groups from tyrosine and... 
High throughput screening | Intrinsic dynamics | Dual-specificity phosphatases | Structure-based virtual screening | Computer-aided drug discovery | Focused library design | Molecular docking | CDC25 PHOSPHATASE | CHEMISTRY, MEDICINAL | ACTIVATED PROTEIN-KINASE | MAP KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CATALYTIC DOMAIN | BINDING DOMAIN | TYROSINE PHOSPHATASES | computer-aided drug discovery | GENETIC ALGORITHM | CELL LUNG-CANCER | molecular docking | intrinsic dynamics | focused library design | LIGAND DOCKING | high throughput screening | PHARMACOLOGY & PHARMACY | structure-based virtual screening | Combinatorial Chemistry Techniques - methods | Amino Acid Sequence | Drug Evaluation, Preclinical - methods | Dual-Specificity Phosphatases - metabolism | Dual Specificity Phosphatase 1 - antagonists & inhibitors | cdc25 Phosphatases - chemistry | Enzyme Inhibitors - pharmacology | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Structure-Activity Relationship | Dual-Specificity Phosphatases - chemistry | Algorithms | Dual Specificity Phosphatase 1 - chemistry | cdc25 Phosphatases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Dual Specificity Phosphatase 1 - metabolism | Protein Conformation | Dual-Specificity Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - metabolism | Binding Sites
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 992 - 9
The compound 29-(4-methylpiperazine)-luepol (M22), a novel derivative of lupeol has shown anti-proliferative effects against the human non-small cell lung... 
DIETARY TRITERPENE | PROSTATE | ACTIVATION | CANCER CELLS | MITOCHONDRIAL | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | DOWN-REGULATION | LUPEOL | NF-KAPPA-B | CARCINOMA | Cyclin D1 - metabolism | Oncogene Proteins - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Reactive Oxygen Species - metabolism | Apoptotic Protease-Activating Factor 1 - agonists | Apoptosis - drug effects | Humans | bcl-2-Associated X Protein - agonists | Caspase 3 - metabolism | Apoptotic Protease-Activating Factor 1 - genetics | Membrane Potential, Mitochondrial - drug effects | Cyclin E - genetics | Reactive Oxygen Species - agonists | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cyclin D1 - antagonists & inhibitors | cdc25 Phosphatases - antagonists & inhibitors | Caspase 3 - genetics | Inhibitory Concentration 50 | Gene Expression Regulation, Neoplastic - drug effects | cdc25 Phosphatases - metabolism | Cyclin E - antagonists & inhibitors | bcl-2-Associated X Protein - genetics | A549 Cells | Cyclin-Dependent Kinase 2 - metabolism | Antineoplastic Agents, Phytogenic - chemical synthesis | Oncogene Proteins - metabolism | bcl-2-Associated X Protein - metabolism | Cyclin-Dependent Kinase 2 - genetics | Pentacyclic Triterpenes - pharmacology | Signal Transduction - genetics | cdc25 Phosphatases - genetics | Piperazines - pharmacology | Apoptotic Protease-Activating Factor 1 - metabolism | Hep G2 Cells | Oncogene Proteins - antagonists & inhibitors | Pentacyclic Triterpenes - chemical synthesis | Cyclin D1 - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Piperazines - chemical synthesis | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cyclin E - metabolism | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Adenocarcinoma | Reactive oxygen species | Bax protein | Bcl-2 protein | Non-small cell lung carcinoma | Caspase | Cyclin D1 | Cyclins | Western blotting | Cdc25A phosphatase | Cyclin-dependent kinase 2 | Mitochondria | Membrane potential | Apoptosis
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 03/2015, Volume 54, Issue 3, pp. 229 - 241
Journal Article