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1. Full Text BIABooster: Online DNA Concentration and Size Profiling with a Limit of Detection of 10 fg/mu L and Application to High-Sensitivity Characterization of Circulating Cell-Free DNA
by Andriamanampisoa, CL and Bancaud, A and Boutonnet-Rodat, A and Didelot, A and Fabre, J and Fina, F and Garlan, F and Garrigou, S and Gaudy, C and Ginot, F and Henaff, D and Laurent-Puig, P and Morin, A and Picot, V and Saias, L and Taly, V and Tomasini, P and Zaanan, A
ANALYTICAL CHEMISTRY, ISSN 0003-2700, 03/2018, Volume 90, Issue 6, pp. 3766 - 3774
We describe a technology to perform sizing and concentration analysis of double stranded DNA with a sensitivity of 10 fg/mu L in an operating time of 20 min.... 
CHEMISTRY, ANALYTICAL | PLASMA | INTEGRITY | MARKER | CFDNA | COLORECTAL-CANCER | TUMOR-DNA
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2. Full Text Seminal cell free DNA concentration levels discriminate between prostate cancer and benign prostatic hyperplasia
by Ponti, Giovanni and Maccaferri, Monia and Micali, Salvatore and Manfredini, Marco and Milandri, Riccardo and Bianchi, Giampaolo and Pellacani, Giovanni and Kaleci, Shaniko and Chester, Johanna and Conti, Andrea and Prete, Chiara Del and Tomasi, Aldo
Anticancer Research, ISSN 0250-7005, 09/2018, Volume 38, Issue 9, pp. 5121 - 5125
Background/Aim: Seminal plasma cfDNA (scfDNA) was recently proposed as a novel PCa biomarker. Our aim was to evaluate whether scfDNA could discriminate PCa... 
Prostate cancer screening | Spermal cfDNA | Seminal plasma cfDNA | Liquid biopsy | Fluorimetry | Urological biomarkers | Prostate cancer | prostate cancer | EARLY-DIAGNOSIS | PLASMA | BIOMARKER | ONCOLOGY | spermal cfDNA | fluorimetry | prostate cancer screening | liquid biopsy | urological biomarkers
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3. Full Text Inside Cover: Valency‐Controlled Framework Nucleic Acid Signal Amplifiers (Angew. Chem. Int. Ed. 24/2018)
by Liu, Qi and Ge, Zhilei and Mao, Xiuhai and Zhou, Guobao and Zuo, Xiaolei and Shen, Juwen and Shi, Jiye and Li, Jiang and Wang, Lihua and Chen, Xiaoqing and Fan, Chunhai
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2018, Volume 57, Issue 24, pp. 6948 - 6948
Ultrasensitive biosensing is made possible by a framework nucleic acids (FNA)‐programmed strategy, designed to develop valence‐controlled signal amplifiers... 
DNA nanostructure | biosensors | framework nucleic acids | valence-engineering | cfDNA
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4. Full Text Development of a method to implement whole-genome bisulfite sequencing of cfDNA from cancer patients and a mouse tumor model
by Maggi, Elaine C and Gravina, Silvia and Cheng, Haiying and Piperdi, Bilal and Yuan, Ziqiang and Dong, Xiao and Libutti, Steven K and Vijg, Jan and Montagna, Cristina
Frontiers in Genetics, ISSN 1664-8021, 01/2018, Volume 9, p. 6
The goal of this study was to develop a method for whole genome cell-free DNA (cfDNA) methylation analysis in humans and mice with the ultimate goal to... 
Biomarker | Circulating DNA, mouse cfDNA | Pancreatic cancer | Cell-free DNA | DNA methylation | CfDNA | Non-invasive blood based screening | mouse cfDNA | HYPERMETHYLATION | non-invasive blood based screening | MAMMARY-GLAND ADENOCARCINOMAS | BLOOD-PLASMA | PANCREATIC-CANCER | circulating DNA | biomarker | HUMAN BREAST-CANCER | pancreatic cancer | CENTROSOME AMPLIFICATION | cfDNA | COLORECTAL-CANCER | PROSTATE-CANCER | GENETICS & HEREDITY | cell-free DNA | Genetic aspects | Gene expression | Health aspects | Carcinogenesis
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5. Full Text Development of a gene panel for nextgeneration sequencing of clinically relevant mutations in cell-free DNA from cancer patients
by Malapelle, U and de-Las-Casas, CM and Rocco, D and Garzon, M and Pisapia, P and Jordana-Ariza, N and Russo, M and Sgariglia, R and De Luca, C and Pepe, F and Martinez-Bueno, A and Morales-Espinosa, D and Gonzalez-Cao, M and Karachaliou, N and Ramirez, SV and Bellevicine, C and Molina-Vila, MA and Rosell, R and Troncone, G
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 03/2017, Volume 116, Issue 6, pp. 802 - 810
Background: When tumour tissue is unavailable, cell-free DNA (cfDNA) can serve as a surrogate for genetic analyses. Because mutated alleles in cfDNA are... 
GEFITINIB | BIOPSY | EGFR MUTATION | BRAF | lung cancer | LUNG-CANCER | CETUXIMAB | solid tumours | ONCOLOGY | cfDNA | COLORECTAL-CANCER | THERAPIES | NGS | INHIBITORS | ASSOCIATION
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6. Full Text Validation and comparison of two NGS assays for the detection of EGFR T790M resistance mutation in liquid biopsies of NSCLC patients
by Vollbrecht, Claudia and Lehmann, Annika and Lenze, Dido and Hummel, Michael
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 26, pp. 18529 - 18539
Analysis of circulating cell-free DNA (cfDNA) derived from peripheral blood ("liquid biopsy") is an attractive alternative to identify non-small cell lung... 
Liquid biopsy | T790M | CfDNA | NGS | NSCLC
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7. Full Text Application of cell-free DNA for genomic tumor profiling: A feasibility study
by Ahlborn, Lise B and Rohrberg, Kristoffer S and Gabrielaite, Migle and Tuxen, Ida V and Yde, Christina W and Spanggaard, Iben and Santoni-Rugiu, Eric and Nielsen, Finn C and Lassen, Ulrik and Mau-Sorensen, Morten and Østrup, Olga
Oncotarget, ISSN 1949-2553, 02/2019, Volume 10, Issue 14, pp. 1388 - 1398
Access to genomic tumor material is required to select patients for targeted therapies. However, tissue biopsies are not always feasible and therefore... 
Genomic profile | Liquid biopsy | CfDNA | WES | Biopsy
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8. Full Text Detection of somatic mutations in cell-free DNA in plasma and correlation with overall survival in patients with solid tumors
by Mehrotra, Meenakshi and Singh, Rajesh R and Loghavi, Sanam and Duose, Dzifa Yawa and Barkoh, Bedia A and Behrens, Carmen and Patel, Keyur P and Routbort, Mark J and Kopetz, Scott and Broaddus, Russell R and Medeiros, L. Jeffrey and Wistuba, Ignacio I and Luthra, Rajyalakshmi
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 12, pp. 10259 - 10271
A suitable clinical-grade platform is required for detection of somatic mutations with high sensitivity in cell-free DNA (cfDNA) of patients with solid tumors.... 
DdPCR | Next-generation sequencing | CfDNA | Genotyping | MassARRAY
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9. Full Text Monitoring BRAF and NRAS mutations with cell-free circulating tumor DNA from metastatic melanoma patients
by Long-Mira, Elodie and Ilie, Marius and Chamorey, Emmanuel and Leduff-Blanc, Florence and Montaudié, Henri and Tanga, Virginie and Allégra, Maryline and Lespinet-Fabre, Virginie and Bordone, Olivier and Bonnetaud, Christelle and Schiappa, Renaud and Butori, Catherine and Bence, Coraline and Lacour, Jean-Philippe and Hofman, Véronique and Hofman, Paul
Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 90, pp. 36238 - 36249
The mutation status of the and genes in tumor tissue is used to select patients with metastatic melanoma for targeted therapy. Cell-free circulating DNA... 
Metastatic melanoma | NRAS | BRAF | IDYLLA | CfDNA
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10. Full Text Clinical relevance of size selection of circulating DNA
by Grunt, Magdalena and Hillebrand, Timo and Schwarzenbach, Heidi
Translational Cancer Research, ISSN 2218-676X, 02/2018, Volume 7, pp. S171 - S184
Circulating cell-free DNA (cfDNA) is a non-invasive and powerful detection, diagnosis, prognosis, therapy response monitoring and recovery prediction tool,... 
Non-invasive diagnosis | CfDNA size profiling | CfDNA size separation | Circulating cell-free DNA (cfDNA) | CARCINOMA PATIENTS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | cfDNA size profiling | MITOCHONDRIAL-DNA | FREE FETAL DNA | NUCLEIC-ACIDS | LUNG-CANCER | CANCER-PATIENTS | cfDNA size separation | MATERNAL PLASMA | ONCOLOGY | GENE AMPLIFICATION | non-invasive diagnosis | CELL-FREE DNA
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11. Full Text Ribosomal DNA as DAMPs signal for MCF7 cancer cells
by Malinovskaya, Elena M and Ershova, Elizaveta S and Okorokova, Natalya A and Veiko, Vladimir P and Konkova, Marina S and Kozhina, Ekaterina A and Savinova, Ekaterina A and Porokhovnik, Lev N and Kutsev, Serguey I and Veiko, Nataly N and Kostyuk, Svetlana V
Frontiers in Oncology, ISSN 2234-943X, 2019, Volume 9, Issue MAY, p. 445
The cell free ribosomal DNA (cf-rDNA) is accrued in the total pool of cell free DNA (cfDNA) in some non-cancer diseases and demonstrates DAMPs characteristics.... 
rDNA | AIM2 | Oxidized cfDNA | TLR9 | Human ribosomal gene | CfDNA | DAMPs | Genetic aspects | Health aspects | DNA | Cancer cells | Cancer | Breast cancer | Research | human ribosomal gene | cfDNA
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12. Full Text Cell-free DNA in medium is associated with the maturation ability of in vitro cultured oocytes
by MUNAKATA, Yasuhisa and SHIRASUNA, Koumei and KUWAYAMA, Takehito and IWATA, Hisataka
Journal of Reproduction and Development, ISSN 0916-8818, 2019, Volume 65, Issue 2, pp. 171 - 175
Follicular fluid contains cell-free DNA (cfDNA), which may serve as a useful biomarker of oocyte ability. The present study evaluates whether nuclear and... 
In vitro cultured oocytes | Nuclear cfDNA | Mitochondrial cfDNA | Oocyte quality | AGRICULTURE, DAIRY & ANIMAL SCIENCE | REPRODUCTIVE BIOLOGY | GRANULOSA-CELLS | GROWTH | IMPROVES | FOLLICLE | CARBOHYDRATE-METABOLISM | Original
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13. Full Text Quick assessment of cell-free DNA in seminal fluid and fragment size for early non-invasive prostate cancer diagnosis
by Ponti, Giovanni and Maccaferri, Monia and Manfredini, Marco and Micali, Salvatore and Torricelli, Federica and Milandri, Riccardo and del Prete, Chiara and Ciarrocchi, Alessia and Ruini, Cristel and Benassi, Luisa and Bettelli, Stefania and Kaleci, Shaniko and Ozben, Tomris and Tomasi, Aldo
Clinica Chimica Acta, ISSN 0009-8981, 10/2019, Volume 497, pp. 76 - 80
Liquid biopsy consists in the quantification and qualification of circulating cell-free DNA (cfDNA) and tumor-derived DNA (ctDNA) for cancer recognition.... 
Benign prostatic hyperplasia | cfDNA fragment size distribution | Non-invasive prostate cancer diagnosis | Seminal cell-free DNA | CIRCULATING DNA | QUANTIFICATION | TUMOR | MEDICAL LABORATORY TECHNOLOGY | Genetic aspects | Diagnosis | Prostate cancer | Analysis | DNA | Cancer
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14. Full Text Spanish- and English-Speaking Pregnant Women’s Views on cfDNA and Other Prenatal Screening: Practical and Ethical Reflections
by Floyd, Erin and Allyse, Megan A and Michie, Marsha
Journal of Genetic Counseling, ISSN 1059-7700, 10/2016, Volume 25, Issue 5, pp. 965 - 977
The rapid clinical implementation of cell-free DNA (cfDNA) screening, a non-invasive method of prenatal genetic screening, has outpaced research on its social... 
Human Genetics | Public Health | Latinas | Gynecology | Clinical Psychology | Ethics | cfDNA screening | Biomedicine | Spanish-speakers | cfDNA | Prenatal screening | NIPS | NIPT | ethics | prenatal screening
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15. Full Text Non-blood sources of cell-free DNA for cancer molecular profiling in clinical pathology and oncology
by Ponti, Giovanni and Manfredini, Marco and Tomasi, Aldo
Critical Reviews in Oncology / Hematology, ISSN 1040-8428, 09/2019, Volume 141, pp. 36 - 42
Liquid biopsy can quantify and qualify cell-free (cfDNA) and tumour-derived (ctDNA) DNA fragments in the bloodstream. CfDNA quantification and mutation... 
Cell-free DNA | Biomarkers | Liquid biopsy | Non blood cfDNA | Cancer management | Cancer diagnosis | ACQUIRED-RESISTANCE | EGFR MUTATIONS | OCCULT BLOOD | CEREBROSPINAL-FLUID | STOOL DNA | KRAS MUTATIONS | MUTATION STATUS | CIRCULATING TUMOR DNA | ONCOLOGY | PROSTATE-CANCER | COLORECTAL NEOPLASIA | HEMATOLOGY | Thyroid cancer | DNA | Genetic research | Genetic aspects | Diagnosis | Prostate cancer | Cancer
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16. Full Text Analysis of microbial sequences in plasma cell-free DNA for early-onset breast cancer patients and healthy females
by Huang, Yu-Feng and Chen, Yen-Ju and Fan, Tan-Chi and Chang, Nai-Chuan and Chen, Yi-Jie and Midha, Mohit K and Chen, Tzu-Han and Yang, Hsiao-Hsiang and Wang, Yu-Tai and Yu, Alice L and Chiu, Kuo-Ping
BMC Medical Genomics, ISSN 1755-8794, 02/2018, Volume 11, Issue Suppl 1, pp. 16 - 41
Background: Cell-free circulating DNA (cfDNA) is becoming a useful biopsy for noninvasive diagnosis of diseases. Microbial sequences in plasma cfDNA may... 
Microbial cfDNA | Microbial cfDNA reads per million quality PE reads (MCRPM) | Cell-free circulating DNA (cfDNA) | HUMANS | VIRAL CARCINOGENESIS | MECHANISMS | BACTERIAL | IDENTIFICATION | DISEASE | GENETICS & HEREDITY | INFECTION | SKIN | VIRUSES | BLOOD | Prognosis | Breast Neoplasms - microbiology | Humans | Biomarkers - blood | Cell-Free Nucleic Acids - genetics | Case-Control Studies | Breast Neoplasms - genetics | DNA, Bacterial - genetics | Breast Neoplasms - pathology | Cell-Free Nucleic Acids - blood | Age of Onset | DNA, Bacterial - blood | Adult | Female | Women | DNA | Breast cancer | Genetic aspects | Research | Health aspects
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17. Full Text Genotyping of circulating cell‐free DNA enables noninvasive tumor detection in myxoid liposarcomas
by Braig, David and Becherer, Caroline and Bickert, Christiane and Braig, Moritz and Claus, Rainer and Eisenhardt, Anja E and Heinz, Juergen and Scholber, Jutta and Herget, Georg W and Bronsert, Peter and Fricke, Alba and Follo, Marie and Stark, G. Bjoern and Bannasch, Holger and Eisenhardt, Steffen U
International Journal of Cancer, ISSN 0020-7136, 08/2019, Volume 145, Issue 4, pp. 1148 - 1161
Soft tissue sarcomas (STS) are rare tumors of mesenchymal origin. About 50% of patients with STS experience relapse and more than 30% will die within 10 years... 
free circulating DNA, cfDNA | soft tissue sarcoma | myxoid liposarcoma | diagnostic biomarker | liquid biopsy | circulating tumor DNA, ctDNA | DIAGNOSIS | SOFT-TISSUE SARCOMAS | MARKER | GENOMIC BREAKPOINTS | CANCER | ctDNA | ONCOLOGY | cfDNA | SEQUENCE | GENES | free circulating DNA | LIQUID BIOPSIES | circulating tumor DNA | Genetic research | Relapse | DNA | Diseases | Tumors | MDM2 protein | Medical imaging | Mesenchyme | Positron emission | Minimal residual disease | Patients | Soft tissues | Fragmentation | Amplification | Alterations | Genotyping | Computed tomography | Liposarcoma | Tomography | Biomarkers | Remission | Bioindicators | Diagnostic systems | Mutation | Deoxyribonucleic acid--DNA
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18. Full Text PIK3CA and KRAS mutations in cell free circulating DNA are useful markers for monitoring ovarian clear cell carcinoma
by Morikawa, Asuka and Hayashi, Tomoatsu and Shimizu, Naomi and Kobayashi, Mana and Taniue, Kenzui and Takahashi, Akiko and Tachibana, Kota and Saito, Misato and Kawabata, Ayako and Iida, Yasushi and Ueda, Kazu and Saito, Motoaki and Yanaihara, Nozomu and Tanabe, Hiroshi and Yamada, Kyosuke and Takano, Hirokuni and Nureki, Osamu and Okamoto, Aikou and Akiyama, Tetsu
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 20, pp. 15266 - 15274
Ovarian clear cell carcinoma (OCCC) exhibits distinct phenotypes, such as resistance to chemotherapy, poor prognosis and an association with endometriosis.... 
OCCC | Digital PCR | KRAS | CfDNA | PIK3CA
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19. Full Text Plasma Cell-free DNA Concentration and Outcomes from Taxane Therapy in Metastatic Castration-resistant Prostate Cancer from Two Phase III Trials (FIRSTANA and PROSELICA)
by Mehra, Niven and Dolling, David and Sumanasuriya, Semini and Christova, Rossitza and Pope, Lorna and Carreira, Suzanne and Seed, George and Yuan, Wei and Goodall, Jane and Hall, Emma and Flohr, Penny and Boysen, Gunther and Bianchini, Diletta and Sartor, Oliver and Eisenberger, Mario A and Fizazi, Karim and Oudard, Stephane and Chadjaa, Mustapha and Macé, Sandrine and de Bono, Johann S
European Urology, ISSN 0302-2838, 09/2018, Volume 74, Issue 3, pp. 283 - 291
Noninvasive biomarkers are needed to guide metastatic castration-resistant prostate cancer (mCRPC) treatment. To clinically qualify baseline and on-treatment... 
Circulating cell-free DNA | cfDNA | Docetaxel | PROSELICA | FIRSTANA | Taxane chemotherapy | Cabazitaxel | CIRCULATING DNA | MITOXANTRONE | BIOMARKER | PHASE-III | SERUM | CHEMOTHERAPY | PREDNISONE | ORIGIN | UROLOGY & NEPHROLOGY
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20. Full Text Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC
by Rolfo, Christian and Mack, Philip C and Scagliotti, Giorgio V and Baas, Paul and Barlesi, Fabrice and Bivona, Trever G and Herbst, Roy S and Mok, Tony S and Peled, Nir and Pirker, Robert and Raez, Luis E and Reck, Martin and Riess, Jonathan W and Sequist, Lecia V and Shepherd, Frances A and Sholl, Lynette M and Tan, Daniel S.W and Wakelee, Heather A and Wistuba, Ignacio I and Wynes, Murry W and Carbone, David P and Hirsch, Fred R and Gandara, David R
Journal of Thoracic Oncology, ISSN 1556-0864, 09/2018, Volume 13, Issue 9, pp. 1248 - 1268
The isolation and analysis of circulating cell-free tumor DNA in plasma is a powerful tool with considerable potential to improve clinical outcomes across... 
Resistance | Targeted therapies | NSCLC | cfDNA | Biomarkers | Liquid biopsy | Molecular analysis | ctDNA | 1ST-LINE TREATMENT | CTDNA ANALYSIS | EGFR MUTATIONS | OPEN-LABEL | EDUCATED PLATELETS | MALIGNANT PLEURAL EFFUSION | DROPLET DIGITAL PCR | CHECKPOINT INHIBITORS | CIRCULATING TUMOR DNA | ONCOLOGY | RESPIRATORY SYSTEM | ABSOLUTE QUANTIFICATION
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