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Biochemical Journal, ISSN 0264-6021, 05/2007, Volume 404, Issue 1, pp. 151 - 157
Several rare and novel NNRTI [non-nucleoside reverse transcriptase (RT) inhibitor] resistance mutations were recently detected at codons 132 and 135 in RTs... 
HIV-1 | Resistance | Non-nucleoside reverse transcriptase inhibitor | Reverse transcriptase | Chimaeric Ty1/HIV-1 reverse transcriptase phenotypic assay | HIGHLY RESISTANT | VARIANTS | reverse transcriptase | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO SELECTION | DRUG-RESISTANCE | resistance | ISOLATE | chimaeric Ty 1/HIV-1 reverse transcriptase phenotypic assay | AMINO-ACID | THERAPY | PURIFICATION | GW678248 | IMMUNODEFICIENCY-VIRUS TYPE-1 | non-nucleoside reverse transcriptase inhibitor | Recombinant Proteins - metabolism | DNA, Viral - biosynthesis | Saccharomyces cerevisiae - genetics | Molecular Conformation | Models, Molecular | Recombinant Proteins - chemistry | Reverse Transcriptase Inhibitors - pharmacology | HIV Reverse Transcriptase - genetics | Protein Subunits - metabolism | Reverse Transcriptase Inhibitors - chemistry | HIV Reverse Transcriptase - metabolism | Cloning, Molecular | HIV-1 - enzymology | Protein Conformation | RNA, Viral - metabolism | Circular Dichroism | HIV Reverse Transcriptase - chemistry | RLU, relative light unit | WT, wild-type | p51, 51 kDa subunit of reverse transcriptase | HIV-1 RT | p66, 66 kDa subunit of reverse transcriptase | NRTI, nucleoside RT inhibitor | TyHRT, Ty1 | NNRTI-BP, NNRTI-binding pocket | chimaeric Ty1 | β-gal, β-galactosidase | RT, reverse transcriptase | NNRTI, non-nucleoside RT inhibitor | HIV-1 reverse transcriptase phenotypic assay
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