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Molecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2189 - 2201
We explored the utility of targeting anaplastic lymphoma kinase (ALK), a cell surface receptor overexpressed on pediatric solid tumors, using chimeric antigen... 
ALK | tumor immunology | CAR | antigen density | anaplastic lymphoma kinase | immunotherapy | neuroblastoma | chimeric antigen receptor | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | TYROSINE KINASE | NEUROBLASTOMA | MODIFIED T-CELLS | ANTITUMOR-ACTIVITY | THERAPEUTIC INDEX | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | ALK KINASE | EXPRESSION | ACTIVATING MUTATIONS | Neoplasms - metabolism | Humans | Recombinant Fusion Proteins | Lymphocyte Activation - immunology | Neoplasms - therapy | Neoplasms - genetics | T-Lymphocytes - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Lentivirus - genetics | Gene Order | Disease Models, Animal | Antigens, Neoplasm - genetics | Gene Expression | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Antigens, Neoplasm - immunology | Receptors, Cell Surface - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | Genetic Vectors - genetics | Xenograft Model Antitumor Assays | Animals | Receptor Protein-Tyrosine Kinases - genetics | Neoplasms - immunology | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Flow cytometry | Pediatrics | Leukemia | Lymphocytes T | Neuroblastoma | Kinases | Cell surface | AACR | Cell activation | Lymphocytes | Immunotherapy | Xenografts | Tumor necrosis factor-TNF | Protein-tyrosine kinase | Medical research | Antigens | Cytokines | Cyclin-dependent kinases | Exploration | Lymphoma | Medical prognosis | Internalization | γ-Interferon | Cell lines | Monoclonal antibodies | Lymphomas | Mutation | Solid tumors | Cancer | Tumors | Original
Journal Article
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 2013, Volume 2, Issue 7, pp. e105 - e105
Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through... 
bispecific chimeric antigen receptor | CAR | molecular modeling | cancer immunotherapy | T-cell therapy | SYSTEM | REGRESSION | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | VARIABLE-DOMAIN IMMUNOGLOBULIN | TUMOR | ANTIBODY | HER2-SPECIFIC T-CELLS | COMPUTATIONAL PROTEIN DESIGN | EXPRESSION | LYMPHOCYTES | Methods - Original
Journal Article
Cancer Discovery, ISSN 2159-8274, 06/2016, Volume 6, Issue 6, pp. 664 - 679
Journal Article
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2017, Volume 25, Issue 3, pp. 570 - 579
The treatment or cure of HIV infection by cell and gene therapy has been a goal for decades. Recent advances in both gene editing and chimeric antigen receptor... 
chimeric antigen receptor | HIV | gene editing | cell therapy | CAR T cell | LOW-LEVEL VIREMIA | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | NEF PROTEIN | HUMAN-IMMUNODEFICIENCY-VIRUS | MESSENGER-RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BROADLY NEUTRALIZING ANTIBODIES | ACTIVE ANTIRETROVIRAL THERAPY | IN-VIVO | HEMATOLOGICAL MALIGNANCIES | GENETICS & HEREDITY | INFECTED PATIENTS | Humans | Antibodies, Neutralizing - metabolism | Receptors, CCR5 - genetics | Lymphocyte Subsets - immunology | Recombinant Fusion Proteins | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | Lymphocyte Subsets - metabolism | Antibodies, Neutralizing - immunology | Lymphocyte Activation - immunology | Receptors, CCR5 - metabolism | HIV Antibodies - immunology | Immunotherapy | Gene Order | HIV Antibodies - metabolism | Receptors, Antigen, T-Cell - metabolism | HIV Infections - genetics | Antibodies, Neutralizing - genetics | Genetic Vectors - genetics | HIV-1 - immunology | Genetic Engineering | Virus Replication | HIV Infections - therapy | Receptors, Antigen, T-Cell - genetics | HIV Antibodies - genetics | Single-Chain Antibodies | Cytotoxicity, Immunologic | Flow cytometry | Antigens | CCR5 protein | Recombination | Cytokines | Cytotoxicity | Homology | Infections | T cell receptors | Glycoproteins | Lymphocytes T | Gene expression | Proteins | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Monoclonal antibodies | Mutation | Gene therapy | Binding sites | Original
Journal Article