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Cell, ISSN 0092-8674, 05/2016, Volume 165, Issue 5, pp. 1037 - 1037
Alirocumab and evolocumab are monoclonal antibodies that block proprotein convertase subtilisin/kexin type 9 (PCSK9), a circulating protein that degrades... 
Antibodies, Monoclonal - therapeutic use | Cholesterol, LDL - blood | Anticholesteremic Agents - therapeutic use | Humans | Monoclonal antibodies | Low density lipoproteins | Trans fatty acids | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2017, Volume 377, Issue 18, pp. 1733 - 1745
Adolescents with type 1 diabetes received one of four regimens: angiotensin-converting–enzyme (ACE) inhibitor–placebo, statin–placebo, ACE inhibitor–statin, or... 
INTIMA-MEDIA THICKNESS | C-REACTIVE PROTEIN | MEDICINE, GENERAL & INTERNAL | INTERVENTION TRIAL ADDIT | CONVERTING-ENZYME-INHIBITOR | GLUCOSE CONTROL | ALBUMIN EXCRETION | HIGH-RISK | MICROALBUMINURIA | YOUNG-PEOPLE | FOLLOW-UP | Albuminuria - etiology | Double-Blind Method | Area Under Curve | Humans | Male | Diabetes Mellitus, Type 1 - complications | Albuminuria - prevention & control | Creatinine - urine | Diabetes Mellitus, Type 1 - urine | Diabetes Mellitus, Type 1 - drug therapy | Medication Adherence | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Diabetes Mellitus, Type 1 - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Lipids - blood | Adolescent | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Female | Drug Therapy, Combination | Child | Type 1 diabetes | Patient outcomes | Analysis | Outcome and process assessment (Health Care) | Dosage and administration | Drug therapy | ACE inhibitors | Statins | Creatinine | Adolescence | Puberty | Enzymes | C-reactive protein | Diabetes mellitus | Albumin | Triglycerides | Apolipoproteins | Cholesterol | Risk factors | Glomerular filtration rate | Apolipoprotein B | Peptidyl-dipeptidase A | Angiotensin | Teenagers | Diabetes | Cardiovascular diseases | Drug dosages | Age | Endocrinology | Index Medicus | Abridged Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2017, Volume 377, Issue 13, pp. 1284 - 1285
Former baseball manager Tony La Russa once said, “Even when you have three strikes, you’re still not out. There is always something else you can do.” This... 
MEDICINE, GENERAL & INTERNAL | HIGH-RISK | Anticholesteremic Agents | Cholesterol Ester Transfer Proteins | Cholesterol, HDL | Humans | Inhibitor drugs | Clinical trials | Cardiovascular disease | Lipids | Apolipoproteins | Drug therapy | Health risk assessment | Low density lipoprotein | Statins | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 01/2019, Volume 124, Issue 1, pp. 32 - 37
PCSK9i (protein convertase subtilisin/kexin type 9 inhibitors) are set to revolutionize the treatment of hypercholesterolemia in the management of... 
PCSK9 inhibitors | COST-EFFECTIVENESS | CARDIAC & CARDIOVASCULAR SYSTEMS | drug adherence | PCSK9 | LDL-cholesterol | RECOMMENDATIONS | HIGH-RISK | PERIPHERAL VASCULAR DISEASE | THERAPIES | UPDATE | HEMATOLOGY | lipoprotein(a) | ASSOCIATION | ACCESS | Care and treatment | Hypercholesterolemia | Risk assessment | Analysis | Atherosclerosis | Research | Risk factors
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 09/2016, Volume 1861, Issue 9, pp. 1180 - 1191
Expression of ATP-binding cassette transporter G1 (ABCG1), a molecule facilitating cholesterol efflux to HDL, is activated by liver X receptor (LXR). In this... 
RCT | MEK1/2 | SIRT1 | ABCG1 | Atherosclerosis | LXR | ATHEROSCLEROTIC LESION DEVELOPMENT | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DENSITY-LIPOPROTEINS | LXR-ALPHA | CELL BIOLOGY | RECEPTOR-DEFICIENT MICE | REACTIVE PROTEIN EXPRESSION | SCAVENGER RECEPTOR | EFFLUX | BIOPHYSICS | LIVER | GENE-TRANSCRIPTION | Atherosclerosis - genetics | Humans | Aorta - metabolism | Cholesterol - genetics | Foam Cells - drug effects | Nitriles - administration & dosage | Flavonoids - administration & dosage | Biological Transport - drug effects | Biological Transport - genetics | Foam Cells - metabolism | Liver X Receptors - biosynthesis | MAP Kinase Kinase 1 - antagonists & inhibitors | Promoter Regions, Genetic | Atherosclerosis - drug therapy | Sirtuin 1 - biosynthesis | MAP Kinase Kinase 1 - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Mice, Knockout | Retinoid X Receptor alpha - agonists | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | MAP Kinase Signaling System - drug effects | Apolipoproteins E - genetics | Butadienes - administration & dosage | Retinoid X Receptor alpha - genetics | Macrophages - drug effects | Mice | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - biosynthesis | ATP Binding Cassette Transporter, Sub-Family G, Member 1 - genetics | Liver X Receptors - genetics | Macrophages | Cholesterol | RNA
Journal Article
Journal Article
Circulation Journal, ISSN 1346-9843, 2019, Volume 83, Issue 2, pp. 267 - 273
Elevated plasma lipid levels are linked to atherosclerosis, a hallmark for coronary artery disease (CAD), documented by animal studies as well as angiographic... 
Antibodies | Arteriosclerosis | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | MONOCLONAL-ANTIBODY | HYPERCHOLESTEROLEMIA | MODULATES HDL | LIPOPROTEIN | GENE | HDL CHOLESTEROL | LIPASE | CORONARY-HEART-DISEASE
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2017, Volume 376, Issue 1, pp. 41 - 51
Journal Article
Journal Article
JAMA, ISSN 0098-7484, 04/2016, Volume 315, Issue 15, pp. 1571 - 1572
Journal Article