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1. Cholesterol regulation of ion channels and receptors
by Levitan, Irena and Barrantes, Francisco J
2012, ISBN 0470874325, xii, 289
Examines new research on the role of cholesterol in regulating ion channels and receptors and its effect on health Drawing together and analyzing all the... 
Ion channels | Metabolism | Cholesterol | Membrane proteins | Life Sciences | Science | Biology | Molecular Biology
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2. Full Text MicroRNAs in metabolism and metabolic disorders
by Rottiers, Veerle and Näär, Anders M
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 04/2012, Volume 13, Issue 4, pp. 239 - 250
MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and... 
SUBCUTANEOUS ADIPOSE-TISSUE | GLUCOSE-METABOLISM | IN-VIVO | FATTY-ACID-METABOLISM | GENE-EXPRESSION | PANCREATIC BETA-CELLS | ADIPOCYTE DIFFERENTIATION | ELEMENT-BINDING PROTEIN | CHOLESTEROL HOMEOSTASIS | HEPATIC LIPID-METABOLISM | CELL BIOLOGY | Fatty Liver - genetics | Fatty Liver - metabolism | Signal Transduction | Humans | Homeostasis | Lipid Metabolism | Metabolic Syndrome - metabolism | MicroRNAs - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Oligoribonucleotides, Antisense - pharmacology | Cholesterol - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Obesity - genetics | Obesity - metabolism | Insulin - metabolism | Metabolic Diseases - metabolism | Metabolic Syndrome - genetics | Endocrine System - metabolism | Non-alcoholic Fatty Liver Disease | Glucose - metabolism | Metabolic Diseases - genetics | MicroRNAs - genetics | MicroRNA | Physiological aspects | Metabolic diseases | Genetic aspects | Research | Lipid metabolism | Genetic regulation | Metabolism | Risk factors
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3. Full Text Metabolic control of YAP and TAZ by the mevalonate pathway
by Sorrentino, Giovanni and Ruggeri, Naomi and Specchia, Valeria and Cordenonsi, Michelangelo and Mano, Miguel and Dupont, Sirio and Manfrin, Andrea and Ingallina, Eleonora and Sommaggio, Roberta and Piazza, Silvano and Rosato, Antonio and Piccolo, Stefano and Del Sal, Giannino
Nature Cell Biology, ISSN 1465-7392, 2014, Volume 16, Issue 4, pp. 357 - 366
The YAP and TAZ mediators of the Hippo pathway ( hereafter called YAP/TAZ) promote tissue proliferation and organ growth. However, how their biological... 
ORGAN GROWTH | CHOLESTEROL | YAP/TAZ | TRANSCRIPTION | HIPPO PATHWAY | STATINS | CELL BIOLOGY | Phosphorylation - physiology | Cell Proliferation | Active Transport, Cell Nucleus - physiology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Phosphoproteins - metabolism | Sterol Regulatory Element Binding Proteins - genetics | Breast Neoplasms - metabolism | Drosophila melanogaster - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | HEK293 Cells | Trans-Activators - genetics | Female | Transcription, Genetic | Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | HCT116 Cells | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Sterol Regulatory Element Binding Proteins - metabolism | Transcription Factors - genetics | Mevalonic Acid - metabolism | Polyisoprenyl Phosphates - metabolism | Transcription Factors - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | rho GTP-Binding Proteins - metabolism | Trans-Activators - metabolism | Mice | Polyisoprenyl Phosphates - biosynthesis | Pyridines - pharmacology | RNA, Small Interfering | Drosophila Proteins - genetics | Adaptor Proteins, Signal Transducing - metabolism | Cell metabolism | Genetic research | Genetic aspects | Research | Cellular control mechanisms
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4. Full Text Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk
by Boulet, Marie Michèle and Chevrier, Geneviève and Grenier-Larouche, Thomas and Pelletier, Mélissa and Nadeau, Mélanie and Scarpa, Julia and Prehn, Cornelia and Marette, André and Adamski, Jerzy and Tchernof, André
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 309, Issue 8, pp. E736 - E746
Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked... 
Branched-chain amino acids | Cardiometabolic risk factors | Visceral obesity | HOMEOSTASIS | PHYSIOLOGY | TRYPTOPHAN-METABOLISM | WEIGHT-LOSS | visceral obesity | PATTERNS | branched-chain amino acids | cardiometabolic risk factors | AMINO-ACID-METABOLISM | METABOLOMICS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | FAT | HUMAN OBESITY | EXPRESSION | Metabolomics | Amino Acids, Branched-Chain - metabolism | Humans | Middle Aged | Gene Expression Profiling | RNA, Messenger - metabolism | Thinness - metabolism | Tryptophan - metabolism | Adipose Tissue - metabolism | Amino Acids - metabolism | Overweight - metabolism | Subcutaneous Fat - metabolism | Adult | Female | Body Fat Distribution | Kynurenine - metabolism | Cardiovascular Diseases - metabolism | Cholesterol, HDL - metabolism | Risk Factors | Insulin Resistance | Cell Size | Adipokines - metabolism | Intra-Abdominal Fat - metabolism | Adipocytes - pathology | Blotting, Western | Obesity - metabolism | Triglycerides - metabolism | Cholesterol, LDL - metabolism | Dyslipidemias - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - genetics | Blood Glucose - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - metabolism | Adipose tissues | Metabolic diseases | Amino acids | Metabolites | Health aspects | Risk factors | Enzymes | Tissue | Obesity | Gene expression
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5. Full Text MiR-33 Contributes to the Regulation of Cholesterol Homeostasis
by Katey J. Rayner and Yajaira Suárez and Alberto Dávalos and Saj Parathath and Michael L. Fitzgerald and Norimasa Tamehiro and Edward A. Fisher and Kathryn J. Moore and Carlos Fernández-Hernando
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol
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6. Full Text Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis
by Nagareddy, Prabhakara R and Murphy, Andrew J and Stirzaker, Roslynn A and Hu, Yunying and Yu, Shiquing and Miller, Rachel G and Ramkhelawon, Bhama and Distel, Emilie and Westerterp, Marit and Huang, Li-Shin and Schmidt, Ann Marie and Orchard, Trevor J and Fisher, Edward A and Tall, Alan R and Goldberg, Ira J
Cell Metabolism, ISSN 1550-4131, 05/2013, Volume 17, Issue 5, pp. 695 - 708
Diabetes is a major risk factor for atherosclerosis. Although atherosclerosis is initiated by deposition of cholesterol-rich lipoproteins in the artery wall,... 
DIABETES-MELLITUS | PLAQUE REGRESSION | INSULIN-RESISTANCE | ADVANCED GLYCATION ENDPRODUCTS | ENDOCRINOLOGY & METABOLISM | LEUKOCYTE COUNT | RECEPTOR | STEM-CELL PROLIFERATION | APOE(-/-) MICE | DEFICIENT MICE | G-CSF | CELL BIOLOGY | Leukocytes - pathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Leukocytosis - metabolism | Coronary Disease - metabolism | Bone Marrow - metabolism | Hyperglycemia - pathology | Monocytes - pathology | Diabetes Mellitus, Experimental - metabolism | Neutrophils - metabolism | Receptor for Advanced Glycation End Products | Leukocytosis - pathology | Neutrophils - pathology | Myeloid Progenitor Cells - metabolism | Atherosclerosis - pathology | Myelopoiesis - physiology | Cytokines - metabolism | Mice, Inbred C57BL | Diabetes Mellitus, Type 1 - pathology | Myeloid Progenitor Cells - pathology | Atherosclerosis - metabolism | Hyperglycemia - metabolism | Coronary Disease - pathology | Animals | Bone Marrow - pathology | Glycation End Products, Advanced - metabolism | Glucose - metabolism | Mice | Leukocytes - metabolism | Receptors, Immunologic - metabolism | Hyperglycemia | Type 1 diabetes | Atherosclerosis | Development and progression | Universities and colleges | Blood lipids | Coronary heart disease | Medicine, Preventive | Cholesterol | Preventive health services
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7. Full Text Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
by Min, Hae-Ki and Kapoor, Ashwani and Fuchs, Michael and Mirshahi, Faridoddin and Zhou, Huiping and Maher, James and Kellum, John and Warnick, Russell and Contos, Melissa J and Sanyal, Arun J
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
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8. Full Text Activation of the Nuclear Receptor FXR Improves Hyperglycemia and Hyperlipidemia in Diabetic Mice
by Yanqiao Zhang and Florence Ying Lee and Gabriel Barrera and Hans Lee and Charisse Vales and Frank J. Gonzalez and Timothy M. Willson and Peter A. Edwards
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2006, Volume 103, Issue 4, pp. 1006 - 1011
Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose... 
Messenger RNA | Diabetes complications | Glycogen | Liver | Adenoviruses | Mice | Liver glycogen | Insulin | Cholesterols | Blood plasma | GW4064 | triglyceride | glucose | TRIGLYCERIDE LEVELS | MYOCARDIAL-INFARCTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | GLYCOGEN-SYNTHASE KINASE-3 | farnesoid x receptor-VP16 | INSULIN-RESISTANCE | GENE-EXPRESSION | cholesterol | FARNESOID-X-RECEPTOR | BILE-ACID BIOSYNTHESIS | LIPID HOMEOSTASIS | CARBOHYDRATE-METABOLISM | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear | DNA-Binding Proteins - metabolism | Lipids - chemistry | Glycogen - metabolism | Time Factors | Adenoviridae - genetics | Diabetes Mellitus, Experimental - metabolism | Gluconeogenesis | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Hyperlipidemias - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Insulin Resistance | Etoposide - metabolism | Mice, Transgenic | Models, Statistical | Cholesterol - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Triglycerides - metabolism | Hyperglycemia - metabolism | Isoxazoles - pharmacology | Transcription Factors - metabolism | Blotting, Northern | Insulin - metabolism | Animals | 3-Hydroxybutyric Acid - metabolism | Glucose - metabolism | Blood Glucose - metabolism | Glucose metabolism | Control | Genes | Rattus | Homeostasis | Rats | Physiological aspects | Research | Structure | Lipids | Diabetes | Glucose | Metabolism | Rodents | Cholesterol | Biological Sciences | farnesoid X receptor-VP16
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9. Full Text Hepatic glucose sensing is required to preserve β cell glucose competence
by Seyer, Pascal and Vallois, David and Poitry-Yamate, Carole and Schütz, Frédéric and Metref, Salima and Tarussio, David and Maechler, Pierre and Staels, Bart and Lanz, Bernard and Grueter, Rolf and Decaris, Julie and Turner, Scott and Da Costa, Anabela and Preitner, Frédéric and Minehira, Kaori and Foretz, Marc and Thorens, Bernard
Journal of Clinical Investigation, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1662 - 1676
Liver glucose metabolism plays a central role in glucose homeostasis and may also regulate feeding and energy expenditure. Here we assessed the impact of... 
MEDICINE, RESEARCH & EXPERIMENTAL | HEPATOCYTES | FARNESOID X RECEPTOR | INSULIN-RESISTANCE | FOOD-INTAKE | MIXED MEAL | MICE | FACTOR-I | DIET-INDUCED OBESITY | BILE-ACIDS | RAT MODEL | Glucose Transporter Type 2 - genetics | Cholesterol - blood | Transcriptome | Fluorodeoxyglucose F18 - metabolism | Homeostasis | Mice, 129 Strain | Liver - physiopathology | Glucose Intolerance - blood | Glucose Transporter Type 2 - metabolism | Radiopharmaceuticals - metabolism | Insulin-Secreting Cells - metabolism | Liver - diagnostic imaging | Nuclear Proteins - genetics | Insulin Secretion | Glucose Intolerance - genetics | Down-Regulation | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Insulin Resistance | Bile Acids and Salts - metabolism | Blood Glucose | Lipid Metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cholesterol - metabolism | Gene Knockout Techniques | Mice, Knockout | Transcription Factors - metabolism | Insulin - metabolism | Animals | Feces - chemistry | Energy Metabolism | Glucose - physiology | Radionuclide Imaging | Glucose - metabolism | Mice
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10. Full Text Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
by Hatori, Megumi and Vollmers, Christopher and Zarrinpar, Amir and DiTacchio, Luciano and Bushong, Eric A and Gill, Shubhroz and Leblanc, Mathias and Chaix, Amandine and Joens, Matthew and Fitzpatrick, James A.J and Ellisman, Mark H and Panda, Satchidananda
Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 848 - 860
While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat... 
CIRCADIAN CLOCK | LEPTIN | OBESITY | LIPID-METABOLISM | PROTEIN | CREB | INSULIN-RESISTANCE | LIVER | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | REV-ERB-ALPHA | CELL BIOLOGY | Liver - pathology | Phosphorylation | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Cholesterol - blood | Adipose Tissue, White - metabolism | Diet, High-Fat - adverse effects | Homeostasis | Male | Adiposity | Time Factors | Adenylate Kinase - metabolism | Weight Gain | Cytokines - genetics | Eating | Gene Expression | Bile Acids and Salts - biosynthesis | Fatty Liver - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Fatty Liver - prevention & control | Oxygen Consumption | Lipid Metabolism | Circadian Rhythm | Energy Intake | Adipose Tissue, Brown - pathology | Animals | Energy Metabolism | Metabolic Diseases - metabolism | Metabolic Diseases - etiology | Cyclic AMP Response Element-Binding Protein - metabolism | Glucose - metabolism | Adipose Tissue, Brown - metabolism | Metabolic Diseases - prevention & control | Mice | Fatty Liver - etiology | Metabolites | Gene expression
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