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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/1976, Volume 73, Issue 5, pp. 1674 - 1678
Clones of embryonic chick chondrocytes have been isolated and collagen biosynthesis has been followed as the clones grow and eventually lose division capacity.... 
Elution | Cell growth | Chondrocytes | Collagens | Cellular senescence | Fibroblasts | Cultured cells | Trimers | Biosynthesis | Subcultures | MULTIDISCIPLINARY SCIENCES
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 1983, Volume 22, Issue 2, pp. 179 - 191
In the experiments described here, we have sought to determine whether primary cultures of cells derived from articular cartilage will, upon subsequent... 
Cartilage | Chondrocyte | Cellular senescence | Cell division | Osteoarthritis
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 1983, Volume 21, Issue 1, pp. 83 - 96
The hypothesis that aging of articular chondrocytes at a cellular level results from loss of DNA repair capability was studied by measuring unscheduled DNA... 
Aging | Transformation | Sulfate incorporation | Chondrocyte | DNA repair | Radiation | Rabbits | Cartilage, Articular - cytology | Cell Survival | Humans | Middle Aged | Cells, Cultured | DNA Repair - radiation effects | Animals | Ultraviolet Rays | Time Factors | Cartilage, Articular - metabolism | Culture Media | Adult | DNA - biosynthesis | Cartilage, Articular - radiation effects
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 1983, Volume 22, Issue 2, pp. 179 - 191
In the experiments described here, we have sought to determine whether primary cultures of cells derived from articular cartilage will, upon subsequent... 
Cell division | Cartilage | Chondrocyte | Osteoarthritis | Cellular senescence | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Cell Line | Rabbits | Animals | Cartilage, Articular - cytology | Cell Survival | Cell Division | Humans | Cells, Cultured | Dogs | Osteoarthritis - pathology
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 1986, Volume 37, Issue 3, pp. 231 - 240
Cell culture techniques have been used extensively in the study of the aging process at the cellular level. The “senescent” articular chondrocyte seems to be a... 
Aging | Flow cytometry | Cytoskeleton | Cultured chondrocytes | Growth kinetics | Cartilage, Articular - ultrastructure | Rabbits | Animals | Flow Cytometry | Cartilage, Articular - cytology | Cell Count | Cells, Cultured | Fluorescent Antibody Technique | Cytoskeleton - ultrastructure
Journal Article
Cytometry, ISSN 0196-4763, 09/1988, Volume 9, Issue 5, pp. 436 - 440
In vitro senescence of chondrocytes, characterized by a decline in the proliferation rate during late passages, resulted from a rapid growth rate in early... 
protein content | Chondrocyte | cytoskeleton | cell size | DNA | in vitro aging | Rabbits | Flow Cytometry - methods | Tubulin - metabolism | Animals | Time Factors | Cartilage, Articular - cytology | Cartilage, Articular - metabolism | Cell Survival | Cell Division | Cells, Cultured | DNA - metabolism | Cartilage, Articular - physiology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/1993, Volume 90, Issue 8, pp. 3289 - 3293
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/1993, Volume 52, Issue 1, pp. 57 - 68
Retinoic acid (RA) has been shown to rapidly modulate the collagen expression pattern of chondrocytes in vitro at doses of 1–10 μM. Embryonic chicken sternal... 
collagen | retinoic acid | sternal cartilage | chondrocytes | CRABP
Journal Article
Journal of Experimental Zoology, ISSN 0022-104X, 03/1993, Volume 265, Issue 3, pp. 285 - 294
Embryonic mouse pre‐metatarsals were removed from embryos at 13 days of gestation and cultured in a defined, serum‐free medium for up to 15 days. By... 
CELLS | COLLAGEN | ZOOLOGY | CHONDROCYTES | LONG-BONE RUDIMENTS | ALKALINE-PHOSPHATASE | INVITRO | DEPOSITION | CHICK LIMB | EXPRESSION | LIMB CARTILAGE DIFFERENTIATION | Animals | Culture Media | Alkaline Phosphatase - metabolism | Metatarsus - anatomy & histology | Collagen - biosynthesis | Metatarsus - embryology | Mice | Organ Culture Techniques
Journal Article
In Vitro Cellular & Developmental Biology. Animal, ISSN 1071-2690, 8/1994, Volume 30A, Issue 8, pp. 547 - 554
Chondrocytes from the hypertrophic and proliferative zones of 16-day-old fetal murine metatarsal bones were enzymatically dissociated and cultured in a... 
Cartilage | Phosphatases | B lymphocytes | Chondrocytes | Collagens | Foot bones | Bones | Cultured cells | Long bones | Growth, Differentiation, and Senescence | Osteoblasts | Life Sciences | Animal Physiology | mouse | chondrocytes | Animal Biochemistry | cell culture | transdifferentiation | osteoblasts | Developmental Biology | Cell Biology | Animal Genetics and Genomics
Journal Article
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 07/1995, Volume 13, Issue 4, pp. 542 - 552
Journal Article
European Journal of Biochemistry, ISSN 0014-2956, 1996, Volume 241, Issue 1, pp. 56 - 63
Tissue inhibitor of metalloproteinases (TIMP) 1, 2 and 3 are related proteins that can form complexes with all known matrix metalloproteinases (MMPs). They... 
Oncostatin M | Tissue inhibitors of metalloproteinases | Rheumatoid arthritis | Interleukin-6 | Synovial lining cells | RHEUMATOID-ARTHRITIS | HUMAN-PLASMA | oncostatin M | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSECT CELLS | HUMAN ARTICULAR CHONDROCYTES | rheumatoid arthritis | interleukin-6 | MATRIX METALLOPROTEINASES | tissue inhibitors of metalloproteinases | POTENTIATING ACTIVITY | synovial lining cells | PHASE RESPONSE FACTOR | TRANSFORMING GROWTH FACTOR-BETA-1 | SIGNAL TRANSDUCER | Knee | Humans | Glycoproteins - metabolism | RNA, Messenger - metabolism | Extracellular Matrix - chemistry | DNA-Binding Proteins - metabolism | Interleukins - pharmacology | Lymphokines - pharmacology | Growth Inhibitors - pharmacology | Leukemia Inhibitory Factor | RNA, Messenger - drug effects | Glycoproteins - genetics | Tissue Inhibitor of Metalloproteinase-3 | Enzyme-Linked Immunosorbent Assay | Gene Expression Regulation - genetics | Cells, Cultured | Tissue Inhibitor of Metalloproteinases | Synovial Membrane - metabolism | Interleukin-1 - pharmacology | Peptides - pharmacology | Down-Regulation - physiology | Proteins - genetics | Transforming Growth Factor beta - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Blotting, Northern | Interleukin-6 - pharmacology | STAT1 Transcription Factor | Signal Transduction - physiology | Trans-Activators - metabolism | STAT3 Transcription Factor
Journal Article