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EUROPEAN HEART JOURNAL, ISSN 0195-668X, 04/2017, Volume 38, Issue 15, pp. 1132 - 1143
Background Compared to heart failure patients with higher systolic blood pressure (SBP), those with lower SBP have a worse prognosis. To make matters worse,... 
Heart failure | TRIAL | AT1-receptor | NEPRILYSIN INHIBITION | CARDIAC & CARDIOVASCULAR SYSTEMS | Angiotensin | Neprilysin | Blood pressure | ENALAPRIL | Valsartan - administration & dosage | Humans | Aminobutyrates - adverse effects | Male | Death, Sudden, Cardiac - etiology | Enalapril - adverse effects | Dose-Response Relationship, Drug | Hypotension - mortality | Tetrazoles - administration & dosage | Angiotensin-Converting Enzyme Inhibitors - adverse effects | Female | Blood Pressure - drug effects | Aminobutyrates - administration & dosage | Drug Therapy, Combination | Enalapril - administration & dosage | Heart Failure - mortality | Drug Administration Schedule | Stroke Volume - physiology | Valsartan - adverse effects | Treatment Outcome | Hospitalization | Hypotension - chemically induced | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Heart Failure - drug therapy | Neprilysin - antagonists & inhibitors | Aged | Tetrazoles - adverse effects | Chronic Disease | Angiotensin Receptor Antagonists - administration & dosage | Angiotensin Receptor Antagonists - adverse effects | Clinical Research | Editor's Choice | Kardiologi | Cardiac and Cardiovascular Systems | enalapril heart failure | chronic hypotension systolic blood pressure heart failure blood pressure cardiovascular system safety ejection fraction cardiovascular death sacubitril / valsartan
Journal Article
Journal Article
Circulation: Heart Failure, ISSN 1941-3289, 04/2018, Volume 11, Issue 4, p. e004745
Journal Article
Journal Article
Herz, ISSN 0340-9937, 8/2019, Volume 44, Issue 5, pp. 425 - 432
The combination drug sacubitril/valsartan was reported to be superior to enalapril in reducing all-cause death, cardiovascular mortality, and heart failure... 
Heart failure | Treatment outcome | Behandlungsergebnis | Medicine & Public Health | Hospitalisierung | Internal Medicine | Sacubitril/valsartan | Neprilysin | Hospitalization | Cardiology | Herzinsuffizienz | CARDIAC & CARDIOVASCULAR SYSTEMS | BRAIN NATRIURETIC PEPTIDE | valsartan | LCZ696 | Sacubitril
Journal Article
Herz, ISSN 0340-9937, 08/2019, Volume 44, Issue 5, pp. 425 - 432
Background The combination drug sacubitril/valsartan was reported to be superior to enalapril in reducing all-cause death, cardiovascular mortality, and heart... 
Heart failure | Heart | Therapy | Renal function | Angioedema | Mortality | Hospitalization | Patients | Beta blockers | Hypotension | Furosemide | Side effects | Hyperkalemia | Angiotensin | Death | Blood pressure | Safety | Ventricle | Angiotensin II | Cardiovascular diseases | Health risk assessment | Mercury | Heart diseases | Ejection
Journal Article
American Journal of Cardiovascular Drugs, ISSN 1175-3277, 02/2019, Volume 19, Issue 1, pp. 1 - 10
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been the cornerstone for the treatment of heart failure (HF) with reduced... 
SYSTOLIC HYPERTENSION | CARDIAC & CARDIOVASCULAR SYSTEMS | CONVERTING ENZYME-INHIBITION | LCZ696 SACUBITRIL/VALSARTAN | CARDIOVASCULAR EVENTS | RECEPTOR NEPRILYSIN INHIBITOR | EJECTION FRACTION | HEART-FAILURE | ASIAN PATIENTS | PHARMACOLOGY & PHARMACY | PARADIGM-HF | BLOOD-PRESSURE | Life Sciences
Journal Article
Journal of Hypertension, ISSN 0263-6352, 07/2019, Volume 37 Suppl 1, pp. e298 - e298
OBJECTIVE:Sacubitril/Valsartan inhibits both the renin-angiotensin-aldosterone system (RAAS) and the degradation of natriuretic peptides. We evaluated the... 
Heart failure | Measurement | Valsartan | Physiological aspects | Blood pressure | Drug therapy | Testing
Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 05/2016, Volume 10, pp. 1627 - 1639
Heart failure is a global problem with elevated prevalence, and it is associated with substantial cardiovascular morbidity and mortality. Treating... 
Heart failure | Neprilysin | Vasopeptidase | Valsartan | Sacubitril | Natriuretic peptides | heart failure | HOSPITAL ADMISSIONS | CHEMISTRY, MEDICINAL | VASOPEPTIDASE INHIBITOR | NEUTRAL ENDOPEPTIDASE INHIBITOR | RANDOMIZED-TRIAL | vasopeptidase | ANGIOTENSIN-CONVERTING ENZYME | natriuretic peptides | BRACHIAL BLOOD-PRESSURE | neprilysin | RECEPTOR-NEPRILYSIN INHIBITOR | ARTERIAL STIFFNESS | valsartan | ATRIAL-NATRIURETIC-FACTOR | PHARMACOLOGY & PHARMACY | sacubitril | PARADIGM-HF | Angiotensin Receptor Antagonists - chemistry | Tetrazoles - pharmacology | Enalapril - analysis | Aminobutyrates - chemistry | Humans | Angiotensin Receptor Antagonists - pharmacology | Heart Failure - physiopathology | Aminobutyrates - pharmacology | Neprilysin - chemistry | Angiotensin-Converting Enzyme Inhibitors - chemistry | Heart Failure - drug therapy | Valsartan - pharmacology | Tetrazoles - chemistry | Neprilysin - antagonists & inhibitors | Enalapril - chemistry | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Angiotensin-converting enzyme inhibitors | Peptides | Cardiovascular disease | Aldosterone | Drug development | Kinases | Renin | Enzyme inhibitors | Peptidyl-dipeptidase A | Vasoactive agents | Inhibition | Heart diseases | Failure | Hypertension | Therapeutic applications | Mortality | Pharmacology | Coronary artery disease | Morbidity | Biological activity | Side effects | Inhibitors | Angiotensin | Fatalities | Cardiovascular diseases | Health risk assessment | Ejection
Journal Article
Journal of Cardiology, ISSN 0914-5087, 10/2019, Volume 74, Issue 4, pp. 372 - 380
Angiotensin receptor and neprilysin inhibition (ARNI) has been shown to reduce cardiovascular mortality by 20% as compared with enalapril in a randomized... 
Heart failure | Sacubitril/valsartan | Chronic kidney disease
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 47, pp. 83323 - 83333
Objectives: The combined neprilysin/rennin-angiotensin system inhibitor sacubitril/valsartan (LCZ696) has shown its superiority over ACEI/ARB therapy. In view... 
Heart failure | Hypertension | Sacubitril/valsartan | LCZ696 | Safety | SYSTOLIC HYPERTENSION | heart failure | EFFICACY | HEART-FAILURE | NEUTRAL ENDOPEPTIDASE INHIBITOR | RECEPTOR | sacubitril/valsartan | CELL BIOLOGY | OMAPATRILAT | safety | EJECTION FRACTION | DISEASE | DOUBLE-BLIND | hypertension | ENALAPRIL
Journal Article
Heart, ISSN 1355-6037, 06/2017, Volume 103, Issue Suppl 5, pp. A1 - A1
IntroductionSacubitril/valsartan (SV) is a new drug that has recently been approved by the National Institute for Health and Care Excellence (NICE) to be used... 
Journal Article