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1. Full Text Rational tuning of visual cycle modulator pharmacodynamics
by Kiser, Philip D and Zhang, Jianye and Badiee, Mohsen and Kinoshita, Junzo and Peachey, Neal S and Tochtrop, Gregory P and Palczewski, Krzysztof and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 07/2017, Volume 362, Issue 1, pp. 131 - 145
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Retinal Diseases - prevention & control | Pigment Epithelium of Eye - drug effects | cis-trans-Isomerases - isolation & purification | Male | Vision, Ocular - drug effects | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - genetics | Cattle | cis-trans-Isomerases - antagonists & inhibitors | ATP-Binding Cassette Transporters - metabolism | Female | cis-trans-Isomerases - metabolism | Binding Sites | Retinal Pigment Epithelium - drug effects | Mice, Inbred C57BL | Models, Molecular | Alcohol Oxidoreductases - metabolism | Microsomes - enzymology | Dermatitis, Phototoxic - prevention & control | cis-trans-Isomerases - chemistry | Regeneration - drug effects | Animals | cis-trans-Isomerases - genetics | Schiff Bases - chemistry | Mice | Kinetics | Index Medicus | Drug Discovery and Translational Medicine
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2. Full Text Inhibition of RPE65 retinol isomerase activity by inhibitors of lipid metabolism
by Eroglu, Abdulkerim and Gentleman, Susan and Poliakov, Eugenia and Redmond, T. Michael
The Journal of biological chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 10, pp. 4966 - 4973
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Humans | Enzyme Inhibitors - pharmacology | Coenzyme A Ligases - antagonists & inhibitors | Molecular Sequence Data | cis-trans-Isomerases - chemistry | Animals | cis-trans-Isomerases - genetics | cis-trans-Isomerases - antagonists & inhibitors | Chickens | HEK293 Cells | Protein Binding | Triazenes - pharmacology | cis-trans-Isomerases - metabolism | Binding Sites | Index Medicus | triacsin C | vision | enzyme inhibitor | retinal metabolism | visual cycle | fatty acyl:CoA ligase | Enzymology | retinoid | liposome | RPE65
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3. Full Text Biochemical characterization and selective inhibition of β‐carotene cis–trans isomerase D27 and carotenoid cleavage dioxygenase CCD8 on the strigolactone biosynthetic pathway
by Harrison, Peter J and Newgas, Sophie A and Descombes, Flora and Shepherd, Sarah A and Thompson, Andrew J and Bugg, Timothy D. H
The FEBS journal, ISSN 1742-464X, 10/2015, Volume 282, Issue 20, pp. 3986 - 4000
enzyme inhibition | strigolactone biosynthesis | D27 | carotenoid cleavage dioxygenase | CCD8 | hydroxamic acid | CCD7 | Dioxygenases - metabolism | Arabidopsis - enzymology | Stereoisomerism | Silver Compounds - pharmacology | Hydroxamic Acids - chemistry | Substrate Specificity | Acetates - chemistry | Enzyme Inhibitors - chemical synthesis | beta Carotene - chemistry | Silver Compounds - chemistry | Arabidopsis Proteins - metabolism | Plant Growth Regulators - chemistry | Plant Proteins - chemistry | cis-trans-Isomerases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Plant Proteins - antagonists & inhibitors | Drug Design | cis-trans-Isomerases - metabolism | Molecular Structure | Plant Proteins - metabolism | Hydroxamic Acids - pharmacology | Peptide Fragments - genetics | Recombinant Proteins - metabolism | Arabidopsis Proteins - genetics | Peptide Fragments - metabolism | Biocatalysis | Dioxygenases - chemistry | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Oryza - enzymology | Plant Growth Regulators - chemical synthesis | beta Carotene - metabolism | cis-trans-Isomerases - chemistry | Plant Proteins - genetics | Dioxygenases - antagonists & inhibitors | Peptide Fragments - chemistry | Dioxygenases - genetics | cis-trans-Isomerases - genetics | Arabidopsis Proteins - chemistry | Peptide Fragments - antagonists & inhibitors | Carotenoids - metabolism | Acetates - pharmacology | Carotenoids - chemistry | Hydroxamic Acids - chemical synthesis | Plant Growth Regulators - pharmacology | Arabidopsis Proteins - antagonists & inhibitors | Hydrogen-Ion Concentration | Index Medicus
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4. Full Text AAV2 gene therapy readministration in three adults with congenital blindness
by Bennett, Jean and Ashtari, Manzar and Wellman, Jennifer and Marshall, Kathleen A and Cyckowski, Laura L and Chung, Daniel C and McCague, Sarah and Pierce, Eric A and Chen, Yifeng and Bennicelli, Jeannette L and Zhu, Xiaosong and Ying, Gui-Shuang and Sun, Junwei and Wright, J Fraser and Auricchio, Alberto and Simonelli, Francesca and Shindler, Kenneth S and Mingozzi, Federico and High, Katherine A and Maguire, Albert M
Science translational medicine, ISSN 1946-6234, 02/2012, Volume 4, Issue 120, pp. 120 - ra15
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Dependovirus - genetics | cis-trans-Isomerases - genetics | Blindness - metabolism | Humans | Adult | cis-trans-Isomerases - metabolism | Blindness - therapy | Blindness - genetics | Genetic Vectors - genetics | Genetic Therapy - methods | Index Medicus
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5. Full Text Cost Utility of Voretigene Neparvovec for Biallelic RPE65-Mediated Inherited Retinal Disease
by Zimmermann, Marita and Lubinga, Solomon J and Banken, Reiner and Rind, David and Cramer, Geri and Synnott, Patricia G and Chapman, Richard H and Khan, Sonya and Carlson, Josh
Value in health, ISSN 1098-3015, 02/2019, Volume 22, Issue 2, pp. 161 - 167
Economics | Social Sciences | Life Sciences & Biomedicine | Health Care Sciences & Services | Business & Economics | Health Policy & Services | Science & Technology | Genetic Therapy - economics | cis-trans-Isomerases - administration & dosage | Retinal Diseases - genetics | Markov Chains | Humans | Middle Aged | Retinal Diseases - therapy | Male | cis-trans-Isomerases - economics | Retinal Diseases - economics | Vision Disorders - therapy | Young Adult | Cost-Benefit Analysis - methods | Vision Disorders - genetics | cis-trans-Isomerases - genetics | Adolescent | Alleles | Adult | Female | Aged | Vision Disorders - economics | Genetic Therapy - methods | Healthy food | Drug abuse | Costs | Visual field | Retina | Markov analysis | Trauma | Indirect costs | Acuity | Health care expenditures | Visual impairment | Blindness | Gene therapy | Cost analysis | Clinical standards | Quality adjusted life years | Index Medicus
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6. Full Text Luxturna: FDA documents reveal the value of a costly gene therapy
by Darrow, Jonathan J
Drug discovery today, ISSN 1359-6446, 04/2019, Volume 24, Issue 4, pp. 949 - 954
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Genetic Therapy - economics | Costs and Cost Analysis | cis-trans-Isomerases - genetics | United States | Humans | Retinal Dystrophies - economics | Retinal Dystrophies - therapy | cis-trans-Isomerases - deficiency | Vision Disorders - economics | United States Food and Drug Administration | Vision Disorders - therapy | Genetic research | Gene therapy | Drug approval | Genes | Blindness | Index Medicus
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7. Full Text Chemistry of the Retinoid (Visual) Cycle
by Kiser, Philip D and Golczak, Marcin and Palczewski, Krzysztof
Chemical reviews, ISSN 0009-2665, 01/2014, Volume 114, Issue 1, pp. 194 - 232
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Retinoids - metabolism | Humans | Retinaldehyde - chemistry | Photoreceptor Cells - chemistry | Retinal Diseases - metabolism | Acyltransferases - metabolism | Mevalonic Acid - metabolism | Retinaldehyde - metabolism | Rhodopsin - metabolism | Mevalonic Acid - chemistry | cis-trans-Isomerases - chemistry | Coenzyme A-Transferases - metabolism | Animals | Retinol-Binding Proteins - metabolism | Photoreceptor Cells - metabolism | Retinoids - chemistry | Retinol-Binding Proteins - chemistry | Retinal Diseases - pathology | cis-trans-Isomerases - metabolism | Acyltransferases - chemistry | Coenzyme A-Transferases - chemistry | Rhodopsin - chemistry | Retinoids | Chemical properties | Research | Visual pathways | Mevalonate | Terpenoids | Chemical research | Retina | Eye diseases | Biochemistry | Eyes & eyesight | Index Medicus | Review
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8. Full Text Molecular pharmacodynamics of emixustat in protection against retinal degeneration
by Zhang, Jianye and Kiser, Philip D and Badiee, Mohsen and Palczewska, Grazyna and Dong, Zhiqian and Golczak, Marcin and Tochtrop, Gregory P and Palczewski, Krzysztof
The Journal of clinical investigation, ISSN 0021-9738, 07/2015, Volume 125, Issue 7, pp. 2781 - 2794
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Free Radical Scavengers - pharmacology | Propanolamines - metabolism | Free Radical Scavengers - chemistry | Stereoisomerism | Retinaldehyde - chemistry | Crystallography, X-Ray | Male | Retinaldehyde - metabolism | Retinal Degeneration - metabolism | Macular Degeneration - drug therapy | Retinal Degeneration - prevention & control | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Phenyl Ethers - chemistry | ATP-Binding Cassette Transporters - genetics | Cattle | cis-trans-Isomerases - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Female | cis-trans-Isomerases - metabolism | Catalytic Domain | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Models, Molecular | Phenyl Ethers - pharmacology | Mice, Knockout | cis-trans-Isomerases - chemistry | Macular Degeneration - metabolism | Animals | Retinaldehyde - toxicity | Propanolamines - chemistry | Mice | Mice, Inbred BALB C | Schiff Bases - metabolism | Phenyl Ethers - metabolism | Propanolamines - pharmacology | Retinal Degeneration - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Vitamin A | Laboratories | Light | Pigments | Data collection | Retina | Cytotoxicity | Photoreceptors | Index Medicus | Abridged Index Medicus
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