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Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2010, Volume 17, Issue 9, pp. 1124 - 1135
Journal Article
Journal Article
International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 1876
Lymphocytes are endowed with unique and specialized enzymatic mutagenic properties that allow them to diversify their antigen receptors, which are crucial... 
Immunoglobulin (Ig) | Recombination activating gene products 1 & 2 (RAG1, RAG2) | DNA damage response (DDR) | V(D)J recombination | B lymphocyte | Somatic hypermutation (SHM) | DNA repair | Activation-induced cytidine deaminase (AID) | Class switch recombination (CSR) | SOMATIC HYPERMUTATION | INDUCED CYTIDINE DEAMINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | recombination activating gene products 1 & 2 (RAG1 | CHEMISTRY, MULTIDISCIPLINARY | GERMINAL-CENTER | GENOMIC INSTABILITY | CHROMOSOMAL TRANSLOCATIONS | class switch recombination (CSR) | somatic hypermutation (SHM) | CLASS-SWITCH RECOMBINATION | HEAVY-CHAIN LOCUS | activation-induced cytidine deaminase (AID) | immunoglobulin (Ig) | RAG2 | NF-KAPPA-B | Somatic Hypermutation, Immunoglobulin - immunology | Cytidine Deaminase - genetics | Humans | Immunity, Humoral - genetics | Mutagenesis - genetics | DNA Damage - immunology | DNA Repair - genetics | Mutagenesis - immunology | V(D)J Recombination - genetics | B-Lymphocytes - immunology | DNA Damage - genetics | DNA Repair - immunology | T-Lymphocytes - immunology | V(D)J Recombination - immunology | Gene Rearrangement - genetics | Gene Rearrangement - immunology | Somatic Hypermutation, Immunoglobulin - genetics | DNA damage | Biological evolution | Activation-induced cytidine deaminase | Activation | Lymphocytes T | Base excision repair | Immunity | Genomic instability | Receptors | Cell activation | Pathways | Lymphocytes | Mismatch repair | Tumorigenesis | Damage | Repair | Deoxyribonucleic acid--DNA | Immune system | Antigens | Immunoglobulins | Stability | Adaptive immunity | Immune response (humoral) | Class switching | Somatic hypermutation | RAG2 protein | Mutagenesis | Lymphocytes B | RAG1 protein | Disturbances | Receptor mechanisms | Aberration | Mutation | Chromosome aberrations | Cytidine deaminase | 2 (RAG1, RAG2) | recombination activating gene products 1 & | V(D)J recombination, immunoglobulin (Ig)
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2018, Volume 9, p. 2986
Intranasal chitosan-formulated DNA vaccination promotes IgA secretion in the intestine. However, the mechanism whereby chitosan-DNA skews IgA class switch... 
class switch recombination (CSR) | chitosan | IgA | TACI | CD103+DC | DENDRITIC CELLS | PEYERS-PATCHES | TRANSCRIPTION | TRIMETHYL CHITOSAN | CD103(+)DC | INDUCTION | IMMUNOLOGY | MUCOSAL VACCINES | DELIVERY | IMMUNIZATION | TRANSMEMBRANE ACTIVATOR | REGULATORY T-CELL
Journal Article
Genes, ISSN 2073-4425, 06/2017, Volume 8, Issue 6, pp. 2 - 9
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 4, pp. 998 - 1007.e6
Background Immunoglobulin class-switch recombination defects (CSR-D) are rare primary immunodeficiencies characterized by impaired production of switched... 
Allergy and Immunology | cohesin | class-switch recombination defect | CSR synapse | Chromatin remodeling | STRAND BREAK REPAIR | HUMAN-CELLS | TRANSCRIPTION | IMMUNOLOGY | ACTIVATION-INDUCED DEAMINASE | YY1 | ALLERGY | DNA | GENE-EXPRESSION | AID | HYPER-IGM | Cell Line | ATPases Associated with Diverse Cellular Activities | Chromosomal Proteins, Non-Histone - metabolism | Humans | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Cell Survival - genetics | Chromatin Assembly and Disassembly | Immunoglobulin Isotypes - genetics | Protein Transport | Genetic Variation | DNA Helicases - metabolism | Carrier Proteins - metabolism | Models, Biological | DNA Repair | Gene Rearrangement | Immunoglobulin Switch Region | Immunologic Deficiency Syndromes - genetics | Immunologic Deficiency Syndromes - metabolism | Protein Binding | Immunologic Deficiency Syndromes - immunology | DNA Helicases - genetics | Immunoglobulin Class Switching | Immunoglobulins | Chromatin | Genomics | Immunodeficiency | Proteins | DNA methylation | Chronic obstructive pulmonary disease | Infections | Mutation | Patients | Age | Deoxyribonucleic acid--DNA | Immune system | Defects | Immune Deficiencies, Infection, and Systemic Immune Disorders | TCR, T-cell receptor | CSR, Class-switch recombination | MMR, Mismatch repair | AID, Activation-induced cytidine deaminase | ChIP, Chromatin immunoprecipitation | CSR-Ds, CSR defects | NHEJ, Non-homologous end joining | GLT, Germ-line transcript | DAPI, 4′,6-Diamidino-2-phenylindole | wt, Wild type
Journal Article
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 06/2005, Volume 1050, Issue 1, pp. 146 - 162
: Immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR) are critical for the maturation of the antibody response. These... 
error‐prone DNA repair | activation‐induced cytosine deaminase (AID) | DNA lesion | V(D)J recombination | class switch recombination (CSR) | pol ι | lesion bypass or translesion DNA polymerase | somatic hypermutation (SHM) | pol θ | pol ζ | double‐strand break (DSB) | Error-prone DNA repair | Activation-induced cytosine deaminase (AID) | Double-strand break (DSB) | Lesion bypass or translesion DNA polymerase | Somatic hypermutation (SHM) | Class switch recombination (CSR) | IMMUNE-RESPONSE | CYTIDINE DEAMINASE AID | MULTIDISCIPLINARY SCIENCES | pol xi | pol theta | DOUBLE-STRAND BREAKS | GERMINAL CENTER | NOVO PROTEIN-SYNTHESIS | B-CELL LINE | GENOMIC INSTABILITY | pol iota | ERROR-PRONE REPAIR | IN-VITRO | activation-induced cytosine deaminase (AID) | error-prone DNA repair | double-strand break (DSB) | POLYMERASE-ZETA | Cytidine Deaminase - immunology | Somatic Hypermutation, Immunoglobulin - immunology | Cytidine Deaminase - genetics | Humans | Immunoglobulin Class Switching - immunology | Phylogeny | Genes, Immunoglobulin | Animals | Recombination, Genetic | DNA Repair | Gene Rearrangement, B-Lymphocyte | Models, Genetic | DNA Damage | DNA-Directed DNA Polymerase - metabolism | Enzyme Activation | Somatic Hypermutation, Immunoglobulin - genetics | Immunoglobulin Class Switching - genetics | DNA-Directed DNA Polymerase - classification
Journal Article