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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2016, Volume 478, Issue 3, pp. 1099 - 1105
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2019, Volume 168, pp. 26 - 37
Constitutive androstane receptor (CAR), a member of the nuclear receptor superfamily, is retained as an inactive form phosphorylated at threonine in the... 
Phenobarbital | Cytoplasmic retention | Nuclear translocation | Constitutive androstane receptor | Three-dimensional culture | Cytochrome P450 3A4 | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 179, pp. 84 - 99
The DNA alkylating prodrug cyclophosphamide (CPA), alone or in combination with other agents, is one of the most commonly used anti-cancer agents. As a... 
Cyclophosphamide | Chemotherapy | Co-culture | Human constitutive androstane receptor | Structure-activity relationship
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 2019, Volume 10, Issue 7, pp. 1039 - 1044
The constitutive androstane receptor (CAR) is a xenobiotic sensor governing the transcription of genes involved in drug disposition, energy homeostasis, and... 
Nuclear receptor | pregnane X receptor | constitutive androstane receptor | structure-activity relationship | ACTIVATION | CHEMISTRY, MEDICINAL | HUMAN CYTOCHROME P4502B6 | CYCLOPHOSPHAMIDE | NUCLEAR RECEPTORS | PXR | IDENTIFICATION | PREGNANE-X-RECEPTOR | DISTINCT CLASSES | CAR | LIVER
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2019, Volume 167, Issue 1, pp. 282 - 292
Abstract The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently... 
quantitative high-throughput screening | ANTAGONIST | human primary hepatocytes | ENVIRONMENTAL CHEMICALS | NITAZOXANIDE | INDUCTION | NUCLEAR TRANSLOCATION | PREGNANE X RECEPTOR | drug-drug interactions | constitutive androstane receptor | CAR | GENES | TOXICOLOGY | INHIBITORS | DRUG-METABOLISM
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 2017, Volume 65, Issue 39, pp. 8606 - 8616
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2019, Volume 167, Issue 1, pp. 172 - 189
Abstract Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane... 
PPAR-ALPHA | Cyp2b | CYTOCHROMES P450 | transcript profiling | MOUSE-LIVER | INDUCTION | PXR | aryl hydrocarbon receptor | MESSENGER-RNA | Nrf2 | constitutive androstane receptor | ARYL-HYDROCARBON RECEPTOR | CAR | MICROSOMES | Keap1 | GENE-EXPRESSION | liver cancer | TOXICOLOGY | peroxisome proliferator-activated receptor | oxidative stress
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 07/2014, Volume 33, Issue 28, pp. 3717 - 3729
Chemotherapy is the most common treatment for cancer. However, multidrug resistance (MDR) remains a major obstacle to effective chemotherapy, limiting the... 
microRNA | MDR1 | miR-137 | doxorubicin | constitutive androstane receptor | CANCER-CELLS | PROMOTER METHYLATION | NUCLEAR RECEPTORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG-RESISTANCE | PREGNANE-X-RECEPTOR | CELL BIOLOGY | LIVER-INJURY | ONCOLOGY | COLORECTAL-CANCER | GENETICS & HEREDITY | GENE-EXPRESSION | MULTIDRUG-RESISTANCE | MICRORNA EXPRESSION | Humans | Male | MicroRNAs - metabolism | Promoter Regions, Genetic - drug effects | Promoter Regions, Genetic - genetics | Neuroblastoma - physiopathology | Base Sequence | Antineoplastic Agents - pharmacology | Neuroblastoma - pathology | Neuroblastoma - genetics | DNA Methylation - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Down-Regulation - drug effects | Down-Regulation - genetics | Drug Resistance, Neoplasm - genetics | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Feedback, Physiological - drug effects | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Neuroblastoma - metabolism | ATP Binding Cassette Transporter, Sub-Family B - genetics | DNA Methylation - drug effects | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Cell receptors | MicroRNA | Genetic research | Genetic aspects | Dosage and administration | Neuroblastoma | Research | Drug resistance | Drug therapy | Genetic regulation | Health aspects | Doxorubicin | Nervous system | Chemotherapy | Gene expression | MicroRNAs | Cancer | Index Medicus
Journal Article
Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2016, Volume 1859, Issue 9, pp. 1100 - 1111
The constitutive androstane receptor (CAR) is a key sensor in xenobiotic detoxification and endobiotic metabolism. Increasing evidence suggests that CAR also... 
Lipogenesis | Constitutive androstane receptor | Rutaecarpine | Evodiamine | Gluconeogenesis | INSULIN ACTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYP2B6 GENE | PREGNANE-X-RECEPTOR | CROSS-TALK | DIABETES-MELLITUS | BIOPHYSICS | CAR | GENE-EXPRESSION | LIPID HOMEOSTASIS | TRANSCRIPTIONAL REGULATION | DRUG-METABOLISM | Glucose-6-Phosphatase - genetics | Evodia - chemistry | Gluconeogenesis - drug effects | Humans | Alkaloids - isolation & purification | Male | Hepatocytes - metabolism | Dose-Response Relationship, Drug | Hepatocytes - cytology | Indole Alkaloids - isolation & purification | Lipogenesis - genetics | Liver - drug effects | Hepatocytes - drug effects | Forkhead Box Protein O1 - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Alkaloids - pharmacology | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Hepatocyte Nuclear Factor 4 - genetics | Receptors, Cytoplasmic and Nuclear - agonists | Receptors, Cytoplasmic and Nuclear - genetics | Quinazolines - isolation & purification | Glucose-6-Phosphatase - metabolism | Hep G2 Cells | Hypoglycemic Agents - pharmacology | Mice, Knockout | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Hypoglycemic Agents - isolation & purification | Animals | Gluconeogenesis - genetics | Indole Alkaloids - pharmacology | Lipogenesis - drug effects | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Liver - cytology | Mice | Primary Cell Culture | Quinazolines - pharmacology | Forkhead Box Protein O1 - genetics | Receptors, Cytoplasmic and Nuclear - metabolism | Type 2 diabetes | Physiological aspects | Alkaloids | Phosphatases
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2019, Volume 378, pp. 114618 - 114618
Polycyclic aromatic hydrocarbons (PAHs) are a class of pervasive global environmental pollutants and adversely affect human health. Among PAHs, phenanthrene... 
Phenanthrene | Hepatotoxicity | Constitutive Androstane Receptor (CAR) | Polycyclic Aromatic Hydrocarbons (PAHs) | POLYCYCLIC AROMATIC-HYDROCARBONS | PAHS | ALPHA | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CANCER | EXPOSURE
Journal Article