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Nature Immunology, ISSN 1529-2908, 12/2013, Volume 14, Issue 12, pp. 1247 - 1255
The inflammasome adaptor ASC contributes to innate immunity through the activation of caspase-1. Here we found that signaling pathways dependent on the kinases... 
LISTERIA-MONOCYTOGENES | AIM2 INFLAMMASOME | PROTEIN | INNATE IMMUNE-RESPONSES | MACROPHAGES | KINASE | HOST-DEFENSE | NLRP3 INFLAMMASOME | IMMUNOLOGY | CASPASE-1 ACTIVATION | VIRAL-INFECTION | Interleukin-18 - immunology | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | JNK Mitogen-Activated Protein Kinases - immunology | Caspase 1 - metabolism | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | RNA Interference | Bone Marrow Cells - immunology | Phosphorylation - immunology | JNK Mitogen-Activated Protein Kinases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | DNA-Binding Proteins | Tyrosine - immunology | Mice, Knockout | Macrophages - metabolism | Tyrosine - metabolism | Lipopolysaccharides - pharmacology | Mice | Interleukin-18 - metabolism | Intracellular Signaling Peptides and Proteins - immunology | JNK Mitogen-Activated Protein Kinases - metabolism | Caspase 1 - immunology | Protein-Tyrosine Kinases - immunology | Protein-Tyrosine Kinases - genetics | HEK293 Cells | Cytoskeletal Proteins - metabolism | Female | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Nuclear Proteins - immunology | Inflammasomes - genetics | Carrier Proteins - genetics | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Macrophages - drug effects | Nigericin - pharmacology | Bone Marrow Cells - metabolism | Tyrosine - genetics | Cellular signal transduction | Inflammation | Genetic aspects | Research | Properties | Phosphotransferases | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2010, Volume 39, Issue 6, pp. 963 - 974
The melanoma antigen (MAGE) family consists of more than 60 genes, many of which are cancer-testis antigens that are highly expressed in cancer and play a... 
NECDIN GENE | EMERGING ROLES | MELANOMA | KAP1 | CANCER/TESTIS ANTIGENS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MDM2 INTERACTION | HOMOLOGOUS RECOMBINATION | CANCER-IMMUNOTHERAPY | CELL-LINES | EXPRESSION | CELL BIOLOGY | Melanoma-Specific Antigens - chemistry | Protein Interaction Domains and Motifs - physiology | Humans | Crystallography, X-Ray | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Neoplasm Proteins - metabolism | RING Finger Domains | Tripartite Motif-Containing Protein 28 | Ubiquitination | Cell Nucleus - metabolism | Transfection | Protein Structure, Quaternary | Antigens, Neoplasm - metabolism | Carrier Proteins - chemistry | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Recombinant Proteins - metabolism | Antigens, Neoplasm - genetics | Cell Line | Biocatalysis | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Repressor Proteins - genetics | Recombinant Proteins - genetics | Ubiquitin-Protein Ligases - chemistry | Carrier Proteins - genetics | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Melanoma-Specific Antigens - metabolism | Cell Line, Tumor | Ubiquitin-Protein Ligases - genetics | Melanoma-Specific Antigens - genetics | Protein Binding - physiology | Ubiquitin | Antigens | Ligases | Crystals | Melanoma | Structure | Tumor proteins | Protein binding | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 03/2007, Volume 128, Issue 6, pp. 1063 - 1076
Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and... 
DOMAIN-CONTAINING PROTEINS | METHYLATION | CAENORHABDITIS-ELEGANS | METHYLTRANSFERASE | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCAPES X-INACTIVATION | TRITHORAX | RETINOBLASTOMA-BINDING PROTEIN-2 | TRANSCRIPTIONAL REGULATION | CELL BIOLOGY | Caenorhabditis elegans Proteins - chemistry | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Phylogeny | Gene Deletion | Tumor Suppressor Proteins - chemistry | Oxidoreductases, N-Demethylating - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Repressor Proteins - metabolism | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Repressor Proteins - genetics | Caenorhabditis elegans - embryology | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Histone Demethylases | Lysine | Drosophila melanogaster - enzymology | Schizosaccharomyces - enzymology | Mice | Histones - metabolism | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Embryonic Stem Cells - metabolism | Oxidoreductases, N-Demethylating - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | Genes, Homeobox | Protein Structure, Tertiary | Repressor Proteins - chemistry | Embryonic Stem Cells - enzymology | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Oxidoreductases, N-Demethylating - chemistry | Proteins - genetics | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Retinoblastoma-Binding Protein 2 | Proteins - chemistry | Methylation | Jumonji Domain-Containing Histone Demethylases | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β... 
STERILE INFLAMMATORY RESPONSE | PROGRAMMED NECROSIS | CASPASE-8 | IL-1-BETA | NLRP3 INFLAMMASOME | TNF-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CIAP1 | NALP3 INFLAMMASOME | CELL-DEATH | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | X-Linked Inhibitor of Apoptosis Protein - deficiency | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Inhibitor of Apoptosis Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - agonists | Carrier Proteins - agonists | Inhibitor of Apoptosis Proteins - deficiency | Molecular Mimicry | Interleukin-1beta - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - metabolism | Macrophages - immunology | Macrophages - cytology | X-Linked Inhibitor of Apoptosis Protein - genetics | Mice, Knockout | Ubiquitin-Protein Ligases | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Mice | Apoptosis | Proteins | Interleukins | Genes | Membranes | Mammals | Immune system | Caspase-8 | DIABLO protein | Cell activation | IAP protein | Reactive oxygen species | Interleukin 1 | Toll-like receptors | XIAP protein | Inflammation | Macrophages | Caspase-1 | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2013, Volume 31, Issue 34, pp. 4333 - 4342
Purpose The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic... 
REGRESSION | ACTIVATION | THERAPY | NOTCH1 | PRETHYMIC PHENOTYPE | ONCOLOGY | PATHWAY | GENES | PTEN | MUTATIONS | EXPRESSION | F-Box-WD Repeat-Containing Protein 7 | Multivariate Analysis | Predictive Value of Tests | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Humans | Male | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - mortality | Young Adult | Time Factors | DNA Mutational Analysis | Gene Deletion | Cell Cycle Proteins - genetics | Adult | Female | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy | PTEN Phosphohydrolase - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Risk Factors | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Phenotype | GTP Phosphohydrolases - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - classification | Mutation | Receptor, Notch1 - genetics | Ubiquitin-Protein Ligases - genetics | F-Box Proteins - genetics | Index Medicus | GTP Phosphohydrolases | ras Proteins | Innate immunity | Life Sciences | F-Box Proteins | Immunology | PTEN Phosphohydrolase | Proto-Oncogene Proteins | Membrane Proteins | Ubiquitin-Protein Ligases | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | Receptor, Notch1 | Cell Cycle Proteins
Journal Article
Journal Article
PLoS Pathogens, ISSN 1553-7366, 04/2013, Volume 9, Issue 4, pp. e1003256 - e1003256
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1 beta response is mediated by innate receptors in... 
INTERLEUKIN-1 | RNA | RESPIRATORY VIRAL-INFECTION | INNATE IMMUNE-RESPONSE | RIG-I | MICROBIOLOGY | INDUCTION | NS1 PROTEIN | ANTIVIRAL RESPONSES | INTERFERON | VIROLOGY | EPITHELIAL-CELLS | PARASITOLOGY | Epithelial Cells - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Male | Tripartite Motif Proteins | Lung - virology | RNA Interference | Respiratory Mucosa - immunology | HEK293 Cells | Cytoskeletal Proteins - metabolism | Lung - metabolism | Toll-Like Receptor 3 - genetics | DEAD-box RNA Helicases - metabolism | Influenza A Virus, H1N1 Subtype - metabolism | Macrophages - immunology | DEAD Box Protein 58 | Respiratory Mucosa - cytology | Signal Transduction | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Ferrets | Toll-Like Receptor 3 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Animals | Carrier Proteins - metabolism | Interferon-beta - metabolism | Caspase 1 - genetics | CARD Signaling Adaptor Proteins | Viral Nonstructural Proteins - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus | Cytoskeletal Proteins | Toll-Like Receptor 3 | Interferon-beta | Lung | Macrophages | Life Sciences | Influenza A Virus, H1N1 Subtype | Caspase 1 | Carrier Proteins | Viral Nonstructural Proteins | DEAD-box RNA Helicases | Inflammasomes | Respiratory Mucosa | Epithelial Cells | Virology | Ubiquitin-Protein Ligases | Microbiology and Parasitology | Adaptor Proteins, Signal Transducing | Transcription Factors | Proteins | Medical research | Experiments | Respiratory diseases | Influenza
Journal Article
Biochemical Journal, ISSN 0264-6021, 02/2013, Volume 449, Issue 3, pp. 613 - 621
The ASC (apoptosis speck-like protein) is a key component of multimeric protein complexes that mediate inflammation and host defence. Comprising a PYD (Pyrin)... 
Salmonella | Caspase activation and recruitment domain (CARD) | Inflammatory cytokine | Nucleotide-binding domain | Death domain | Signalling platform formation | Innate immunity | Caspase 1 | Inflammasome | Leucine-rich repeat-containing receptor (NLR) | NLR family CARD domain-containing protein 4 (NLRC4) | IMMUNITY | ACTIVATION | CASPASE-1 | INTERLEUKIN-1-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | PYROPTOSOME | IDENTIFICATION | IPAF | caspase activation and recruitment domain (CARD) | CELL-DEATH | inflammatory cytokine | innate immunity | leucine-rich repeat-containing receptor (NLR) | inflammasome | DISEASE | signalling platform formation | death domain | nucleotide-binding domain | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Multiprotein Complexes - genetics | CARD Signaling Adaptor Proteins - genetics | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | HEK293 Cells | Cytoskeletal Proteins - metabolism | Mutant Proteins - immunology | DNA-Binding Proteins | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | CARD Signaling Adaptor Proteins - immunology | Cell Line | Salmonella typhimurium - immunology | Salmonella typhimurium - pathogenicity | Signal Transduction | Inflammasomes - chemistry | Mutant Proteins - genetics | Models, Molecular | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | Cytoskeletal Proteins - chemistry | Immunity, Innate | Inflammasomes - genetics | Multiprotein Complexes - chemistry | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | Inflammasomes - immunology | Mutant Proteins - chemistry | CARD Signaling Adaptor Proteins - chemistry | Mice | HeLa Cells | Calcium-Binding Proteins - genetics | Index Medicus | signaling platform formation | inflammatory cytokines | NLRC4 | death domains | CARD | Caspase-1 | Nod-like receptors (NLRs)
Journal Article
Journal Article
Nature, ISSN 0028-0836, 12/2001, Volume 414, Issue 6864, pp. 652 - 656
Journal Article