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1. Full Text Subbasal Nerve Plexus Changes in Chronic Migraine
by Shetty, Rohit and Deshmukh, Rashmi and Shroff, Rushad and Dedhiya, Charmy and Jayadev, Chaitra
Cornea, ISSN 0277-3740, 01/2018, Volume 37, Issue 1, pp. 72 - 75
PURPOSE:Migraine is a multifactorial disorder that presents with unilateral headache and several sensory symptoms. Photophobia is one of the ophthalmic... 
subbasal nerve plexus | migraine | HEADACHES | LIGHT | DIABETIC PERIPHERAL NEUROPATHY | OPHTHALMOLOGY | CORNEAL CONFOCAL MICROSCOPY | SYMPTOMS | photophobia
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2. Full Text Focused tortuosity definitions based on expert clinical assessment of corneal subbasal nerves
by Lagali, Neil and Poletti, Enea and Patel, Dipika V and McGhee, Charles N. J and Hamrah, Pedram and Kheirkhah, Ahmad and Tavakoli, Mitra and Petropoulos, Ioannis N and Malik, Rayaz A and Utheim, Tor Paaske and Zhivov, Andrey and Stachs, Oliver and Falke, Karen and Peschel, Sabine and Guthoff, Rudolf and Chao, Cecilia and Golebiowski, Blanka and Stapleton, Fiona and Ruggeri, Alfredo and Avdelningen för neuro- och inflammationsvetenskap and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Ögonkliniken US/LiM and Sinnescentrum
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2015, Volume 56, Issue 9, pp. 5102 - 5109
PURPOSE. We examined agreement among experts in the assessment of corneal subbasal nerve tortuosity. METHODS. Images of corneal subbasal nerves were obtained... 
Plexus | Subbasal nerve | Corneal nerves | Tortuosity | In vivo confocal microscopy | POLYNEUROPATHY | VIVO CONFOCAL MICROSCOPY | subbasal nerve | in vivo confocal microscopy | SKIN BIOPSY | plexus | DIABETIC-NEUROPATHY | IMAGES | DRY EYE | tortuosity | DISEASE | OPHTHALMOLOGY | PERIPHERAL NEUROPATHY | RETINOPATHY | corneal nerves | MORPHOLOGY | Cornea - innervation | Torsion Abnormality - diagnosis | Microscopy, Confocal - methods | Humans | Ophthalmic Nerve - pathology | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | subbasal nerve; plexus; in vivo confocal microscopy; tortuosity; corneal nerves
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3. Full Text The relationship between subbasal nerve morphology and corneal sensation in ocular surface disease
by Labbé, Antoine and Alalwani, Haiyan and Van Went, Charles and Brasnu, Emmanuelle and Georgescu, Dan and Baudouin, Christophe
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 07/2012, Volume 53, Issue 8, pp. 4926 - 4931
PURPOSE. The purpose of this study was to evaluate the relationship between the in vivo confocal microscopic (IVCM) morphology of subbasal corneal nerves and... 
VIVO-CONFOCAL-MICROSCOPY | NONCONTACT ESTHESIOMETRY | PRIMARY SJOGRENS-SYNDROME | LASER-SCANNING MICROSCOPY | DRY EYE | IN-VIVO | SENSITIVITY | INNERVATION | OPHTHALMOLOGY | GLAUCOMA | PLEXUS | Nerve Fibers - pathology | Nerve Tissue - pathology | Ocular Hypertension - pathology | Humans | Middle Aged | Male | Case-Control Studies | Dry Eye Syndromes - pathology | Microscopy, Confocal | Ophthalmic Nerve - pathology | Aged, 80 and over | Cornea - innervation | Female | Aged | Glaucoma - pathology
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4. Full Text Mosaicking the subbasal nerve plexus by guided eye movements
by Allgeier, Stephan and Maier, Susanne and Mikut, Ralf and Peschel, Sabine and Reichert, Klaus-Martin and Stachs, Oliver and Köhler, Bernd
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2014, Volume 55, Issue 9, pp. 6082 - 6089
PURPOSE. A growing number of studies provide evidence that the morphology of the corneal subbasal nerve plexus (SNP), examined by corneal confocal microscopy... 
Guided eye movements | Cornea | Subbasal nerve plexus | Mosaic image montage | subbasal nerve plexus | cornea | SJOGRENS-SYNDROME | SENSITIVITY | KERATITIS | HUMAN DIABETIC-NEUROPATHY | VIVO-CONFOCAL-MICROSCOPY | DRY EYE | FIBER DAMAGE | OPHTHALMOLOGY | mosaic image montage | guided eye movements | SENSATION | MORPHOLOGY | CORNEAL INNERVATION | Nerve Fibers - pathology | Ophthalmic Nerve - anatomy & histology | Eye Movements | Humans | Middle Aged | Male | Image Processing, Computer-Assisted - methods | Fixation, Ocular | Microscopy, Confocal - methods | Young Adult | Diabetic Neuropathies - pathology | Image Processing, Computer-Assisted - instrumentation | Adult | Cornea - innervation | Female | Aged | Software | Microscopy, Confocal - instrumentation
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5. Full Text Subbasal nerve morphology, corneal sensation, and tear film evaluation after refractive femtosecond laser lenticule extraction
by Vestergaard, Anders H and Grønbech, Keea T and Grauslund, Jakob and Ivarsen, Anders R and Hjortdal, Jesper Ø
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 11/2013, Volume 251, Issue 11, pp. 2591 - 2600
The purpose of this study was to compare corneal subbasal nerve morphology, corneal sensation, and tear film parameters after femtosecond lenticule extraction... 
Tear film evaluation | Femtosecond laser | Ophthalmology | Corneal sensation | Medicine & Public Health | Corneal subbasal nerve morphology | SURGERY | IN-SITU KERATOMILEUSIS | OPTICAL COHERENCE TOMOGRAPHY | VIVO CONFOCAL MICROSCOPY | SENSITIVITY | LASIK | HINGE | MYOPIA | OPHTHALMOLOGY | DRY EYE DISEASE | ASSOCIATION | Single-Blind Method | Surgical Flaps | Prospective Studies | Sensation - physiology | Tomography, Optical Coherence | Humans | Middle Aged | Cornea - physiology | Male | Corneal Surgery, Laser | Corneal Topography | Lasers, Excimer - therapeutic use | Microscopy, Confocal | Corneal Stroma - innervation | Ophthalmic Nerve - pathology | Corneal Stroma - surgery | Myopia, Degenerative - surgery | Adult | Female | Tears - physiology | Myopia, Degenerative - physiopathology | Lasers | Clinical trials
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6. Full Text Langerhans cells prevent subbasal nerve damage and upregulate neurotrophic factors in dry eye disease
by Choi, Eun Young and Kang, Hyun Goo and Lee, Chul Hee and Yeo, Areum and Noh, Hye Mi and Gu, Nayeong and Kim, Myoung Joon and Song, Jong Suk and Kim, Hyeon Chang and Lee, Hyung Keun
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, p. e0176153
The functional role of Langerhans cells (LCs) in ocular surface inflammation and nerve damage in dry eye (DE) disease has yet to be determined. This study was... 
CORNEAL | DENSITY | TEARS | CYTOKINES | DENDRITIC CELL | REGENERATION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | CONFOCAL MICROSCOPIC EVALUATION | RECEPTOR | STRESS | Mannose-Binding Lectins - metabolism | Inflammation - pathology | Up-Regulation | Cell Count | Humans | Middle Aged | Male | Nerve Growth Factors - metabolism | Lectins, C-Type - genetics | Case-Control Studies | Young Adult | Dry Eye Syndromes - pathology | Lectins, C-Type - metabolism | Inflammation - metabolism | Antigens, Surface - metabolism | Adult | Female | Disease Models, Animal | Cross-Sectional Studies | Cytokines - metabolism | Antigens, Surface - genetics | Microscopy, Confocal | Animals | Mannose-Binding Lectins - genetics | Dry Eye Syndromes - metabolism | Aged | Mice | Langerhans Cells - metabolism | Prevention | Dry eye syndromes | Langerhans cells | Nervous system | Degeneration | Research | Health aspects | Neurotrophic functions | Health care | Neuroprotection | Flow cytometry | Animal models | Cornea | Deformation | Physicians | Confocal microscopy | mRNA | Single-nucleotide polymorphism | Inactivation | Density | CD45 antigen | Cell density | Fibers | Immunology | Nerves | Diphtheria toxin | Antigens | CD11b antigen | CD19 antigen | Dendritic cells | Data processing | Diphtheria | Neurotrophic factors | Gene expression | Interleukin 17 | CD4 antigen | Medicine | Studies | Neurotransmitters | Microscopy | Neural networks | Eye diseases | Skin
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7. Full Text Diabetes mellitus leads to accumulation of dendritic cells and nerve fiber damage of the subbasal nerve plexus in the cornea
by Leppin, Katja and Behrendt, Ann-Kathrin and Reichard, Maria and Stachs, Oliver and Guthoff, Rudolf F and Baltrusch, Simone and Eule, Johanna C and Vollmar, Brigitte
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 04/2014, Volume 55, Issue 6, pp. 3603 - 3615
PURPOSE. To evaluate whether nerve fibers of the subbasal nerve plexus (SNP) and dendritic cells (DCs) are in association with each other leading to neuropathy... 
Dendritic cells | Diabetes mellitus | Subbasal nerve plexus | subbasal nerve plexus | MOUSE | diabetes mellitus | DENSITY | MEMBRANE NANOTUBES | dendritic cells | INFLAMMATION | CONFOCAL MICROSCOPIC EVALUATION | IN-VIVO | ANIMAL-MODELS | OPHTHALMOLOGY | PERIPHERAL NEUROPATHY | ANTIGEN-PRESENTING CELLS | STREPTOZOTOCIN | Nerve Fibers - pathology | Cell Count | Corneal Diseases - etiology | Dendritic Cells - pathology | Microscopy, Confocal | Animals | Ophthalmic Nerve - pathology | Diabetes Mellitus, Experimental - pathology | Cornea - innervation | Female | Cornea - pathology | Diabetes Mellitus, Experimental - complications | Mice | Mice, Inbred BALB C | Corneal Diseases - pathology
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8. Full Text Imaging and Quantification of Subbasal Nerve Plexus in Healthy Volunteers and Diabetic Patients with or without Retinopathy
by Zhivov, Andrey and Winter, Karsten and Hovakimyan, Marine and Peschel, Sabine and Harder, Volker and Schober, Hans-Christof and Kundt, Guenther and Baltrusch, Simone and Guthoff, Rudolf F and Stachs, Oliver
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e52157
Background: The alterations of subbasal nerve plexus (SBP) innervation and corneal sensation were estimated non-invasively and compared with the values in... 
POPULATION | PERCEPTION | VIVO CONFOCAL MICROSCOPY | MULTIDISCIPLINARY SCIENCES | FIBER DAMAGE | CORNEAL NERVES | SENSITIVITY | PERIPHERAL NEUROPATHY | PREVALENCE | MORPHOLOGY | SEVERITY | Diagnostic Imaging - methods | Diabetic Retinopathy - diagnosis | Microscopy, Confocal | Demography | Health | Humans | Cornea - innervation | Female | Male | Aged | Cornea - pathology | Fundus Oculi | Type 2 diabetes | Diabetic retinopathy | Diabetics | Care and treatment | Diabetic neuropathies | Algorithms | Comparative analysis | Diabetes therapy | Neurophysiology | Cornea | Retinopathy | Image processing | Innervation | Retina | Diabetic neuropathy | Neuropathy | Confocal | Peripheral neuropathy | Subgroups | Image acquisition | Eye (anatomy) | Quantitative analysis | Automation | Internal medicine | Diabetes mellitus | Mathematical morphology | Patients | Medicine | Studies | Image analysis | Microscopy | Morphology | In vivo methods and tests | Diabetes | Scanning microscopy
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9. Full Text Sensory Adaptation to Silicone Hydrogel Contact Lens Wear Is Not Associated With Alterations in the Corneal Subbasal Nerve Plexus
by Kocabeyoglu, Sibel and Colak, Dilan and Mocan, Mehmet C and Irkec, Murat
Cornea, ISSN 0277-3740, 09/2019, Volume 38, Issue 9, pp. 1142 - 1146
PURPOSE:To evaluate corneal subbasal nerve alterations in contact lens (CL)-naive silicone hydrogel CL wearers and to investigate the relationship between... 
silicone hydrogel contact lens | VIVO-CONFOCAL-MICROSCOPY | OCULAR SURFACE SENSITIVITY | LONG-TERM | corneal sensitivity | IN-VIVO | OPHTHALMOLOGY | in vivo confocal microscopy | HEALTH | corneal subbasal nerve plexus | MORPHOLOGY
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10. Full Text Morphologic Alterations of Both the Stromal and Subbasal Nerves in the Corneas of Patients with Diabetes
by Mocan, Mehmet C and Durukan, Irfan and Irkec, Murat and Orhan, Mehmet
Cornea, ISSN 0277-3740, 08/2006, Volume 25, Issue 7, pp. 769 - 773
PURPOSE:To evaluate the subbasal and the stromal nerves of the corneas of patients with type 2 diabetes with in vivo confocal microscopy and to compare them... 
Keratopathy | Stromal nerve | Subbasal nerve | Diabetic | keratopathy | EYE | diabetic | CONFOCAL MICROSCOPY | NEUROPATHY | subbasal nerve | SENSITIVITY | OPHTHALMOLOGY | ALDOSE REDUCTASE INHIBITOR | stromal nerve | CT-112 | Severity of Illness Index | Corneal Stroma - innervation | Descemet Membrane - innervation | Humans | Middle Aged | Female | Male | Diabetes Mellitus, Type 2 - pathology | Microscopy, Confocal - methods | Peripheral Nerves - pathology
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11. Full Text Image reconstruction of the subbasal nerve plexus with in vivo confocal microscopy
by Allgeier, Stephan and Zhivov, Andrey and Eberle, Franz and Koehler, Bernd and Maier, Susanne and Bretthauer, Georg and Guthoff, Rudolf F and Stachs, Oliver
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 08/2011, Volume 52, Issue 9, pp. 5022 - 5028
PURPOSE. To overcome the anterior corneal mosaic (ACM) phenomenon in in vivo confocal laser scanning microscopy (CLSM) and to reconstruct undistorted images of... 
OCULAR SURFACE | EYE | SURROGATE | LASER-SCANNING MICROSCOPY | CORNEAL STRUCTURES | FIBER DAMAGE | DISEASE | OPHTHALMOLOGY | CONJUNCTIVA | KERATOCONUS | Nerve Net - ultrastructure | Ophthalmic Nerve - anatomy & histology | Bowman Membrane - innervation | Humans | Middle Aged | Male | Microscopy, Confocal - methods | Artifacts | Algorithms | Nerve Net - anatomy & histology | Ophthalmic Nerve - ultrastructure | Adult | Female | Epithelium, Corneal - innervation | Nerve Fibers
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12. Full Text Two-dimensional plane for multi-scale quantification of corneal subbasal nerve tortuosity
by Annunziata, Roberto and Kheirkhah, Ahmad and Aggarwal, Shruti and Cavalcanti, Bernardo M and Hamrah, Pedram and Trucco, Emanuele
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 03/2016, Volume 57, Issue 3, pp. 1132 - 1139
PURPOSE. To assess the performance of a novel system for automated tortuosity estimation and interpretation. METHODS. A supervised strategy (driven by... 
Tortuosity plane | Confocal microscopy | Corneal subbasal nerve plexus | VIVO-CONFOCAL-MICROSCOPY | OCULAR SURFACE | NEUROPATHY | tortuosity plane | confocal microscopy | IMAGES | OPHTHALMOLOGY | KERATITIS | RETINOPATHY | corneal subbasal nerve plexus | VESSEL WIDTH | FEATURES | Nerve Tissue - abnormalities | Microscopy, Confocal | Pilot Projects | Torsion Abnormality - diagnosis | Humans | Middle Aged | Cornea - innervation | Female | Male | Image Processing, Computer-Assisted - methods | Ophthalmic Nerve - abnormalities | Corneal Diseases - diagnosis | Cornea
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13. Full Text Morphometric stability of the corneal subbasal nerve plexus in healthy individuals: A 3-year longitudinal study using corneal confocal microscopy
by Dehghani, Cirous and Pritchard, Nicola and Edwards, Katie and Vagenas, Dimitrios and Russell, Anthony W and Malik, Rayaz A and Efron, Nathan
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 04/2014, Volume 55, Issue 5, pp. 3195 - 3199
PURPOSE. We examined the age-dependent alterations and longitudinal course of subbasal nerve plexus (SNP) morphology in healthy individuals. METHODS.... 
Subbasal nerve plexus | Corneal confocal microscopy | Age | Natural history | subbasal nerve plexus | REGENERATION | INNERVATION | SENSITIVITY | natural history | DIABETIC-NEUROPATHY | KERATOCONUS | DENSITY | NONCONTACT ESTHESIOMETRY | DRY EYE | IN-VIVO | OPHTHALMOLOGY | age | MORPHOLOGY | corneal confocal microscopy | Ophthalmic Nerve - cytology | Follow-Up Studies | Time Factors | Humans | Middle Aged | Cornea - innervation | Female | Male | ROC Curve | Reference Values | Nerve Fibers - ultrastructure | Microscopy, Confocal - methods
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14. Full Text Characterization of the Corneal Subbasal Nerve Plexus in Limbal Stem Cell Deficiency
by Chuephanich, Pichaya and Supiyaphun, Chantaka and Aravena, Carolina and Bozkurt, Tahir Kansu and Yu, Fei and Deng, Sophie X
Cornea, ISSN 0277-3740, 03/2017, Volume 36, Issue 3, pp. 347 - 352
PURPOSE:To quantify the changes in the subbasal nerve plexus in patients with limbal stem cell deficiency (LSCD) using in vivo laser scanning confocal... 
limbal stem cell | diagnosis | in vivo confocal microscopy | limbal stem cell deficiency | corneal nerve | OCULAR SURFACE | VIVO-CONFOCAL-MICROSCOPY | NEUROTROPHIC FACTORS | NEUROPATHY | EPITHELIUM | DRY EYE | DISEASE | OPHTHALMOLOGY | TORTUOSITY | EXPRESSION | IMPRESSION CYTOLOGY | Limbus Corneae - diagnostic imaging | Cross-Sectional Studies | Humans | Middle Aged | Male | Ophthalmic Nerve - diagnostic imaging | Limbus Corneae - pathology | Corneal Diseases - diagnosis | Cranial Nerve Diseases - diagnosis | Young Adult | Microscopy, Confocal | Ophthalmic Nerve - pathology | Aged, 80 and over | Stem Cells - pathology | Adult | Cornea - innervation | Female | Aged | Retrospective Studies
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15. Full Text Fully Automated, Semiautomated, and Manual Morphometric Analysis of Corneal Subbasal Nerve Plexus in Individuals With and Without Diabetes
by Dehghani, Cirous and Pritchard, Nicola and Edwards, Katie and Russell, Anthony W and Malik, Rayaz A and Efron, Nathan
Cornea, ISSN 0277-3740, 07/2014, Volume 33, Issue 7, pp. 696 - 702
PURPOSE:The aim of the study was to determine the association, agreement, and detection capability of manual, semiautomated, and fully automated methods of... 
corneal nerve fiber length | morphometric analysis | diabetic neuropathy | corneal confocal microscopy | SURROGATE | VIVO CONFOCAL MICROSCOPY | SENSORIMOTOR POLYNEUROPATHY | DIAGNOSE | REPEATABILITY | FIBER DAMAGE | DISEASE | OPHTHALMOLOGY | PERIPHERAL NEUROPATHY | MORPHOLOGY | SEVERITY | Diabetes Mellitus, Type 1 - diagnosis | Diabetes Mellitus, Type 2 - diagnosis | Microscopy, Confocal | Humans | Middle Aged | Ophthalmic Nerve - pathology | Cornea - innervation | Diabetic Neuropathies - diagnosis | Nerve Fibers | Cranial Nerve Diseases - diagnosis | Diagnostic Techniques, Ophthalmological
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16. Full Text Corneal Subbasal Nerve Density and Sensitivity After Pars Plana Vitrectomy Using Contact or Noncontact Wide-Angle Viewing Systems
by Tosi, Gian Marco and Bacci, Tommaso and Tarantello, Antonio and Martone, Gianluca and Traversi, Claudio and Marigliani, Davide and Cevenini, Gabriele and Virgili, Gianni
Cornea, ISSN 0277-3740, 06/2018, Volume 37, Issue 9, pp. 1130 - 1137
PURPOSE:To assess corneal subbasal nerve density (SBND) and corneal sensitivity (CS) after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment... 
DEFECTS | EPITHELIAL DEBRIDEMENT | VIVO CONFOCAL MICROSCOPY | in vivo confocal microscopy | CATARACT-SURGERY | pars plana vitrectomy | SEW-ON | 360-DEGREE LASER RETINOPEXY | rhegmatogenous retinal detachment | noncontact panoramic viewing system | CLOSED VITRECTOMY | corneal sensitivity | RETINAL-DETACHMENT | OPHTHALMOLOGY | COMPLICATIONS | SENSATION | contact panoramic viewing system | corneal subbasal nerve plexus | Complications and side effects | Vitrectomy | Cornea | Medical examination | Patient outcomes
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17. Full Text Subbasal Nerve Regeneration After Penetrating Keratoplasty
by Darwish, Taym and Brahma, Arun and Efron, Nathan and OʼDonnell, Clare
Cornea, ISSN 0277-3740, 09/2007, Volume 26, Issue 8, pp. 935 - 940
PURPOSE:To evaluate subbasal nerve regeneration, corneal sensitivity, and tear film function after penetrating keratoplasty. METHODS:Twenty keratoplasty... 
Tear film | Confocal microscopy | Keratoplasty | Esthesiometry | keratoplasty | tear film | IN-SITU KERATOMILEUSIS | confocal microscopy | VIVO CONFOCAL MICROSCOPY | SENSITIVITY | OPHTHALMOLOGY | esthesiometry | NONCONTACT CORNEAL AESTHESIOMETER | PHOTOREFRACTIVE KERATECTOMY | PLEXUS | TRANSPLANTATION | Humans | Middle Aged | Nerve Regeneration - physiology | Cornea - physiology | Male | Corneal Diseases - surgery | Ophthalmic Nerve - physiology | Microscopy, Confocal | Nerve Fibers - physiology | Time Factors | Keratoplasty, Penetrating | Adult | Cornea - innervation | Female | Tears - physiology
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