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1. Full Text Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas
by Dombi, Eva and Baldwin, Andrea and Marcus, Leigh J and Fisher, Michael J and Weiss, Brian and Kim, AeRang and Whitcomb, Patricia and Martin, Staci and Aschbacher-Smith, Lindsey E and Rizvi, Tilat A and Wu, Jianqiang and Ershler, Rachel and Wolters, Pamela and Therrien, Janet and Glod, John and Belasco, Jean B and Schorry, Elizabeth and Brofferio, Alessandra and Starosta, Amy J and Gillespie, Andrea and Doyle, Austin L and Ratner, Nancy and Widemann, Brigitte C
The New England journal of medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 26, pp. 2550 - 2560
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Neurofibroma, Plexiform - diagnostic imaging | Protein Kinase Inhibitors - pharmacokinetics | Humans | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Benzimidazoles - pharmacokinetics | Child, Preschool | Male | Protein Kinase Inhibitors - adverse effects | Neurofibroma, Plexiform - drug therapy | Disease Progression | Magnetic Resonance Imaging | Protein Kinase Inhibitors - administration & dosage | Animals | Benzimidazoles - administration & dosage | Neurofibromatosis 1 - drug therapy | Adolescent | Female | Mice | Benzimidazoles - adverse effects | Child | Disease Models, Animal | Drugs | Care and treatment | Usage | Neurofibromatosis | Extracellular signal-regulated kinases | Dosage and administration | Diagnosis | Research | Pediatrics | Creatine kinase | Plexiform neurofibroma | Clinical trials | MAP kinase | Creatine | Kinases | Recklinghausen's disease | Children & youth | Pain | Magnetic resonance imaging | Protein kinase | Children | Pharmacokinetics | Drug therapy | Tumors | Index Medicus | Abridged Index Medicus
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2. Full Text A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours
by de Weger, Vincent A and de Jonge, Maja and Langenberg, Marlies H G and Schellens, Jan H M and Lolkema, Martijn and Varga, Anea and Demers, Brigitte and Thomas, Koruth and Hsu, Karl and Tuffal, Gilles and Goodstal, Samantha and Macé, Sanine and Deutsch, Eric
British journal of cancer, ISSN 0007-0920, 02/2019, Volume 120, Issue 3, pp. 286 - 293
Thrombocytopenia/chemically induced | Humans | Middle Aged | Proto-Oncogene Proteins p21(ras)/genetics | Proto-Oncogene Proteins B-raf/genetics | MAP Kinase Kinase Kinases/antagonists & inhibitors | Male | Gene Expression Regulation, Neoplastic/drug effects | Tumor Suppressor Protein p53/genetics | Niacinamide/administration & dosage | Spiro Compounds/administration & dosage | Proto-Oncogene Proteins c-mdm2/antagonists & inhibitors | Dose-Response Relationship, Drug | Indoles/administration & dosage | Protein Kinase Inhibitors/administration & dosage | Maximum Tolerated Dose | Neoplasms/classification | Adult | Female | Aged | Antineoplastic Combined Chemotherapy Protocols/administration & dosage | Life Sciences & Biomedicine | Oncology | Science & Technology | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Proto-Oncogene Proteins p21(ras) - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Spiro Compounds - administration & dosage | Protein Kinase Inhibitors - adverse effects | Spiro Compounds - adverse effects | Indoles - administration & dosage | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Niacinamide - pharmacokinetics | Gene Expression Regulation, Neoplastic - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase Kinases - genetics | Niacinamide - adverse effects | Neoplasms - classification | Thrombocytopenia - chemically induced | Thrombocytopenia - pathology | Spiro Compounds - pharmacokinetics | Neoplasms - drug therapy | Niacinamide - administration & dosage | Protein Kinase Inhibitors - administration & dosage | Indoles - adverse effects | Proto-Oncogene Proteins B-raf - genetics | Indoles - pharmacokinetics | Neoplasms - pathology | Index Medicus | Targeted therapies | Outcomes research
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3. Full Text Mitochondrial creatine kinase activity prevents reactive oxygen species generation: Antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity
by Meyer, Laudiene Evangelista and Machado, Lilia Bender and Santiago, Ana Paula S. A and Da-Silva, Wagner Seixas and De Felice, Fernanda G and Holub, Oliver and Oliveira, Marcus F and Galina, Antonio
The Journal of biological chemistry, ISSN 0021-9258, 12/2006, Volume 281, Issue 49, pp. 37361 - 37371
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Creatine Kinase, Mitochondrial Form - metabolism | Reactive Oxygen Species - metabolism | Rats, Wistar | Antioxidants - metabolism | Cells, Cultured | Oxygen Consumption | Rats | Male | Mitochondria - metabolism | Substrate Cycling | Hydrogen Peroxide - metabolism | Brain - metabolism | Hyperglycemia - metabolism | Animals | Models, Biological | Creatine - metabolism | Membrane Potential, Mitochondrial | Phosphocreatine - metabolism | Adenosine Diphosphate - metabolism | In Vitro Techniques | Index Medicus
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4. Full Text Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement
by Alvin, Matthew D and Jaffe, Allan S and Ziegelstein, Roy C and Trost, Jeffrey C
JAMA internal medicine, ISSN 2168-6106, 10/2017, Volume 177, Issue 10, pp. 1508 - 1512
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Quality Improvement | Humans | Myocardium - metabolism | Acute Coronary Syndrome - diagnosis | Creatine Kinase, MB Form - blood | Biomarkers - blood | Acute Coronary Syndrome - blood | Index Medicus | Abridged Index Medicus
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5. Full Text Occupational exposure to manganese and risk of creatine kinase and creatine kinase‐MB elevation among ferromanganese refinery workers
by Huang, Sifang and Liu, Zhenfang and Ge, Xiaoting and Luo, Xiaoyu and Zhou, Yanting and Li, Defu and Li, Longman and Chen, Xiang and Huang, Lulu and Cheng, Hong and Hou, Qingzhi and Zan, Gaohui and Tan, Yanli and Liu, Chaoqun and Zou, Yunfeng and Yang, Xiaobo
American journal of industrial medicine, ISSN 0271-3586, 05/2020, Volume 63, Issue 5, pp. 394 - 401
creatine kinase | occupation | manganese | myocardial enzyme | creatine kinase‐MB | Life Sciences & Biomedicine | Public, Environmental & Occupational Health | Science & Technology | Hypertension | Enzymes | Dehydrogenases | Creatine kinase | Transaminase | Risk | Exposure | Creatine | Kinases | Dehydrogenase | Occupational exposure | Serum levels | Confidence intervals | Body mass index | Body mass | Body size | Refineries | Aspartate transaminase | Occupational health | Smoking | Manganese | Ferromanganese | Index Medicus
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6. Full Text The structure of lombricine kinase: Implications for phosphagen kinase conformational changes
by Bush, D. Jeffrey and Kirillova, Olga and Clark, Shawn A and Davulcu, Omar and Fabiola, Felcy and Xie, Qing and Somasundaram, Thayumanasamy and Ellington, W. Ross and Chapman, Michael S
The Journal of biological chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 11, pp. 9338 - 9350
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Catalytic Domain | Protein Structure, Secondary | Models, Molecular | Phosphotransferases (Nitrogenous Group Acceptor) - metabolism | Crystallography, X-Ray | Phosphotransferases (Nitrogenous Group Acceptor) - chemistry | Adenosine Diphosphate - chemistry | Annelida - enzymology | Animals | Adenosine Triphosphate - metabolism | Computer Simulation | Nuclear Magnetic Resonance, Biomolecular | Adenosine Diphosphate - metabolism | Adenosine Triphosphate - chemistry | Index Medicus | Enzyme Structure | Arginine Kinase | Protein Structure and Folding | Crystal Structure | Creatine Kinase | Protein Structure | Creatine | Crystallography
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7. Full Text The creatine kinase system and pleiotropic effects of creatine
by Wallimann, Theo and Tokarska-Schlattner, Malgorzata and Schlattner, Uwe
Amino acids, ISSN 0939-4451, 5/2011, Volume 40, Issue 5, pp. 1271 - 1296
Life Sciences | Biochemistry, general | Microcompartments | Analytical Chemistry | Creatine kinase isoforms | Life Sciences, general | Neurobiology | Proteomics | Biochemical Engineering | Beneficial effects of creatine supplementation | Creatine Kinase - metabolism | Phosphocreatine - metabolism | Animals | Phosphocreatine - biosynthesis | Humans | Creatine - metabolism | Purines | Glucose metabolism | Starvation | Biological products | Pregnant women | Creatine kinase | Analysis | Physiological aspects | Infants | Permeability | Adenosine triphosphatase | Index Medicus | Creatine Kinase | Biochemistry, Molecular Biology | Phosphocreatine | Creatine | Invited Review
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8. Full Text Prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurement after noncardiac surgery: A systematic review and meta-analysis
by Levy, Michael and Heels-Ansdell, Diane and Hiralal, Rajesh and Bhandari, Mohit and Guyatt, Gordon and Yusuf, Salim and Cook, Deborah and Villar, Juan Carlos and McQueen, Matthew and McFalls, Edward and Filipovic, Miodrag and Schünemann, Holger and Sear, John and Foex, Pierre and Lim, Wendy and Landesberg, Giora and Godet, Gilles and Poldermans, Don and Bursi, Francesca and Kertai, Miklos D and Bhatnagar, Neera and Devereaux, P.J
Anesthesiology (Philadelphia), ISSN 0003-3022, 2011, Volume 114, Issue 4, pp. 796 - 806
Life Sciences & Biomedicine | Anesthesiology | Science & Technology | Biological and medical sciences | Anesthesia | Medical sciences | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Prognosis | Creatine Kinase, MB Form - analysis | Surgical Procedures, Operative - mortality | Humans | Biomarkers - analysis | Cardiovascular Diseases - mortality | Troponin - analysis | Cardiovascular Diseases - diagnosis | Index Medicus | Abridged Index Medicus | Brain | Troponin | Reviews | Creatine kinase | Isoenzymes | Calcium-binding protein | Mortality | Surgery | Muscles | Data processing
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9. Full Text Creatine kinase monitoring in sport medicine
by Brancaccio, Paola and Maffulli, Nicola and Limongelli, Francesco Mario
British medical bulletin, ISSN 0007-1420, 2007, Volume 81-82, Issue 1, pp. 209 - 230
Creatine kinase | Muscular enzymes | Stress test | Myopathy | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Medical sciences | Sports - physiology | Muscle, Skeletal - enzymology | Creatine Kinase - blood | Humans | Muscular Diseases - prevention & control | Exercise - physiology | Biomarkers - blood | Muscle, Skeletal - physiology | Index Medicus
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