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1. Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug
by Bourgault, S and Chatenet, D and Wurtz, O and Doan, N.D and Leprince, J and Vaudry, H and Fournier, A and Vaudry, D
Current pharmaceutical design, ISSN 1381-6128, 04/2011, Volume 17, Issue 10, pp. 1002 - 1024
G protein-coupled receptor | Neuroprotection | Stroke | Bioactive conformation | Traumatic brain injury | PACAP | Peptide drug design | VIP | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Neuroprotective Agents - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Apoptosis - drug effects | Brain Injuries - drug therapy | Humans | Astrocytes - pathology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Drug Discovery - methods | Nerve Growth Factors - metabolism | Brain Ischemia - immunology | Brain Injuries - immunology | Neuroprotective Agents - adverse effects | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Cytokines - immunology | Astrocytes - drug effects | Cell Survival - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide - adverse effects | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - therapeutic use | Brain Ischemia - drug therapy | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Brain Ischemia - pathology | Brain Injuries - pathology | Astrocytes - metabolism | Drugs | Cytokines | Astrocytes | Macromolecules | Inflammation | Drug development | Neuroprotective agents | Blood | Microglia | Pituitary adenylate cyclase-activating polypeptide | Chemical modification | Neurotransmitters | Side effects | Molecular modelling | Ischemia | Pharmacokinetics | Apoptosis
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2. Full Text Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
by Fabio Malavasi and Silvia Deaglio and Ada Funaro and Enza Ferrero and Alberto L. Horenstein and Erika Ortolan and Tiziana Vaisitti and Semra Aydin
Physiological Reviews, ISSN 0031-9333, 07/2008, Volume 88, Issue 3, pp. 841 - 886
Life Sciences & Biomedicine | Physiology | Science & Technology | Antigens, CD - immunology | Immunotherapy - methods | Humans | GPI-Linked Proteins | Antibodies, Monoclonal - therapeutic use | Phylogeny | Antigens, CD - genetics | Antigens, CD - metabolism | Tissue Distribution | Signal Transduction - immunology | ADP-ribosyl Cyclase 1 - immunology | Immunoconjugates - therapeutic use | Models, Animal | Antigens, CD - chemistry | ADP-ribosyl Cyclase - genetics | Disease Models, Animal | ADP-ribosyl Cyclase - immunology | ADP-ribosyl Cyclase 1 - genetics | Models, Molecular | ADP-ribosyl Cyclase - metabolism | ADP-ribosyl Cyclase - chemistry | Immunity, Innate | ADP-ribosyl Cyclase 1 - chemistry | Animals | ADP-ribosyl Cyclase 1 - metabolism | Ligands | Protein Conformation | Evolution, Molecular | Ribosomal proteins | Research | Membrane proteins | Proteins | Pathology | Enzymes | Anatomy & physiology | Evolutionary biology | Index Medicus
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3. Full Text Structure-guided design and functional characterization of an artificial red light–regulated guanylate/adenylate cyclase for optogenetic applications
by Etzl, Stefan and Lindner, Robert and Nelson, Matthew D and Winkler, Andreas
The Journal of biological chemistry, ISSN 0021-9258, 06/2018, Volume 293, Issue 23, pp. 9078 - 9089
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amino Acid Sequence | Optogenetics - methods | Crystallography, X-Ray | Recombinant Fusion Proteins - chemistry | Molecular Dynamics Simulation | Deinococcus - genetics | Caenorhabditis elegans | Animals | Phytochrome - chemistry | Synechocystis - enzymology | Light | Adenylyl Cyclases - chemistry | Recombinant Fusion Proteins - genetics | Guanylate Cyclase - genetics | Protein Conformation | Deinococcus - chemistry | Synechocystis - genetics | Adenylyl Cyclases - genetics | Guanylate Cyclase - chemistry | Phytochrome - genetics | Index Medicus | hydrogen-deuterium exchange | photosensor | Protein Structure and Folding | photoreceptor | optogenetics | light regulation | guanylate cyclase (guanylyl cyclase) | adenylyl cyclase | bacteriophytochrome | adenylate cyclase (adenylyl cyclase) | allosteric regulation
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4. Full Text Enzymatic Properties and Regulation of the Native Isozymes of Retinal Membrane Guanylyl Cyclase (RetGC) from Mouse Photoreceptors
by Peshenko, Igor V and Olshevskaya, Elena V and Savchenko, Andrey B and Karan, Sukanya and Palczewski, Krzysztof and Baehr, Wolfgang and Dizhoor, Alexander M
Biochemistry (Easton), ISSN 0006-2960, 06/2011, Volume 50, Issue 25, pp. 5590 - 5600
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Calcium Signaling - physiology | Guanylate Cyclase-Activating Proteins - physiology | Guanylate Cyclase - antagonists & inhibitors | Isoenzymes - chemistry | Receptors, Cell Surface - antagonists & inhibitors | Cattle | Receptors, Cell Surface - chemistry | Membrane Proteins - metabolism | Catalysis | Guanylate Cyclase - chemistry | Guanylate Cyclase-Activating Proteins - chemistry | Isoenzymes - genetics | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Guanylate Cyclase - metabolism | Mice, Transgenic | Mice, Knockout | Photoreceptor Cells, Vertebrate - enzymology | Animals | Membrane Proteins - antagonists & inhibitors | Membrane Proteins - chemistry | Mice | Guanylate Cyclase-Activating Proteins - deficiency | Calcium Signaling - genetics | Rod Cell Outer Segment - enzymology | Enzymes | Isoenzymes | Structure-activity relationship | Analysis | Photoreceptors | Research | Guanylate cyclase | Structure | Index Medicus | photoreceptors | guanylyl cyclase activating proteins | guanylyl cyclase | cGMP | retina
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5. Full Text Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
by David Vaudry and Anthony Falluel-Morel and Steve Bourgault and Magali Basille and Delphine Burel and Olivier Wurtz and Alain Fournier and Billy K. C. Chow and Hitoshi Hashimoto and Ludovic Galas and Hubert Vaudry
Pharmacological reviews, ISSN 0031-6997, 09/2009, Volume 61, Issue 3, pp. 283 - 357
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Animals | Humans | Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - chemistry | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Index Medicus | Life Sciences | Neurons and Cognition
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