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Lipids, ISSN 0024-4201, 1/2014, Volume 49, Issue 1, pp. 49 - 57
Neutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase... 
Life Sciences | Neurochemistry | Medicinal Chemistry | Protectin DX | Lipidology | Human neutrophils | Nutrition | Microbial Genetics and Genomics | NADPH oxidase | ROS-derived oxidative stress | Medical Biochemistry | Inflammation | ROS‐derived oxidative stress | RHEUMATOID-ARTHRITIS | COLONY-STIMULATING FACTOR | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOPEROXIDASE | NUTRITION & DIETETICS | INFLAMMATORY-BOWEL-DISEASE | N-3 | CANCER-RISK | POLYUNSATURATED FATTY-ACIDS | TNF-ALPHA | Reactive Oxygen Species - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Humans | NADPH Oxidases - metabolism | Immunoblotting | Isomerism | Dose-Response Relationship, Drug | Lipoxygenase - metabolism | Time Factors | Superoxides - metabolism | N-Formylmethionine Leucyl-Phenylalanine - pharmacology | Phosphorylation - drug effects | Neutrophils - metabolism | Cyclooxygenase Inhibitors - metabolism | Docosahexaenoic Acids - chemistry | Neutrophils - drug effects | Cyclooxygenase Inhibitors - chemistry | Serine - metabolism | Cyclooxygenase Inhibitors - pharmacology | Docosahexaenoic Acids - pharmacology | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Cyclooxygenase 1 - metabolism | Docosahexaenoic Acids - metabolism | Peroxidase - metabolism | Prostaglandins - metabolism | Oxidases | Properties | Identification and classification | Omega-3 fatty acids | Neutrophils | Testing | Phosphorylation | Tetradecanoylphorbol Acetate | Reactive Oxygen Species | Cyclooxygenase Inhibitors | Cyclooxygenase 2 | Serine | Cyclooxygenase 1 | Lipopolysaccharides | Docosahexaenoic Acids | Prostaglandins | Superoxides | Food and Nutrition | Peroxidase | Lipoxygenase | N-Formylmethionine Leucyl-Phenylalanine | NADPH Oxidase | inflammation | protectin DX
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2010, Volume 429, Issue 2, pp. 273 - 282
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2010, Volume 107, Issue 1, pp. 28 - 33
Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A₂... 
Enzymes | Prostaglandins | Active sites | Cyclooxygenase inhibitors | Atoms | Dimers | Platelet aggregation | Platelets | Fatty acids | Monomers | Platelet | Prostaglandin | Arachidonic acid | Adrenic acid | Nonsteroidal antiinflammatory drugs | arachidonic acid | SELECTIVE-INHIBITION | CONTACTS | adrenic acid | MECHANISM | prostaglandin | ENDOPEROXIDE-H SYNTHASE-1 | OXYGENATION | MULTIDISCIPLINARY SCIENCES | INDOMETHACIN | FATTY-ACIDS | CELECOXIB | RESPONSES | nonsteroidal antiinflammatory drugs | platelet | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Crystallography, X-Ray | Isoenzymes - chemistry | Cyclooxygenase 2 Inhibitors - chemistry | Protein Subunits - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Aspirin - metabolism | Isoenzymes - metabolism | Cyclooxygenase 1 - chemistry | Platelet Aggregation Inhibitors - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Platelet Aggregation - drug effects | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Aspirin - pharmacology | Platelet Aggregation Inhibitors - metabolism | Catalytic Domain | Cyclooxygenase Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Models, Molecular | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Dogs | Aspirin - chemistry | Protein Binding | Protein Conformation | Protein Subunits - chemistry | Cyclooxygenase 1 - metabolism | Aspirin | Usage | Physiological aspects | Cyclooxygenases | Genetic aspects | Research | Health aspects | CATALYSIS | MONOMERS | THROMBOSIS | ARACHIDONIC ACID | PROCESSING | DIMERS | 60 APPLIED LIFE SCIENCES | ACETYLSALICYLIC ACID | PROSTAGLANDINS | IN VITRO | INFLAMMATION | TARGETS | SIDE EFFECTS | Biological Sciences
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1 - 14
Journal Article
Inflammopharmacology, ISSN 0925-4692, 6/2013, Volume 21, Issue 3, pp. 201 - 232
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the... 
Prostaglandin | COX-2 | Dermatology | Diabetes, rhabdomyolysis | Rheumatology | COX-3 | Inflammation | Prostacyclin | MIF | Allergology | Analgesia | Cyclooxygenase, COX-1 | Paracetamol | Biomedicine | Immunology | Pain | Acetaminophen | Gastroenterology | Atherosclerosis | Resveratrol | Myeloperoxidase | Peroxidase | Thromboxane | Pharmacology/Toxicology | ACETYLSALICYLIC-ACID | INHIBITORY FACTOR MIF | ACETAMINOPHEN PARACETAMOL | RENAL-FUNCTION | IMMUNOLOGY | SPINAL PROSTAGLANDIN E-2 | CYCLOOXYGENASE-3 PUZZLE | TOXICOLOGY | ANALGESIC EFFICACY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | DOUBLE-BLIND | SELECTIVE INHIBITORS | Acetaminophen - adverse effects | Inflammation - pathology | Humans | Analgesics, Non-Narcotic - pharmacology | Cyclooxygenase 2 - drug effects | Analgesics, Non-Narcotic - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Acetaminophen - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Inflammation - drug therapy | Analgesics, Non-Narcotic - adverse effects | Cyclooxygenase 2 - metabolism | Cyclooxygenase 1 - drug effects | Acetaminophen - therapeutic use | Cyclooxygenase 1 - metabolism | Cyclooxygenase Inhibitors - adverse effects | Cyclooxygenase Inhibitors - therapeutic use | COX-2 inhibitors | Rheumatoid factor | Unsaturated fatty acids | Prostaglandins | Isoenzymes | Physiological aspects | Pharmacology | Health aspects | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2014, Volume 289, Issue 10, pp. 6799 - 6808
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 24, pp. 7349 - 7353
A series of novel 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-ones were synthesized. Some of them displayed potent inhibitory activities against... 
Cyclooxygenase | Amino/methylsufonylphenyl | Anti-inflammatory agents | Indolin-2-one derivatives | 5-Lipoxygenase | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | EVENTS | RAT | CHEMISTRY, ORGANIC | LEUKOTRIENES | TOXICITY | TENIDAP | METABOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | SELECTIVE INHIBITORS | Analgesics - pharmacology | Indoles - chemical synthesis | Male | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Benzylidene Compounds - chemistry | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Analgesics - chemical synthesis | Arachidonate 5-Lipoxygenase - chemistry | Cyclooxygenase 1 - chemistry | Indoles - pharmacology | Cyclooxygenase 2 Inhibitors - chemical synthesis | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Cyclooxygenase 2 - chemistry | Rats | Benzylidene Compounds - chemical synthesis | Cyclooxygenase Inhibitors - chemistry | Cyclooxygenase Inhibitors - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzylidene Compounds - pharmacology | Analgesics - chemistry | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Anti-Inflammatory Agents - chemical synthesis | Mice | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2013, Volume 56, Issue 11, pp. 4277 - 4299
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of... 
CROSS-TALK | CHEMISTRY, MEDICINAL | LOW-DOSE ASPIRIN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEALTHY-SUBJECTS | STRUCTURAL BASIS | ACTIVE-SITE | VESSEL WALL INTERACTIONS | THROMBOXANE BIOSYNTHESIS | PROSTANOID FORMATION | ARACHIDONIC-ACID | Fibrinolytic Agents - chemistry | Epoprostenol - metabolism | Furans - pharmacology | Humans | Structure-Activity Relationship | Cyclooxygenase 2 Inhibitors - chemistry | Isoxazoles - chemical synthesis | Platelet Aggregation Inhibitors - chemical synthesis | Furans - chemistry | Platelet Aggregation Inhibitors - pharmacology | Thromboxane A2 - antagonists & inhibitors | Female | Fibrinolytic Agents - chemical synthesis | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Thromboxane A2 - biosynthesis | Cyclooxygenase 2 Inhibitors - chemical synthesis | Cell Line | Cyclooxygenase 2 Inhibitors - pharmacology | Mice, Inbred C57BL | Cyclooxygenase Inhibitors - chemistry | Isoxazoles - chemistry | Cyclooxygenase Inhibitors - pharmacology | Isoxazoles - pharmacology | Fibrinolytic Agents - pharmacology | Animals | Blood Platelets - metabolism | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Platelet Aggregation Inhibitors - chemistry | Platelet-Rich Plasma | Mice | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Furans - chemical synthesis
Journal Article
Journal Article