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Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2010, Volume 425, Issue 1, pp. 137 - 148
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis-trans isomerases). In some... 
Ischaemia | Cyclosporin A (CsA) | Hippocampal neuron | Glutamate toxicity | Cyclophilin (CyP) | Necrosis | glutamate toxicity | PERMEABILITY TRANSITION PORE | OXIDATIVE STRESS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | NEURONAL CELL-DEATH | INORGANIC-PHOSPHATE | HIPPOCAMPAL-NEURONS | cyclosporin A (CsA) | hippocampal neuron | ischaemia | cyclophilin (CyP) | necrosis | ISCHEMIA-REPERFUSION | CASPASE ACTIVATION | GLUTAMATE EXCITOTOXICITY | Oxygen - pharmacology | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | Neurons - cytology | Cyclophilins - metabolism | Membrane Potential, Mitochondrial - drug effects | Oxygen - metabolism | Mitochondria, Liver - physiology | Cyclophilins - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Cytoprotection - drug effects | Cyclosporine - pharmacokinetics | Cyclophilin A - genetics | Molecular Structure | Neurons - metabolism | Neurons - drug effects | Animals, Newborn | Cyclophilin A - metabolism | Cell Survival - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Cyclophilins - genetics | Glucose - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Animals | Cyclosporine - chemistry | Cell Line, Tumor | Glucose - metabolism | Protein Binding | Calcineurin - metabolism | ESI–MS, electrospray ionization MS | NBA, Neurobasal A | THF, tetrahydrofuran | PyBOP, benzotriazol-1-yl-tris-pyrrolidinophosphonium hexafluorophosphate | CsA, cyclosporin A | DCM, dichloromethane | L-NAME, NG-nitro-L-arginine-methyl ester | DMEM, Dulbecco's minimal essential medium | R, ischaemia | NBQX, 2,3-dihydro-6-nitro-7-sulfamoylbenzoquinoxaline | HBSS, Hanks balanced salt solution | OGD, oxygen and glucose deprivation | PPIase, peptidylprolyl cis–trans isomerase | DMF, dimethylformamide | TMRE, tetramethylrhodamine ethyl ester | reperfusion | TPP+, triphenylphosphonium | PT, permeability transition | CyP, cyclophilin | FBS, fetal bovine serum | Fmoc, fluoren-9-ylmethoxycarbonyl | SMBz-CsA, [sarcosine-3(4-methylbenzoate)]-CsA | LDA, lithium diisopropylamide | mtCsA, mitochondrially targeted CsA | NMDA, N-methyl-D-aspartate | CyP-D+, cell line overexpressing CyP-D
Journal Article
Nature, ISSN 0028-0836, 12/2009, Volume 462, Issue 7273, pp. 669 - 673
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Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 512 - 516
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Journal of Virology, ISSN 0022-538X, 09/2012, Volume 86, Issue 18, pp. 9875 - 9887
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Journal of Hepatology, ISSN 0168-8278, 2014, Volume 61, Issue 5, pp. 1166 - 1174
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Journal Article