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FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3760 - 3772
Glial cell line-derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in... 
Rearranged during transfection | Parkinson disease | Drug addiction | Mouse model | Dopaminergic system | Glia cell line-derived neurotrophic factor | MAOA/MAOB | orphan nuclear receptor and transcription factor | cytoplasmic SH2 domain containing protein tyrosine phosphatase | Ras | RRF | COMT | PTEN-induced putative kinase 1 | SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | PI3K | sorting protein-related receptor with A-type repeats, a member of the mammal Vps10p domain receptor | subunits of the Ca2+-sensitive, voltage gated A-type K+ channel | SH2 domain containing transforming protein 1 | Nurr1 | proprotein convertases | protein kinase B, serine/threonine-specific protein kinase | calcium-calmodulin-dependent protein kinase II β isoform | FRS2 | phosphatase and tensin homolog | catecholamine | SHP-2 | growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | fibroblast growth factor receptor substrate 2, adaptor protein | monoamine oxidases A and B | carbonyl cyanide m-chlorophenyl hydrazone | ERK | brain derived neurotrophic factor | deglycase, oxidative stress sensor and redox-sensitive chaperone and protease | VTA | tyrosines, which can be phosphorylated | cAMP | extracellular-signal-regulated kinases, classical MAPKs | CaMKIIβ | Kv4.3 and KChip3 | GRB2/7/10 | Ser/Thr | SNP | endoplasmatic reticulum | nerve growth factor | monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | TGF-β | Akt, PKB | phospholipase γ cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) ppp3R1/ppp3CB, calcineurin subunits | PC5A, PC5B, and PC7 | EGR1 | proprotein convertase subtilisin/kexin type 6 | substantia nigra | phosphotyrosine-interaction domain | BDNF | adaptor protein of the PDZ-LIM family | γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | Tyr | FosB/ΔFosB | IRS1/2 | LIM | dopamine transporter | enhanced green fluorescent protein | GDNF | DAT | SOS | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | retro-rubal field | transforming growth factor β is a secreted protein that controls proliferation and cellular differentiation | MPTP | GTPase | hypoxia-inducible factor-1alpha | GDNF family of ligands | Ret | GPI | Shank3 | NCAM | Enigma | JNK | (rearranged during transfection) canonical GDNF receptor, a receptor tyrosine kinase | PTEN | 6-OHDA | DJ-1 | (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | SHC | NF-κB | (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | phosphotyrosine-binding domains | insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | Rac1 | GFRα | nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | catechol-O-methyltransferase | early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | serine and threonine, which can be phosphorylated | GDNF family receptor α | PKA | protein kinase A, a family of cAMP-dependent protein kinase | MAPK | NGF | SorLA | ventral tegmental area | son of sevenless, family of guanine nucleotide exchange factors that act on Ras | GABA | HIF-1a | Ras-related C3 botulinum toxin substrate 1 (Rho family), a small GTPase, like CDC42 | GAP1/2 | PTB | (Rat sarcoma) family of small membrane-associated GTPase | cycles between an active GTP-bound and an inactive GDP-bound state | glycogen synthase kinase 3β | Src | glia cell line-derived neurotrophic factor | PACE4, PCSK6 | pleckstrin homology domain | co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | c-Jun N-terminal kinases, members of the MAPK family of proteins | EGFP | cell division control protein 42 homolog, a plasma membrane-associated small GTPase of the Rho family | (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | CCCP | (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | DOK1/4/5/6 | (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | single-nucleotide polymorphism analysis | VPS10P | Rho | MEN2B | phosphatidylinositol-4,5-bisphosphate 3-kinase | 6-hydroxy-dopamine | mitogen-activated protein kinase, can phosphorylate serine, threonine, and tyrosine, e.g. p38MAPK | Cdc42 | docking proteins, have a PH and SH3 domain | GFLs | PDZ | vacuolar protein sorting 10 protein-domain receptors are type 1 transmembrane proteins | PLCγ | GTPase-activating proteins 1 and 2 | 3′,5′-cyclic adenosine monophosphate | neuronal cell adhesion molecule | TIEG | TGF-β-inducible early-response gene, a zinc finger transcription factor Vav2, adaptor protein and guanine nucleotide exchange factor for the Rho family of Ras-related GTPases | PINK1 | Raf | CoREST | multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | dopaminergic | glycosylphosphatidylinositol | FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | gsk3β | ENTERIC NERVOUS-SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUBSTANTIA-NIGRA | CELL BIOLOGY | MICE LACKING GDNF | C-RET | BIOPHYSICS | NEUROTROPHIC FACTOR PROMOTES | MULTIPLE ENDOCRINE NEOPLASIA | SURVIVAL IN-VIVO | RECEPTOR TYROSINE KINASE | CELL-LINE | EARLY-ONSET PARKINSONISM | Glial Cell Line-Derived Neurotrophic Factor - physiology | Parkinson Disease - pathology | Animals | Proto-Oncogene Proteins c-ret - physiology | Dopamine - physiology | Mesencephalon - metabolism | Humans | Dopaminergic Neurons - physiology | Parkinson Disease - metabolism | Synaptic Transmission | Mesencephalon - pathology | Physiological aspects | Neurons | Parkinson's disease
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2000, Volume 275, Issue 17, pp. 12848 - 12856
Interleukin-6 is involved in the regulation of many biological activities such as gene expression, cell proliferation, and differentiation. The control of the... 
CYTOPLASMIC DOMAIN | SH2 DOMAIN | STAT3 ACTIVATION | CELLS | DIFFERENTIAL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | RECEPTOR | PHASE RESPONSE FACTOR/STAT3 | KINASE JAK1 | PROTEIN-TYROSINE-PHOSPHATASE | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Interleukin-6 - antagonists & inhibitors | Membrane Glycoproteins - metabolism | Humans | Repressor Proteins | alpha-Macroglobulins - genetics | Suppressor of Cytokine Signaling 1 Protein | Immunoblotting | Protein Tyrosine Phosphatases - metabolism | Suppressor of Cytokine Signaling Proteins | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Protein Tyrosine Phosphatases - chemistry | Cell Nucleus - metabolism | Transfection | Tumor Cells, Cultured | Interleukin-6 - metabolism | Tyrosine - chemistry | Promoter Regions, Genetic | Proteins - physiology | Cytokine Receptor gp130 | Signal Transduction | Glutathione Transferase - metabolism | Intracellular Signaling Peptides and Proteins | Precipitin Tests | src Homology Domains | Suppressor of Cytokine Signaling 3 Protein | Blotting, Northern | Carrier Proteins - metabolism | Proteins - metabolism | alpha-Macroglobulins - antagonists & inhibitors | SH2 Domain-Containing Protein Tyrosine Phosphatases | Protein Binding | Transcription Factors | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | glycoprotein gp130
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2012, Volume 447, Issue 1, pp. 125 - 136
Phosphorylation of STAT3 (signal transducer and activator of transcription 3) is critical for its nuclear import and transcriptional activity. Although a... 
Signal transducer and activator of transcription 3 (STAT3) | Transcriptome analysis | Interleukin-6 (IL-6) | Nucleocytoplasmic trafficking | Transcription factor | Cytokine | cytokine | transcription factor | nucleocytoplasmic trafficking | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-CELLS | interleukin-6 (IL-6) | UNPHOSPHORYLATED STAT3 | STAT3 ISOFORMS | ACTIVATED STAT3 | PATHWAY | signal transducer and activator of transcription 3 (STAT3) | EPIDERMAL-GROWTH-FACTOR | transcriptome analysis | PROTEIN-TYROSINE-PHOSPHATASE | SIGNAL TRANSDUCER | Mutagenesis, Site-Directed | Alternative Splicing | Gene Expression - drug effects | Humans | Cells, Cultured | DNA Primers - genetics | STAT3 Transcription Factor - chemistry | Gene Knockout Techniques | src Homology Domains | Animals | Cell Nucleus - metabolism | Base Sequence | HEK293 Cells | STAT3 Transcription Factor - deficiency | Mice | Kinetics | Phosphorylation - drug effects | Cell Nucleus - drug effects | Cytokines - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine - chemistry | Amino Acid Substitution | ERt, substrate-binding portion of the oestrogen receptor | WT, wild-type | HEK, human embryonic kidney | VP16, viral protein 16 | Fc, cytoplasmic fluorescence | gp130, glycoprotein 130 | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | MEF, murine embryonic fibroblast | iSTAT3, inducible specific STAT3 spliceform | Fn, nuclear fluorescence | GO, gene ontology | FBS, fetal bovine serum | STAT3, signal transducer and activator of transcription 3 | OSM, oncostatin M | CLSM, confocal laser-scanning microscopy | DAPI, 4′,6-diamidino-2-phenylindole | SHP, SH2 domain-containing protein tyrosine phosphatase | JAK, Janus kinase | IL, interleukin | Fc, ratio of nuclear to cytoplasmic fluorescence | SH2, Src homology 2 | Hsp90, heat-shock protein of 90 kDa | MAPK, mitogen-activated protein kinase
Journal Article
Cell, ISSN 0092-8674, 1997, Volume 90, Issue 2, pp. 293 - 301
Two signaling molecules have been implicated in the modulation of immune receptor activation by inhibitory coreceptors: an inositol polyphosphate 5'-... 
CYTOPLASMIC DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYMPHOCYTES-B | CROSS-LINKING | FC-GAMMA-RIIB | CELL BIOLOGY | IMMUNOGLOBULIN-SUPERFAMILY | K CQ BIOCHEMISTRY & MOLECULAR BIOLOGY | B-CELL ACTIVATION | NEGATIVE SELECTION | K DR CELL BIOLOGY | CLASS-I MOLECULES | PROTEIN-TYROSINE-PHOSPHATASE | SELF-TOLERANCE | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Calcium - metabolism | Protein Tyrosine Phosphatases - metabolism | src Homology Domains - genetics | Oncogene Proteins - physiology | Receptors, IgG - metabolism | Antigens, CD - metabolism | Protein Tyrosine Phosphatases - immunology | Immediate-Early Proteins - metabolism | Protein Tyrosine Phosphatases - genetics | Phosphoric Monoester Hydrolases - immunology | Fura-2 | Proto-Oncogene Proteins | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Phosphoric Monoester Hydrolases - genetics | Cells, Cultured | Intracellular Signaling Peptides and Proteins | Proto-Oncogene Proteins c-bcr | Antibodies, Monoclonal | Monomeric GTP-Binding Proteins | B-Lymphocytes - chemistry | Animals | Chickens | SH2 Domain-Containing Protein Tyrosine Phosphatases | Signal Transduction - physiology | Mice | src Homology Domains - immunology | Apoptosis - physiology | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Tyrosine Kinases | Fluorescent Dyes | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | GTP-Binding Proteins - metabolism | Cell receptors | Phosphatases | Immune response | Research | Cell death
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 08/1999, Volume 19, Issue 8, pp. 5326 - 5338
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE | SH2 DOMAIN | CYTOPLASMIC DOMAIN | RESPONSE ELEMENT | GROWTH-FACTOR RECEPTOR | STAT3 ACTIVATION | COLONY-STIMULATING FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | TISSUE INHIBITOR | PHOSPHATIDYLINOSITOL 3'-KINASE | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 | Humans | Transcriptional Activation | Acute-Phase Reaction - genetics | Receptors, Interleukin-6 - drug effects | Trans-Activators - physiology | Protein-Tyrosine Kinases - physiology | Membrane Glycoproteins - physiology | Liver - drug effects | Interleukin-6 - physiology | Liver Neoplasms - pathology | Transcription, Genetic | Neoplasm Proteins - genetics | Mitogen-Activated Protein Kinases | DNA-Binding Proteins - physiology | Cytokine Receptor gp130 | Liver Neoplasms - genetics | Liver - metabolism | Rats | Janus Kinase 1 | Adaptor Proteins, Signal Transducing | Liver Neoplasms - metabolism | SH2 Domain-Containing Protein Tyrosine Phosphatases | Antigens, CD - physiology | Protein Processing, Post-Translational | Enzyme Activation | Acute-Phase Proteins - biosynthesis | Protein Tyrosine Phosphatase, Non-Receptor Type 6 | Carcinoma, Hepatocellular - metabolism | Protein Tyrosine Phosphatases - physiology | Phosphorylation | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Acute-Phase Proteins - genetics | Liver Neoplasms, Experimental - metabolism | Transfection | Carcinoma, Hepatocellular - genetics | Liver Neoplasms, Experimental - genetics | Liver Neoplasms, Experimental - pathology | Calcium-Calmodulin-Dependent Protein Kinases - physiology | Neoplasm Proteins - biosynthesis | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Receptors, Interleukin-6 - physiology | Animals | Proteins - metabolism | GRB2 Adaptor Protein | Carcinoma, Hepatocellular - pathology | Signal Transduction - physiology | STAT3 Transcription Factor | Mitogen-Activated Protein Kinase 1 | Mitogen-Activated Protein Kinase 3 | Cell Growth and Development
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/1998, Volume 335, Issue 3, pp. 557 - 565
Stimulation of the interleukin-6 (IL-6) signalling pathway occurs via the IL-6 receptor-glycoprotein 130 (IL-6R-gp130) receptor complex and results in the... 
SH2-CONTAINING PHOSPHOTYROSINE PHOSPHATASE | INSULIN-RECEPTOR | HUMAN HEPATOCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | SYP | EPIDERMAL GROWTH-FACTOR | CYTOPLASMIC REGION | ASSOCIATION | SH2 DOMAINS | BETA-RECEPTOR
Journal Article