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The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 2, pp. 402 - 412
Background Mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency (CID) also classified as autosomal recessive (AR) hyper-IgE...
Allergy and Immunology | Primary combined immunodeficiency | autosomal recessive hyper-IgE syndrome | signal transducer and activator of transcription 3 | Molluscum contagiosum | hyper-IgE syndrome | dedicator of cytokinesis 8 | SURVIVAL | BONE-MARROW-TRANSPLANTATION | STAT3 | GLYCOSYLATION | IMMUNOLOGY | ALLERGY | DOCK8 DEFICIENCY | DISORDER | MUTATIONS | STEM-CELL TRANSPLANTATION | IMMUNODEFICIENCY | Job Syndrome - genetics | Job Syndrome - mortality | Humans | Middle Aged | Child, Preschool | Male | Support Vector Machine | Virus Diseases - complications | Eosinophils - immunology | Immunoglobulin E - blood | CD4-Positive T-Lymphocytes - immunology | Bacterial Infections - genetics | Eosinophils - pathology | Virus Diseases - genetics | Child | Guanine Nucleotide Exchange Factors - deficiency | STAT3 Transcription Factor - genetics | Skin Diseases - mortality | Immunoglobulin M - genetics | Guanine Nucleotide Exchange Factors - genetics | Virus Diseases - immunology | Skin Diseases - immunology | Antigens, Viral - immunology | Phenotype | Skin Diseases - complications | Job Syndrome - complications | Adolescent | Survival Analysis | Virus Diseases - mortality | Mutation | STAT3 Transcription Factor - immunology | CD8-Positive T-Lymphocytes - immunology | Bacterial Infections - mortality | Job Syndrome - immunology | CD8-Positive T-Lymphocytes - pathology | Skin Diseases - genetics | Antigens, Bacterial - immunology | Infant | Antigens, Bacterial - blood | CD4-Positive T-Lymphocytes - pathology | Antigens, Viral - blood | Bacterial Infections - complications | Immunoglobulin E - genetics | Bacterial Infections - immunology | Adult | Female | Immunoglobulin M - blood | Guanine Nucleotide Exchange Factors - immunology | Lymphocyte Count | Genotype & phenotype | Immunoglobulins | Laboratories | Lymphocytes | Families & family life | Lymphomas | Viral infections | Deoxyribonucleic acid--DNA | Immunoglobulin M | Immunoglobulin E | CD8-Positive T-Lymphocytes | Life Sciences | Antigens, Viral | Bacterial Infections | Job Syndrome | CD4-Positive T-Lymphocytes | Virus Diseases | Skin Diseases | Antigens, Bacterial | Guanine Nucleotide Exchange Factors | STAT3 Transcription Factor | Eosinophils
Allergy and Immunology | Primary combined immunodeficiency | autosomal recessive hyper-IgE syndrome | signal transducer and activator of transcription 3 | Molluscum contagiosum | hyper-IgE syndrome | dedicator of cytokinesis 8 | SURVIVAL | BONE-MARROW-TRANSPLANTATION | STAT3 | GLYCOSYLATION | IMMUNOLOGY | ALLERGY | DOCK8 DEFICIENCY | DISORDER | MUTATIONS | STEM-CELL TRANSPLANTATION | IMMUNODEFICIENCY | Job Syndrome - genetics | Job Syndrome - mortality | Humans | Middle Aged | Child, Preschool | Male | Support Vector Machine | Virus Diseases - complications | Eosinophils - immunology | Immunoglobulin E - blood | CD4-Positive T-Lymphocytes - immunology | Bacterial Infections - genetics | Eosinophils - pathology | Virus Diseases - genetics | Child | Guanine Nucleotide Exchange Factors - deficiency | STAT3 Transcription Factor - genetics | Skin Diseases - mortality | Immunoglobulin M - genetics | Guanine Nucleotide Exchange Factors - genetics | Virus Diseases - immunology | Skin Diseases - immunology | Antigens, Viral - immunology | Phenotype | Skin Diseases - complications | Job Syndrome - complications | Adolescent | Survival Analysis | Virus Diseases - mortality | Mutation | STAT3 Transcription Factor - immunology | CD8-Positive T-Lymphocytes - immunology | Bacterial Infections - mortality | Job Syndrome - immunology | CD8-Positive T-Lymphocytes - pathology | Skin Diseases - genetics | Antigens, Bacterial - immunology | Infant | Antigens, Bacterial - blood | CD4-Positive T-Lymphocytes - pathology | Antigens, Viral - blood | Bacterial Infections - complications | Immunoglobulin E - genetics | Bacterial Infections - immunology | Adult | Female | Immunoglobulin M - blood | Guanine Nucleotide Exchange Factors - immunology | Lymphocyte Count | Genotype & phenotype | Immunoglobulins | Laboratories | Lymphocytes | Families & family life | Lymphomas | Viral infections | Deoxyribonucleic acid--DNA | Immunoglobulin M | Immunoglobulin E | CD8-Positive T-Lymphocytes | Life Sciences | Antigens, Viral | Bacterial Infections | Job Syndrome | CD4-Positive T-Lymphocytes | Virus Diseases | Skin Diseases | Antigens, Bacterial | Guanine Nucleotide Exchange Factors | STAT3 Transcription Factor | Eosinophils
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 11/2016, Volume 138, Issue 5, pp. 1384 - 1384
Background: The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal...
suppressor of cytokine signaling 3 | STAT3 MUTATIONS | INFECTIONS | PROTEIN | PHOSPHORYLATION | DOCK8 | PHENOTYPE | signal transducer and activator of transcription 3 | IMMUNOLOGY | IDENTIFICATION | hyper-IgE syndrome | dedicator of cytokinesis 8 | DEFICIENCY | guanine nucleotide exchange factor | ALLERGY | PATHWAY | Cell division cycle 42 | mucocutaneous candidiasis | T(H)17
suppressor of cytokine signaling 3 | STAT3 MUTATIONS | INFECTIONS | PROTEIN | PHOSPHORYLATION | DOCK8 | PHENOTYPE | signal transducer and activator of transcription 3 | IMMUNOLOGY | IDENTIFICATION | hyper-IgE syndrome | dedicator of cytokinesis 8 | DEFICIENCY | guanine nucleotide exchange factor | ALLERGY | PATHWAY | Cell division cycle 42 | mucocutaneous candidiasis | T(H)17
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 133, Issue 6, pp. 1667 - 1675
Background Autosomal recessive loss-of-function mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency characterized by atopy,...
Allergy and Immunology | Dedicator of cytokinesis 8 | reversion | somatic repair | recombination | intragenic single crossover | allergy | T cell | immunodeficiency | gene conversion | natural killer cell | T cell | SURVIVAL | HUMANS | IMMUNOLOGY | HYPER-IGE SYNDROME | KINETICS | DOCK8 DEFICIENCY | STEM-CELL TRANSPLANTATION | MOSAICISM | T-Lymphocyte Subsets - immunology | Guanine Nucleotide Exchange Factors - genetics | Humans | Child, Preschool | Genotype | Immunophenotyping | Phenotype | B-Lymphocyte Subsets - metabolism | T-Lymphocytes - metabolism | DNA Mutational Analysis | Guanine Nucleotide Exchange Factors - metabolism | Immunologic Deficiency Syndromes - mortality | T-Lymphocyte Subsets - metabolism | DNA Repair | Adolescent | Germ-Line Mutation | Immunologic Deficiency Syndromes - genetics | Killer Cells, Natural - immunology | B-Lymphocyte Subsets - immunology | T-Lymphocytes - immunology | Killer Cells, Natural - metabolism | Mutation | Immunologic Deficiency Syndromes - diagnosis | Child | Genetic aspects | Cells | Immunodeficiency | Food allergies | Disease | Cell division | Infections | Patients | Dermatitis | Proteins | Studies | Genotype & phenotype | Lymphocytes | Protein expression | Viral infections | Deoxyribonucleic acid--DNA | Immune system
Allergy and Immunology | Dedicator of cytokinesis 8 | reversion | somatic repair | recombination | intragenic single crossover | allergy | T cell | immunodeficiency | gene conversion | natural killer cell | T cell | SURVIVAL | HUMANS | IMMUNOLOGY | HYPER-IGE SYNDROME | KINETICS | DOCK8 DEFICIENCY | STEM-CELL TRANSPLANTATION | MOSAICISM | T-Lymphocyte Subsets - immunology | Guanine Nucleotide Exchange Factors - genetics | Humans | Child, Preschool | Genotype | Immunophenotyping | Phenotype | B-Lymphocyte Subsets - metabolism | T-Lymphocytes - metabolism | DNA Mutational Analysis | Guanine Nucleotide Exchange Factors - metabolism | Immunologic Deficiency Syndromes - mortality | T-Lymphocyte Subsets - metabolism | DNA Repair | Adolescent | Germ-Line Mutation | Immunologic Deficiency Syndromes - genetics | Killer Cells, Natural - immunology | B-Lymphocyte Subsets - immunology | T-Lymphocytes - immunology | Killer Cells, Natural - metabolism | Mutation | Immunologic Deficiency Syndromes - diagnosis | Child | Genetic aspects | Cells | Immunodeficiency | Food allergies | Disease | Cell division | Infections | Patients | Dermatitis | Proteins | Studies | Genotype & phenotype | Lymphocytes | Protein expression | Viral infections | Deoxyribonucleic acid--DNA | Immune system
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 11/2016, Volume 138, Issue 5, pp. 1384 - 1394.e2
The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES...
suppressor of cytokine signaling 3 | guanine nucleotide exchange factor | Cell division cycle 42 | mucocutaneous candidiasis | signal transducer and activator of transcription 3 | hyper-IgE syndrome | TH17 | dedicator of cytokinesis 8 | Proteins | Phosphorylation | Bacterial infections | Microscopy | Liver | Cell division | Infections | Mutation | Patients | Crystal structure
suppressor of cytokine signaling 3 | guanine nucleotide exchange factor | Cell division cycle 42 | mucocutaneous candidiasis | signal transducer and activator of transcription 3 | hyper-IgE syndrome | TH17 | dedicator of cytokinesis 8 | Proteins | Phosphorylation | Bacterial infections | Microscopy | Liver | Cell division | Infections | Mutation | Patients | Crystal structure
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 6, pp. 1365 - 1374
Background Dedicator of cytokinesis 8 (DOCK8) deficiency is typified by recurrent infections, increased serum IgE levels, eosinophilia, and a high incidence of...
Allergy and Immunology | Dedicator of cytokinesis 8 | regulatory T cells | B-cell tolerance | autoimmunity | BAFF | PROFILES | LYMPHOCYTE | IMMUNOLOGY | TRANSPLANTATION | REMOVAL | ALLERGY | EXPANSION | DOCK8 DEFICIENCY | LIGAND | AUTOANTIBODY PRODUCTION | EXPRESSION | Autoantibodies - blood | Humans | Child, Preschool | Infant | Male | T-Lymphocytes, Regulatory - immunology | B-Lymphocytes - immunology | Immune Tolerance - immunology | Adolescent | Guanine Nucleotide Exchange Factors - immunology | Lymphocyte Count | Female | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Immunoglobulin E | T cells | Autoimmunity | Analysis | Antigens | Mutation | Autoimmune diseases | Kinases | Immune system
Allergy and Immunology | Dedicator of cytokinesis 8 | regulatory T cells | B-cell tolerance | autoimmunity | BAFF | PROFILES | LYMPHOCYTE | IMMUNOLOGY | TRANSPLANTATION | REMOVAL | ALLERGY | EXPANSION | DOCK8 DEFICIENCY | LIGAND | AUTOANTIBODY PRODUCTION | EXPRESSION | Autoantibodies - blood | Humans | Child, Preschool | Infant | Male | T-Lymphocytes, Regulatory - immunology | B-Lymphocytes - immunology | Immune Tolerance - immunology | Adolescent | Guanine Nucleotide Exchange Factors - immunology | Lymphocyte Count | Female | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Immunoglobulin E | T cells | Autoimmunity | Analysis | Antigens | Mutation | Autoimmune diseases | Kinases | Immune system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 3, pp. 852 - 859.e3
Background Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). Reports of outcomes are...
Allergy and Immunology | hematopoietic stem cell transplantation | dedicator of cytokinesis 8 deficiency | mixed chimerism | conditioning | Primary immunodeficiency | HYPER-IGE SYNDROME | SURVIVAL | ALLERGY | DOCK8 DEFICIENCY | PHENOTYPE | MUTATIONS | IMMUNOLOGY | conditioning mixed chimerism | Humans | Child, Preschool | Hematopoietic Stem Cell Transplantation | Male | Treatment Outcome | B-Lymphocytes - immunology | Leukocytes, Mononuclear - immunology | Female | T-Lymphocytes - immunology | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Cytokines - immunology | Patient outcomes | Children's hospitals | Immunodeficiency | Stem cells | Transplantation | Children | Research institutes | Health aspects | Hematopoietic stem cells | Diseases | Analysis | Food allergies | Flow cytometry | Transplants & implants | Cytokines | Laboratories | Mortality | Eczema | Infections | Patients | Viral infections | Age | DOCK8 deficiency
Allergy and Immunology | hematopoietic stem cell transplantation | dedicator of cytokinesis 8 deficiency | mixed chimerism | conditioning | Primary immunodeficiency | HYPER-IGE SYNDROME | SURVIVAL | ALLERGY | DOCK8 DEFICIENCY | PHENOTYPE | MUTATIONS | IMMUNOLOGY | conditioning mixed chimerism | Humans | Child, Preschool | Hematopoietic Stem Cell Transplantation | Male | Treatment Outcome | B-Lymphocytes - immunology | Leukocytes, Mononuclear - immunology | Female | T-Lymphocytes - immunology | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Cytokines - immunology | Patient outcomes | Children's hospitals | Immunodeficiency | Stem cells | Transplantation | Children | Research institutes | Health aspects | Hematopoietic stem cells | Diseases | Analysis | Food allergies | Flow cytometry | Transplants & implants | Cytokines | Laboratories | Mortality | Eczema | Infections | Patients | Viral infections | Age | DOCK8 deficiency
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 03/2017, Volume 139, Issue 3, pp. 933 - 949
Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency caused by autosomal recessive loss-of-function mutations in . This disorder is...
Dedicator of cytokinesis 8 | atopic disease | CD4+ T-cell differentiation | TH2 skewing | allergy | chronic mucocutaneous candidiasis | viral immunity | CD4 | 2 skewing | T-cell differentiation | Food allergies | Antigens | Cytomegalovirus | Disease | Transplants & implants | Cytokines | Bias | T cell receptors | Infections | Asthma | Defects | Lymphocytes | Herpes viruses | Eczema | Stem cells | Lymphomas | Mutation | Viral infections | Food
Dedicator of cytokinesis 8 | atopic disease | CD4+ T-cell differentiation | TH2 skewing | allergy | chronic mucocutaneous candidiasis | viral immunity | CD4 | 2 skewing | T-cell differentiation | Food allergies | Antigens | Cytomegalovirus | Disease | Transplants & implants | Cytokines | Bias | T cell receptors | Infections | Asthma | Defects | Lymphocytes | Herpes viruses | Eczema | Stem cells | Lymphomas | Mutation | Viral infections | Food
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 2017, Volume 23, Issue 6, pp. 980 - 990
Highlights • Allogeneic transplantation for dedicator-of-cytokinesis 8 (DOCK8) deficiency using haploidentical donors with post-transplantation...
Hematology, Oncology and Palliative Medicine | Immune reconstitution | Dedicator-of-cytokinesis-8 (DOCK8) deficiency | Haploidentical transplantation | BONE-MARROW-TRANSPLANTATION | CHRONIC GRANULOMATOUS-DISEASE | ALPHA-BETA | IMMUNOLOGY | VERSUS-HOST-DISEASE | NONMALIGNANT DISORDERS | TRANSPLANTATION | HYPER-IGE SYNDROME | COMBINED IMMUNODEFICIENCY | DOCK8 DEFICIENCY | HEMATOLOGY | HEMATOLOGIC MALIGNANCIES | BLOOD | Immunologic Deficiency Syndromes - therapy | Humans | Survival Rate | Treatment Outcome | Hematopoietic Stem Cell Transplantation - mortality | Transplantation, Haploidentical - mortality | Cyclophosphamide - therapeutic use | Transplantation, Haploidentical - methods | Immunologic Deficiency Syndromes - mortality | Graft vs Host Disease - prevention & control | Hematopoietic Stem Cell Transplantation - methods | Transplantation Conditioning - methods | Guanine Nucleotide Exchange Factors - deficiency | Cyclophosphamide | Transplantation | Hematopoietic stem cells | Stem cells | Usage | Bone marrow | Mycophenolate mofetil | Dedicator-of-cytokinesis-8 | (DOCK8) deficiency
Hematology, Oncology and Palliative Medicine | Immune reconstitution | Dedicator-of-cytokinesis-8 (DOCK8) deficiency | Haploidentical transplantation | BONE-MARROW-TRANSPLANTATION | CHRONIC GRANULOMATOUS-DISEASE | ALPHA-BETA | IMMUNOLOGY | VERSUS-HOST-DISEASE | NONMALIGNANT DISORDERS | TRANSPLANTATION | HYPER-IGE SYNDROME | COMBINED IMMUNODEFICIENCY | DOCK8 DEFICIENCY | HEMATOLOGY | HEMATOLOGIC MALIGNANCIES | BLOOD | Immunologic Deficiency Syndromes - therapy | Humans | Survival Rate | Treatment Outcome | Hematopoietic Stem Cell Transplantation - mortality | Transplantation, Haploidentical - mortality | Cyclophosphamide - therapeutic use | Transplantation, Haploidentical - methods | Immunologic Deficiency Syndromes - mortality | Graft vs Host Disease - prevention & control | Hematopoietic Stem Cell Transplantation - methods | Transplantation Conditioning - methods | Guanine Nucleotide Exchange Factors - deficiency | Cyclophosphamide | Transplantation | Hematopoietic stem cells | Stem cells | Usage | Bone marrow | Mycophenolate mofetil | Dedicator-of-cytokinesis-8 | (DOCK8) deficiency
Journal Article
Microchimica Acta, ISSN 0026-3672, 12/2019, Volume 186, Issue 12, pp. 1 - 9
The autosomal recessive-hyper immunoglobulin E syndromes (AR-HIES) are inherited inborn primary immunodeficiency disorders caused mainly by mutations in the...
Chemistry | Analytical Chemistry | Microengineering | Characterization and Evaluation of Materials | Voltammetry | Dedicator of cytokinesis 8 (DOCK8) | Electrochemical SELEX | Nanochemistry | Aptasensor | Nanotechnology | Electrochemical impedance spectroscopy
Chemistry | Analytical Chemistry | Microengineering | Characterization and Evaluation of Materials | Voltammetry | Dedicator of cytokinesis 8 (DOCK8) | Electrochemical SELEX | Nanochemistry | Aptasensor | Nanotechnology | Electrochemical impedance spectroscopy
Journal Article
European Journal of Haematology, ISSN 0902-4441, 10/2013, Volume 91, Issue 4, pp. 369 - 375
Dedicator of cytokinesis 8 (DOCK8) deficiency is an innate error of adaptive immunity characterized by recurrent infections with viruses, bacteria and fungi,...
multiplex ligation‐dependent probe amplification | novel mutations | dedicator of cytokinesis 8 | Dedicator of cytokinesis 8 | Novel mutations | Multiplex ligation-dependent probe amplification | SURVIVAL | INFECTIONS | MLPA | B-CELL ACTIVATION | DOCK8 DEFICIENCY | HYPER-IGE SYNDROMES | HEMATOLOGY | IMMUNODEFICIENCY | multiplex ligation-dependent probe amplification | MANIFESTATIONS | Adaptive Immunity | Immunologic Deficiency Syndromes - pathology | Sequence Deletion | Guanine Nucleotide Exchange Factors - genetics | Multiplex Polymerase Chain Reaction - methods | Exons | Humans | Molecular Sequence Data | Leukocytes, Mononuclear - pathology | Pedigree | Base Sequence | Leukocytes, Mononuclear - immunology | Guanine Nucleotide Exchange Factors - immunology | Immunologic Deficiency Syndromes - genetics | Female | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Siblings | Genetic research | Immunoglobulin E | Genetic aspects | Health aspects | Analysis | Investigations | Cytokinesis
multiplex ligation‐dependent probe amplification | novel mutations | dedicator of cytokinesis 8 | Dedicator of cytokinesis 8 | Novel mutations | Multiplex ligation-dependent probe amplification | SURVIVAL | INFECTIONS | MLPA | B-CELL ACTIVATION | DOCK8 DEFICIENCY | HYPER-IGE SYNDROMES | HEMATOLOGY | IMMUNODEFICIENCY | multiplex ligation-dependent probe amplification | MANIFESTATIONS | Adaptive Immunity | Immunologic Deficiency Syndromes - pathology | Sequence Deletion | Guanine Nucleotide Exchange Factors - genetics | Multiplex Polymerase Chain Reaction - methods | Exons | Humans | Molecular Sequence Data | Leukocytes, Mononuclear - pathology | Pedigree | Base Sequence | Leukocytes, Mononuclear - immunology | Guanine Nucleotide Exchange Factors - immunology | Immunologic Deficiency Syndromes - genetics | Female | Immunologic Deficiency Syndromes - immunology | Child | Guanine Nucleotide Exchange Factors - deficiency | Siblings | Genetic research | Immunoglobulin E | Genetic aspects | Health aspects | Analysis | Investigations | Cytokinesis
Journal Article
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 03/2017, Volume 139, Issue 3, pp. 933 - 949
Background: Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency caused by autosomal recessive loss-of- function mutations in DOCK8....
Dedicator of cytokinesis 8 | BONE-MARROW-TRANSPLANTATION | allergy | LINKED LYMPHOPROLIFERATIVE DISEASE | HUMAN B-CELLS | IMMUNOLOGY | chronic mucocutaneous candidiasis | viral immunity | HYPER-IGE SYNDROME | ATOPIC-DERMATITIS | atopic disease | MEMORY | T(H)2 skewing | CD4(+) T-cell differentiation | DOCK8 DEFICIENCY | MUTATIONS | TH17 CELLS
Dedicator of cytokinesis 8 | BONE-MARROW-TRANSPLANTATION | allergy | LINKED LYMPHOPROLIFERATIVE DISEASE | HUMAN B-CELLS | IMMUNOLOGY | chronic mucocutaneous candidiasis | viral immunity | HYPER-IGE SYNDROME | ATOPIC-DERMATITIS | atopic disease | MEMORY | T(H)2 skewing | CD4(+) T-cell differentiation | DOCK8 DEFICIENCY | MUTATIONS | TH17 CELLS
Journal Article
European Journal of Immunology, ISSN 0014-2980, 05/2019, Volume 49, Issue 5, pp. 770 - 781
Mutation of Dedicator of cytokinesis 8 (DOCK8) has previously been reported to provide resistance to the Th17 cell dependent EAE in mice. Contrary to...
migration | CD4 T cells | experimental autoimmune encephalomyelitis | dedicator of Cytokinesis 8 | Th17 cells | SURVIVAL | RECRUITMENT | ACTIVATION | ROR-GAMMA-T | IMMUNOLOGY | DEDICATOR | T(H)17 | ALPHA-4 INTEGRIN | T-H-17 CELLS | EXPRESSION | T cells | Cell differentiation | Analysis | Bias | Helper cells | Differentiation (biology) | Lymphocytes T | Cytokinesis | Experimental allergic encephalomyelitis | CCR6 protein | Disease resistance | Elevation | Lymphocytes | Mice | Infiltration | Mutation | Autoimmune diseases | Cell migration
migration | CD4 T cells | experimental autoimmune encephalomyelitis | dedicator of Cytokinesis 8 | Th17 cells | SURVIVAL | RECRUITMENT | ACTIVATION | ROR-GAMMA-T | IMMUNOLOGY | DEDICATOR | T(H)17 | ALPHA-4 INTEGRIN | T-H-17 CELLS | EXPRESSION | T cells | Cell differentiation | Analysis | Bias | Helper cells | Differentiation (biology) | Lymphocytes T | Cytokinesis | Experimental allergic encephalomyelitis | CCR6 protein | Disease resistance | Elevation | Lymphocytes | Mice | Infiltration | Mutation | Autoimmune diseases | Cell migration
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 12/2014, Volume 134, Issue 6, pp. 1365 - 1374
Journal Article
Dermatologic Clinics, ISSN 0733-8635, 01/2017, Volume 35, Issue 1, pp. 11 - 19
DOCK8 deficiency is an autosomal recessive combined immunodeficiency disease associated with elevated IgE, atopy, recurrent sinopulmonary and cutaneous viral...
Dedicator of cytokinesis 8 | Malignancy | Cutaneous viral infection | Atopic dermatitis | Dedicator of cytokinesis 2 | Immunodeficiency | PHENOTYPE | IMMUNE-DEFICIENCY | IDENTIFICATION | DERMATOLOGY | HYPER-IGE SYNDROME | ATOPIC-DERMATITIS | LUNG-CANCER | DOCK8-DEFICIENT PATIENTS | MUTATIONS | STEM-CELL TRANSPLANTATION | HOMOZYGOUS DELETIONS | Lymphoma, T-Cell, Cutaneous - virology | Recurrence | Skin Diseases, Bacterial - immunology | Lymphoma, T-Cell, Cutaneous - immunology | Carcinoma, Squamous Cell - virology | Germinal Center - immunology | Humans | Warts - immunology | Immunoglobulin E - immunology | Sinusitis - immunology | Dermatitis, Atopic - immunology | Killer Cells, Natural - immunology | Papillomavirus Infections - immunology | Pneumonia - immunology | Immunologic Deficiency Syndromes - immunology | Guanine Nucleotide Exchange Factors - deficiency | Guanine Nucleotide Exchange Factors - genetics | Skin Neoplasms - immunology | Epstein-Barr Virus Infections - immunology | Lymphoma - immunology | Cellulitis - immunology | Carcinoma, Squamous Cell - immunology | Skin Diseases, Viral - immunology | Animals | B-Lymphocytes - immunology | Skin Neoplasms - virology | Guanine Nucleotide Exchange Factors - immunology | Immunologic Deficiency Syndromes - genetics | T-Lymphocytes - immunology | Mice | Lymphoma - virology
Dedicator of cytokinesis 8 | Malignancy | Cutaneous viral infection | Atopic dermatitis | Dedicator of cytokinesis 2 | Immunodeficiency | PHENOTYPE | IMMUNE-DEFICIENCY | IDENTIFICATION | DERMATOLOGY | HYPER-IGE SYNDROME | ATOPIC-DERMATITIS | LUNG-CANCER | DOCK8-DEFICIENT PATIENTS | MUTATIONS | STEM-CELL TRANSPLANTATION | HOMOZYGOUS DELETIONS | Lymphoma, T-Cell, Cutaneous - virology | Recurrence | Skin Diseases, Bacterial - immunology | Lymphoma, T-Cell, Cutaneous - immunology | Carcinoma, Squamous Cell - virology | Germinal Center - immunology | Humans | Warts - immunology | Immunoglobulin E - immunology | Sinusitis - immunology | Dermatitis, Atopic - immunology | Killer Cells, Natural - immunology | Papillomavirus Infections - immunology | Pneumonia - immunology | Immunologic Deficiency Syndromes - immunology | Guanine Nucleotide Exchange Factors - deficiency | Guanine Nucleotide Exchange Factors - genetics | Skin Neoplasms - immunology | Epstein-Barr Virus Infections - immunology | Lymphoma - immunology | Cellulitis - immunology | Carcinoma, Squamous Cell - immunology | Skin Diseases, Viral - immunology | Animals | B-Lymphocytes - immunology | Skin Neoplasms - virology | Guanine Nucleotide Exchange Factors - immunology | Immunologic Deficiency Syndromes - genetics | T-Lymphocytes - immunology | Mice | Lymphoma - virology
Journal Article
Electroanalysis, ISSN 1040-0397, 09/2018, Volume 30, Issue 9, pp. 2021 - 2027
Hyper Immunoglobulin E syndrome (HIES) is a rare inherited inborn error of primary immunodeficiency. HIES is characterized by high levels of serum...
impedance | biosensor | Immunodeficiency | Dedicator of cytokinesis 8, signal transducer and activator of transcription 3 | Dedicator of cytokinesis 8 | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | IGE SYNDROME | ELECTROCHEMICAL BIOSENSORS | DISEASE | signal transducer and activator of transcription 3 | MUTATIONS | DEFICIENCY | Proteins |
impedance | biosensor | Immunodeficiency | Dedicator of cytokinesis 8, signal transducer and activator of transcription 3 | Dedicator of cytokinesis 8 | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | IGE SYNDROME | ELECTROCHEMICAL BIOSENSORS | DISEASE | signal transducer and activator of transcription 3 | MUTATIONS | DEFICIENCY | Proteins |