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bradykinin (56) 56
des-arg (35) 35
animals (33) 33
bradykinin - analogs & derivatives (30) 30
pharmacology & pharmacy (30) 30
bradykinin - pharmacology (29) 29
male (24) 24
des-arg-bradykinin (23) 23
rats (18) 18
bradykinin receptor antagonists (14) 14
des-arg9-bradykinin (14) 14
dose-response relationship, drug (14) 14
kinins (14) 14
leu (14) 14
in vitro techniques (13) 13
receptor (13) 13
antagonists (12) 12
hoe 140 (12) 12
inflammation (12) 12
receptor, bradykinin b1 (12) 12
responses (12) 12
pharmacology (11) 11
biochemistry & molecular biology (10) 10
invitro (10) 10
kinin receptors (10) 10
des-arg 9-bradykinin (9) 9
female (9) 9
hoe-140 (9) 9
nitric oxide (9) 9
receptors, bradykinin - physiology (9) 9
bk (8) 8
indomethacin - pharmacology (8) 8
induction (8) 8
bradykinin b (7) 7
expression (7) 7
physiology (7) 7
rabbit (7) 7
rat (7) 7
rats, wistar (7) 7
receptor, bradykinin b2 (7) 7
analysis of variance (6) 6
bradykinin receptor (6) 6
mice (6) 6
nitric-oxide (6) 6
rats, sprague-dawley (6) 6
receptors, bradykinin - agonists (6) 6
receptors, bradykinin - metabolism (6) 6
blood pressure - drug effects (5) 5
bradykinin b-1 receptor (5) 5
des‐arg9‐bradykinin (5) 5
endothelium (5) 5
hyperalgesia (5) 5
k tu pharmacology & pharmacy (5) 5
kallidin - analogs & derivatives (5) 5
kallidin - pharmacology (5) 5
papers (5) 5
peripheral vascular disease (5) 5
receptor induction (5) 5
receptors (5) 5
time factors (5) 5
vasodilation (5) 5
amino acid sequence (4) 4
b1 receptor (4) 4
binding (4) 4
bradykinin - administration & dosage (4) 4
bradykinin b 1 receptor (4) 4
bradykinin receptors (4) 4
cardiac & cardiovascular systems (4) 4
chloride secretion (4) 4
cloning (4) 4
dogs (4) 4
expression cloning (4) 4
humans (4) 4
invivo (4) 4
kallidin (4) 4
lipopolysaccharides - pharmacology (4) 4
mechanisms (4) 4
molecular sequence data (4) 4
muscle relaxation - drug effects (4) 4
pharmacological characterization (4) 4
potent (4) 4
relaxation (4) 4
smooth-muscle (4) 4
acetylcholine - pharmacology (3) 3
angiotensin-converting enzyme inhibitors - pharmacology (3) 3
anti-inflammatory agents, non-steroidal - pharmacology (3) 3
aorta (3) 3
arginine - analogs & derivatives (3) 3
arginine - pharmacology (3) 3
arteries (3) 3
arthritis (3) 3
b (3) 3
b-1 receptor (3) 3
b-1 receptors (3) 3
bradykinin - metabolism (3) 3
carrageenan - pharmacology (3) 3
des-arg-kinins (3) 3
dexamethasone - pharmacology (3) 3
dinoprostone - pharmacology (3) 3
drug interactions (3) 3
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Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/1999, Volume 126, Issue 3, pp. 649 - 656
Journal Article
Journal of Neuroscience Methods, ISSN 0165-0270, 2008, Volume 168, Issue 1, pp. 76 - 87
The discovery of novel analgesic compounds that target some receptors can be challenging due to species differences in ligand pharmacology. If a putative... 
HOE 140 | B 1 | B 2 | NSAID | Bradykinin | Opioid | Morphine | Electrovonfrey | [des-Arg 10,Leu 9]-kallidin | Indomethacin | Carrageenan | des-Arg | Leu | kallidin | RAT | RECOGNITION | SPECIES-SELECTIVITY | PHARMACOLOGICAL CHARACTERIZATION | opioid | B-2 | BIOCHEMICAL RESEARCH METHODS | MODEL | FENTANYL ANTINOCICEPTION | NEUROSCIENCES | RECEPTOR ANTAGONIST | morphine | indomethacin | Electrovonfrey (R) | carrageenan | [des-Arg,Leu9]-kallidin | bradykinin B-1 | NONPEPTIDE | BINDING | Bradykinin - analogs & derivatives | Inflammation - chemically induced | Pain Measurement - instrumentation | Hydrocarbons, Fluorinated - blood | Indomethacin - administration & dosage | Hyperalgesia - pathology | Dose-Response Relationship, Drug | Inflammation - complications | Drug Interactions | Pain - complications | Time Factors | Reaction Time - drug effects | Kallidin - analogs & derivatives | Pain - etiology | Pain Threshold - drug effects | Metacarpus - physiopathology | Spectrum Analysis | Kallidin - administration & dosage | Rabbits | Metacarpus - drug effects | Hyperalgesia - prevention & control | Pain Measurement - methods | Animals | Analysis of Variance | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Hyperalgesia - etiology | Ethers - blood | Bradykinin - administration & dosage | Measurement | Analysis | Methods
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 02/2000, Volume 278, Issue 2, pp. 367 - 372
Our previous ex vivo and in vivo studies reported that expression of the recombinant endothelial nitric oxide (NO) synthase (eNOS) gene in adventitial... 
Des-Arg | bradykinin | Hoe-140 | Gene transfer | Leu
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 04/1996, Volume 117, Issue 8, pp. 1619 - 1624
1 Various bradykinin derivatives, acting preferentially at B1 or B2 receptors, were tested in the isolated longitudinal smooth muscle of rat ileum. Experiments... 
Kinins | [des‐Arg9]‐BK | bradykinin B1 receptor | [des‐Arg10]‐Hoe 140 | [Leu8, des‐Arg9]‐BK | (rat) ileum | Hoe 140 | receptor | Bradykinin B | des-Arg | BK | Leu
Journal Article
Pain, ISSN 0304-3959, 1996, Volume 66, Issue 1, pp. 99 - 103
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 02/1993, Volume 108, Issue 2, pp. 318 - 322
1 We studied the role of bradykinin (BK) and its active metabolite Des‐Arg9‐BK on noradrenaline release in association with the incidence of ventricular... 
Hoe 140 | arrhythmias | Lys [Leu8] Des‐Arg9‐BK | bradykinin | Des‐Arg9‐BK | noradrenaline | Myocardial ischaemia‐reperfusion | Des-Arg | Des‐Arg | Bradykinin | Myocardial ischaemia-reperfusion | BK | Lys [Leu | Noradrenaline | Arrhythmias
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/1995, Volume 116, Issue 5, pp. 2473 - 2481
1 Rings of bovine left anterior descending coronary artery (LAD) were contracted with the thromboxane A2‐mimetic, U46619 (1–30 nM), to approximately 40% of... 
des‐Arg9‐bradykinin | cycloheximide | endothelium | actinomycin D | bovine coronary artery | nitric oxide | Bradykinin | Hoe‐140 | des‐Arg9‐[Leu8]‐bradykinin | B1, B2 kinin receptors | Actinomycin D | B | des-Arg | des‐Arg | Endothelium | kinin receptors | Cycloheximide | Hoe-140 | Nitric oxide | Bovine coronary artery | Leu
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/1997, Volume 121, Issue 3, pp. 526 - 530
Journal Article
BRITISH JOURNAL OF PHARMACOLOGY, ISSN 0007-1188, 02/1999, Volume 126, Issue 3, pp. 649 - 656
1 The effects of BK agonists and antagonists, and other hyperalgesic/antihyperalgesic drugs were measured (3 h after injection of hyperalgesic drugs) in a... 
inflammatory hyperalgesia | THERMAL HYPERALGESIA | RAT | INTERLEUKIN-1-BETA | bradykinin | MECHANISMS | interleukin-8 | SENSORY NEURONS | [des-Arg(9,) Leu]BK | prostaglandin E-2 | NERVE GROWTH-FACTOR | PAIN | PHARMACOLOGY & PHARMACY | [des-Arg]BK | ANTAGONISTS | tumour necrosis factor alpha | ASPIRIN-LIKE DRUGS
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 1997, Volume 321, Issue 1, pp. 33 - 38
Journal Article
Journal Article
Pain, ISSN 0304-3959, 1996, Volume 66, Issue 1, pp. 99 - 103
Research has documented the differential role of bradykinin (BK) B 1 and B 2 receptors in the mediation of inflammatory nociception and this research suggests... 
Place preference | HOE 140 | Des-Arg 9,(Leu 8)-BK | Antinociception | Adjuvant inflammation | Formalin test | STIMULATION | antinociception | CHRONIC PAIN | MORPHINE | adjuvant inflammation | MODEL | NEUROSCIENCES | CLINICAL NEUROLOGY | Des-Arg,(Leu)-BK | place preference | REINFORCEMENT | formalin test
Journal Article