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1. Full Text The Desmoplastic Reaction Surrounding Hepatic Colorectal Adenocarcinoma Metastases Aids Tumor Growth and Survival via αv Integrin Ligation
by John A. Conti and Timothy J. Kendall and Adrian Bateman and Thomas A. Armstrong and Andrew Papa-Adams and Qian Xu and Graham Packham and John N. Primrose and R. Christopher Benyon and John P. Iredale
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 20, pp. 6405 - 6413
Purpose: The treatment of metastatic colorectal carcinoma represents a major clinical challenge. We investigated the hypothesis that the desmoplastic reaction... 
hepatic metastasis | desmoplasia | integrins
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2. Full Text Periorbital desmoplastic squamous cell carcinoma
by Botha, Verona E and Chow, Kent T. K and Salmon, Paul J. M and El-Khayat, Rami H and Sun, Michelle T and Selva, Dinesh and Ng, Stephen G. J
Orbit, ISSN 0167-6830, 05/2019, Volume 38, Issue 3, pp. 240 - 243
Desmoplasia is the formation of a dense collagenous stroma around a neoplasm. It occurs in a variety of malignancies including squamous cell carcinoma (SCC).... 
Desmoplasia | malignancy | periorbital cancer | squamous cell carcinoma
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3. Full Text SPARC expression in desmoplastic and non desmoplastic pancreatic carcinoma and cholangiocarcinoma
by Khetan, Khusbu and Baloda, Vandana and Sahoo, Ranjit K and Vishnubhathla, Sreenivas and Yadav, Rajni and Saraya, Anoop and Sharma, Atul and Gupta, Siddhartha Datta and Das, Prasenjit
Pathology - Research and Practice, ISSN 0344-0338, 12/2019, Volume 215, Issue 12, p. 152685
The pancreatobiliary carcinomas are characterized by presence of desmoplastic stroma. Overexpression of secreted protein acid and rich in cysteine (SPARC), a... 
Stromal desmoplasia | Pancreatic adenocarcinoma | SPARC | Pancreatobiliary carcinoma | Cholangiocarcinoma
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4. Full Text Tumor reactive stroma in cholangiocarcinoma:The fuel behind cancer aggressiveness
by Simone Brivio Massimiliano Cadamuro Mario Strazzabosco Luca Fabris
世界肝病学杂志：英文版（电子版）, ISSN 1948-5182, 2017, Volume 9, Issue 9, pp. 455 - 468
Cholangiocarcinoma(CCA) is a highly aggressive epithelial malignancy still carrying a dismal prognosis, owing to early lymph node metastatic dissemination and... 
Inflammation | Tumor-associated macrophage | Tumor microenvironment | Desmoplasia; cancer-associated fibroblast | Lymphatic endothelial cell | Mesenchymal stem cellExtracellular matrix | Mesenchymal stem cell | Cancer-associated fibroblast | Desmoplasia | Extracellular matrix
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5. Full Text The pancreas cancer microenvironment
by Feig, Christine and Gopinathan, Aarthi and Neesse, Albrecht and Chan, Derek S and Cook, Natalie and Tuveson, David A
Clinical Cancer Research, ISSN 1078-0432, 08/2012, Volume 18, Issue 16, pp. 4266 - 4276
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in more than 250,000 deaths per year worldwide. Despite extensive efforts,... 
PHASE-III TRIAL | STEM-CELLS | STELLATE-CELLS | ONCOLOGY | DUCTAL ADENOCARCINOMA | SECRETING TUMOR VACCINE | CLINICAL-TRIALS | IMMUNE ACTIVATION | PROGNOSTIC-SIGNIFICANCE | ENDOTHELIAL GROWTH-FACTOR | HYPOXIA-INDUCIBLE FACTORS | Extracellular Matrix | Humans | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - pathology | Pancreatic Stellate Cells | Pancreatic Neoplasms - drug therapy | Tumor Microenvironment - immunology | Carcinoma, Pancreatic Ductal - drug therapy | Stromal Cells | Animals | Tumor Microenvironment - genetics | Fibroblasts | Hypoxia | vasculature | pancreatic cancer | desmoplasia | immunotherapy | GEMM
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6. Full Text Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors
by Kasai, Yosuke and Mahuron, Kelly and Hirose, Kenzo and Corvera, Carlos U and Kim, Grace E and Hope, Thomas A and Shih, Brandon E and Warren, Robert S and Bergsland, Emily K and Nakakura, Eric K
Journal of Surgical Oncology, ISSN 0022-4790, 12/2019, Volume 120, Issue 8, pp. 1311 - 1317
Background and Objectives Ileal neuroendocrine tumors (i‐NETs) frequently metastasize to mesenteric lymph nodes and the liver. Regional lymphadenopathy is... 
liver metastasis | small bowel | mesenteric desmoplasia | lymph node metastasis
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7. Full Text Surgical aspects of neuroendocrine tumors of the small intestine
by Weber, F and Dralle, H
Chirurg, ISSN 0009-4722, 06/2018, Volume 89, Issue 6, pp. 428 - 433
Lymphadenectomy | Desmoplasia | Mesenterial fibrosis | Localized disease | Skip metastases
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8. Full Text Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer (vol 10, 1394, 2019)
by Landskron, G and Lopez, MDLF and Dubois-Camacho, K and Diaz-Jimenez, D and Orellana-Serradell, O and Romero, D and Sepulveda, SA and Salazar, C and Parada-Venegas, D and Quera, R and Simian, D and Gonzalez, MJ and Lopez-Kostner, F and Kronberg, U and Abedrapo, M and Gallegos, I and Contreras, HR and Pena, C and Diaz-Araya, G and Roa, JC and Hermoso, MA
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 09/2019, Volume 10
interleukin 33 | colorectal cancer | desmoplasia | epithelial-mesenchymal transition | IMMUNOLOGY | cancer associated fibroblasts
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9. Full Text Corrigendum: Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer
by Landskron, Glauben and De la Fuente López, Marjorie and Dubois-Camacho, Karen and Díaz-Jiménez, David and Orellana-Serradell, Octavio and Romero, Diego and Sepúlveda, Santiago A and Salazar, Christian and Parada-Venegas, Daniela and Quera, Rodrigo and Simian, Daniela and González, María-Julieta and López-Köstner, Francisco and Kronberg, Udo and Abedrapo, Mario and Gallegos, Iván and Contreras, Héctor R and Peña, Cristina and Díaz-Araya, Guillermo and Roa, Juan Carlos and Hermoso, Marcela A
Frontiers in Immunology, ISSN 1664-3224, 09/2019, Volume 10
interleukin 33 | epithelial-mesenchymal transition | colorectal cancer | desmoplasia | cancer associated fibroblasts
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10. Full Text Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer
by Jennifer M. Bailey and Benjamin J. Swanson and Tomofumi Hamada and John P. Eggers and Pankaj K. Singh and Thomas Caffery and Michel M. Ouellette and Michael A. Hollingsworth
Clinical Cancer Research, ISSN 1078-0432, 10/2008, Volume 14, Issue 19, pp. 5995 - 6004
Purpose: We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression. Experimental Design: We expressed SHH in a transformed... 
Desmoplasia | Sonic Hedgehog | Pancreatic Cancer | EPITHELIAL-CELLS | ONCOLOGY | GROWTH | CARCINOMAS | FIBRONECTIN | STROMA | INDUCTION | ANIMAL DEVELOPMENT | PROTEINS | EXPRESSION | IMMORTALIZATION | Neoplasm Transplantation | Pancreatic Neoplasms - metabolism | Neoplasm Invasiveness | Humans | Gene Expression Regulation, Neoplastic | Hedgehog Proteins - metabolism | Hedgehog Proteins - physiology | Pancreas - metabolism | Fibrosis - metabolism | Animals | Cell Transformation, Neoplastic | Mice, Nude | Cell Line, Tumor | Mice | Fibrosis - pathology | Cell Line, Transformed | Fibroblasts - metabolism | Pancreatic Neoplasms - therapy
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11. Full Text Desmoplastic ameloblastoma – An unusual presentation
by Kallam, Shanmukha Reddy and Arutla, Rashmitha and Gadwalwari, Sai Sravanthi and Kubbi, Jithender Reddy and Shylaja, Sanjeeva Reddy Gari
Journal of Clinical and Diagnostic Research, ISSN 2249-782X, 10/2015, Volume 9, Issue 10, pp. ZJ04 - ZJ05
Ameloblastomas are the most common and represents a family of diseases with diverse biological behaviour and contribute to 11-18% of odontogenic epithelial... 
Mandible | Honey comb appearance | Desmoplasia
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12. Full Text Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
by Provenzano, P.P and Hingorani, S.R
British Journal of Cancer, ISSN 0007-0920, 01/2013, Volume 108, Issue 1, pp. 1 - 8
Pancreatic ductal adenocarcinomas (PDAs) are notoriously aggressive and resistant to treatment. They distinguish themselves further by their robust... 
hyaluronidase | stromal resistance | desmoplasia | Pancreatic ductal adenocarcinoma | interstitial fluid pressure | hyaluronic acid | CELLS | SOLID TUMORS | DUCTAL ADENOCARCINOMA | INTERSTITIAL FLUID | RANDOMIZED CONTROLLED-TRIAL | GEMCITABINE | pancreatic ductal adenocarcinoma | PHASE-III TRIAL | TRANSPORT | THERAPY | ONCOLOGY | ENDOTHELIAL GROWTH-FACTOR | Extracellular Fluid - physiology | Pancreatic Neoplasms - drug therapy | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Stromal Cells - pathology | Humans | Hyaluronic Acid - metabolism | Tumor Microenvironment | Drug Resistance, Neoplasm | Hydrodynamics | Carcinoma, Pancreatic Ductal - physiopathology | Pancreatic Neoplasms - physiopathology | Minireview
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13. Full Text Pancreatic cancer: why is it so hard to treat?
by Oberstein, Paul E and Olive, Kenneth P
Therapeutic Advances in Gastroenterology, ISSN 1756-283X, 7/2013, Volume 6, Issue 4, pp. 321 - 337
No common malignancy is as rapidly and inevitably fatal as pancreatic ductal adenocarcinoma (PDA). This grim fact has driven substantial research efforts into... 
chemotherapy resistance | pancreatic cancer | tumor desmoplasia | ENHANCED ENDOSCOPIC ULTRASONOGRAPHY | ONCOGENIC KRAS | TUMOR RESPONSE | ADJUVANT TREATMENT | RANDOMIZED-TRIAL | GEMCITABINE PLUS PLACEBO | PHASE-III TRIAL | STROMAL BIOLOGY | HOSPITAL VOLUME | EQUILIBRATIVE NUCLEOSIDE TRANSPORTER-1 | GASTROENTEROLOGY & HEPATOLOGY | Reviews
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14. Full Text Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer
by Malik, Ruchi and Lelkes, Peter I and Cukierman, Edna
Trends in Biotechnology, ISSN 0167-7799, 2015, Volume 33, Issue 4, pp. 230 - 236
Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM... 
Internal Medicine | integrins | cell–ECM dynamic reciprocity | biomechanical and biochemical cues | Rho–ROCK | desmoplasia | extracellular matrix | Cell-ECM dynamic reciprocity | Extracellular matrix | Desmoplasia | Biomechanical and biochemical cues | Rho-ROCK | Integrins | LYSYL OXIDASE | TISSUE ARCHITECTURE | I COLLAGEN | MUSCLE ACTIN EXPRESSION | METALLOPROTEINASES | FIBROBLASTS | INVASION | FOCAL ADHESION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CELL-MIGRATION | RHO | cell-ECM dynamic reciprocity | Neoplasms - chemistry | Animals | Humans | Cell Line, Tumor | Extracellular Matrix - metabolism | Biomedical Research | Mice | Neoplasms - physiopathology | Tumor Microenvironment - physiology | Extracellular Matrix - chemistry | Cancer | Biomechanics | Enzymes | Genotype & phenotype | Wound healing | Collagen | Pancreatic cancer | Homeostasis | Breast cancer | Physiology | Tumorigenesis | Behavior | Biomechanical & Biochemical cues | Cell-ECM Dynamic Reciprocity
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15. Full Text Desmoplastic Ameloblastoma – An Unusual Presentation
by Kallam, Shanmukha Reddy and Arutla, Rashmitha and Gadwalwari, Sai Sravanthi and Kubbi, Jithender Reddy and Shylaja, Sanjeeva Reddy Gari
Journal of Clinical and Diagnostic Research : JCDR, ISSN 2249-782X, 10/2015, Volume 9, Issue 10, pp. ZJ04 - ZJ05
Ameloblastomas are the most common and represents a family of diseases with diverse biological behaviour and contribute to 11-18% of odontogenic epithelial... 
Mandible | Desmoplasia | Dentistry Section | Honey comb appearance
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16. Full Text Prenatal Bisphenol a Exposure Induces Preneoplastic Lesions in the Mammary Gland in Wistar Rats
by Milena Durando and Laura Kass and Julio Piva and Carlos Sonnenschein and Ana M. Soto and Enrique H. Luque and Mónica Muñoz-de-Toro
Environmental Health Perspectives, ISSN 0091-6765, 1/2007, Volume 115, Issue 1, pp. 80 - 86
Background: Humans are routinely exposed to bisphenol A (BPA), an estrogenic compound that leaches from dental materials, food and beverage containers, and... 
Business publications audits | Bisphenols | Epithelial cells | Estrogens | Rats | Mammary glands | Mast cells | Research | Dosage | Lesions | Tumors | Desmoplasia | Bisphenol A (BPA) | Endocrine disruptor | N-nitroso-N-methylurea (NMU) | Mammary tumor | Hyperplastic ducts | bisphenol A (BPA) | desmoplasia | MAST-CELLS | TISSUE | TUMOR | mast cells | CANCER | BREAST | UTERINE CERVIX | ENVIRONMENTAL SCIENCES | hyperplastic ducts | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | EPITHELIAL-CELLS | CARCINOMAS | endocrine disruptor | mammary tumor | STROMA | TOXICOLOGY | ALTERS | Prenatal Exposure Delayed Effects | Benzhydryl Compounds | Rats, Wistar | Mammary Glands, Animal - pathology | Phenols - toxicity | Mammary Glands, Animal - drug effects | Alkylating Agents | Sexual Maturation - drug effects | Mammary Glands, Animal - growth & development | Pregnancy | Animals | Breast Neoplasms - pathology | Estrogens, Non-Steroidal - toxicity | Methylnitrosourea | Female | Breast Neoplasms - chemically induced | Tumor | Mammary | Bispheno A (BPA | Care and treatment | Cancer
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17. Full Text Differentiation of Desmoplastic Spitz Nevus from Similar Conditions
by Min-woo Kim and and Ji Soo Lim and Yun Seon Choe and Jung Ho Kim and Hyun-sun Yoon and Soyun Cho and Hyun-sun Park
대한피부과학회지, ISSN 0494-4739, 2016, Volume 54, Issue 9, p. 766
The diagnosis of classic Spitz nevus with characteristic histopathologic findings is often straightforward, but unusual variants can cause diagnostic... 
Desmoplastic Spitz nevus | Desmoplasia | Desmoplastic malignant melanoma
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18. Full Text Desmoplasia in pancreatic ductal adenocarcinoma: Insight into pathological function and therapeutic potential
by Cannon, Andrew and Thompson, Christopher and Hall, Bradley R and Jain, Maneesh and Kumar, Sushil and Batra, Surinder K
Genes and Cancer, ISSN 1947-6019, 03/2018, Volume 9, Issue 3-4, pp. 78 - 86
Extensive desmoplasia is a prominent feature of the pancreatic ductal adenocarcinoma (PDAC) microenvironment. Initially, studies demonstrated that desmoplasia... 
Cancer-associated fibroblast | Extracellular matrix | SHH | Desmoplasia | Pancreatic ductal adenocarcinoma | cancer-associated fibroblast | Review | desmoplasia | extracellular matrix | pancreatic ductal adenocarcinoma
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19. Full Text Cancer‐associated fibroblasts predict poor outcome and promote periostin‐dependent invasion in oesophageal adenocarcinoma
by Underwood, Timothy J and Hayden, Annette L and Derouet, Mathieu and Garcia, Edwin and Noble, Fergus and White, Michael J and Thirdborough, Steve and Mead, Abbie and Clemons, Nicholas and Mellone, Massimiliano and Uzoho, Chudy and Primrose, John N and Blaydes, Jeremy P and Thomas, Gareth J
The Journal of Pathology, ISSN 0022-3417, 02/2015, Volume 235, Issue 3, pp. 466 - 477
Interactions between cancer cells and cancer‐associated fibroblasts (CAFs) play an important role in tumour development and progression. In this study we... 
tumour microenvironment | CAFs | periostin | oesophageal cancer | Oesophageal cancer | Tumour microenvironment | Periostin | SURVIVAL | PANCREATIC-CANCER | TISSUE | DESMOPLASIA | BARRETTS-ESOPHAGUS | PATHOLOGY | ONCOLOGY | DISEASE | SQUAMOUS-CELL CARCINOMA | STROMAL MYOFIBROBLASTS | DIFFERENTIATION | EXPRESSION | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Actins - metabolism | Tumor Microenvironment | Male | Phosphatidylinositol 3-Kinases - metabolism | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | Heterografts | Esophageal Neoplasms - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Esophageal Neoplasms - mortality | Adult | Cell Adhesion Molecules - pharmacology | Female | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | Cells, Cultured | Survival Rate | Fibroblasts - pathology | Mice, SCID | Cell Movement - drug effects | Esophagus - pathology | Animals | Signal Transduction - physiology | Aged | Mice | In Vitro Techniques | Adenocarcinoma - mortality | Cohort Studies | Adenocarcinoma | Analysis | Mortality | Transforming growth factors | Esophageal cancer | Integrins | Medical research | Kinases | Cancer | Original Papers
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