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Molecular Cell, ISSN 1097-2765, 03/2015, Volume 57, Issue 5, pp. 901 - 911
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 12, pp. 4572 - 4582
Chemoresistance is a leading obstacle in effective management of advanced prostate cancer (PCa). A better understanding of the molecular mechanisms involved in... 
ubiquitylation (ubiquitination) | pre-B cell leukemia homeobox-1 | prostate cancer | deubiquitylation (deubiquitination) | USP9x | apoptosis | cancer | cancer biology | drug resistance | protein degradation | TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CHEMORESISTANCE
Journal Article
Journal of biological chemistry, ISSN 0021-9258, 2016, Volume 291, Issue 9, pp. 4813 - 4825
Cholesterol metabolism is subject to complex transcriptional and nontranscriptional regulation. Herein, the role of ubiquitylation is emerging as an important... 
DEUBIQUITINATING ENZYME | FAMILIAL HYPERCHOLESTEROLEMIA | LDL RECEPTOR | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | LYSOSOMAL DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | CHOLESTEROL HOMEOSTASIS | INDUCIBLE DEGRADER | LEUCINE ZIPPER PROTEIN | LXR-ALPHA | Transcription, Genetic - drug effects | Ubiquitin-Specific Proteases - genetics | Humans | Lysosomes - enzymology | Orphan Nuclear Receptors - metabolism | Promoter Regions, Genetic - drug effects | Recombinant Fusion Proteins - metabolism | Proteolysis - drug effects | Lysosomes - metabolism | Ubiquitination - drug effects | Human Umbilical Vein Endothelial Cells - cytology | Liver X Receptors | Lipoproteins, LDL - metabolism | Ubiquitin-Specific Proteases - metabolism | Genes, Reporter | Lysosomes - drug effects | Recombinant Proteins - metabolism | Absorption, Physiological - drug effects | Cell Line | Receptors, LDL - genetics | Ubiquitin-Specific Proteases - antagonists & inhibitors | Cells, Cultured | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Receptors, LDL - metabolism | Recombinant Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Ubiquitin-Protein Ligases - chemistry | Orphan Nuclear Receptors - genetics | Animals | Mice | Mutation | Amino Acid Substitution | deubiquitylation (deubiquitination) | lipoprotein receptor | cholesterol metabolism | post-transcriptional regulation | LXR | Lipids | nuclear receptor | E3 ubiquitin ligase | IDOL | LDLR
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 01/2019, Volume 119, Issue 1, pp. 104 - 116
Abstract Platelet activators stimulate post-translational modification of signalling proteins to change their activity or their molecular interactions leading... 
Cellular Haemostasis and Platelets | deubiquitylation inhibition | GPVI | platelets | sites of ubiquitinylation | SYK | SPECIFICITY | TYROSINE KINASE | C-CBL | PHOSPHATASE | RECEPTOR | RELEASE | UBIQUITINATION | INHIBITION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | AGGREGATION
Journal Article
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 10/2014, Volume 26, Issue 10, pp. 2186 - 2192
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2014, Volume 289, Issue 39, pp. 27278 - 27289
Journal Article
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 07/2017, Volume 8, p. 489
In epithelia, the intermediate conductance, Ca2+ -activated K+ channel (KCa3.1) is targeted to the basolateral membrane (BLM) where this channel plays numerous... 
DCEBIO | Deubiquitylation | K | channels | Ubiquitylation | Clotrimazole | DEUBIQUITINATING ENZYME | PLASMA-MEMBRANE KCA3.1 | PHYSIOLOGY | clotrimazole | STIMULATES CL-SECRETION | CA2+-ACTIVATED K+ CHANNEL | HEREDITARY XEROCYTOSIS | SODIUM-CHANNEL | deubiquitylation | K+ channels | ACTIVATED POTASSIUM CHANNEL | SMOOTH-MUSCLE-CELLS | CYSTIC-FIBROSIS | ubiquitylation | CHLORIDE SECRETION
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2014, Volume 289, Issue 41, pp. 28595 - 28606
The telomeric shelterin component TPP1 has critical functions in telomeric protein complex assembly and telomerase recruitment and regulation. Here we identify... 
RECRUITMENT | MAINTENANCE | COMPLEX | TELOMERE LENGTH REGULATOR | RECOGNITION | PROTEIN TPP1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | END-PROTECTION | POT1 | P53 | PROCESSIVITY | Serine Proteases - genetics | Saccharomyces cerevisiae - genetics | Humans | Molecular Sequence Data | Saccharomyces cerevisiae - metabolism | Telomere-Binding Proteins - genetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism | Telomerase - genetics | Proteolysis | Aminopeptidases - chemistry | HEK293 Cells | Ubiquitin Thiolesterase - metabolism | Serine Proteases - chemistry | Telomerase - metabolism | Protein Interaction Domains and Motifs | Telomere - metabolism | Protein Stability | Telomere-Binding Proteins - metabolism | Aminopeptidases - metabolism | Binding Sites | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Recombinant Proteins - metabolism | Serine Proteases - metabolism | Amino Acid Sequence | Aminopeptidases - genetics | Gene Expression | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - chemistry | Ubiquitin Thiolesterase - genetics | Telomere - chemistry | Two-Hybrid System Techniques | Telomerase - chemistry | Protein Binding | Telomere-Binding Proteins - chemistry | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Ubiquitin Thiolesterase - chemistry | Ubiquitin-Specific Peptidase 7 | DNA and Chromosomes | USP7 | Shelterin | TPP1 | Post-translational Modification (PTM) | Telomerase | Telomere | Deubiquitylation (Deubiquitination)
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 2015, Volume 29, Issue 9, pp. 3889 - 3898
Journal Article