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1. Full Text Cardiac structure and function in heart failure with preserved ejection fraction: Baseline findings from the echocardiographic study of the treatment of preserved cardiac function heart failure with an aldosterone antagonist trial
by Shah, Amil M and Shah, Sanjiv J and Anand, Inder S and Sweitzer, Nancy K and O'Meara, Eileen and Heitner, John F and Sopko, George and Li, Guichu and Assmann, Susan F and McKinlay, Sonja M and Pitt, Bertram and Pfeffer, Marc A and Solomon, Scott D and TOPCAT Investigators
Circulation: Heart Failure, ISSN 1941-3289, 2014, Volume 7, Issue 1, pp. 104 - 115
Background Heart failure with preserved ejection fraction (HFpEF) is associated with substantial morbidity and mortality. Existing data on cardiac structure... 
Heart failure | Diastolic heart failure | Echocardiography | Spironolactone | Randomized controlled trial | heart failure | EUROPEAN-ASSOCIATION | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | DIASTOLIC FUNCTION | echocardiography | EXERCISE CAPACITY | RANDOMIZED CONTROLLED-TRIAL | MITRAL REGURGITATION | SYSTOLIC FUNCTION | spironolactone | LEFT-VENTRICULAR HYPERTROPHY | randomized controlled trial | RECOMMENDATIONS | diastolic heart failure | AMERICAN-SOCIETY
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2. Full Text The Relationship Between Renal Function and Cardiac Structure, Function, and Prognosis After Myocardial Infarction. The VALIANT Echo Study
by Verma, Anil and Anavekar, Nagesh S and Meris, Alessandra and Thune, Jens Jakob and Arnold, J. Malcolm O and Ghali, Jalal K and Velazquez, Eric J and McMurray, John J.V and Pfeffer, Marc A and Solomon, Scott D
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2007, Volume 50, Issue 13, pp. 1238 - 1245
Objectives: The purpose of this study was to determine whether alterations in cardiac structure or function contribute to the increased risk associated with... 
CARDIAC & CARDIOVASCULAR SYSTEMS | VENTRICULAR DIASTOLIC DYSFUNCTION | RISK-FACTOR | QUANTIFICATION | REGURGITATION | CARDIOVASCULAR-DISEASE | INSUFFICIENCY | ECHOCARDIOGRAPHY | CONGESTIVE-HEART-FAILURE | CHRONIC KIDNEY-DISEASE | LEFT ATRIAL VOLUME | Kidney Diseases - physiopathology | Multivariate Analysis | Myocardial Infarction - mortality | Prognosis | Ultrasonography, Doppler, Color | Humans | Middle Aged | Heart Failure - physiopathology | Male | Myocardial Infarction - diagnostic imaging | Heart Atria - diagnostic imaging | Heart Ventricles - diagnostic imaging | Female | Myocardial Infarction - physiopathology | Heart Atria - physiopathology | Heart Failure - diagnostic imaging | Glomerular Filtration Rate | Proportional Hazards Models | Cardiac Volume - physiology | Diastole - physiology | Ventricular Dysfunction, Left - diagnostic imaging | Ventricular Dysfunction, Left - physiopathology | Heart Ventricles - physiopathology | Creatinine - blood | Aged | Confidence intervals | Heart failure | Heart attacks | Mortality | Flow velocity | Chronic obstructive pulmonary disease | Kidney diseases | Patients
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3. Full Text Subclinical Thyroid Dysfunction, Cardiac Function, and the Risk of Heart Failure. The Cardiovascular Health Study
by Rodondi, Nicolas and Bauer, Douglas C and Cappola, Anne R and Cornuz, Jacques and Robbins, John and Fried, Linda P and Ladenson, Paul W and Vittinghoff, Eric and Gottdiener, John S and Newman, Anne B
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2008, Volume 52, Issue 14, pp. 1152 - 1159
Objectives: The goal of this study was to determine whether subclinical thyroid dysfunction was associated with incident heart failure (HF) and echocardiogram... 
heart failure | cohort study | subclinical thyroid dysfunction | echocardiography | CARDIAC & CARDIOVASCULAR SYSTEMS | DIASTOLIC FUNCTION | STIMULATING HORMONE | THYROXINE THERAPY | HYPOTHYROIDISM | DISEASE | MASS | DOUBLE-BLIND | ASSOCIATION | LEFT-VENTRICULAR FUNCTION | Heart - physiopathology | Echocardiography | Hypothyroidism - physiopathology | Humans | Hypertrophy, Left Ventricular - etiology | Hypothyroidism - complications | Risk Factors | Heart Failure - physiopathology | Male | Hyperthyroidism - physiopathology | Time Factors | Aged, 80 and over | Hyperthyroidism - complications | Female | Aged | Heart Failure - etiology | Heart Function Tests | Cohort Studies | Confidence intervals | Heart failure | Task forces | Ultrasonic imaging | Older people | Hyperthyroidism | Flow velocity | Hormones | Hypothyroidism | Heart Failure | Cohort Study | Subclinical Thyroid Dysfunction
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4. Full Text Alternative Splicing of Titin Restores Diastolic Function in an HFpEF-Like Genetic Murine Model (TtnΔIAjxn)
by Bull, Mathew and Methawasin, Mei and Strom, Joshua and Nair, Pooja and Hutchinson, Kirk and Granzier, Henk
Circulation Research, ISSN 0009-7330, 09/2016, Volume 119, Issue 6, pp. 764 - 772
RATIONALE:Patients with heart failure with preserved ejection fraction (HFpEF) experience elevated filling pressures and reduced ventricular compliance. The... 
myocardium | hypertrophy | diastolic heart failure | compliance | diastole | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | PHOSPHORYLATION | HEART-FAILURE | CARDIAC TITIN | PRESERVED EJECTION FRACTION | PREVALENCE | SKELETAL-MUSCLE | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | STRESS | HEMATOLOGY | EXPRESSION | Connectin - biosynthesis | Stroke Volume - physiology | Connectin - genetics | Alternative Splicing - physiology | Heart Failure - genetics | Male | Mice, Transgenic | Heart Failure - metabolism | Physical Conditioning, Animal - physiology | Animals | Protein Isoforms - biosynthesis | Myocytes, Cardiac - physiology | Blood Pressure - physiology | Mice | Disease Models, Animal | Protein Isoforms - genetics | Contractile Function | HFpEF | diastolic function | Titin | diastolic dysfunction | Heart Failure | RBM20 | Myocardial Biology | Physiology | Basic Science Research
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5. Full Text Effect of Spironolactone on Diastolic Function and Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction: The Aldo-DHF Randomized Controlled Trial
by Edelmann, Frank and Wachter, Rolf and Schmidt, Albrecht G and Kraigher-Krainer, Elisabeth and Colantonio, Caterina and Kamke, Wolfram and Duvinage, André and Stahrenberg, Raoul and Durstewitz, Kathleen and Löffler, Markus and Düngen, Hans-Dirk and Tschöpe, Carsten and Herrmann-Lingen, Christoph and Halle, Martin and Hasenfuss, Gerd and Gelbrich, Götz and Pieske, Burkert and Aldo-DHF Investigators
JAMA, ISSN 0098-7484, 02/2013, Volume 309, Issue 8, pp. 781 - 791
IMPORTANCE Diastolic heart failure (ie, heart failure with preserved ejection fraction) is a common condition without established therapy, and aldosterone... 
ANGIOTENSIN RECEPTOR BLOCKADE | CARDIAC-FUNCTION | MORTALITY | MEDICINE, GENERAL & INTERNAL | BRAIN NATRIURETIC PEPTIDE | I-PRESERVE | ALDOSTERONE ANTAGONISM | DOUBLE-BLIND | ALDACTONE EVALUATION | DYSFUNCTION | ECHOCARDIOGRAPHY | Echocardiography | Prospective Studies | Double-Blind Method | Heart Failure, Diastolic - drug therapy | Humans | Middle Aged | Ventricular Function, Left - drug effects | Male | Treatment Outcome | Diastole - physiology | Mineralocorticoid Receptor Antagonists - therapeutic use | Stroke Volume | Heart Failure, Diastolic - physiopathology | Exercise Test | Ventricular Remodeling | Quality of Life | Female | Aged | Spironolactone - therapeutic use
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6. Full Text Meal fatty acids have differential effects on postprandial blood pressure and biomarkers of endothelial function but not vascular reactivity in postmenopausal women in the randomized controlled dietary intervention and vascular function (DIVAS)-2 study
by Rathnayake, Kumari M and Weech, Michelle and Jackson, Kim G and Lovegrove, Julie A
Journal of Nutrition, ISSN 0022-3166, 03/2018, Volume 148, Issue 3, pp. 348 - 357
Background: Elevated postprandial triacylglycerol concentrations, impaired vascular function, and hypertension are important independent cardiovascular disease... 
Postprandial lipemia | Monounsaturated fat | Diastolic blood pressure | Saturated fat | Vascular function | N-6 polyunsaturated fat | Nitrate and nitrite | Cell adhesion molecules | LIPEMIA | vascular function | cell adhesion molecules | CARDIOVASCULAR EVENTS | saturated fat | RISK | HEALTHY | INSULIN SENSITIVITY | postprandial lipemia | monounsaturated fat | n-6 polyunsaturated fat | BRACHIAL-ARTERY | NUTRITION & DIETETICS | diastolic blood pressure | FLOW-MEDIATED VASODILATION | NONFASTING TRIGLYCERIDES | nitrate and nitrite | RICH | Physiological aspects | Postmenopausal women | Diagnosis | Observations | Biological markers | Food and nutrition | Cardiovascular diseases | Essential fatty acids | Risk factors
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7. Full Text Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: Results of the Ex-DHF (exercise training in diastolic heart failure) pilot study
by Edelmann, Frank and Gelbrich, Götz and Dngen, Hans-Dirk and Fröhling, Stefan and Wachter, Rolf and Stahrenberg, Raoul and Binder, Lutz and Töpper, Agnieszka and Lashki, Diana Jahandar and Schwarz, Silja and Herrmann-Lingen, Christoph and Löffler, Markus and Hasenfuss, Gerd and Halle, Martin and Pieske, Burkert
Journal of the American College of Cardiology, ISSN 0735-1097, 10/2011, Volume 58, Issue 17, pp. 1780 - 1791
Objectives: We sought to determine whether structured exercise training (ET) improves maximal exercise capacity, left ventricular diastolic function, and... 
diastolic dysfunction | heart failure with preserved ejection fraction | therapy | exercise training | CONTROLLED-TRIAL | DIAGNOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | BRAIN NATRIURETIC PEPTIDE | METAANALYSIS | PERFORMANCE | SYSTOLIC FUNCTION | BODY-MASS | QUALITY-OF-LIFE | DYSFUNCTION | ECHOCARDIOGRAPHY | Prospective Studies | Diastole | Heart Failure, Diastolic - therapy | Humans | Middle Aged | Male | Resistance Training | Pilot Projects | Exercise Tolerance | Quality of Life | Female | Aged | Heart Function Tests | Exercise | Heart attacks | Cardiology | Drug therapy
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8. Full Text Heart failure with preserved left ventricular systolic function: epidemiology, clinical characteristics, and prognosis
by Hogg, Karen and Swedberg, Karl and McMurray, John and Hjärt-kärlinstitutionen and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Cardiovascular Institute and Sahlgrenska Academy
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2004, Volume 43, Issue 3, pp. 317 - 327
Recent cross-sectional, population-based echocardiographic studies show that about half of all patients with heart failure have preserved left ventricular... 
MORTALITY | READMISSION | PATHOGENESIS | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | COMMUNITY | EJECTION FRACTION | PREVALENCE | OUTCOMES | DIASTOLIC DYSFUNCTION | FEATURES | Prognosis | Comorbidity | Humans | Middle Aged | Heart Failure - physiopathology | Male | Heart Failure - drug therapy | Cardiovascular Agents - therapeutic use | Aged, 80 and over | Quality of Life | Adult | Female | Ventricular Function, Left - physiology | Aged | Hypertension - epidemiology | Heart Failure - economics | Heart Failure - epidemiology | Hospitalization - economics | Myocardial Ischemia - epidemiology | Cardiology | Epidemiology | Heart attacks | Hospitalization/economics | Cardiovascular Agents/therapeutic use | Ventricular Function | Congestive/drug | Hypertension/epidemiology | therapy/economics/epidemiology/physiopathology | Left/physiology | Kardiologi | 80 and over | Cardiac and Cardiovascular Systems | Heart Failure | Myocardial Ischemia/epidemiology
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9. Full Text Maternal Cardiovascular Function in Normal Pregnancy: Evidence of Maladaptation to Chronic Volume Overload
by Melchiorre, Karen and Sharma, Rajan and Khalil, Asma and Thilaganathan, Baskaran
Hypertension, ISSN 0194-911X, 04/2016, Volume 67, Issue 4, pp. 754 - 762
The aim of this study was to investigate cardiac functional status in pregnancy using a comprehensive approach taking into account the simultaneous changes in... 
diastolic dysfunction | remodeling | LV hypertrophy | tissue Doppler | echocardiography | pregnancy | STRAIN-RATE | PREECLAMPSIA | ECHOCARDIOGRAPHIC-ASSESSMENT | HEMODYNAMICS | UTERINE ARTERY DOPPLER | HEART | WOMEN | RECOMMENDATIONS | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | PRETERM | Cardiac Output, High - diagnostic imaging | Prospective Studies | Cross-Sectional Studies | Risk Assessment | Humans | Myocardial Contraction - physiology | Stroke Volume - physiology | Adaptation, Physiological - physiology | Reference Values | United Kingdom | Gestational Age | Vascular Resistance - physiology | Statistics, Nonparametric | Adult | Echocardiography, Doppler - methods | Female | Ultrasonography, Prenatal - methods | Ventricular Function, Left - physiology | Pregnancy - physiology | Cardiac Output, High - physiopathology
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10. Full Text Wall stress determines systolic and diastolic function — Characteristics of heart failure
by Alter, Peter and Koczulla, A. Rembert and Nell, Christoph and Figiel, Jens H and Vogelmeier, Claus F and Rominger, Marga B
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 202, pp. 685 - 693
Abstract Introduction Heart failure can be caused by systolic or diastolic dysfunction. Diagnosing diastolic dysfunction remains challenging, although several... 
Cardiovascular | Heart failure | CMR | Heart function | HFpEF, HFrEF, Diastolic dysfunction | Wall stress index | Dyspnea | Dilated cardiomyopathy | Ventricular wall stress | Ventricular filling | Cardiac output | Pulmonary pressure | Cardiac magnetic resonance imaging | Ventricular ejection fraction | BREATH-HOLD TECHNIQUE | CARDIAC & CARDIOVASCULAR SYSTEMS | IDIOPATHIC DILATED CARDIOMYOPATHY | CARDIOVASCULAR MAGNETIC-RESONANCE | MYOCARDIAL OXYGEN-CONSUMPTION | NATRIURETIC PEPTIDE | LATE GADOLINIUM ENHANCEMENT | VENTRICULAR EJECTION | TAKOTSUBO CARDIOMYOPATHY | EJECTION FRACTION | FRANK-STARLING MECHANISM | Dyspnea Cardiac magnetic resonance imaging | Heart Failure, Diastolic - diagnosis | Diastole | Humans | Middle Aged | Male | Systole | Heart Ventricles - diagnostic imaging | Young Adult | Heart Failure, Diastolic - complications | Ultrasonography | Adult | Female | Ventricular Function, Left - physiology | Heart Ventricles - pathology | Stroke Volume - physiology | Ventricular Dysfunction, Left - etiology | Cardiac Volume - physiology | Myocardium - pathology | Ventricular Dysfunction, Left - diagnosis | Magnetic Resonance Imaging, Cine | Ventricular Dysfunction, Left - physiopathology | Heart Failure, Diastolic - physiopathology | Heart Ventricles - physiopathology | Heart Failure, Systolic - physiopathology | Adolescent | Heart Failure, Systolic - diagnosis | Heart Failure, Systolic - complications
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11. Full Text Right heart function in impaired left ventricular diastolic function: 2D speckle tracking echocardiography-based and Doppler tissue imaging-based analysis of right atrial and ventricular function
by Brand, A and Bathe, M and Oertelt-Prigione, S and Seeland, U and Rucke, M and Regitz-Zagrosek, V and Stangl, K and Knebel, F and Stangl, V and ger, H
Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, ISSN 0742-2822, 2018, Volume 35, Issue 1, pp. 47 - 55
AIM: The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking... 
myocardial strain | Doppler tissue imaging | right atrial function | impaired diastolic function | 2D speckle tracking echocardiography | right ventricular function | CARDIAC & CARDIOVASCULAR SYSTEMS | PRESERVED EJECTION FRACTION | EUROPEAN ASSOCIATION | FAILURE | MECHANICS | COMMUNITY | RECOMMENDATIONS | DYSFUNCTION | HYPERTENSION | AMERICAN SOCIETY | CARDIAC CHAMBER | Heart | Echocardiography
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12. Full Text Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction JACC State-of-the-Art Review
by Thomas, L and Marwick, TH and Popescu, BA and Donal, E and Badano, LP
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ISSN 0735-1097, 04/2019, Volume 73, Issue 15, pp. 1961 - 1977
Defining left atrial (LA) function has recently emerged as a powerful parameter, particularly in evaluation of left ventricular (LV) diastolic dysfunction... 
3-dimensional echocardiography | STRAIN-RATE | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | phasic function | volumes | left ventricular diastolic function | PRESERVED EJECTION FRACTION | left atrial fibrosis | DEFORMATION PREDICTS | CLINICAL-RELEVANCE | COMPREHENSIVE ASSESSMENT | 2-dimensional echocardiography | heart failure with preserved ejection fraction | speckle-tracking echocardiography | PROGNOSTIC-SIGNIFICANCE | left atrium | NONINVASIVE ASSESSMENT | 3D ECHOCARDIOGRAPHY | Heart | Analysis | Volumetric analysis | Systolic pressure | Evaluation | Echocardiography | Medical imaging | Compliance | Pulmonary arteries | Hospitalization | Velocity | Pulmonary artery | Biomarkers | Blood pressure | Ventricle | Heart diseases | Ejection | Structure-function relationships | Life Sciences | Bioengineering
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13. Full Text The Pathophysiology of Heart Failure With Normal Ejection Fraction. Exercise Echocardiography Reveals Complex Abnormalities of Both Systolic and Diastolic Ventricular Function Involving Torsion, Untwist, and Longitudinal Motion
by Tan, Yu Ting and Wenzelburger, Frauke and Lee, Eveline and Heatlie, Grant and Leyva, Francisco and Patel, Kiran and Frenneaux, Michael and Sanderson, John E
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2009, Volume 54, Issue 1, pp. 36 - 46
Objectives: The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to... 
strain | heart failure | diastolic | untwist | rotation | MITRAL ANNULUS VELOCITY | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | LONG AXIS FUNCTION | NATRIURETIC PEPTIDE | HYPERTROPHY | SPECKLE TRACKING ECHOCARDIOGRAPHY | CHAMBER STIFFNESS | INCREMENTAL PROGNOSTIC VALUE | INDEX | DYSFUNCTION | Diastole | Humans | Heart Failure, Diastolic - diagnostic imaging | Oxygen Consumption | Ventricular Function | Male | Systole | Rotation | Case-Control Studies | Heart Failure, Diastolic - physiopathology | Echocardiography, Doppler, Color - statistics & numerical data | Exercise Test | Female | Aged | Exercise - physiology | Torsion Abnormality | Hemodynamics | Observer Variation | Studies | Heart rate | Heart failure | Heart attacks | Cardiovascular disease | Software | Cardiology | Fractions
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14. Full Text Usefulness of Left Atrial Volume in Predicting First Congestive Heart Failure in Patients ≥65 Years of Age With Well-Preserved Left Ventricular Systolic Function
by Takemoto, Yasuhiko and Barnes, Marion E and Seward, James B and Lester, Steven J and Appleton, Christopher A and Gersh, Bernard J and Bailey, Kent R and Tsang, Teresa S.M
The American Journal of Cardiology, ISSN 0002-9149, 2005, Volume 96, Issue 6, pp. 832 - 836
Left atrial (LA) volume is a barometer of diastolic dysfunction. Whether it predicts congestive heart failure (CHF) in patients with preserved left ventricular... 
FIBRILLATION | POPULATION | HYPERTROPHY | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK | ECHOCARDIOGRAPHY | DIASTOLIC DYSFUNCTION | HISTORY | Predictive Value of Tests | Echocardiography | Prognosis | Follow-Up Studies | Ventricular Function, Left | Humans | Risk Factors | Heart Failure - physiopathology | Male | Minnesota | Aged, 80 and over | Atrial Function, Left | Female | Aged | Heart Failure - diagnostic imaging
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15. Full Text Effect of obesity and overweight on left ventricular diastolic function: A community-based study in an elderly cohort
by Russo, Cesare and Jin, Zhezhen and Homma, Shunichi and Rundek, Tatjana and Elkind, Mitchell S.V and Sacco, Ralph L and Di Tullio, Marco R
Journal of the American College of Cardiology, ISSN 0735-1097, 03/2011, Volume 57, Issue 12, pp. 1368 - 1374
Objectives: The purpose of this study was to assess the independent effect of increased body size on left ventricular (LV) diastolic function. Background:... 
diastolic dysfunction | risk factors | overweight | obesity | echocardiography | POPULATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | ATHEROSCLEROSIS | HYPERTROPHY | INSULIN-RESISTANCE | BODY-MASS INDEX | DYSFUNCTION | HYPERTENSION | ASSOCIATION | Body Mass Index | Multivariate Analysis | Ventricular Dysfunction, Left - epidemiology | Humans | Middle Aged | Heart Failure - physiopathology | Male | Obesity - physiopathology | Overweight - physiopathology | Diastole - physiology | Overweight - epidemiology | Obesity - epidemiology | Aged, 80 and over | Female | Aged | Heart Failure - epidemiology | Obesity | Body mass index | Cardiology | Drug therapy
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