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dibenzylbutyrolactone lignans (41) 41
lignans (40) 40
dibenzylbutyrolactone (38) 38
chemistry, organic (35) 35
index medicus (21) 21
chemistry, medicinal (20) 20
chemistry, multidisciplinary (19) 19
arctigenin (18) 18
pharmacology & pharmacy (18) 18
lignans - chemistry (17) 17
lignans - pharmacology (17) 17
humans (16) 16
lignan (16) 16
plant sciences (15) 15
molecular structure (14) 14
asymmetric-synthesis (13) 13
enantioselective synthesis (13) 13
animals (10) 10
dibenzylbutyrolactone lignan (10) 10
furans - pharmacology (10) 10
natural dibenzylbutyrolactone lignans (10) 10
4-butyrolactone - analogs & derivatives (9) 9
constituents (9) 9
derivatives (9) 9
lactones (9) 9
neolignans (9) 9
analysis (8) 8
biochemistry & molecular biology (8) 8
biosynthesis (8) 8
conjugate addition (8) 8
lignans - isolation & purification (8) 8
4-butyrolactone - chemistry (7) 7
chemistry (7) 7
chemistry, applied (7) 7
enterolactone (7) 7
lignans - chemical synthesis (7) 7
male (7) 7
phenylpropanoid dibenzylbutyrolactone lignan (7) 7
stereoisomerism (7) 7
acid (6) 6
furans - chemistry (6) 6
gamma-alkoxybutenolides (6) 6
in-vitro (6) 6
lignans - therapeutic use (6) 6
matairesinol (6) 6
plant extracts - chemistry (6) 6
-enterolactone (5) 5
alkaloids (5) 5
asymmetric total synthesis (5) 5
catalysis (5) 5
cell survival - drug effects (5) 5
cells (5) 5
diazoacetates (5) 5
formal synthesis (5) 5
furans - therapeutic use (5) 5
gamma-butyrolactones (5) 5
inhibition (5) 5
mice (5) 5
podophyllotoxin (5) 5
rats (5) 5
-hinokinin (4) 4
activation (4) 4
alpha (4) 4
asteraceae (4) 4
cells, cultured (4) 4
chemistry, inorganic & nuclear (4) 4
chemistry, physical (4) 4
conjugate-addition (4) 4
crystal structure (4) 4
dibenzylbutyrolactones (4) 4
furans - chemical synthesis (4) 4
furofuran (4) 4
identification (4) 4
inflammation (4) 4
kappa-b (4) 4
lactones - chemistry (4) 4
life sciences (4) 4
plant extracts - pharmacology (4) 4
research (4) 4
rutaceae (4) 4
seeds (4) 4
spectroscopy (4) 4
spiro-cyclopropane derivatives (4) 4
stereoselective synthesis (4) 4
-podophyllotoxin (3) 3
4-butyrolactone - chemical synthesis (3) 3
absolute configuration (3) 3
anti-inflammatory agents, non-steroidal - pharmacology (3) 3
antineoplastic agents - pharmacology (3) 3
antineoplastic agents, phytogenic - isolation & purification (3) 3
apoptosis (3) 3
arctium (3) 3
asiaticum var intermedium (3) 3
asymmetric synthesis (3) 3
biological activity (3) 3
cancer-cells (3) 3
cell line, tumor (3) 3
chemical-constituents (3) 3
chemistry, analytical (3) 3
chemotaxonomy (3) 3
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Journal of International Pharmaceutical Research, ISSN 1674-0440, 06/2014, Volume 41, Issue 3, pp. 275 - 281
Journal Article
Natural Product Reports, ISSN 0265-0568, 2009, Volume 26, Issue 10, pp. 1251 - 1292
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 05/2018, Volume 66, Issue 17, pp. 4551 - 4558
The relationship between the structure of lignano-9,9′-lactone (2,3-dibenzylbutyrolactone) and its activity as a plant growth regulator has been clarified.... 
dibenzylbutyrolactone | lignan | phytotoxic activity | lignano-9,9'-lactone | plant growth regulatory activity | lignano-9,9 '-lactone | ALLELOCHEMICALS | (-)-HINOKININ | FOOD SCIENCE & TECHNOLOGY | LEAVES | NEOLIGNANS | FRUCTUS | AGRICULTURE, MULTIDISCIPLINARY | LIGNANS | BEARING | CHEMISTRY, APPLIED
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 06/2011, Volume 9, Issue 11, pp. 4007 - 4016
The synthetic potential of highly directional formal insertion of a carbene between carbon and hydrogen of a carbon-hydrogen bond has recently been developed... 
METAL CARBENE TRANSFORMATIONS | NATURAL DIBENZYLBUTYROLACTONE LIGNANS | FORMAL SYNTHESIS | CARBOXYLIC-ACID ESTERS | ENANTIOSELECTIVE CONJUGATE ADDITION | ALPHA,BETA-UNSATURATED ALDEHYDES | BAEYER-VILLIGER OXIDATION | CHEMISTRY, ORGANIC | HUMAN INTESTINAL BACTERIA | C-H ACTIVATION | MICHAEL ADDITION
Journal Article
Arkivoc, ISSN 1551-7004, 03/2018, Volume 2018, Issue 4, pp. 76 - 93
Lignans are a class of compounds found in plants, especially fiber-rich foods such as flax seeds, whole grains, berries and vegetables. A diet rich in lignans... 
Lignan | Enterolactone | Enantioselective synthesis | Estrogen | enantioselective synthesis | estrogen | NATURAL DIBENZYLBUTYROLACTONE LIGNANS | ASYMMETRIC-SYNTHESIS | enterolactone | FORMAL SYNTHESIS | CHEMISTRY, ORGANIC | EXCRETION | PHYTOESTROGENS | BUTYROLACTONES | (-)-ENTEROLACTONE | CONJUGATE ADDITION
Journal Article
International Journal of Oncology, ISSN 1019-6439, 02/2017, Volume 50, Issue 2, pp. 727 - 735
Arctigenin is a plant lignan extracted from Arctium lappa that has been shown to have estrogenic properties. In spite of the health benefits of phytoestrogens... 
Arctigenin | Phytoestrogen | Estrogen receptor | Metastasis | MCF-7 and MDA-MB-231 human breast cancer cells | APOPTOSIS | estrogen receptor | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CYCLE ARREST | ALPHA | ANTITUMOR-ACTIVITY | IDENTIFICATION | PHENYLPROPANOID DIBENZYLBUTYROLACTONE LIGNAN | phytoestrogen | arctigenin | INHIBITION | ONCOLOGY | metastasis | PATHWAY
Journal Article
Biochemical Systematics and Ecology, ISSN 0305-1978, 08/2018, Volume 79, pp. 50 - 53
Journal Article
Acta Pharmacologica Sinica, ISSN 1671-4083, 05/2018, Volume 39, Issue 5, pp. 787 - 801
Arctigenin (AR) and its glycoside, arctiin, are two major active ingredients of Arctium lappa L (A lappa), a popular medicinal herb and health supplement... 
arctigenin | arctiin | Fructus Arctii | Arctium lappa L | pharmacokinetics | anti-inflammatory agents | clinical efficacy | CANCER-CELLS | NITRIC-OXIDE SYNTHASE | STRUCTURAL TRANSFORMATION | KAPPA-B | CHEMISTRY, MULTIDISCIPLINARY | PHENYLPROPANOID DIBENZYLBUTYROLACTONE LIGNAN | PLANT LIGNAN | SESQUITERPENE LACTONES | HUMAN INTESTINAL BACTERIUM | IN-VITRO | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | Anti-Infective Agents - pharmacology | Furans - pharmacology | Humans | Diabetic Nephropathies - drug therapy | Glucosides - pharmacokinetics | Antineoplastic Agents - administration & dosage | Lignans - pharmacology | Furans - therapeutic use | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Lignans - therapeutic use | Pancreatic Neoplasms - drug therapy | Furans - pharmacokinetics | Neuroprotective Agents - pharmacology | Neuroprotective Agents - pharmacokinetics | Arctium | Glucosides - therapeutic use | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Neuroprotective Agents - administration & dosage | Glucosides - pharmacology | Lignans - administration & dosage | Lignans - pharmacokinetics | Animals | Anti-Infective Agents - administration & dosage | Glucosides - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Anti-Infective Agents - pharmacokinetics | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Cell Line, Tumor | Furans - administration & dosage | Medicinal plants | Effectiveness | Cytokines | Liver | Oral administration | Pharmacology | Inflammation | Chemical compounds | Biological activity | Nitric-oxide synthase | Herbal medicine | Intestine | Nitric oxide | Pharmacokinetics | Review
Journal Article
Process Biochemistry, ISSN 1359-5113, 12/2015, Volume 50, Issue 12, pp. 2281 - 2288
[Display omitted] •A simple, effective method was developed to prepare the precious lignan arctigenin.•Method was based on the enzymatic hydrolysis of S.... 
Arctigenin | Isolation | Lignan | Arctium | Microtubule | Serratula | DIBENZYLBUTYROLACTONE LIGNANS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | SEEDS | ENGINEERING, CHEMICAL | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PODOPHYLLOTOXIN | CELL | CYTOTOXICITY | Hydrolysis | Enzymes | Fruit
Journal Article
International Immunopharmacology, ISSN 1567-5769, 2011, Volume 11, Issue 8, pp. 1095 - 1102
Arctigenin has been demonstrated to have an anti-inflammatory function, but the precise mechanisms of its action remain to be fully defined. In the present... 
Arctigenin | iNOS | JAK-STAT | Anti-inflammation | DIBENZYLBUTYROLACTONE LIGNANS | OXIDE SYNTHASE GENE | ACTIVATION | PHOSPHORYLATION | MACROPHAGES | TRANSCRIPTION | INDUCTION | IMMUNOLOGY | PROTECTS | TRANSDUCERS | PHARMACOLOGY & PHARMACY | REQUIREMENT | Interleukin-6 - antagonists & inhibitors | Furans - pharmacology | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Lignans - pharmacology | STAT1 Transcription Factor - metabolism | Drug Interactions | Mitochondrial Proteins - metabolism | Nitric Oxide Synthase Type II - antagonists & inhibitors | Janus Kinase 2 - metabolism | Membrane Proteins - metabolism | Phosphorylation - drug effects | Janus Kinase 2 - antagonists & inhibitors | STAT3 Transcription Factor - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Line | Cell Survival - drug effects | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Mitochondrial Proteins - antagonists & inhibitors | Chemokine CCL2 - genetics | STAT1 Transcription Factor - antagonists & inhibitors | Macrophages - metabolism | Animals | Membrane Proteins - antagonists & inhibitors | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Chemokine CCL2 - antagonists & inhibitors | STAT3 Transcription Factor - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Mitogens
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 10/2007, Volume 32, Issue 20, pp. 2089 - 2094
Journal Article
Revista Brasileira de Farmacognosia, ISSN 0102-695X, 05/2016, Volume 26, Issue 3, pp. 296 - 303
[Display omitted] Recent publications have highlighted the numerous biological activities attributed to the lignan (−)-cubebin (1), Piper cubeba L. f.,... 
Semisynthetic derivatives | Antibacterial activity | Piper cubeba | (−)-cubebin | Lignans | CHEMISTRY, MEDICINAL | TRYPANOSOMA-CRUZI | INHIBITORY-ACTIVITY | PLAQUE | DIBENZYLBUTYROLACTONE | ACTIVATING-FACTOR RECEPTOR | IN-VITRO | NIGRUM LEAF | TARGETS | PHARMACOLOGY & PHARMACY | (-)-cubebin | CONSTITUENTS
Journal Article