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1. Full Text Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
by Capasso, Clemente and Supuran, Claudiu T
Journal of enzyme inhibition and medicinal chemistry, ISSN 1475-6366, 6/2014, Volume 29, Issue 3, pp. 379 - 387
carbonic anhydrase | Antibacterial | dihydropteroate synthase | sulfa drug | trimethoprim | dihydrofolate reductase | Trimethoprim | Dihydropteroate synthase | Sulfa drug | Dihydrofolate reductase | Carbonic anhydrase | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Trimethoprim - chemical synthesis | Bacterial Proteins - antagonists & inhibitors | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Antimetabolites - chemical synthesis | Dihydropteroate Synthase - antagonists & inhibitors | Bacteria - drug effects | Bacterial Proteins - chemistry | Enzyme Inhibitors - pharmacology | Carbonic Anhydrase Inhibitors - chemical synthesis | Carbonic Anhydrase Inhibitors - pharmacology | Carbonic Anhydrases - chemistry | Enzyme Inhibitors - chemical synthesis | Anti-Bacterial Agents - chemical synthesis | Trimethoprim - analogs & derivatives | Dihydropteroate Synthase - chemistry | Bacteria - enzymology | Anti-Bacterial Agents - pharmacology | Folic Acid Antagonists - chemical synthesis | Sulfanilamides - chemical synthesis | Folic Acid Antagonists - pharmacology | Antimetabolites - pharmacology | Sulfanilamides - pharmacology | Index Medicus
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2. Full Text Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies
by Tsang, Becky L and Devine, Owen J and Cordero, Amy M and Marchetta, Claire M and Mulinare, Joseph and Mersereau, Patricia and Guo, Jing and Qi, Yan Ping and Berry, Robert J and Rosenthal, Jorge and Crider, Krista S and Hamner, Heather C
The American journal of clinical nutrition, ISSN 0002-9165, 06/2015, Volume 101, Issue 6, pp. 1286 - 1294
Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Humans | Middle Aged | Risk Factors | Neural Tube Defects - genetics | Genotype | Neural Tube Defects - prevention & control | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Polymorphism, Genetic | Randomized Controlled Trials as Topic | Young Adult | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Sensitivity and Specificity | Adolescent | Alleles | Folic Acid - blood | Observational Studies as Topic | Adult | Female | Child | Databases, Factual | Neural tube | Abnormalities | Physiological aspects | Genetic aspects | Single nucleotide polymorphisms | Research | Dihydrofolate reductase | Health aspects | Folic acid | Risk factors | Enzymes | Vitamin B | Clinical trials | Systematic review | Blood | Polymorphism | Meta-analysis | Index Medicus | Abridged Index Medicus
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3. Full Text Large cosolutes, small cosolutes, and dihydrofolate reductase activity
by Acosta, Luis C and Perez Goncalves, Gerardo M and Pielak, Gary J and Gorensek‐Benitez, Annelise H
Protein science, ISSN 0961-8368, 12/2017, Volume 26, Issue 12, pp. 2417 - 2425
crowding and enzyme activity | size‐dependent crowding | concentration‐dependent crowding | macromolecular crowding | enzyme kinetics | size-dependent crowding | concentration-dependent crowding | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Recombinant Proteins - metabolism | Escherichia coli - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Recombinant Proteins - chemistry | Dextrans - chemistry | Escherichia coli Proteins - metabolism | Recombinant Proteins - genetics | Ficoll - chemistry | Tetrahydrofolate Dehydrogenase - metabolism | Particle Size | Macromolecular Substances - chemistry | Escherichia coli - genetics | Escherichia coli Proteins - genetics | Kinetics | Escherichia coli Proteins - chemistry | Polyvinyls - chemistry | Macromolecular Substances - metabolism | Tetrahydrofolate Dehydrogenase - genetics | Dextran | Dihydrofolate reductase | Enzyme kinetics | Analysis | Escherichia coli | Viscosity | Sucrose | Catalysts | Low concentrations | Macromolecules | Polyvinylpyrrolidone | Monomers | Crowding | Dilution | E coli | Reaction kinetics | Polymers | Buffers | Sugars | Index Medicus
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4. Full Text The Dynamic Energy Landscape of Dihydrofolate Reductase Catalysis
by David D. Boehr and Dan McElheny and H. Jane Dyson and Peter E. Wright
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2006, Volume 313, Issue 5793, pp. 1638 - 1642
Enzymes | Chemical equilibrium | Energy | Active sites | Energy value | Ligands | Ground state | Reports | Hydrides | Kinetics | Catalysis | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Conformational dynamics in molecular biology | Molecular biophysics | Escherichia coli - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Models, Molecular | Tetrahydrofolate Dehydrogenase - metabolism | Tetrahydrofolates - metabolism | Thermodynamics | Nuclear Magnetic Resonance, Biomolecular | Protein Binding | Protein Conformation | NADP - metabolism | Binding Sites | Research | Dihydrofolate reductase | Escherichia coli | Analysis | Enzymatic analysis | NMR | Nuclear magnetic resonance | E coli | Index Medicus
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5. Full Text Divergent evolution of protein conformational dynamics in dihydrofolate reductase
by Bhabha, Gira and Ekiert, Damian C and Jennewein, Madeleine and Zmasek, Christian M and Tuttle, Lisa M and Kroon, Gerard and Dyson, H. Jane and Godzik, Adam and Wilson, Ian A and Wright, Peter E
Nature structural & molecular biology, ISSN 1545-9993, 11/2013, Volume 20, Issue 11, pp. 1243 - 1249
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Amino Acid Sequence | Genetic Drift | Escherichia coli - enzymology | Tetrahydrofolate Dehydrogenase - chemistry | Humans | Selection, Genetic | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Genetic Complementation Test | Molecular Dynamics Simulation | Sequence Alignment | Protein Conformation | Mutation | Evolution, Molecular | Tetrahydrofolate Dehydrogenase - genetics | Physiological aspects | Research | Dihydrofolate reductase | Structure | Divergent evolution | Proteins | Enzymes | Genetics | Catalysis | Evolutionary biology | Molecular biology | Index Medicus
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6. Full Text Genetic variants in 3′-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans
by Jeon, Young Joo and Kim, Jong Woo and Park, Hye Mi and Kim, Jung O and Jang, Hyo Geun and Oh, Jisu and Hwang, Seong Gyu and Kwon, Sung Won and Oh, Doyeun and Kim, Nam Keun
Scientific reports, ISSN 2045-2322, 06/2015, Volume 5, Issue 1, pp. 11006 - 11006
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetic Predisposition to Disease | Genetic Association Studies | Colorectal Neoplasms - blood | Adenocarcinoma - blood | Colorectal Neoplasms - genetics | Gene Frequency | Humans | Middle Aged | Homocysteine - blood | Male | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Folic Acid - blood | Female | Adenocarcinoma - genetics | Aged | Polymorphism, Single Nucleotide | 3' Untranslated Regions | Republic of Korea | Colorectal carcinoma | Colorectal cancer | Methylenetetrahydrofolate reductase | Gene polymorphism | Folic acid | Metastases | Polymerase chain reaction | Restriction fragment length polymorphism | Genotyping | 3' Untranslated regions | miRNA | Dihydrofolate reductase | Homocysteine | Polymorphism | Index Medicus
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7. Full Text The Methylenetetrahydrofolate Reductase 677C→T Polymorphism as a Modulator of a B Vitamin Network with Major Effects on Homocysteine Metabolism
by Hustad, Steinar and Midttun, Øivind and Schneede, Jørn and Vollset, Stein Emil and Grotmol, Tom and Ueland, Per Magne
American journal of human genetics, ISSN 0002-9297, 2007, Volume 80, Issue 5, pp. 846 - 855
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Multivariate Analysis | Humans | Middle Aged | Homocysteine - blood | Genotype | Male | Homocysteine - metabolism | Methylenetetrahydrofolate Reductase (NADPH2) - metabolism | Vitamin B 12 - blood | Vitamin B 6 - blood | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Folic Acid - blood | Female | Polymorphism, Single Nucleotide | Riboflavin - blood | Vitamin B Complex - metabolism | Vitamin B complex | Genetic aspects | Research | Dihydrofolate reductase | Metabolism | Vitamin B | Enzymes | Genotype & phenotype | Amino acids | Carbon | Polymorphism | Index Medicus
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8. Full Text Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin
by Jansen, Thomas and Hortmann, Marcus and Oelze, Matthias and Opitz, Benjamin and Steven, Sebastian and Schell, Richard and Knorr, Maike and Karbach, Susanne and Schuhmacher, Swenja and Wenzel, Philip and Münzel, Thomas and Daiber, Andreas
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2010, Volume 49, Issue 2, pp. 186 - 195
Cardiovascular | Peroxynitrite | Human umbilical vein endothelial cells | Hydrogen peroxide | Hemin | Biliverdin | Heme oxygenase-1 | Lipopolysaccharide | Biliverdin reductase | Superoxide | Bilirubin | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology | Heme Oxygenase-1 - metabolism | Bilirubin - metabolism | Gene Silencing - drug effects | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Humans | Gene Knockdown Techniques | Respiratory Burst - drug effects | Cytoprotection - drug effects | Neutrophils - metabolism | Umbilical Veins - cytology | Xanthine Oxidase - metabolism | Angiotensin II - pharmacology | Free Radical Scavengers - metabolism | Neutrophils - drug effects | Biliverdine - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Oxidoreductases Acting on CH-CH Group Donors - metabolism | Tyrosine - metabolism | Endothelial Cells - cytology | Models, Biological | Nitrosation - drug effects | Lipopolysaccharides - pharmacology | Peroxynitrous Acid - metabolism | Leukocytes - drug effects | Endothelial Cells - enzymology | Leukocytes - metabolism | Endothelial Cells - drug effects | Oxidases | Nervous system diseases | Albumin | Endothelium | Antioxidants | Molybdenum compounds | Heterocyclic compounds | Analysis | Heme | Dihydrofolate reductase | Mitogens | Index Medicus
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