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Journal Article
Coordination Chemistry Reviews, ISSN 0010-8545, 01/2013, Volume 257, Issue 2, pp. 541 - 563
[Display omitted] ► The Cupin fold provides metal binding motif plasticity. ► The 2-His binding motif offers a platform for halogenations. ► The 3-His binding... 
Metal binding motif | Dioxygenase | Structure–function relationships | Facial triad | Enzyme catalysis | Dioxygen activation | Structure-function relationships | RING-CLEAVING DIOXYGENASES | MOUSE CYSTEINE DIOXYGENASE | TAURINE/ALPHA-KETOGLUTARATE DIOXYGENASE | METHIONINE SALVAGE PATHWAY | CHEMISTRY, INORGANIC & NUCLEAR | PSEUDOMONAS-PAUCIMOBILIS TMY1009 | NONHEME IRON ENZYMES | 2-HIS-1-CARBOXYLATE FACIAL TRIAD | ELECTRON-PARAMAGNETIC-RESONANCE | CYANOBACTERIUM LYNGBYA-MAJUSCULA | CONTAINING QUERCETIN 2,3-DIOXYGENASE | Enzymes | Taurine | Flavonoids | Cysteine | Peptides | Flavones | Bioflavonoids | Collateralized debt obligations | TauD, taurine hydroxylase | acac, acetylacetone (2,4-pentanedione) | BsQDO, quercetin 2,3-dioxygenase from Bacillus subtilis | 2OH-1,3-Ph2PD, 2-hydroxy-1,3-diphenylpropanedione | CS2, clavaminate synthase | 6-Ph2TPA, N,N-bis[(6-phenyl-2-pyridyl)methyl]-N-[(2-pyridyl)-methyl]amine | QDO, quercetin 2,3-dioxygenase | MNHEs, mononuclear non-heme-Fe(II) dependent enzymes | EPR, electron paramagnetic resonance | XAS, X-ray absorption spectroscopy | Review | Dke1, diketone dioxygenase | ADO, cysteamine dioxygenase | GDO, gentisate 1,2-dioxygenase | fla, flavonolate | SDO, salicylate 1,2-dioxygenase | HNDO, hydroxy-2-naphthoate dioxygenase | CDO, cysteine dioxygenase | HADO, 3-hydroxyanthranilate 3,4-dioxygenase | HGDO, homogentisate 1,2-dioxygenase | NRP, nonribosomal peptide | EXAFS, extended X-ray absorption fine structure spectroscopy | α-KG, α-ketoglutarate | DFT, density functional theory | CarOs, carotenoid oxygenases | MCD, magnetic circular dichroism | AO, apocarotenoid 15,15′-oxygenase | ARD, aci-reductone dioxygenase | PDB, protein data bank | CGDO, 5-chloro-gentisate 1,2-dioxygenase | OTf-, trifluormethanesulfonate | 1,3-bis(2-pyridylimino)isoindoline, ind | CD, circular dichroism
Journal Article
The FEBS Journal, ISSN 1742-464X, 03/2019, Volume 286, Issue 5, pp. 975 - 990
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 19, Issue 1, pp. 17 - 30
IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of... 
BREAST-CANCER | TRANSCRIPTIONAL ACTIVITY | IDH2 MUTATIONS | ONCOLOGY | PROLYL HYDROXYLATION | INTEGRATED GENOMIC ANALYSIS | 2-OXOGLUTARATE OXYGENASES | ACUTE MYELOID-LEUKEMIA | HIF-ALPHA | HISTONE DEMETHYLATION | FAMILY | CELL BIOLOGY | Dioxygenases - metabolism | Histone Demethylases - antagonists & inhibitors | Gene Expression - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Ketoglutaric Acids - chemistry | Glioma - genetics | F-Box Proteins | Oxidoreductases, N-Demethylating - antagonists & inhibitors | Ketoglutaric Acids - pharmacology | Cytosine - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glutarates - chemistry | Oxidoreductases, N-Demethylating - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Glioma - enzymology | Endostatins - metabolism | Models, Molecular | Isocitrate Dehydrogenase - genetics | Histone Demethylases - metabolism | Dioxygenases - antagonists & inhibitors | Amino Acid Substitution - physiology | Procollagen-Proline Dioxygenase - genetics | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Glutarates - pharmacology | Histones - metabolism | Jumonji Domain-Containing Histone Demethylases - metabolism | Caenorhabditis elegans - enzymology | Cytosine - analogs & derivatives | Gene Expression - drug effects | Caenorhabditis elegans Proteins - metabolism | Isocitrate Dehydrogenase - antagonists & inhibitors | Glioma - metabolism | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Mixed Function Oxygenases | Biocatalysis - drug effects | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Jumonji Domain-Containing Histone Demethylases - chemistry | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Ketoglutaric Acids - metabolism | Oxalates - pharmacology | Binding, Competitive | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Catalytic Domain | Proto-Oncogene Proteins - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Animals | 5-Methylcytosine - metabolism | Caenorhabditis elegans Proteins - antagonists & inhibitors | Glutarates - metabolism
Journal Article
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 118, Issue 6, pp. 781 - 794
Reactive oxygen species (ROS) are implicated in the pathophysiology of various diseases, including cancer. In this study, we show that JunD, a member of the... 
HYPOXIA-INDUCIBLE FACTOR | PARAMAGNETIC-RESONANCE | MITOCHONDRIAL RESPIRATORY-CHAIN | MESSENGER-RNA | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | FACTOR-I | CYCLE PROGRESSION | ENDOTHELIAL GROWTH-FACTOR | TRANSCRIPTIONAL RESPONSE | CELL BIOLOGY | Neoplasms - metabolism | Proto-Oncogene Proteins c-jun - physiology | Reactive Oxygen Species - metabolism | Antioxidants - metabolism | Humans | ras Proteins - metabolism | Vascular Endothelial Growth Factor A - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit | Procollagen-Proline Dioxygenase - metabolism | Neoplasms - genetics | Neovascularization, Pathologic - physiopathology | Gene Expression Regulation, Neoplastic - genetics | Proto-Oncogene Proteins c-jun - genetics | Oxidative Stress - genetics | Neoplasms - blood supply | Up-Regulation - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases | Dioxygenases | Iron - metabolism | Hydrogen Peroxide - metabolism | Transcription Factors - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | Neovascularization, Pathologic - genetics | Neovascularization, Pathologic - metabolism | Oxidative stress | Genetic transcription | Research | Neovascularization | Up-Regulation | Vascular Endothelial Growth Factor A | Reactive Oxygen Species | ras Proteins | Oxidative Stress | Hydrogen Peroxide | Biochemistry, Molecular Biology | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Iron | Neoplasms | Antioxidants | Life Sciences | Transcription Factors | Procollagen-Proline Dioxygenase | Proto-Oncogene Proteins c-jun | Cancer
Journal Article
Journal Article