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dlk1 (201) 201
index medicus (137) 137
animals (108) 108
humans (86) 86
expression (78) 78
mice (65) 65
female (64) 64
intercellular signaling peptides and proteins - genetics (61) 61
intercellular signaling peptides and proteins - metabolism (53) 53
cell biology (50) 50
male (50) 50
membrane proteins - genetics (49) 49
genomic imprinting (48) 48
biochemistry & molecular biology (47) 47
gene expression (47) 47
pref-1 (46) 46
protein (46) 46
genetics & heredity (41) 41
analysis (38) 38
membrane proteins - metabolism (38) 38
growth (36) 36
dna methylation (34) 34
gtl2 (34) 34
methylation (33) 33
adipocyte differentiation (32) 32
differentiation (32) 32
stem-cells (32) 32
genes (30) 30
identification (30) 30
cell differentiation (29) 29
research (29) 29
oncology (27) 27
stem cells (27) 27
cancer (26) 26
gene-expression (26) 26
adipogenesis (25) 25
gene (24) 24
imprinted genes (24) 24
proteins (24) 24
mutation (23) 23
phenotype (22) 22
preadipocyte factor 1 (22) 22
developmental biology (21) 21
endocrinology & metabolism (21) 21
genetic research (21) 21
locus (21) 21
genetic aspects (20) 20
molecular sequence data (20) 20
polar overdominance (20) 20
rna, long noncoding (20) 20
sheep (20) 20
skeletal-muscle (20) 20
base sequence (19) 19
cell proliferation (19) 19
domain (19) 19
imprinting (19) 19
proteins - genetics (19) 19
uniparental disomy (19) 19
biotechnology & applied microbiology (18) 18
inhibits adipocyte differentiation (18) 18
meg3 (18) 18
mouse (18) 18
adult (17) 17
mice, inbred c57bl (17) 17
cells (16) 16
gene expression regulation, developmental (16) 16
notch (16) 16
agriculture, dairy & animal science (15) 15
article (15) 15
rna (15) 15
activation (14) 14
biology (14) 14
dlk1 gene (14) 14
factor-i pref-1 (14) 14
hypertrophy (14) 14
pregnancy (14) 14
progenitor cells (14) 14
proliferation (14) 14
signal transduction (14) 14
alleles (13) 13
cell line (13) 13
egf-like repeats (13) 13
epigenetics (13) 13
fetal antigen-1 (13) 13
gene expression regulation (13) 13
growth-hormone (13) 13
immunohistochemistry (13) 13
life sciences (13) 13
liver (13) 13
mice, knockout (13) 13
middle aged (13) 13
reverse transcriptase polymerase chain reaction (13) 13
cell line, tumor (12) 12
cells, cultured (12) 12
cluster (12) 12
epidermal growth factor (12) 12
gene expression regulation, neoplastic (12) 12
inhibition (12) 12
medicine (12) 12
muscle, skeletal - metabolism (12) 12
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1. Full Text MEG3 imprinted gene contribution in tumorigenesis
by Benetatos, Leonidas and Vartholomatos, George and Hatzimichael, Eleftheria
International Journal of Cancer, ISSN 0020-7136, 08/2011, Volume 129, Issue 4, pp. 773 - 779
Maternally expressed gene 3 (MEG3) is a maternally expressed imprinted gene representing a large noncoding RNA in which microRNAs (miRNAs) and small nucleolar... 
MEG3 | cancer | noncoding RNA | delta‐like 1 homolog (DLK1) | imprinting | methylation | delta-like 1 homolog (DLK1) | METHYLATION ANALYSIS | DOMAIN | DNA METHYLATION | TUMOR | UNIPARENTAL DISOMY | GTL2 | ONCOLOGY | NONCODING RNAS | PROMOTER REGION | EXPRESSION | TRANSGENIC MICE | Proteins - genetics | Genomic Imprinting | Animals | Neoplasms - etiology | Humans | RNA, Long Noncoding | Mice | Neoplasms - pathology
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2. Full Text MiR-129-5p inhibits non-small cell lung cancer cell sternness and chemoresistance through targeting DLK1
by Ma, Z and Cai, HF and Zhang, Y and Chang, L and Cui, YB
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 08/2017, Volume 490, Issue 2, pp. 309 - 316
Non-small cell lung cancer (NSCLC) sternness and chemoresistance represent significant barriers to successful treatment. Downregulation of microRNA 129... 
Sternness | STEM-CELLS | MICRORNA BIOGENESIS | PROTEINS DLK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Chemoresistance | NOTCH1 RECEPTOR | DLK1 | HEPATOCELLULAR-CARCINOMA | BIOPHYSICS | PROGNOSTIC BIOMARKER | GASTRIC-CANCER | Non-small cell lung cancer | DYSREGULATION | GROWTH | DIFFERENTIATION | MiR-129-5p
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3. Full Text Microarray analysis of blood microvessels from PDGF-B and PDGF-Rβ mutant mice identifies novel markers for brain pericytes
by Bondjers, Cecilia and He, Liqun and Takemoto, Minoru and Norlin, Jenny and Asker, Noomi and Hellström, Mats and Lindahl, Per and Betsholtz, Christer
FASEB Journal, ISSN 0892-6638, 08/2006, Volume 20, Issue 10, pp. E1005 - E1013
RGS5 | Kir6.1 | SUR2 | Vascular stability | DLK1
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4. Full Text Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance
by Yun-Qian Gao and Xin Chen and Pei Wang and Lei Lu and Wei Zhao and Chen Chen and Cai-Ping Chen and Tao Tao and Jie Sun and Yan-Yan Zheng and Jie Du and Chao-Jun Li and Zhen-Ji Gan and Xiang Gao and Hua-Qun Chen and Min-Sheng Zhu
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 44, pp. 13627 - 13632
Inheritance of the callipyge phenotype in sheep is an example of polar overdominance inheritance, an unusual mode of inheritance. To investigate the underlying... 
Muscle hypertrophy | Callipyge | MIR-379/MIR-544 cluster | DLK1 | callipyge | MEAT QUALITY | RETROTRANSPOSON-LIKE GENE | 1 HOMOLOG DLK1 | MULTIDISCIPLINARY SCIENCES | SHEEP | miR-379/miR-544 cluster | LOCUS | IMPRINTED GENES | SKELETAL-MUSCLE | HYPERTROPHY | muscle hypertrophy | TRANS-INTERACTION | MICRORNA | Genomic Imprinting | Multigene Family | Animals | Intercellular Signaling Peptides and Proteins - genetics | Female | Mice | MicroRNAs - genetics | Genetic aspects | Research | Gene expression | Atrophy, Muscular | Biological Sciences | miR-544 cluster | miR-379
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5. Full Text Deletion of Dlk1 increases the vulnerability to developing anxiety-like behaviors and ethanol consumption in mice
by García-Gutiérrez, María S and Navarrete, Francisco and Laborda, Jorge and Manzanares, Jorge
Biochemical Pharmacology, ISSN 0006-2952, 12/2018, Volume 158, pp. 37 - 44
Anxiety and alcohol use disorders (AUD) often present together, constituting a significant public health problem worldwide. In this study, we investigated the... 
Anxiety-related behavior | Ethanol consumption | NOTCH signaling pathway | Gene expression | Ethanol-reinforcing properties | Dlk1 | EXTRACELLULAR DOPAMINE LEVELS | STEM-CELLS | PROTEINS DLK1 | ANXIOLYTIC ACTION | NOTCH1 RECEPTOR | RELEASE | REWARD | MU-OPIOID RECEPTOR | RAT NUCLEUS-ACCUMBENS | NEURONS | PHARMACOLOGY & PHARMACY | Tyrosine | Neurosciences | Alcohol, Denatured | Epidermal growth factor | Genes | Alcohol
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6. Full Text LncRNA DLX6-AS1/miR-129-5p/DLK1 axis aggravates stemness of osteosarcoma through Wnt signaling
by Zhang, Rong-mou and Tang, Ting and Yu, Hai-Ming and Yao, Xue-Dong
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2018, Volume 507, Issue 1-4, pp. 260 - 266
Osteosarcoma is the most common primary bone tumor and occurs most frequently in adolescents. Cancer stem cells (CSCs) are resistant to chemotherapy and... 
Stemness | DLX6-AS1 | Osteosarcoma | DLK1 | miR-129-5p | Medical colleges | Medical research | Chemotherapy | RNA | Stem cells | Medicine, Experimental | Cancer
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7. Full Text Membrane-bound delta-like 1 homolog (Dlk1) promotes while soluble Dlk1 inhibits myogenesis in C2C12 cells
by Shin, Sangsu and Suh, Yeunsu and Zerby, Henry N and Lee, Kichoon
FEBS Letters, ISSN 0014-5793, 04/2014, Volume 588, Issue 7, pp. 1100 - 1108
Delta-like 1 homolog ( ) is important in myogenesis. However, the roles of different Dlk1 isoforms have not been investigated. In C2C12 cell lines producing... 
Muscle development | myogenesis | Soluble Dlk1 | C2C12 cell | Membrane-bound Dlk1 | MRF | Myog | Noggin | reverse-transcription quantitative PCR | hemagglutinin | Murf1 | paired box 7 | myostatin | reverse transcription | muscle-specific RING finger protein 1 | callipyge mutation | caveolin3 | myogenic differentiation | ribosomal protein, large, P0 | myogenic regulatory factor | RT-qPCR | Foxo3 | delta-like 1 homolog | Mstn | Cav3 | MyoD | myogenin | EGF | Fst | Nog | TACE | follistatin | tumor necrosis factor-alpha converting enzyme | Dlk1 | Bmp4 | myogenic factor 5 | Pax7 | Rplp0 | epidermal growth factor | forkhead box O3 | bone morphogenetic protein 4 | Myf5 | CLPG | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | NOTCH | UNIPARENTAL DISOMY | SATELLITE CELLS | SKELETAL-MUSCLE DEVELOPMENT | CELL BIOLOGY | BIOPHYSICS | GENE | FACTOR-I PREF-1 | CALLIPYGE PHENOTYPE | ADIPOCYTE DIFFERENTIATION | EXPRESSION | Cell Line | Gene Expression | Gene Expression Regulation | Solubility | Cell Size | Mice, Inbred ICR | Protein Isoforms - physiology | Intercellular Signaling Peptides and Proteins - physiology | Muscle Proteins - genetics | Muscle Development | Animals | Membrane Proteins - physiology | Muscle Proteins - metabolism | Sheep | Cell Differentiation | Mice | Muscle Fibers, Skeletal - physiology
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8. Full Text Expressed alleles of imprinted IGF2, DLK1 and MEG3 colocalize in 3D-preserved nuclei of porcine fetal cells
by Lahbib-Mansais, Yvette and Barasc, Harmonie and Marti-Marimon, Maria and Mompart, Florence and Iannuccelli, Eddie and Robelin, David and Riquet, Juliette and Yerle-Bouissou, Martine
BMC Cell Biology, ISSN 1471-2121, 10/2016, Volume 17, Issue 1, p. 35
To explore the relationship between spatial genome organization and gene expression in the interphase nucleus, we used a genomic imprinting model, which offers... 
3D RNA-DNA FISH | Colocalization | DLK1/MEG3 | Fetal pig | Imprinting | Interchromosomal associations | Liver | IGF2 | Muscle | Genomic Imprinting | RNA Transport | Membrane Proteins - genetics | Cell Count | Liver - metabolism | RNA, Messenger - genetics | In Situ Hybridization, Fluorescence | RNA, Long Noncoding - genetics | Genetic Loci | RNA, Messenger - metabolism | Insulin-Like Growth Factor II - metabolism | DNA - genetics | Fetus - cytology | Animals | Cell Nucleus - metabolism | Insulin-Like Growth Factor II - genetics | Alleles | Liver - cytology | Membrane Proteins - metabolism | Chromosomes, Mammalian - metabolism | Muscles - metabolism | Sus scrofa - embryology | RNA, Long Noncoding - metabolism | Muscles - cytology | Allelomorphism | Research | Genetic transcription | Gene expression | Analysis
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9. Full Text DIk1-Mediated Temporal Regulation of Notch Signaling Is Required for Differentiation of Alveolar Type II to Type I Cells during Repair
by Finn, J and Sottoriva, K and Pajcini, KV and Kitajewski, JK and Chen, C and Zhang, W and Malik, AB and Liu, YR
CELL REPORTS, ISSN 2211-1247, 03/2019, Volume 26, Issue 11, pp. 2942 - 2942
Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering similar to 95% of... 
STEM-CELLS | PROGENITOR | PROTEIN | GENE | PATHWAY | KAPPA-B | LIGAND | DELTA-LIKE | PROMOTES | DLK1 | CELL BIOLOGY
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10. Full Text Similarities and differences in tissue distribution of DLK1 and DLK2 during E16.5 mouse embryogenesis
by Garcia-Gallastegi, P and Ruiz-García, A and Ibarretxe, G and Rivero-Hinojosa, S and González-Siccha, A D and Laborda, J and Crende, O and Unda, F and García-Ramírez, J J
Histochemistry and Cell Biology, ISSN 0948-6143, 7/2019, Volume 152, Issue 1, pp. 47 - 60
DLK1 and DLK2 are transmembrane proteins belonging to the EGF-like repeat-containing family that function as non-canonical NOTCH inhibitory ligands. DLK1 is... 
Biomedicine, general | Biochemistry, general | Biomedicine | Tissue distribution | Developmental Biology | Embryo development | DLK1 | Cell Biology | DLK2 | PREF-1 | STEM-CELLS | PROTEIN | 1 HOMOLOG DLK1 | NOTCH1 RECEPTOR | MICROSCOPY | NEGATIVE REGULATOR | CELL BIOLOGY | SKELETAL-MUSCLE | INTERACTS | DIFFERENTIATION | EXPRESSION | Embryonic development | Epidermal growth factor | Analysis | Liver | Muscles | Cell differentiation | Cells | Membrane proteins | Ectoderm | Vertebrae | Kidneys | Mesoderm | Salivary gland | Preadipocyte factor 1 | Embryos | Skeletal muscle | Thymus | Morphogenesis | Proteins | Cartilage | Embryogenesis | Intestine | Pancreas | Endoderm
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11. Full Text Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth
by Carreras-Badosa, G and Remesar, X and Prats-Puig, A and Xargay-Torrent, S and Lizarraga-Mollinedo, E and de Zegher, F and Ibanez, L and Bassols, J and Lopez-Bermejo, A
PEDIATRIC RESEARCH, ISSN 0031-3998, 08/2019, Volume 86, Issue 2, pp. 195 - 201
BACKGROUND: Although prenatal and postnatal programming of metabolic diseases in adulthood is well established, the mechanisms underpinning metabolic... 
OBESITY | WISTAR | 1 HOMOLOG DLK1 | SENSITIVITY | MUSCLE | PEDIATRICS | ADIPOSE-TISSUE
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12. Full Text LncRNA DLX6-AS1/miR-129-5p/DLK1 axis aggravates sternness of osteosarcoma through Wnt signaling
by Zhang, RM and Tang, T and Yu, HM and Yao, XD
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 12/2018, Volume 507, Issue 1-4, pp. 260 - 266
Osteosarcoma is the most common primary bone tumor and occurs most frequently in adolescents. Cancer stem cells (CSCs) are resistant to chemotherapy and... 
CROSS-TALK | Stemness | STEM-CELLS | BIOPHYSICS | LONG NONCODING RNA | Osteosarcoma | BIOCHEMISTRY & MOLECULAR BIOLOGY | DLX6-AS1 | CANCER | DLK1 | PROGRESSION | miR-129-5p
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13. Full Text H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1
by Paul Monnier and Clémence Martinet and Julien Pontis and Irina Stancheva and Slimane Ait-Si-Ali and Luisa Dandolo
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 12/2013, Volume 110, Issue 51, pp. 20693 - 20698
The H19 gene controls the expression of several genes within the Imprinted Gene Network (IGN), involved in growth control of the embryo. However, the... 
Long noncoding RNA partner | Embryonic growth | Cdkn1c | Dlk1 | Genomic imprinting | SYSTEM | METHYLATION | MULTIDISCIPLINARY SCIENCES | IGF2 | CPG-BINDING-PROTEINS | genomic imprinting | PRINCIPLES | DELETION | ELEMENT | LONG NONCODING RNA | DNA | GROWTH | long noncoding RNA partner | embryonic growth | Ribonucleoproteins - metabolism | Gene Regulatory Networks - physiology | DNA-Binding Proteins - genetics | Embryo, Mammalian - metabolism | Mice, Knockout | DNA-Binding Proteins - metabolism | Animals | Alleles | Genomic Imprinting - physiology | Ribonucleoproteins - genetics | Mice | DNA Methylation - physiology | RNA, Long Noncoding - metabolism | Gene Expression Regulation, Developmental - physiology | Biological Sciences
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14. Full Text Deletion of delta-like 1 homologue accelerates fibroblast–myofibroblast differentiation and induces myocardial fibrosis
by Rodriguez, Patricia and Sassi, Yassine and Troncone, Luca and Benard, Ludovic and Ishikawa, Kiyotake and Gordon, Ronald E and Lamas, Santiago and Laborda, Jorge and Hajjar, Roger J and Lebeche, Djamel
European Heart Journal, ISSN 0195-668X, 03/2019, Volume 40, Issue 12, pp. 967 - 978
Abstract Aims Myocardial fibrosis is associated with profound changes in ventricular architecture and geometry, resulting in diminished cardiac function. There... 
Cardiac fibrosis | Fibroblast–myofibroblast transdifferentiation | miR-370 | TGF-β signalling | Dlk1 | PREF-1 | TGF- signalling | STEM-CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | Fibroblast-myofibroblast transdifferentiation | NOTCH | PHENOTYPE | FACTOR-I | REGULATOR
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15. Full Text Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice
by McGowan, Stephen E and McCoy, Diann M
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 10/2014, Volume 307, Issue 8, pp. L618 - L631
Signaling through platelet-derived growth factor receptor-alpha (PDGFR alpha) is required for alveolar septation and participates in alveolar regeneration... 
Adipocyte | Preadipocyte factor-1 | Sex-determining region Y box 9 | Platelet-derived growth factor | Delta-like ligand-1 (Dlk1) | Stem cell | Stereology | Lung alveolarization | PROGENITOR CELLS | STEM-CELLS | PHYSIOLOGY | RECEPTOR-ALPHA EXPRESSION | lung alveolarization | 1 HOMOLOG DLK1 | sex-determining region Y box 9 | stereology | BRANCHING MORPHOGENESIS | platelet-derived growth factor | delta-like ligand-1 (Dlk1) | SKELETAL-MUSCLE | preadipocyte factor-1 | stem cell | RESPIRATORY SYSTEM | adipocyte | PDGFR-ALPHA | LUNG FIBROBLASTS | PPAR-GAMMA | SWITCH GENE 2 | SOX9 Transcription Factor - metabolism | Signal Transduction | Lipids - physiology | Biomarkers - analysis | Cells, Cultured | Microfilament Proteins - physiology | Male | Mice, Knockout | Myofibroblasts - cytology | Myofibroblasts - metabolism | Receptor, Platelet-Derived Growth Factor alpha - physiology | Phenotype | Animals | Flow Cytometry | Pulmonary Alveoli - metabolism | Pulmonary Alveoli - cytology | Female | Integrases - metabolism | Cell Differentiation | Fibroblasts - cytology | Mice | Respiratory Mechanics | Muscle Proteins - physiology | Fibroblasts - metabolism | Cell research | Fibroblasts | Genetic research | Genetic aspects | Lipid metabolism | Research | Health aspects
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16. Full Text The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptake
by Jensen, Charlotte Harken and Kosmina, Rok and Rydén, Mikael and Baun, Christina and Hvidsten, Svend and Andersen, Marianne Skovsager and Andersen, Ditte Caroline and Christensen, Louise Lehmann and Gastaldelli, Amalia and Marraccini, Paolo and Arner, Peter and Jørgensen, Christian Damsgaard and Laborda, Jorge and Holst, Jens Juul
EBioMedicine, ISSN 2352-3964, 08/2019, Volume 46, pp. 368 - 380
The imprinted gene Delta like non-canonical Notch ligand 1 ( ) is considered an inhibitor of adipogenesis, but its impact on fat mass indeed remains elusive... 
Type 2 diabetes | Obesity | Insulin resistance | Glucose uptake | Dlk1 | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PROTEIN | RECEPTOR | METABOLISM | FACTOR-I PREF-1 | SERUM-LEVELS | FAT | DIFFERENTIATION | HOMOLOG DLK1 | GLUT4
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