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1. Full Text Enantioselective total synthesis of (-)-kainic acid and (+)-acromelic acid C: Via Rh(i)-catalyzed asymmetric enyne cycloisomerization
by Lei, Honghui and Xin, Shan and Qiu, Yifan and Zhang, Xumu
Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 7, pp. 727 - 730
A diversity-oriented synthetic strategy was developed for the total synthesis of kainoid amino acids, which led to the enantioselective synthesis of (-)-kainic... 
CATALYZED CYCLOISOMERIZATIONS | HUNTINGTONS-CHOREA | NEUROEXCITATORY AMINO-ACIDS | ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS | (-)-ALPHA-KAINIC ACID | ACROMELIC ACID | KAINIC ACID | (+)-ALPHA-ALLOKAINIC ACID | CHEMISTRY, MULTIDISCIPLINARY | CLITOCYBE-ACROMELALGA | DOMOIC ACID | Amino acids | Amides | Chemical synthesis | Vinyl acetate | Isomerization
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2. Full Text Liquid Chromatography–Tandem Mass Spectrometry Method for the Screening of Eight Paralytic Shellfish Poisoning Toxins, Domoic Acid, 13-Desmethyl Spirolide C, Palytoxin and Okadaic Acid in Seawater
by Riccardi, Carmela and Buiarelli, Francesca and Di Filippo, Patrizia and Distratis, Sisto and Giannetti, Luigi and Manganelli, Maura and Neri, Bruno and Pomata, Donatella and Stefanelli, Mara
Chromatographia, ISSN 0009-5893, 2/2018, Volume 81, Issue 2, pp. 277 - 288
A quick and reproducible screening analytical method for the simultaneous determination of algal toxins, belonging to different chemical classes, was developed... 
Column liquid chromatography | Chemistry | Analytical Chemistry | Harmful algal blooms | Pharmacy | Proteomics | Algal toxins | Laboratory Medicine | Seawater samples | Chromatography | Solid-phase extraction | CHEMISTRY, ANALYTICAL | PROFILES | PUTATIVE PALYTOXIN | PSP TOXINS | RED TIDE | BIOCHEMICAL RESEARCH METHODS | OSTREOPSIS-OVATA | LC-MS | MARINE BIOTOXINS | OVATOXIN-A | Marine toxins | Paralytic shellfish poisoning | Liquid chromatography | Medical screening | Mass spectrometry | Sea-water | Methods | Elution | Shellfish | Ions | Ecological risk assessment | Screening | Acids | Ionization | Cartridges | Toxins | Poisoning | Seawater
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3. Domoic acid toxicity
: proceedings of a symposium : Ottawa, Ontario 11-12 April 1989
by Hynie, I and Todd, E.C.D and Laboratory Centre for Disease Control (Canada) and Canada. Food Directorate
1990, 16S1E., Volume 16S1E., 123
toxicity | INE | marine water | paralytic shellfish poisoning | Mytilus edulis | human diseases | human physiology | Canada | biological poisons | domoic acid | red tide | public health | conferences | food poisoning
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4. Full Text A general synthetic approach to the amnesic shellfish toxins: Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F
by Lemière, Gilles and Sedehizadeh, Simon and Toueg, Julie and Fleary-Roberts, Nadia and Clayden, Jonathan
Chemical Communications, ISSN 1359-7345, 04/2011, Volume 47, Issue 13, pp. 3745 - 3747
The alkynylpyrrolidine 4 was made via a dearomatising cyclisation of an aromatic amide, and was elaborated by stannylcupration and palladium-catalysed coupling... 
ORGANIC-SYNTHESIS | (-)-KAINIC ACID | ASYMMETRIC-SYNTHESIS | ISODOMOIC ACIDS | CHONDRIA-ARMATA | VIVO SEIZURE INDUCTION | STEREOSELECTIVE-SYNTHESIS | CHIRAL LITHIUM AMIDES | DEAROMATISING CYCLIZATION | CHEMISTRY, MULTIDISCIPLINARY | DOMOIC ACID | Models, Molecular | Heptanoic Acids - chemical synthesis | Cyclization | Isomerism | Shellfish - analysis | Marine Toxins - chemical synthesis
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5. Full Text Climatic regulation of the neurotoxin domoic acid
by McKibben, S. Morgaine and Peterson, William and Wood, A. Michelle and Trainer, Vera L and Hunter, Matthew and White, Angelicque E
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, pp. 239 - 244
Domoic acid is a potent neurotoxin produced by certain marine microalgae that can accumulate in the foodweb, posing a health threat to human seafood consumers... 
El Niño | Domoic acid | Northern California Current | Pacific Decadal Oscillation | Pseudo-nitzschia | HARMFUL ALGAL BLOOMS | PACIFIC | MULTIDISCIPLINARY SCIENCES | RAZOR CLAMS | UPWELLING SYSTEMS | domoic acid | El Nino | ENSO TELECONNECTIONS | IMPACTS | ECOSYSTEM | EL-NINO | Marine Toxins - analysis | Oregon | Kainic Acid - analysis | Climate | Environmental Monitoring | Animals | Bivalvia | Kainic Acid - analogs & derivatives | California | Neurotoxins - analysis | Shellfish - analysis | Washington | Health aspects | Neurotoxic agents | Shellfish | Food chains | Risk assessment | Ocean currents | Biological Sciences | Physical Sciences
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6. Full Text Domoic acid epileptic disease
by Ramsdell, John S and Gulland, Frances M
Marine Drugs, ISSN 1660-3397, 2014, Volume 12, Issue 3, pp. 1185 - 1207
Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was... 
Rat | Aggression | Olfactory | Piriform cortex | Epilepsy | Seizure | Amnesic shellfish poison | Domoic acid | Sea lion | epilepsy | AGGRESSIVE-BEHAVIOR | CHEMISTRY, MEDICINAL | seizure | rat | TEMPORAL-LOBE EPILEPSY | piriform cortex | CALIFORNIA SEA LIONS | KAINIC ACID | aggression | ANTERIOR OLFACTORY NUCLEUS | domoic acid | sea lion | ZALOPHUS-CALIFORNIANUS | olfactory | amnesic shellfish poison | EXPOSURE | BRAIN | Recurrence | Food Contamination | Humans | Middle Aged | Kainic Acid - analogs & derivatives | Shellfish Poisoning - diagnosis | Marine Toxins - poisoning | Epilepsy, Temporal Lobe - physiopathology | Male | Seizures - chemically induced | Neuromuscular Depolarizing Agents - poisoning | Olfactory Pathways - physiopathology | Amnesia - chemically induced | Bivalvia | Neurotoxins - poisoning | Aged, 80 and over | Behavior, Animal - drug effects | Female | Seizures - veterinary | Kainic Acid - poisoning | Amnesia - psychology | Epilepsy, Temporal Lobe - chemically induced | Rats | Seizures - diagnosis | Animal Diseases - diagnosis | Animal Diseases - chemically induced | Epilepsy - diagnosis | Animals | Aging - physiology | Epilepsy - chemically induced | Sea Lions - physiology | Epilepsy - veterinary | Shellfish Poisoning - veterinary | Aged | Animal Diseases - physiopathology | Hippocampus - physiopathology | Shellfish Poisoning - physiopathology
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7. Full Text Morphology and molecular phylogeny of Nitzschia bizertensis sp. nov.—A new domoic acid-producer
by Smida, Donia Bouchouicha and Lundholm, Nina and Kooistra, Wiebe H.C.F and Sahraoui, Inès and Ruggiero, Maria Valeria and Kotaki, Yuichi and Ellegaard, Marianne and Lambert, Christophe and Mabrouk, Hassine Hadj and Hlaili, Asma Sakka
Harmful Algae, ISSN 1568-9883, 02/2014, Volume 32, pp. 49 - 63
A new toxin-producing marine diatom, sp. nov., isolated from the Bizerte Lagoon (Tunisia, Southwest Mediterranean Sea) is, based on studies on eight different... 
Toxin | LSU rDNA | ITS rDNA | Diatom | SSU rDNA | Phylogeny | Domoic acid | Nitzschia bizertensis sp. nov | NAVIS-VARINGICA | BACILLARIACEAE | Nitzschia bizertensis sp nov | MULTISERIES | IDENTIFICATION | PSEUDO-NITZSCHIA | AMINO-ACID | MARINE & FRESHWATER BIOLOGY | RDNA SEQUENCES | SHELLFISH | BACILLARIOPHYCEAE | Environmental Sciences
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8. Full Text Metal–organic framework UiO-66 modified magnetite@silica core–shell magnetic microspheres for magnetic solid-phase extraction of domoic acid from shellfish samples
by Zhang, Lan and Zhang, Wenmin and Yan, Zhiming and Gao, Jia and Tong, Ping and Liu, Wei
Journal of Chromatography A, ISSN 0021-9673, 06/2015, Volume 1400, pp. 10 - 18
Fe O @SiO @UiO-66 core–shell magnetic microspheres were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, X-ray... 
HPLC–MS/MS | Magnetic solid-phase extraction | Core–shell magnetic microsphere | Domoic acid | Metal–organic frameworks | Core-shell magnetic microsphere | HPLC-MS/MS | Metal-organic frameworks | CHEMISTRY, ANALYTICAL | POLYCYCLIC AROMATIC-HYDROCARBONS | BIOCHEMICAL RESEARCH METHODS | TANDEM MASS-SPECTROMETRY | PERFORMANCE LIQUID-CHROMATOGRAPHY | NANOPARTICLES | POISONING TOXINS | MICROEXTRACTION | ENVIRONMENTAL WATER SAMPLES | ELECTROPHORESIS | CAPILLARY ELECTROCHROMATOGRAPHY | OPTIMIZATION | Magnetite | Safety and security measures | Silica | Analysis | Food
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9. Full Text Domoic acid in a marine pelagic food web: Exposure of southern right whales Eubalaena australis to domoic acid on the Península Valdés calving ground, Argentina
by D’Agostino, Valeria C and Degrati, Mariana and Sastre, Viviana and Santinelli, Norma and Krock, Bernd and Krohn, Torben and Dans, Silvana L and Hoffmeyer, Mónica S
Harmful Algae, ISSN 1568-9883, 09/2017, Volume 68, pp. 248 - 257
The gulfs that surround Península Valdés (PV), Golfo Nuevo and Golfo San José in Argentina, are important calving grounds for the southern right whale .... 
Eubalaena australis | Península Valdés | Right whale | Domoic acid | Pseudo-nitzschia | Domoic acid trophic transfer | ALEXANDRIUM | TAMARENSE LEBOUR BALECH | SEA LIONS | PSEUDO-NITZSCHIA BACILLARIOPHYCEAE | Peninsula Valdes | LIONS ZALOPHUS-CALIFORNIANUS | MORTALITY EVENT | RED-TIDE | GOLFO-NUEVO | CALANUS-AUSTRALIS | MARINE & FRESHWATER BIOLOGY | SHELLFISH TOXIN | Geography | Argentina | Environmental Monitoring | Kainic Acid - analogs & derivatives | Environmental Exposure - analysis | Chlorophyll A - analysis | Food Chain | Animals | Feces - chemistry | Zooplankton - metabolism | Female | Seasons | Whales - metabolism | Kainic Acid - toxicity | Cetacea | Mass spectrometry | Health aspects | Analysis | Mortality
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10. Full Text Ursolic acid improves domoic acid-induced cognitive deficits in mice
by Wu, Dong-mei and Lu, Jun and Zhang, Yan-qiu and Zhang, Zi-feng and Zheng, Yuan-lin and Hu, Bin and Cheng, Wei and Li, Meng-qiu
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2013, Volume 271, Issue 2, pp. 127 - 136
Our previous findings suggest that mitochondrial dysfunction is the mechanism underlying cognitive deficits induced by domoic acid (DA). Ursolic acid (UA), a... 
Ursolic acid | FoxO1 knockdown | Mitochondrial dysfunction | Domoic acid | Cognitive deficits | MOUSE-BRAIN | ACTIVATION | PROTEIN-KINASE | INDUCTION | MEDIATED INFLAMMATORY PATHWAYS | ESTROGEN-RECEPTOR | FOXO1 | D-GALACTOSE | TROXERUTIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCED NEUROTOXICITY | Cognition Disorders - chemically induced | Neuromuscular Depolarizing Agents - adverse effects | Triterpenes - therapeutic use | Kainic Acid - analogs & derivatives | Male | Phosphatidylinositol 3-Kinases - metabolism | Hippocampus - drug effects | Cognition Disorders - prevention & control | Forkhead Transcription Factors - metabolism | Mitochondrial Diseases - chemically induced | Kainic Acid - toxicity | Oncogene Protein v-akt - metabolism | Cognition Disorders - psychology | Mitochondrial Diseases - prevention & control | Animals, Genetically Modified | Psychomotor Performance - drug effects | Dependovirus | Maze Learning - drug effects | Mice, Inbred ICR | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Fluorescent Antibody Technique | Neuromuscular Depolarizing Agents - toxicity | Forkhead Box Protein O1 | Mice | Oxidative Stress - drug effects | Genetic Vectors | Kainic Acid - antagonists & inhibitors | Cyclooxygenase Inhibitors - therapeutic use | Index Medicus | HIPPOCAMPUS | BIOLOGICAL FUNCTIONS | FLUORESCENCE | HEME | ELECTRONS | PHOSPHORYLATION | MITOCHONDRIA | MICE | PROTEINS | 60 APPLIED LIFE SCIENCES | ATP
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11. Full Text Domoic acid in the tropical South Atlantic Ocean – An environment case study
by Fonseca Costa, Luiza Dy and De Souza, Márcio Silva and Werlang, Chariane Camila and Saint Pastous Madureira, Lauro Antônio and Weigert, Stefan Cruz and Coletto, Juliano Lauser and Peres de Pinho, Marcelo and Yunes, João Sarkis
Toxicon, ISSN 0041-0101, 09/2019, Volume 167, pp. 101 - 105
Domoic acid (DA) or Amnesic Shellfish Poisoning (ASP) produced by the genus diatom was investigated in two seasonal periods in fishing areas of in the South... 
Harmful algal blooms | Brazilian coast/environment | Pseudo-nitzschia spp | Skipjack tuna | Domoic acid | MORTALITY | COMPLEX BACILLARIOPHYCEAE | PSEUDODELICATISSIMA | BLOOMS | PUNGENS | PSEUDO-NITZSCHIA | VARIABILITY | PHARMACOLOGY & PHARMACY | SHELLFISH | TOXICOLOGY | DIATOM | DE-FUCA EDDY | Case studies | Ocean | Air pollution | Fishing | Index Medicus
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12. Amnesic shellfish poisoning
: domoic acid production by Pseudo-nitzschia diatoms
by Bates, S.S
2004, Aqua Info : aquaculture notes, Volume AIN 16.2004., 4
Canada | domoic acid | paralytic shellfish poisoning | Prince Edward I | Pseudo-nitzschia | mussel culture
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13. Domoic acid and Pseudo-nitzschia references [electronic resource]
: References sur l'acide domoique et sur les Pseudo-nitzschia
by Bates, S.S
2003
human food | poisonous orgamisms | seafood poisoning | biological poisons | marine toxins | Pseudo-nitzschia | toxicity tests | fish poisoning | bibliographies | poisonous shellfish | domoic acid toxicity
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14. Full Text Domoic acid and human exposure risks: A review
by Lefebvre, Kathi A and Robertson, Alison
Toxicon, ISSN 0041-0101, 2010, Volume 56, Issue 2, pp. 218 - 230
Domoic acid is a potent neurotoxin that is naturally produced by several diatom species of the genus . The toxin acts as a glutamate agonist and is excitotoxic... 
Harmful algal blooms | Amnesic shellfish poisoning | Excitotoxicity | Seafood safety | Review | Domoic acid | Chronic exposure | CEREBELLAR GRANULE NEURONS | LINKED-IMMUNOSORBENT-ASSAY | LIONS ZALOPHUS-CALIFORNIANUS | PRINCE-EDWARD-ISLAND | PERFORMANCE LIQUID-CHROMATOGRAPHY | AMINO-ACID | DIATOM PSEUDO-NITZSCHIA | PHARMACOLOGY & PHARMACY | SHELLFISH POISONING TOXIN | TOXICOLOGY | MONKEYS MACACA-FASCICULARIS | Neurotoxins - chemistry | Environmental Monitoring | Harmful Algal Bloom | Risk Assessment | Humans | Kainic Acid - analogs & derivatives | Marine Toxins - poisoning | Shellfish Poisoning - etiology | Animals | Marine Toxins - chemistry | Neurotoxins - poisoning | Ecosystem | Molecular Structure | Shellfish Poisoning - prevention & control | Shellfish - analysis | Kainic Acid - chemistry | Kainic Acid - poisoning | Index Medicus | Human | Marine | Populations | Health | Risk | Poisoning | Toxins | Glutamates | Monitoring
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