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1. Functional selectivity and classical concepts of quantitative pharmacology
by Urban, Jonathan D and Clarke, William P and Von Zastrow, Mark and Nichols, David E and Kobilka, Brian and Weinstein, Harel and Javitch, Jonathan A and Roth, Bryan L and Christopoulos, Arthur and Sexton, Patrick M and Miller, Keith J and Spedding, Michael and Mailman, Richard B
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2007, Volume 320, Issue 1, pp. 1 - 13
The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century, yet recent data have revealed that many ligands can differentially... 
METABOTROPIC GLUTAMATE-RECEPTOR | PROTEIN-COUPLED RECEPTOR | DOPAMINE SYSTEM STABILIZERS | BETA-ADRENERGIC-RECEPTOR | PHOSPHOLIPASE-C | 5-HYDROXYTRYPTAMINE(2A) RECEPTOR | PHARMACOLOGY & PHARMACY | AGONIST-DIRECTED TRAFFICKING | ADENYLATE-CYCLASE | MU-OPIOID RECEPTOR | MESSENGER-RNA LEVELS | Receptors, Adrenergic, beta-2 - physiology | Humans | Receptors, Adrenergic, beta-2 - drug effects | Receptors, Vasopressin - drug effects | Receptors, Adrenergic, beta-2 - chemistry | Receptors, Vasopressin - chemistry | Receptors, Cell Surface - drug effects | Receptors, Dopamine D2 - drug effects | Receptors, Dopamine D2 - chemistry | Receptors, Cell Surface - chemistry | Receptors, Cell Surface - physiology | Receptors, G-Protein-Coupled - drug effects | Receptors, Dopamine D1 - chemistry | Receptors, G-Protein-Coupled - physiology | Receptors, Opioid, mu - chemistry | Signal Transduction | Receptors, Opioid, mu - drug effects | Receptors, Dopamine D1 - drug effects | Animals | Receptors, Dopamine D1 - physiology | Receptors, Vasopressin - physiology | Ligands | Protein Conformation | Receptors, Dopamine D2 - physiology | Receptors, G-Protein-Coupled - chemistry | Receptors, Opioid, mu - physiology
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2. Full Text Asenapine: a novel psychopharmacologic agent with a unique human receptor signature
by Shahid, M and Walker, GB and Zorn, SH and Wong, Ehf
Journal of Psychopharmacology, ISSN 0269-8811, 01/2009, Volume 23, Issue 1, pp. 65 - 73
Asenapine is a novel psychopharmacologic agent under development for the treatment of schizophrenia and bipolar disorder. We determined and compared the human... 
Schizophrenia | Affinity | Bipolar disorder | Asenapine | Human receptor | NEGATIVE SYMPTOMS | PSYCHIATRY | FOCUS | SEROTONIN RECEPTORS | DISORDERS | RISPERIDONE | schizophrenia | COGNITION | NEUROSCIENCES | CLINICAL NEUROLOGY | bipolar disorder | DOPAMINE D-3 RECEPTOR | PSYCHOSIS | ATYPICAL ANTIPSYCHOTIC-DRUG | PHARMACOLOGY & PHARMACY | asenapine | human receptor | affinity | Humans | Receptors, Serotonin - drug effects | Substrate Specificity | Receptors, Serotonin - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Psychotropic Drugs - therapeutic use | Receptors, Dopamine - drug effects | Clozapine - pharmacology | Histamine Release - genetics | Receptors, Muscarinic - drug effects | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Receptors, Adrenergic - drug effects | Psychotropic Drugs - pharmacology | Cloning, Molecular | Receptors, Adrenergic - genetics | Receptors, Dopamine D2 - drug effects | Inhibitory Concentration 50 | Molecular Structure | Radioligand Assay | Histamine Release - drug effects | Receptors, Muscarinic - genetics | Benzodiazepines - pharmacology | Heterocyclic Compounds, 4 or More Rings - chemistry | Clinical Trials as Topic | Psychotropic Drugs - chemistry | Bipolar Disorder - drug therapy | Receptors, Dopamine D2 - physiology | Schizophrenia - drug therapy | Receptors, Dopamine - genetics | Histamine receptors | Drugs | Neuroleptics | Olanzapine | Acetylcholine receptors (muscarinic) | Mental disorders | Dopamine D4 receptors | Serotonin S1 receptors | Serotonin S7 receptors | Psychotropic drugs | Receptors | Histamine H2 receptors | Risperidone | Dopamine D2 receptors | Dopamine receptors | Binding | Dopamine | Serotonin | Dopamine D3 receptors | Serotonin S6 receptors | Serotonin S2 receptors | Histamine | Dopamine D1 receptors | Serotonin receptors | Receptors (physiology) | Index Medicus
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3. Full Text Pharmacological properties of S1RA, a new sigma‐1 receptor antagonist that inhibits neuropathic pain and activity‐induced spinal sensitization
by Romero, L and Zamanillo, D and Nadal, X and Sánchez‐Arroyos, R and Rivera‐Arconada, I and Dordal, A and Montero, A and Muro, A and Bura, A and Segalés, C and Laloya, M and Hernández, E and Portillo‐Salido, E and Escriche, M and Codony, X and Encina, G and Burgueño, J and Merlos, M and Baeyens, JM and Giraldo, J and López‐García, JA and Maldonado, R and Plata‐Salamán, CR and Vela, JM
British Journal of Pharmacology, ISSN 0007-1188, 08/2012, Volume 166, Issue 8, pp. 2289 - 2306
BACKGROUND AND PURPOSE The sigma‐1 (σ 1 ) receptor is a ligand‐regulated molecular chaperone that has been involved in pain, but there is limited understanding... 
central sensitization | neuropathic pain | S1RA (E‐52862) | sigma‐1 receptor | S1RA (E-52862)σ-1 receptor | NMDA RECEPTOR | ACTIVATION | RAT | PHOSPHORYLATION | S1RA (E-52862) | sigma-1 receptor | GUINEA-PIG BRAIN | PERIPHERAL-NERVE INJURY | CORTICAL-NEURONS | OPIOID ANALGESIA | PHARMACOLOGY & PHARMACY | FORMALIN TEST | METHYL-D-ASPARTATE | Analgesics - pharmacology | Electric Stimulation | Capsaicin - toxicity | Gene Expression Regulation - physiology | Morpholines - pharmacology | Male | Receptors, sigma - antagonists & inhibitors | Neuralgia - drug therapy | Behavior, Animal | Gene Expression Regulation - drug effects | Animals | Mice | Formaldehyde - toxicity | Pain Measurement | Pyrazoles - pharmacology | Physiological aspects | Care and treatment | Pain | Analysis | Medical research | Research Papers
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4. Full Text Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine – searching for the connections
by Danysz, Wojciech and Parsons, Chris G
British Journal of Pharmacology, ISSN 0007-1188, 09/2012, Volume 167, Issue 2, pp. 324 - 352
β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying Alzheimer's disease (AD), although there is presently lively debate... 
β ‐amyloid | NMDA | LTP | memantine | Alzheimer's disease | glutamate | β -amyloid | D-ASPARTATE RECEPTORS | ss -amyloid | NITRIC-OXIDE-SYNTHASE | CULTURED HIPPOCAMPAL-NEURONS | EXCITATORY AMINO-ACIDS | DEPENDENT CALCIUM-CHANNELS | TUMOR-NECROSIS-FACTOR | A-BETA | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | TRANSGENIC MOUSE MODEL | IMPAIR SYNAPTIC PLASTICITY | Memantine - pharmacology | Amyloid beta-Peptides - genetics | Humans | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Alzheimer Disease - drug therapy | Glutamic Acid - metabolism | Dopamine Agents - therapeutic use | Receptors, N-Methyl-D-Aspartate - genetics | Reviews
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5. Dopamine receptor technologies
by Tiberi, Mario
2015, 2015, Neuromethods, ISBN 9781493921959, Volume 96., xiv, 379 pages
Medicine | Neurochemistry | Neurosciences | Receptors | Dopamine | Receptors, Dopamine | Dopamine Agents | Biomedicine
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6. Full Text Time-resolved FRET between GPCR ligands reveals oligomers in native tissues
by Kralikova, Michaela and Stoev, Stoytcho and Seyer, René and Roux, Thomas and Cottet, Martin and Javitch, Jonathan and Brabet, Isabelle and Lamarque, Laurent and Newman, Amy and Pin, Jean-Philippe and Bourrier, Emmanuel and Albizu, Laura and Breton, Christophe and Bazin, Hervé and Trinquet, Eric and Rives, Marie-Laure and Manning, Maurice and Mouillac, Bernard and Durroux, Thierry
Nature Chemical Biology, ISSN 1552-4450, 08/2010, Volume 6, Issue 8, pp. 587 - 594
G protein-coupled receptor (GPCR) oligomers have been proposed to play critical roles in cell signaling, but confirmation of their existence in a native... 
VASOPRESSIN RECEPTOR | HORMONE-RECEPTORS | HUMAN OXYTOCIN RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-COUPLED-RECEPTORS | IN-VIVO | PEPTIDE ANTAGONIST | DIMERIC GPCR | BINDING-PROPERTIES | HUMAN V1A | FLUORESCENCE ENERGY-TRANSFER | Receptors, G-Protein-Coupled - metabolism | Receptors, Vasopressin - metabolism | Cercopithecus aethiops | Receptors, G-Protein-Coupled - agonists | Receptors, Dopamine D2 - metabolism | Receptors, Oxytocin - agonists | Female | Radioligand Assay | Dimerization | Oligopeptides - chemistry | Receptors, Vasopressin - agonists | Cell Line | Receptors, Oxytocin - antagonists & inhibitors | Receptors, Dopamine D2 - agonists | Models, Molecular | Rats | Oligopeptides - metabolism | Receptors, Oxytocin - metabolism | Algorithms | Animals | Mammary Glands, Animal - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | Fluorescence Resonance Energy Transfer - methods | Ligands | Antidiuretic Hormone Receptor Antagonists | COS Cells | Dopamine D2 Receptor Antagonists | Fluorescent Dyes | Proteins | Fluorescence | Signal transduction | Biochemistry | Cellular biology
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7. Neurotransmitter receptors
by Enna, S. J and Yamamura, Henry I
1980, Receptors and recognition., ISBN 9780412231308, Volume 9-10., 2 v.
Neurotransmitter receptors | Récepteurs neurotransmetteurs
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8. Dopamine receptors
by Creese, Ian and Fraser, Claire M
1987, Receptor biochemistry and methodology, ISBN 9780845137079, Volume 8, ix, 261
Receptors, Dopamine | Receptors | Dopamine
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9. The dopamine receptors
by Neve, Kim A and Neve, Rachael L
1997, Receptors, ISBN 089603433X, xi, 553
physiology | Receptors | Dopamine | Receptors, Dopamine
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10. Full Text Biased ligand modulation of seven transmembrane receptors (7TMRs): Functional implications for drug discovery
by Correll, Craig C and McKittrick, Brian A
Journal of Medicinal Chemistry, ISSN 0022-2623, 2014, Volume 57, Issue 16, pp. 6887 - 6896
Seven transmembrane receptors (7TMRs), also known as G-protein-coupled receptors (GPCRs), have proven to be valuable targets for the development of... 
BETA-ARRESTIN 2 | 7-TRANSMEMBRANE RECEPTORS | CHEMISTRY, MEDICINAL | NICOTINIC-ACID RECEPTOR | CARDIAC MYOCYTES | HEART-FAILURE | PROTEIN-COUPLED RECEPTORS | ANGIOTENSIN-II | ENERGY-TRANSFER BRET | MU-OPIOID RECEPTOR | BETA-ADRENERGIC RECEPTOR | Receptors, Nicotinic - metabolism | Receptors, Opioid, mu - chemistry | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Receptors, Opioid, mu - metabolism | Humans | Receptors, Dopamine D2 - agonists | Drug Discovery - methods | Receptors, Adrenergic, beta-1 - metabolism | Receptors, Adrenergic, beta-1 - chemistry | Receptors, Dopamine D2 - metabolism | Arrestins - metabolism | Receptors, Adrenergic, beta-2 - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Animals | Receptors, Nicotinic - chemistry | beta-Arrestins | Receptors, Dopamine D2 - chemistry | Ligands | Protein Conformation | Receptors, G-Protein-Coupled - chemistry | Index Medicus
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11. Full Text The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors-relevance to Parkinson's disease
by Marwarha, Gurdeep and Rhen, Turk and Schommer, Trevor and Ghribi, Othman
Journal of Neurochemistry, ISSN 0022-3042, 12/2011, Volume 119, Issue 5, pp. 1119 - 1136
Loss of dopaminergic neurons and a-synuclein accumulation are the two major pathological hallmarks of Parkinsons disease. Currently, the mechanisms governing... 
Parkinson's disease | 27-hydroxycholesterol | liver X receptor | estrogen receptors | α-synuclein | tyrosine hydroxylase | CAMP RESPONSE ELEMENT | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | MESSENGER-RNA LEVELS | LXR-ALPHA | NUCLEAR RECEPTOR | BETA-DEFICIENT MICE | GENE-EXPRESSION | INDUCED DOPAMINE DEPLETION | NEURONAL CELLS | RAT-BRAIN | a-synuclein | Humans | Neuroblastoma - enzymology | Estrogen Receptor alpha - agonists | Estrogen Receptor beta - agonists | alpha-Synuclein - biosynthesis | Estrogen Receptor beta - biosynthesis | Liver X Receptors | Up-Regulation - physiology | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Estrogen Receptor beta - antagonists & inhibitors | Neuroblastoma - pathology | Orphan Nuclear Receptors - agonists | Tyrosine 3-Monooxygenase - antagonists & inhibitors | Estrogen Receptor alpha - antagonists & inhibitors | Signal Transduction - genetics | Down-Regulation - drug effects | Hydroxycholesterols - pharmacology | Orphan Nuclear Receptors - biosynthesis | Disease Progression | Down-Regulation - physiology | Up-Regulation - drug effects | Tyrosine 3-Monooxygenase - biosynthesis | Tyrosine 3-Monooxygenase - genetics | Orphan Nuclear Receptors - antagonists & inhibitors | Parkinson Disease - prevention & control | Parkinson Disease - enzymology | Cell Line, Tumor | Signal Transduction - physiology | Estrogen Receptor alpha - biosynthesis | Neuroblastoma - metabolism
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12. More about receptors
by Lamble, John W
1982, Current reviews in biomedicine, ISBN 0444804285, Volume 2, xii, 179
Hormone receptors | Receptors, Hormone | Pharmacology | Receptors, Drug | Biopharmaceutics | Collected works | Drug receptors
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13. Full Text Drug targets for cognitive enhancement in neuropsychiatric disorders
by Wallace, Tanya L and Ballard, Theresa M and Pouzet, Bruno and Riedel, Wim J and Wettstein, Joseph G
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 2011, Volume 99, Issue 2, pp. 130 - 145
The investigation of novel drug targets for treating cognitive impairments associated with neurological and psychiatric disorders remains a primary focus of... 
Dopamine | Serotonin | Memory | Attention | Schizophrenia | Glutamate | Glycine | Learning | Histamine | GABA | Acetylcholine | Phosphodiesterase | Alzheimer's | POSITIVE ALLOSTERIC MODULATOR | CONTAINING GABA(A) RECEPTORS | GILL-WITHDRAWAL REFLEX | ALPHA-7 NICOTINIC RECEPTOR | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | LONG-TERM POTENTIATION | METABOTROPIC GLUTAMATE-RECEPTOR | NEUROSCIENCES | MUSCARINIC ACETYLCHOLINE-RECEPTORS | EVENT-RELATED POTENTIALS | HISTAMINE H-3 RECEPTOR | Memory - drug effects | Receptors, Histamine - physiology | Receptors, Serotonin - physiology | Cognition Disorders - physiopathology | Learning - drug effects | Humans | Receptors, Cholinergic - drug effects | Receptors, Serotonin - drug effects | Phosphodiesterase Inhibitors - pharmacology | Receptors, Histamine - drug effects | Cognition Disorders - drug therapy | Receptors, Glutamate - drug effects | Receptors, Cholinergic - physiology | Receptors, Dopamine - drug effects | Learning - physiology | Animals | Glycine Plasma Membrane Transport Proteins - drug effects | Glycine Plasma Membrane Transport Proteins - physiology | Receptors, GABA - physiology | Nootropic Agents - pharmacology | Receptors, Dopamine - physiology | Receptors, Glutamate - physiology | Memory - physiology | Receptors, GABA - drug effects | Nervous system diseases | Attention-deficit hyperactivity disorder | Amyloid beta-protein | Alzheimer's disease
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